{"id":"https://openalex.org/W2807224704","doi":"https://doi.org/10.3389/fphar.2018.00696","title":"Patient-Specific iPSC-Based Models of Huntington\u2019s Disease as a Tool to Study Store-Operated Calcium Entry Drug Targeting","display_name":"Patient-Specific iPSC-Based Models of Huntington\u2019s Disease as a Tool to Study Store-Operated Calcium Entry Drug Targeting","publication_year":2018,"publication_date":"2018-06-29","ids":{"openalex":"https://openalex.org/W2807224704","doi":"https://doi.org/10.3389/fphar.2018.00696","mag":"2807224704","pmid":"https://pubmed.ncbi.nlm.nih.gov/30008670","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6033963"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2018.00696","doi":"https://doi.org/10.3389/fphar.2018.00696","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.00696","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00696/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00696/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079797927","display_name":"Vladimir A. Vigont","orcid":"https://orcid.org/0000-0001-8389-7316","observed_orcids":["https://orcid.org/0000-0001-8389-7316"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir Vigont","raw_affiliation_strings":["Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108602676","display_name":"Evgeny D. Nekrasov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210148309","display_name":"Vavilov Institute of General Genetics","ror":"https://ror.org/05ermrg42","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210148309"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeny Nekrasov","raw_affiliation_strings":["Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210148309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057710730","display_name":"Alexey V. Shalygin","orcid":"https://orcid.org/0000-0002-9896-1832","observed_orcids":["https://orcid.org/0000-0002-9896-1832"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey Shalygin","raw_affiliation_strings":["Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004452758","display_name":"Konstantin O. Gusev","orcid":"https://orcid.org/0000-0002-3577-7093","observed_orcids":["https://orcid.org/0000-0002-3577-7093"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin Gusev","raw_affiliation_strings":["Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091763808","display_name":"Sergey Klushnikov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey Klushnikov","raw_affiliation_strings":["Scientific Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210159010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037780193","display_name":"Sergey Nikolaevich Illarioshkin","orcid":"https://orcid.org/0000-0002-2704-6282","observed_orcids":["https://orcid.org/0000-0002-2704-6282"]},"institutions":[{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey Illarioshkin","raw_affiliation_strings":["Scientific Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210159010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025518139","display_name":"Maria A. Lagarkova","orcid":"https://orcid.org/0000-0001-9594-1134","observed_orcids":["https://orcid.org/0000-0001-9594-1134"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210141537","display_name":"Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin","ror":"https://ror.org/03snjhe90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210141537","https://openalex.org/I64264942"]},{"id":"https://openalex.org/I4210148309","display_name":"Vavilov Institute of General Genetics","ror":"https://ror.org/05ermrg42","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210148309"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria Lagarkova","raw_affiliation_strings":["Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia","Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia","institution_ids":["https://openalex.org/I4210141537"]},{"raw_affiliation_string":"Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210148309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060065641","display_name":"\u0421. \u041b. \u041a\u0438\u0441\u0435\u043b\u0435\u0432","orcid":"https://orcid.org/0000-0001-7921-6987","observed_orcids":["https://orcid.org/0000-0001-7921-6987"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210148309","display_name":"Vavilov Institute of General Genetics","ror":"https://ror.org/05ermrg42","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210148309"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey L. Kiselev","raw_affiliation_strings":["Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210148309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087845947","display_name":"Elena V. Kaznacheyeva","orcid":"https://orcid.org/0000-0003-1273-1188","observed_orcids":["https://orcid.org/0000-0003-1273-1188"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Elena Kaznacheyeva","raw_affiliation_strings":["Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087845947"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.9777,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.68251904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"696","last_page":"696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.08179999887943268,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9679999947547913},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/patient-specific-disease-models","display_name":"patient-specific disease models","score":0.7870000004768372},{"id":"https://openalex.org/keywords/striatal-medium-spiny-neurons","display_name":"striatal medium spiny neurons","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.8040000200271606},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.6320000290870667},{"id":"https://openalex.org/keywords/isoc","display_name":"ISOC","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6769999861717224},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7200000286102295},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6499866247177124},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5801183581352234},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.5531993508338928},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5024435520172119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4667627513408661},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4602365493774414},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3549901247024536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21066275238990784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14034637808799744}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphar.2018.00696","doi":"https://doi.org/10.3389/fphar.2018.00696","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.00696","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00696/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4996708","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6033963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30008670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30008670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6033963","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6033963/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:37561a70256a4dc488738b4fe63e6e30","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/37561a70256a4dc488738b4fe63e6e30","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2018.00696","doi":"https://doi.org/10.3389/fphar.2018.00696","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.00696","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00696/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1961770241","display_name":null,"funder_award_id":"17-54-80006","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G5147022690","display_name":null,"funder_award_id":"17-74-20068","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807224704.pdf","grobid_xml":"https://content.openalex.org/works/W2807224704.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1918236976","https://openalex.org/W1934528477","https://openalex.org/W1974888639","https://openalex.org/W1975897042","https://openalex.org/W1976611051","https://openalex.org/W1977044826","https://openalex.org/W1978300668","https://openalex.org/W1984064516","https://openalex.org/W1989113354","https://openalex.org/W1996195786","https://openalex.org/W1997836607","https://openalex.org/W2011086190","https://openalex.org/W2011152653","https://openalex.org/W2013582153","https://openalex.org/W2015480034","https://openalex.org/W2029590802","https://openalex.org/W2035763500","https://openalex.org/W2036145275","https://openalex.org/W2036924692","https://openalex.org/W2056505626","https://openalex.org/W2062104253","https://openalex.org/W2070838966","https://openalex.org/W2084235363","https://openalex.org/W2091352240","https://openalex.org/W2097294305","https://openalex.org/W2105403888","https://openalex.org/W2134131869","https://openalex.org/W2134583973","https://openalex.org/W2135896102","https://openalex.org/W2137084498","https://openalex.org/W2137258759","https://openalex.org/W2140135385","https://openalex.org/W2154778779","https://openalex.org/W2185060905","https://openalex.org/W2187516654","https://openalex.org/W2335878205","https://openalex.org/W2402366460","https://openalex.org/W2511879481","https://openalex.org/W2516276224","https://openalex.org/W2516388133","https://openalex.org/W2529866404","https://openalex.org/W2547026764","https://openalex.org/W2734887025","https://openalex.org/W2743490504","https://openalex.org/W2800906377","https://openalex.org/W2949644565","https://openalex.org/W2999063211","https://openalex.org/W4206144694","https://openalex.org/W4255760236"],"related_works":["https://openalex.org/W3127788298","https://openalex.org/W7039458799","https://openalex.org/W2914519079","https://openalex.org/W2070718688","https://openalex.org/W1918236976","https://openalex.org/W2792912769","https://openalex.org/W3114758799","https://openalex.org/W4205419698","https://openalex.org/W7136270402","https://openalex.org/W4390457460"],"abstract_inverted_index":{"Neurodegenerative":[0],"pathologies":[1,68],"are":[2],"among":[3],"the":[4,34,40,49,63,105,114,156],"most":[5],"serious":[6],"and":[7,17,103,143,197],"socially":[8],"significant":[9],"problems":[10],"of":[11,42,51,65,73,91,99,108,146,172],"modern":[12],"medicine,":[13],"\u0430long":[14],"with":[15,155],"cardiovascular":[16],"oncological":[18],"diseases.":[19],"Several":[20],"attempts":[21],"have":[22,187],"been":[23],"made":[24],"to":[25,33,113,186],"prevent":[26],"neuronal":[27],"death":[28],"using":[29,95],"novel":[30],"drugs":[31],"targeted":[32,112],"cell":[35],"calcium":[36,93,115,121,162],"signaling":[37],"machinery,":[38],"but":[39],"lack":[41],"adequate":[43],"models":[44,64],"for":[45],"screening":[46],"markedly":[47],"impairs":[48],"development":[50],"relevant":[52],"drugs.":[53],"A":[54],"potential":[55,178],"breakthrough":[56],"in":[57,76,123,151,165,169,190],"this":[58],"field":[59],"is":[60],"offered":[61],"by":[62,133],"hereditary":[66],"neurodegenerative":[67],"based":[69],"on":[70],"endogenous":[71],"expression":[72],"mutant":[74],"proteins":[75],"neurons":[77,128,153],"differentiated":[78],"from":[79],"patient-specific":[80],"induced":[81],"pluripotent":[82],"stem":[83],"cells":[84],"(iPSCs).":[85],"Here":[86],"we":[87],"study":[88],"specific":[89,110],"features":[90],"store-operated":[92,120],"entry":[94,122],"an":[96],"iPSCs-based":[97],"model":[98],"Huntington\u2019s":[100],"disease":[101],"(HD)":[102],"analyze":[104],"pharmacological":[106],"effects":[107],"a":[109],"drug":[111,180],"channels.":[116],"We":[117],"show":[118],"that":[119],"GABA-ergic":[124],"striatal":[125],"medium":[126],"spiny":[127],"(GABA":[129],"MSNs)":[130],"was":[131,183],"mediated":[132],"currents":[134],"through":[135],"at":[136],"least":[137],"two":[138],"different":[139,191],"channel":[140],"groups,":[141],"ICRAC":[142,174,196],"ISOC.":[144,176,198],"Both":[145],"these":[147],"groups":[148],"were":[149],"upregulated":[150],"HD":[152,192],"compared":[154],"wild":[157],"type":[158],"neurons.":[159],"Thapsigargin-induced":[160],"intracellular":[161],"store":[163],"depletion":[164],"GABA":[166],"MSNs":[167],"resulted":[168],"predominant":[170],"activation":[171],"either":[173],"or":[175],"The":[177],"anti-HD":[179],"EVP4593,":[181],"which":[182],"previously":[184],"shown":[185],"neuroprotective":[188],"activity":[189],"models,":[193],"affected":[194],"both":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}