{"id":"https://openalex.org/W2807285609","doi":"https://doi.org/10.3174/ajnr.a5687","title":"Global and Widespread Local White Matter Abnormalities in Juvenile Neuronal Ceroid Lipofuscinosis","display_name":"Global and Widespread Local White Matter Abnormalities in Juvenile Neuronal Ceroid Lipofuscinosis","publication_year":2018,"publication_date":"2018-05-31","ids":{"openalex":"https://openalex.org/W2807285609","doi":"https://doi.org/10.3174/ajnr.a5687","mag":"2807285609","pmid":"https://pubmed.ncbi.nlm.nih.gov/29853519","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7655432"},"language":"en","primary_location":{"id":"doi:10.3174/ajnr.a5687","doi":"https://doi.org/10.3174/ajnr.a5687","is_oa":true,"landing_page_url":"https://doi.org/10.3174/ajnr.a5687","pdf_url":"http://www.ajnr.org/content/ajnr/39/7/1349.full.pdf","source":{"id":"https://openalex.org/S101278519","display_name":"American Journal of Neuroradiology","issn_l":"0195-6108","issn":["0195-6108","1936-959X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316165","host_organization_name":"American Society of Neuroradiology","host_organization_lineage":["https://openalex.org/P4310316165"],"host_organization_lineage_names":["American Society of Neuroradiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Neuroradiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.ajnr.org/content/ajnr/39/7/1349.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084858413","display_name":"Ulrika Roine","orcid":"https://orcid.org/0000-0002-6985-4261","observed_orcids":["https://orcid.org/0000-0002-6985-4261"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"U. Roine","raw_affiliation_strings":["From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center ulrika.roine@helsinki.fi","aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center"],"raw_orcid":"https://orcid.org/0000-0002-6985-4261","affiliations":[{"raw_affiliation_string":"From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center ulrika.roine@helsinki.fi","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028336276","display_name":"Timo Roine","orcid":"https://orcid.org/0000-0002-3104-9734","observed_orcids":["https://orcid.org/0000-0002-3104-9734"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["BE","FI"],"is_corresponding":false,"raw_author_name":"T.J. Roine","raw_affiliation_strings":["From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","imec-Vision Lab (T.J.R.), Department of Physics, University of Antwerp, Wilrijk (Antwerp), Belgium","aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","dimec-Vision Lab (T.J.R.), Department of Physics, University of Antwerp, Wilrijk (Antwerp), Belgium"],"raw_orcid":"https://orcid.org/0000-0002-3104-9734","affiliations":[{"raw_affiliation_string":"From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"imec-Vision Lab (T.J.R.), Department of Physics, University of Antwerp, Wilrijk (Antwerp), Belgium","institution_ids":["https://openalex.org/I149213910"]},{"raw_affiliation_string":"aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"dimec-Vision Lab (T.J.R.), Department of Physics, University of Antwerp, Wilrijk (Antwerp), Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Hakkarainen","orcid":"https://orcid.org/0000-0002-7367-2532","observed_orcids":["https://orcid.org/0000-0002-7367-2532"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A. Hakkarainen","raw_affiliation_strings":["From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center"],"raw_orcid":"https://orcid.org/0000-0002-7367-2532","affiliations":[{"raw_affiliation_string":"From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074387916","display_name":"Anna M. Tokola","orcid":"https://orcid.org/0000-0002-5135-2191","observed_orcids":["https://orcid.org/0000-0002-5135-2191"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A. Tokola","raw_affiliation_strings":["From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center"],"raw_orcid":"https://orcid.org/0000-0002-5135-2191","affiliations":[{"raw_affiliation_string":"From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017524671","display_name":"Marja H. Balk","orcid":"https://orcid.org/0000-0002-6573-246X","observed_orcids":["https://orcid.org/0000-0002-6573-246X"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M.H. Balk","raw_affiliation_strings":["From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center"],"raw_orcid":"https://orcid.org/0000-0002-6573-246X","affiliations":[{"raw_affiliation_string":"From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048788605","display_name":"Minna Mannerkoski","orcid":"https://orcid.org/0000-0002-3812-8427","observed_orcids":["https://orcid.org/0000-0002-3812-8427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Mannerkoski","raw_affiliation_strings":["Departments of Child Psychiatry (M.M.)","bDepartments of Child Psychiatry (M.M.)"],"raw_orcid":"https://orcid.org/0000-0002-3812-8427","affiliations":[{"raw_affiliation_string":"Departments of Child Psychiatry (M.M.)","institution_ids":[]},{"raw_affiliation_string":"bDepartments of Child Psychiatry (M.M.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059101342","display_name":"Laura E \u00c5berg","orcid":"https://orcid.org/0000-0001-8781-1153","observed_orcids":["https://orcid.org/0000-0001-8781-1153"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"L.E. \u00c5berg","raw_affiliation_strings":["Psychiatry (L.E.\u00c5), University of Helsinki and Helsinki University Hospital, Helsinki, Finland","cPsychiatry (L.E.\u00c5), University of Helsinki and Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-8781-1153","affiliations":[{"raw_affiliation_string":"Psychiatry (L.E.\u00c5), University of Helsinki and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"cPsychiatry (L.E.\u00c5), University of Helsinki and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055881297","display_name":"Tuula R I L\u00f6nnqvist","orcid":"https://orcid.org/0000-0001-9737-7020","observed_orcids":["https://orcid.org/0000-0001-9737-7020"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. L\u00f6nnqvist","raw_affiliation_strings":["Department of Child Neurology (T.L.), Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland","eDepartment of Child Neurology (T.L.), Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-9737-7020","affiliations":[{"raw_affiliation_string":"Department of Child Neurology (T.L.), Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210090554"]},{"raw_affiliation_string":"eDepartment of Child Neurology (T.L.), Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210090554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070668037","display_name":"Taina H Autti","orcid":"https://orcid.org/0000-0001-9065-9818","observed_orcids":["https://orcid.org/0000-0001-9065-9818"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. Autti","raw_affiliation_strings":["From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center"],"raw_orcid":"https://orcid.org/0000-0001-9065-9818","affiliations":[{"raw_affiliation_string":"From the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"aFrom the Department of Radiology (U.R., T.J.R., A.H., A.T., M.H.B., T.A.), HUS Medical Imaging Center","institution_ids":["https://openalex.org/I2800394112"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8737,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.71232877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"39","issue":"7","first_page":"1349","last_page":"1354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.24729999899864197,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/batten-disease","display_name":"Batten disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.8579999804496765},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"diffusion MRI","score":0.753000020980835},{"id":"https://openalex.org/keywords/white-matter-abnormalities","display_name":"white matter abnormalities","score":0.5979999899864197},{"id":"https://openalex.org/keywords/lysosomal-storage-disorders","display_name":"lysosomal storage disease","score":0.7269999980926514},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.41100001335144043},{"id":"https://openalex.org/keywords/constrained-spherical-deconvolution","display_name":"constrained spherical deconvolution","score":0.8130000233650208},{"id":"https://openalex.org/keywords/whole-brain-tractography","display_name":"whole-brain tractography","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tract-based-spatial-statistics","display_name":"tract-based spatial statistics","score":0.9340000152587891},{"id":"https://openalex.org/keywords/white-matter-microstructural-changes","display_name":"white matter microstructural changes","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7324694395065308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6156941652297974},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4703657329082489},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.46855291724205017},{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.46474286913871765},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.41756439208984375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3825371563434601},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37275758385658264},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3426600694656372},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3362146317958832},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2001752257347107},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1932072639465332}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009472","descriptor_name":"Neuronal Ceroid-Lipofuscinoses","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009472","descriptor_name":"Neuronal Ceroid-Lipofuscinoses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3174/ajnr.a5687","doi":"https://doi.org/10.3174/ajnr.a5687","is_oa":true,"landing_page_url":"https://doi.org/10.3174/ajnr.a5687","pdf_url":"http://www.ajnr.org/content/ajnr/39/7/1349.full.pdf","source":{"id":"https://openalex.org/S101278519","display_name":"American Journal of Neuroradiology","issn_l":"0195-6108","issn":["0195-6108","1936-959X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316165","host_organization_name":"American Society of Neuroradiology","host_organization_lineage":["https://openalex.org/P4310316165"],"host_organization_lineage_names":["American Society of Neuroradiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Neuroradiology","raw_type":"journal-article"},{"id":"pmid:29853519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29853519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJNR. American journal of neuroradiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7655432","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7655432/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJNR Am J Neuroradiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3174/ajnr.a5687","doi":"https://doi.org/10.3174/ajnr.a5687","is_oa":true,"landing_page_url":"https://doi.org/10.3174/ajnr.a5687","pdf_url":"http://www.ajnr.org/content/ajnr/39/7/1349.full.pdf","source":{"id":"https://openalex.org/S101278519","display_name":"American Journal of Neuroradiology","issn_l":"0195-6108","issn":["0195-6108","1936-959X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316165","host_organization_name":"American Society of Neuroradiology","host_organization_lineage":["https://openalex.org/P4310316165"],"host_organization_lineage_names":["American Society of Neuroradiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Neuroradiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308508","display_name":"Batten Disease Support and Research Association","ror":"https://ror.org/00821cz13"},{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320324406","display_name":"Paulon S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/048e7gn38"},{"id":"https://openalex.org/F4320324452","display_name":"Suomen Aivos\u00e4\u00e4ti\u00f6","ror":"https://ror.org/01qe64w73"},{"id":"https://openalex.org/F4320338282","display_name":"Actelion Pharmaceuticals","ror":"https://ror.org/001yedb91"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807285609.pdf","grobid_xml":"https://content.openalex.org/works/W2807285609.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W3067256","https://openalex.org/W1024451551","https://openalex.org/W1540274096","https://openalex.org/W1556167233","https://openalex.org/W1964802316","https://openalex.org/W1967424170","https://openalex.org/W1968602556","https://openalex.org/W1970046799","https://openalex.org/W1978960907","https://openalex.org/W1985055689","https://openalex.org/W1986269945","https://openalex.org/W1988334189","https://openalex.org/W1988358599","https://openalex.org/W2001611992","https://openalex.org/W2006096283","https://openalex.org/W2010126457","https://openalex.org/W2010740985","https://openalex.org/W2022530159","https://openalex.org/W2034252184","https://openalex.org/W2036785860","https://openalex.org/W2038299792","https://openalex.org/W2041057649","https://openalex.org/W2044650614","https://openalex.org/W2052713823","https://openalex.org/W2053884965","https://openalex.org/W2060441085","https://openalex.org/W2063001897","https://openalex.org/W2069988696","https://openalex.org/W2071496441","https://openalex.org/W2074888367","https://openalex.org/W2078557934","https://openalex.org/W2084220365","https://openalex.org/W2088234686","https://openalex.org/W2096958018","https://openalex.org/W2106841463","https://openalex.org/W2108601769","https://openalex.org/W2112111016","https://openalex.org/W2118811112","https://openalex.org/W2119450847","https://openalex.org/W2121941288","https://openalex.org/W2126693856","https://openalex.org/W2137679584","https://openalex.org/W2142900310","https://openalex.org/W2150433430","https://openalex.org/W2150667092","https://openalex.org/W2154452584","https://openalex.org/W2165020904","https://openalex.org/W2168844688","https://openalex.org/W2292756937","https://openalex.org/W2417627110","https://openalex.org/W2750623447","https://openalex.org/W4249888301"],"related_works":["https://openalex.org/W2985050036","https://openalex.org/W1978960907","https://openalex.org/W2039570934","https://openalex.org/W2052398620","https://openalex.org/W1970046799","https://openalex.org/W2041057649","https://openalex.org/W2358885453","https://openalex.org/W1991921373","https://openalex.org/W7097914706","https://openalex.org/W2012700121"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,101],"PURPOSE:":[2],"Juvenile":[3],"neuronal":[4,116,203],"ceroid":[5,117,204],"lipofuscinosis":[6,118,205],"is":[7],"a":[8,97,158,232],"progressive":[9,44],"neurodegenerative":[10],"lysosomal":[11],"storage":[12],"disease":[13],"of":[14,20,25,73,77],"childhood.":[15],"It":[16],"manifests":[17],"with":[18,114,201],"loss":[19,24],"vision,":[21],"seizures,":[22],"and":[23,27,41,51,106,127,168,195,208,223],"cognitive":[26],"motor":[28],"functions":[29],"leading":[30],"to":[31,81],"premature":[32],"death.":[33],"Previous":[34],"MR":[35,62,85,143],"imaging":[36,63,86,144],"studies":[37,216],"have":[38],"reported":[39],"cerebral":[40],"cerebellar":[42],"atrophy,":[43,46],"hippocampal":[45],"thalamic":[47],"signal":[48],"intensity":[49],"alterations,":[50],"decreased":[52],"white":[53,91,108,164,212],"matter":[54,92,109,165,213],"volume":[55],"in":[56,90,111,211],"the":[57,193],"corona":[58],"radiata.":[59],"However,":[60,187],"conventional":[61],"findings":[64],"are":[65,228],"usually":[66],"normal":[67],"at":[68,96,231],"younger":[69,98,233],"than":[70],"10":[71,125],"years":[72,147],"age.":[74,99,234],"The":[75,199],"purpose":[76],"our":[78],"study":[79,224],"was":[80],"investigate":[82],"whether":[83,225],"diffusion":[84],"could":[87,217],"reveal":[88],"changes":[89],"microstructure":[93],"already":[94,229],"present":[95,230],"MATERIALS":[100],"METHODS:":[102],"We":[103,156],"investigated":[104,176],"global":[105,159,207],"local":[107,177,209],"abnormalities":[110,179,210,227],"14":[112,128],"children":[113],"juvenile":[115,202],"(mean":[119,131,148],"age,":[120,132,149],"9.6":[121],"\u00b1":[122,134,151],"3.4":[123],"years;":[124,136,153],"boys)":[126],"control":[129],"subjects":[130],"11.2":[133],"2.3":[135],"7":[137],"boys).":[138,155],"Twelve":[139],"patients":[140,200],"underwent":[141],"follow-up":[142],"after":[145],"2":[146,162],"11.4":[150],"3.2":[152],"8":[154],"performed":[157],"analysis":[160],"using":[161,180],"approaches:":[163],"tract":[166],"skeleton":[167],"constrained":[169],"spherical":[170],"deconvolution-based":[171],"whole-brain":[172],"tractography.":[173],"Then,":[174],"we":[175,188],"microstructural":[178,221],"Tract-Based":[181],"Spatial":[182],"Statistics.":[183],"RESULTS:":[184],"<":[185],".001).":[186],"found":[189],"no":[190],"differences":[191],"between":[192],"first":[194],"second":[196],"acquisitions.":[197],"CONCLUSIONS:":[198],"exhibited":[206],"microstructure.":[214],"Future":[215],"apply":[218],"more":[219],"specific":[220],"models":[222],"these":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}