{"id":"https://openalex.org/W2807205041","doi":"https://doi.org/10.1249/01.mss.0000538234.47519.b7","title":"Systemic and Local Alterations in Extracellular RNA (exRNA) Following Traumatic Knee Injury Implicate Catabolic and Inflammatory Pathways","display_name":"Systemic and Local Alterations in Extracellular RNA (exRNA) Following Traumatic Knee Injury Implicate Catabolic and Inflammatory Pathways","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2807205041","doi":"https://doi.org/10.1249/01.mss.0000538234.47519.b7","mag":"2807205041"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000538234.47519.b7","doi":"https://doi.org/10.1249/01.mss.0000538234.47519.b7","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000538234.47519.b7","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089163662","display_name":"Anthony J. Griswold","orcid":"https://orcid.org/0000-0003-1925-7810","observed_orcids":["https://orcid.org/0000-0003-1925-7810"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. Griswold","raw_affiliation_strings":["University of Miami, Miami, FL","(No relevant relationships reported)","(Sponsor: Thomas Best, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"(No relevant relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Thomas Best, FACSM)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040949007","display_name":"Natalia K. Hofmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia K. Hofmann","raw_affiliation_strings":["University of Miami, Miami, FL","(No relevant relationships reported)","(Sponsor: Thomas Best, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"(No relevant relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Thomas Best, FACSM)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040279086","display_name":"Thomas Michael Best","orcid":"https://orcid.org/0000-0003-2836-161X","observed_orcids":["https://orcid.org/0000-0003-2836-161X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Best","raw_affiliation_strings":["Sponsor: Thomas Best, FACSM)","University of Miami, Miami, FL","(No relevant relationships reported)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sponsor: Thomas Best, FACSM)","institution_ids":[]},{"raw_affiliation_string":"University of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"(No relevant relationships reported)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039717261","display_name":"Jeffery M. Vance","orcid":"https://orcid.org/0000-0003-3815-8199","observed_orcids":["https://orcid.org/0000-0003-3815-8199"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery M. Vance","raw_affiliation_strings":["University of Miami, Miami, FL","(No relevant relationships reported)","(Sponsor: Thomas Best, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"(No relevant relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Thomas Best, FACSM)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069324665","display_name":"Margaret Ann Pericak\u2010Vance","orcid":"https://orcid.org/0000-0001-7283-8804","observed_orcids":["https://orcid.org/0000-0001-7283-8804","https://orcid.org/0000-0002-3309-1303"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Pericak-Vance","raw_affiliation_strings":["University of Miami, Miami, FL","(No relevant relationships reported)","(Sponsor: Thomas Best, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"(No relevant relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Thomas Best, FACSM)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041863942","display_name":"Lee D. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee D. Kaplan","raw_affiliation_strings":["University of Miami, Miami, FL","(No relevant relationships reported)","(Sponsor: Thomas Best, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"(No relevant relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Thomas Best, FACSM)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"5S","first_page":"677","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-rna","display_name":"extracellular RNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/traumatic-knee-injury","display_name":"traumatic knee injury","score":0.8450000286102295},{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/anterior-cruciate-ligament-injury","display_name":"anterior cruciate ligament injury","score":0.7319999933242798},{"id":"https://openalex.org/keywords/meniscus-injury","display_name":"meniscal injury","score":0.9300000071525574},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6029999852180481},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6679999828338623},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.7839999794960022},{"id":"https://openalex.org/keywords/adamts8","display_name":"ADAMTS8","score":0.9789999723434448},{"id":"https://openalex.org/keywords/knee-osteoarthritis-risk","display_name":"knee osteoarthritis risk","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7558091878890991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.598936140537262},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5827127695083618},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5034863352775574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40211719274520874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3306286334991455},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3234623670578003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2226436734199524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09184420108795166},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000538234.47519.b7","doi":"https://doi.org/10.1249/01.mss.0000538234.47519.b7","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000538234.47519.b7","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2767466937","https://openalex.org/W2617201193","https://openalex.org/W4367834178","https://openalex.org/W2607086498","https://openalex.org/W4306399288","https://openalex.org/W4320496087","https://openalex.org/W2332544519","https://openalex.org/W3133469457","https://openalex.org/W3017509338","https://openalex.org/W2507575776"],"abstract_inverted_index":{"Traumatic":[0],"injuries":[1],"are":[2,310],"strong":[3],"risk":[4],"factors":[5],"for":[6,149,254,338],"future":[7,270],"osteoarthritis":[8],"(OA)":[9],"of":[10,27,38,47,77,105,141,153,178,190,195,221,242,272,319,327],"the":[11,18,45,51,103,205,256,316,323],"knee.":[12],"Molecular":[13],"changes":[14],"initiated":[15],"soon":[16],"after":[17],"trauma":[19,267],"may":[20,43,332],"lead":[21,31,333],"to":[22,32,59,82,91,130,160,268,312,334],"this":[23],"increased":[24],"susceptibility.":[25],"Identification":[26],"these":[28,320],"pathways":[29],"could":[30],"early":[33],"intervention":[34],"and":[35,133,143,151,173,199,226,233,235,237,246,258,282,304,322,325],"potential":[36,259,305],"limitation":[37],"damage.":[39],"One":[40],"such":[41],"mechanism":[42],"be":[44,280],"release":[46,330],"RNA":[48,63,67,136,162,191],"molecules":[49],"by":[50,65],"affected":[52],"tissues.":[53],"PURPOSE:":[54],"This":[55,274],"study":[56,275],"set":[57],"out":[58],"characterize":[60,315],"systemic":[61],"extracellular":[62],"(exRNA)":[64],"charactizing":[66],"from":[68,120,125,139,284,296],"plasma":[69,142,285,295],"following":[70],"traumatic":[71],"injury.":[72],"METHODS:":[73],"Our":[74,291],"cohort":[75],"consisted":[76],"14":[78],"subjects":[79,297],"(ages":[80],"19":[81],"47)":[83],"undergoing":[84],"ACL":[85],"and/or":[86],"meniscal":[87],"repair":[88],"surgery":[89],"(0.5":[90],"180":[92],"months":[93],"post":[94],"injury).":[95],"Radiograph":[96],"analysis":[97],"found":[98],"no":[99,208],"existing":[100],"OA":[101],"at":[102],"time":[104],"surgery,":[106],"though":[107],"Outerbridge":[108,212],"chondral":[109],"damage":[110],"assessment":[111],"indicated":[112,185],"average":[113,170],"scores":[114,172,213],"across":[115,204],"four":[116],"knee":[117,266],"compartments":[118],"ranging":[119],"0-1.25.":[121],"Plasma":[122],"was":[123,137,218],"isolated":[124,281],"whole":[126],"blood":[127],"via":[128,145],"centrifugation":[129],"remove":[131],"cells":[132],"platelets.":[134],"Total":[135],"extracted":[138],".05mL":[140],"analyzed":[144],"massively":[146],"parallel":[147],"sequencing":[148],"quantification":[150],"characterization":[152],"exRNA.":[154],"Generalized":[155],"linear":[156],"models":[157],"were":[158,202],"used":[159],"identify":[161],"differentially":[163],"present":[164,192],"in":[165,263,286],"low":[166],"vs":[167,175],"high":[168,288],"(0.5)":[169],"Outerbridsge":[171],"acute":[174],"chronic":[176],"duration":[177],"injury":[179,215],"(4":[180],"months).":[181],"RESULTS:":[182],"exRNA":[183,278,321],"profiles":[184],"more":[186,313],"than":[187],"10,000":[188],"types":[189],"including":[193],"fragments":[194],"protein":[196],"coding":[197],"genes":[198,223,229],"miRNAs.":[200],"Profiles":[201],"consistent":[203],"samples":[206],"with":[207,265,298,340],"differences":[209],"when":[210],"comparing":[211],"or":[214],"duration.":[216],"There":[217,249],"noted":[219],"expression":[220],"inflammatory":[222],"(CXCL5,":[224],"CCL5,":[225],"IL16),":[227],"catabolic":[228],"(MMP":[230],"-21,":[231],"-17,":[232],"-13,":[234],"ADAMTS8),":[236],"previously":[238],"reported":[239],"miRNA":[240],"biomarkers":[241],"arthritis":[243],"(MIR16,":[244],"MIR20b,":[245],"MIR146a).":[247],"CONCLUSIONS:":[248],"is":[250],"an":[251],"unmet":[252],"need":[253],"determining":[255],"etiology":[257],"novel":[260],"treatment":[261,336],"approaches":[262],"patients":[264,339],"mitigate":[269],"progression":[271],"OA.":[273,342],"demonstrates":[276],"that":[277,294,331],"can":[279],"characterized":[283],"a":[287],"throughput":[289],"manner.":[290],"results":[292],"indicate":[293],"injured":[299],"knees":[300],"contains":[301],"inflammatory,":[302],"catabolic,":[303],"arthritic":[306],"biomarkers.":[307],"Future":[308],"studies":[309],"required":[311],"fully":[314],"biological":[317],"roles":[318],"timing":[324],"cadence":[326],"their":[328],"respective":[329],"translational":[335],"options":[337],"post-traumatic":[341]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-13T00:00:00"}
