{"id":"https://openalex.org/W2807250734","doi":"https://doi.org/10.1038/s41598-018-26761-2","title":"Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics","display_name":"Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics","publication_year":2018,"publication_date":"2018-05-29","ids":{"openalex":"https://openalex.org/W2807250734","doi":"https://doi.org/10.1038/s41598-018-26761-2","mag":"2807250734","pmid":"https://pubmed.ncbi.nlm.nih.gov/29867083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986741"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-26761-2","doi":"https://doi.org/10.1038/s41598-018-26761-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-26761-2","pdf_url":"https://www.nature.com/articles/s41598-018-26761-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-26761-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100602020","display_name":"Kun Han","orcid":"https://orcid.org/0000-0001-9272-5567","observed_orcids":["https://orcid.org/0000-0001-9272-5567"]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Han","raw_affiliation_strings":["Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014538004","display_name":"Tingyuan Lang","orcid":"https://orcid.org/0000-0001-6457-6736","observed_orcids":["https://orcid.org/0000-0001-6457-6736"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingyuan Lang","raw_affiliation_strings":["Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077065458","display_name":"Zhiqi Zhang","orcid":"https://orcid.org/0000-0001-7565-5456","observed_orcids":["https://orcid.org/0000-0001-7565-5456"]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqi Zhang","raw_affiliation_strings":["Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064440091","display_name":"Yongning Sun","orcid":"https://orcid.org/0000-0002-7675-1367","observed_orcids":["https://orcid.org/0000-0002-7675-1367"]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongning Sun","raw_affiliation_strings":["Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023752798","display_name":"Zan Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zan Shen","raw_affiliation_strings":["Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Roger W. Beuerman","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore, 119228, Singapore","Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, 8 college Road, Singapore, 169857, Singapore","Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower level 6, Singapore, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore, 119228, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, 8 college Road, Singapore, 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower level 6, Singapore, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674991","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-5893-6002","observed_orcids":["https://orcid.org/0000-0001-5893-6002","https://orcid.org/0000-0001-8251-3974","https://orcid.org/0009-0007-9394-309X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore, 119228, Singapore. zhou.lei@seri.com.sg","Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, 8 college Road, Singapore, 169857, Singapore. zhou.lei@seri.com.sg","Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower level 6, Singapore, 169856, Singapore. zhou.lei@seri.com.sg","Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower level 6, Singapore, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore, 119228, Singapore. zhou.lei@seri.com.sg","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, 8 college Road, Singapore, 169857, Singapore. zhou.lei@seri.com.sg","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower level 6, Singapore, 169856, Singapore. zhou.lei@seri.com.sg","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower level 6, Singapore, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068938480","display_name":"Daliu Min","orcid":"https://orcid.org/0000-0001-9589-4032","observed_orcids":["https://orcid.org/0000-0001-9589-4032"]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Daliu Min","raw_affiliation_strings":["Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China. doctor_mindaliu@163.com","Department of Medical Oncology, The Affiliated 6th People\u2019s Hospital of Shanghai Jiaotong University, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China. doctor_mindaliu@163.com","institution_ids":["https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Department of Medical Oncology, The Affiliated 6th People\u2019s Hospital of Shanghai Jiaotong University, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068938480","https://openalex.org/A5100674991"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210116917","https://openalex.org/I4210126319","https://openalex.org/I4210144482","https://openalex.org/I4210150261"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.5967,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.93344456,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"8537","last_page":"8537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.3422999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.9610000252723694},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fzd6","display_name":"FZD6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.7910000085830688},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9539999961853027},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8550000190734863},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8963806629180908},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.807884931564331},{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.7282148599624634},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6369242668151855},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.6184917688369751},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6106221675872803},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5166711807250977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4892592430114746},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47289717197418213},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45289722084999084},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.4285748302936554},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4268658459186554},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.40726733207702637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1450594961643219},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078722","descriptor_name":"PC-3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047311","descriptor_name":"Luteolin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-26761-2","doi":"https://doi.org/10.1038/s41598-018-26761-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-26761-2","pdf_url":"https://www.nature.com/articles/s41598-018-26761-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4945922","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5986741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986741","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:29867083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29867083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Comparative Study"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/152467","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/152467","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:c27fd85e7e104ad0a19e47e943b7c974","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c27fd85e7e104ad0a19e47e943b7c974","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-26761-2","doi":"https://doi.org/10.1038/s41598-018-26761-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-26761-2","pdf_url":"https://www.nature.com/articles/s41598-018-26761-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7824102875","display_name":null,"funder_award_id":"81572080","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807250734.pdf","grobid_xml":"https://content.openalex.org/works/W2807250734.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W35348220","https://openalex.org/W1462606079","https://openalex.org/W1507187131","https://openalex.org/W1778439928","https://openalex.org/W1970760700","https://openalex.org/W1974175131","https://openalex.org/W1976309438","https://openalex.org/W1977529632","https://openalex.org/W2002953019","https://openalex.org/W2025678572","https://openalex.org/W2033773245","https://openalex.org/W2047278741","https://openalex.org/W2051767957","https://openalex.org/W2069381736","https://openalex.org/W2072833707","https://openalex.org/W2097640458","https://openalex.org/W2109069677","https://openalex.org/W2112142922","https://openalex.org/W2129585034","https://openalex.org/W2137429553","https://openalex.org/W2137841107","https://openalex.org/W2137958038","https://openalex.org/W2154972152","https://openalex.org/W2158217645","https://openalex.org/W2163835566","https://openalex.org/W2164050810","https://openalex.org/W2174580351","https://openalex.org/W2176023620","https://openalex.org/W2178388817","https://openalex.org/W2267696663","https://openalex.org/W2270095349","https://openalex.org/W2294015830","https://openalex.org/W2318062977","https://openalex.org/W2399318124","https://openalex.org/W2407498829","https://openalex.org/W2417468040","https://openalex.org/W2421311443","https://openalex.org/W2472156661","https://openalex.org/W2481479138","https://openalex.org/W2528500517","https://openalex.org/W2553012279","https://openalex.org/W2575074986","https://openalex.org/W2588947843","https://openalex.org/W2721174362","https://openalex.org/W2739205192","https://openalex.org/W4237646278"],"related_works":["https://openalex.org/W2892315415","https://openalex.org/W4416598844","https://openalex.org/W3008795135","https://openalex.org/W7222129380","https://openalex.org/W2022653867","https://openalex.org/W2407498829","https://openalex.org/W1977529632","https://openalex.org/W4403943333","https://openalex.org/W3006084123","https://openalex.org/W4404399139"],"abstract_inverted_index":{"The":[0],"mechanisms":[1],"underlying":[2,119],"luteolin-induced":[3,120],"inhibition":[4,121],"of":[5,26,44,79,86,109,114,122,140],"prostate":[6,45,134],"cancer":[7,46,135],"(PCa)":[8],"stemness":[9,20,85],"have":[10],"remained":[11],"elusive.":[12],"Here,":[13],"we":[14,57,90],"report":[15],"that":[16,71,97,107],"luteolin":[17,72],"suppresses":[18],"PCa":[19,34,87,100,123],"through":[21],"Wnt":[22,74,110,141],"signaling":[23,75,111],"by":[24,76,112,137],"upregulation":[25,78,113],"FZD6":[27,92,115],"(frizzled":[28],"class":[29],"receptor":[30],"6).":[31],"Luteolin":[32],"inhibits":[33,73],"cell":[35,48],"proliferation,":[36],"migration,":[37],"self-renewal":[38],"as":[39,41,93],"well":[40],"the":[42,84],"expression":[43],"stem":[47],"markers":[49],"in":[50,63],"vitro.":[51],"Through":[52],"iTRAQ-based":[53],"quantitative":[54],"proteomics":[55],"study,":[56],"identified":[58,91],"208":[59],"differentially":[60],"expressed":[61],"proteins":[62],"luteolin-treated":[64],"PC-3":[65],"cells.":[66,88],"Subsequent":[67],"mechanistic":[68],"analysis":[69],"revealed":[70],"transcriptional":[77],"FZD6,":[80],"and":[81],"thereby":[82],"suppressing":[83],"Furthermore,":[89],"a":[94,117,128],"tumor":[95],"suppressor":[96],"can":[98],"abolish":[99],"stemness.":[101,124],"In":[102],"summary,":[103],"our":[104],"findings":[105],"demonstrate":[106],"suppression":[108],"is":[116],"mechanism":[118],"Our":[125],"work":[126],"suggests":[127],"new":[129],"therapeutic":[130],"strategy":[131],"against":[132],"human":[133],"caused":[136],"aberrant":[138],"activation":[139],"signaling.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
