{"id":"https://openalex.org/W2807270513","doi":"https://doi.org/10.18632/oncotarget.25502","title":"Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells","display_name":"Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells","publication_year":2018,"publication_date":"2018-06-04","ids":{"openalex":"https://openalex.org/W2807270513","doi":"https://doi.org/10.18632/oncotarget.25502","mag":"2807270513","pmid":"https://pubmed.ncbi.nlm.nih.gov/29930757","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6007466"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.25502","doi":"https://doi.org/10.18632/oncotarget.25502","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25502","pdf_url":"https://www.oncotarget.com/article/25502/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/25502/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026989558","display_name":"Aina Bernal","orcid":"https://orcid.org/0000-0002-6754-5668","observed_orcids":["https://orcid.org/0000-0002-6754-5668"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aina Bernal","raw_affiliation_strings":["Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051535295","display_name":"Marc Molt\u00f3\u2010Abad","orcid":"https://orcid.org/0000-0002-6364-4570","observed_orcids":["https://orcid.org/0000-0002-6364-4570"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marc Molt\u00f3-Abad","raw_affiliation_strings":["Current address: Unitat de Malalties Minorit\u00e0ries, Hospital Universitari de la Vall d\u2019Hebron, 08035 Barcelona, Spain","Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Unitat de Malalties Minorit\u00e0ries, Hospital Universitari de la Vall d\u2019Hebron, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Dom\u00ednguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel Dom\u00ednguez","raw_affiliation_strings":["Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040846168","display_name":"Laura Tusell","orcid":"https://orcid.org/0000-0002-2848-345X","observed_orcids":["https://orcid.org/0000-0002-2848-345X"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Laura Tusell","raw_affiliation_strings":["Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Biologia Cel\u00b7lular, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain","institution_ids":["https://openalex.org/I123044942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040846168"],"corresponding_institution_ids":["https://openalex.org/I123044942"],"apc_list":null,"apc_paid":null,"fwci":0.1991,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43093451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"43","first_page":"27151","last_page":"27170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere-dysfunction","display_name":"telomere dysfunction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.7979999780654907},{"id":"https://openalex.org/keywords/breakage-fusion-bridge-cycles","display_name":"breakage-fusion-bridge cycles","score":0.9819999933242798},{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.7459999918937683},{"id":"https://openalex.org/keywords/shelterin","display_name":"shelterin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/telomere-uncapping","display_name":"telomere uncapping","score":0.718999981880188},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.7450000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4749999940395355},{"id":"https://openalex.org/keywords/cell-cycle-withdrawal","display_name":"cell cycle withdrawal","score":0.47200000286102295},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.884844958782196},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5700632333755493},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5667012929916382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4486796259880066},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.366983562707901},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36229121685028076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3169274926185608},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.253462553024292},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.21114811301231384}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.18632/oncotarget.25502","doi":"https://doi.org/10.18632/oncotarget.25502","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25502","pdf_url":"https://www.oncotarget.com/article/25502/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4963545","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6007466","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6007466","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6007466","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:29930757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29930757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:ddd.uab.cat:238827","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/238827","pdf_url":null,"source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:recercat.cat:2072/448018","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2072/448018","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.25502","doi":"https://doi.org/10.18632/oncotarget.25502","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25502","pdf_url":"https://www.oncotarget.com/article/25502/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5751660886","display_name":null,"funder_award_id":"2014 SGR 524","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G8739020986","display_name":null,"funder_award_id":"456-01-1/2012","funder_id":"https://openalex.org/F4320326826","funder_display_name":"Universitat Aut\u00f2noma de Barcelona"},{"id":"https://openalex.org/G985971609","display_name":null,"funder_award_id":"2014SGR","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"}],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320323428","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57"},{"id":"https://openalex.org/F4320326826","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94"},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807270513.pdf","grobid_xml":"https://content.openalex.org/works/W2807270513.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1498688899","https://openalex.org/W1517965589","https://openalex.org/W1543500873","https://openalex.org/W1565166977","https://openalex.org/W1586705704","https://openalex.org/W1896854564","https://openalex.org/W1899376386","https://openalex.org/W1964949716","https://openalex.org/W1966933830","https://openalex.org/W1970891016","https://openalex.org/W1972655555","https://openalex.org/W1973483964","https://openalex.org/W1979165906","https://openalex.org/W1982199027","https://openalex.org/W1983931124","https://openalex.org/W1984896609","https://openalex.org/W1995635039","https://openalex.org/W2004633166","https://openalex.org/W2008341238","https://openalex.org/W2010941702","https://openalex.org/W2016393918","https://openalex.org/W2019864024","https://openalex.org/W2025088179","https://openalex.org/W2027345413","https://openalex.org/W2032407757","https://openalex.org/W2033673317","https://openalex.org/W2035389897","https://openalex.org/W2037803457","https://openalex.org/W2043486701","https://openalex.org/W2050866625","https://openalex.org/W2050974174","https://openalex.org/W2053300345","https://openalex.org/W2061928415","https://openalex.org/W2063158632","https://openalex.org/W2068954038","https://openalex.org/W2072744580","https://openalex.org/W2074392869","https://openalex.org/W2081944825","https://openalex.org/W2088926897","https://openalex.org/W2100072286","https://openalex.org/W2102839588","https://openalex.org/W2105184570","https://openalex.org/W2106996266","https://openalex.org/W2108355069","https://openalex.org/W2109961065","https://openalex.org/W2117250543","https://openalex.org/W2122672345","https://openalex.org/W2126815966","https://openalex.org/W2130758991","https://openalex.org/W2131268542","https://openalex.org/W2142113620","https://openalex.org/W2145802624","https://openalex.org/W2163071635","https://openalex.org/W2164580633","https://openalex.org/W2168684318","https://openalex.org/W2169967640","https://openalex.org/W2197269124","https://openalex.org/W2393644277","https://openalex.org/W2525286384","https://openalex.org/W2577194681"],"related_works":["https://openalex.org/W3085571056","https://openalex.org/W2157382114","https://openalex.org/W1995635039","https://openalex.org/W1558165792","https://openalex.org/W2034563381","https://openalex.org/W2003924514","https://openalex.org/W2162227162","https://openalex.org/W2096133386","https://openalex.org/W2883812242","https://openalex.org/W2039765008"],"abstract_inverted_index":{"//":[0],"Aina":[1],"Bernal":[2],"1":[3,12,16,17],",":[4,9],"Marc":[5],"Molt\u00f3-Abad":[6],"1,":[7],"2":[8,34],"Daniel":[10],"Dom\u00ednguez":[11],"and":[13,108],"Laura":[14,52],"Tusell":[15],"Unitat":[18,37],"de":[19,23,27,38,43],"Biologia":[20],"Cel\u00b7lular,":[21],"Facultat":[22],"Bioci\u00e8ncies,":[24],"Universitat":[25],"Aut\u00f2noma":[26],"Barcelona,":[28,48],"08193":[29],"Cerdanyola":[30],"del":[31],"Vall\u00e8s,":[32],"Spain":[33,49],"Current":[35],"address:":[36],"Malalties":[39],"Minorit\u00e0ries,":[40],"Hospital":[41],"Universitari":[42],"la":[44],"Vall":[45],"d\u2019Hebron,":[46],"08035":[47],"Correspondence":[50],"to:":[51],"Tusell,":[53],"email:":[54],"laura.tusell@uab.cat":[55],"Keywords:":[56],"MCF-10A;":[57],"breast":[58],"epithelial":[59],"cells;":[60],"chromosome":[61,82],"instability;":[62],"telomere-dysfunction;":[63],"TRF2":[64,153,181],"\u0394B\u0394M":[65,155,182],"Received:":[66],"June":[67,75],"28,":[68],"2017":[69],"Accepted:":[70],"May":[71],"13,":[72],"2018":[73,77],"Published:":[74],"05,":[76],"ABSTRACT":[78],"Telomere":[79],"dysfunction":[80],"drives":[81],"instability":[83],"through":[84],"endless":[85],"breakage-fusion-bridge":[86],"(BFB)":[87],"cycles":[88,171],"that":[89,272],"promote":[90],"the":[91,114,150,191,216,236,252,261,273,290,304],"formation":[92],"of":[93,99,117,121,129,144,149,168,193,200,215,251,263,266,275,289,306],"highly":[94],"rearranged":[95],"genomes.":[96],"However,":[97],"reactivation":[98],"telomerase":[100],"or":[101,259,268],"ALT-pathway":[102],"is":[103],"required":[104],"for":[105,280],"genome":[106],"stabilisation":[107],"full":[109],"malignant":[110],"transformation.":[111],"To":[112],"allow":[113],"unrestricted":[115],"proliferation":[116,176,188],"cells":[118,137,157,230,241],"at":[119,256],"risk":[120],"transformation,":[122],"we":[123],"have":[124],"established":[125],"a":[126,145,232,281,286],"conditional":[127],"system":[128],"telomere":[130,159,203,217],"deprotection":[131,222,274],"in":[132,185,190,208,226,240,285],"p16":[133],"INK4a":[134],"-deficient":[135],"MCF-10A":[136],"with":[138,158,231],"modified":[139],"checkpoints.":[140],"After":[141],"sustained":[142],"expression":[143,183],"dominant":[146],"negative":[147],"form":[148],"shelterin":[151],"protein":[152],"(TRF2":[154],"),":[156],"fusion":[160],"did":[161,205,224],"progress":[162],"to":[163,219],"anaphase":[164],"but":[165],"no":[166],"signs":[167],"ongoing":[169],"BFB":[170],"were":[172],"observed,":[173],"thus":[174],"anticipating":[175],"defects.":[177],"Indeed,":[178],"96":[179,201],"h":[180,202],"resulted":[184],"noticeable":[186],"growth":[187,237],"defects":[189],"absence":[192],"cell":[194,209,298,301],"cycle":[195,210],"disturbances.":[196],"Further":[197],"transient":[198],"periods":[199,223],"uncapping":[204],"not":[206,225,246],"result":[207],"disturbances":[211],"either.":[212],"And":[213],"reduction":[214],"damage":[218,254],"short":[220,282],"acute":[221],"any":[227],"case":[228],"engender":[229],"reorganised":[233],"karyotype.":[234],"Strikingly,":[235],"arrest":[238],"imposed":[239],"showing":[242],"dysfunctional":[243],"telomeres":[244,277],"was":[245],"accompanied":[247],"by":[248,260],"an":[249],"activation":[250,288],"DNA":[253],"response":[255,293],"cellular":[257,291],"level,":[258],"presence":[262],"visible":[264],"markers":[265],"senescence":[267],"apoptosis.":[269],"We":[270],"propose":[271],"many":[276],"simultaneously,":[278],"even":[279],"time,":[283],"results":[284],"local":[287],"stress":[292],"which":[294],"consequently":[295],"triggers":[296],"gradual":[297],"withdrawal":[299],"from":[300],"cycle,":[302],"restraining":[303],"onset":[305],"genomic":[307],"instability.":[308]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}