{"id":"https://openalex.org/W2807200716","doi":"https://doi.org/10.1016/j.tcb.2018.05.004","title":"Analyzing Circulating Tumor Cells One at a Time","display_name":"Analyzing Circulating Tumor Cells One at a Time","publication_year":2018,"publication_date":"2018-06-08","ids":{"openalex":"https://openalex.org/W2807200716","doi":"https://doi.org/10.1016/j.tcb.2018.05.004","mag":"2807200716","pmid":"https://pubmed.ncbi.nlm.nih.gov/29891227","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6153072"},"language":"en","primary_location":{"id":"doi:10.1016/j.tcb.2018.05.004","doi":"https://doi.org/10.1016/j.tcb.2018.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tcb.2018.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S118628157","display_name":"Trends in Cell Biology","issn_l":"0962-8924","issn":["0962-8924","1879-3088"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6153072","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004150146","display_name":"Veronica Ortiz","orcid":"https://orcid.org/0000-0002-6928-8458","observed_orcids":["https://orcid.org/0000-0002-6928-8458"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Ortiz","raw_affiliation_strings":["Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039053483","display_name":"Min Yu","orcid":"https://orcid.org/0000-0002-3969-8720","observed_orcids":["https://orcid.org/0000-0002-3969-8720"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Yu","raw_affiliation_strings":["Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: minyu@med.usc.edu","Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: minyu@med.usc.edu","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039053483"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.6942,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.59679144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"28","issue":"10","first_page":"764","last_page":"775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.4745999872684479,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":1.0},{"id":"https://openalex.org/keywords/single-cell-sequencing","display_name":"single-cell sequencing","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rare-cell-detection","display_name":"rare cell detection","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.5849999785423279},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6980000138282776},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6980000138282776},{"id":"https://openalex.org/keywords/single-cell-dna-sequencing","display_name":"single-cell DNA sequencing","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8780637979507446},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.8117190003395081},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.640244722366333},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5625342130661011},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.44134122133255005},{"id":"https://openalex.org/C174749747","wikidata":"https://www.wikidata.org/wiki/Q15917269","display_name":"Single cell sequencing","level":5,"score":0.4412478506565094},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.27116572856903076},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2350572943687439},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20616701245307922},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.19634497165679932},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.17678067088127136},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.11964982748031616}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.tcb.2018.05.004","doi":"https://doi.org/10.1016/j.tcb.2018.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tcb.2018.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S118628157","display_name":"Trends in Cell Biology","issn_l":"0962-8924","issn":["0962-8924","1879-3088"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Cell Biology","raw_type":"journal-article"},{"id":"pmid:29891227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29891227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6153072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6153072","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6153072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6153072","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1484546266","display_name":"Characterizing the role of TAK1 in breast cancer metastasis","funder_award_id":"K22CA175228","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2632735604","display_name":"Developing Individualized Medicine Targeting Metastatic Breast Cancer Stem Cells","funder_award_id":"DP2CA206653","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5212974104","display_name":"Heterogeneity of DNA methylomes between circulating tumor cells","funder_award_id":"F31CA213970","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6668384209","display_name":null,"funder_award_id":"F31CA213970","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306148","display_name":"Pew Charitable Trusts","ror":"https://ror.org/02xhk2825"},{"id":"https://openalex.org/F4320306523","display_name":"Alexander and Margaret Stewart Trust","ror":"https://ror.org/03nsgj842"},{"id":"https://openalex.org/F4320309839","display_name":"Donald E. and Delia B. Baxter Foundation","ror":"https://ror.org/03ht4bd53"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1580018887","https://openalex.org/W1594190228","https://openalex.org/W1602702667","https://openalex.org/W1701091641","https://openalex.org/W1967489571","https://openalex.org/W1968049436","https://openalex.org/W1981509058","https://openalex.org/W1984562049","https://openalex.org/W1987264156","https://openalex.org/W1987370132","https://openalex.org/W1989568035","https://openalex.org/W1993913242","https://openalex.org/W2008628868","https://openalex.org/W2012987872","https://openalex.org/W2014691022","https://openalex.org/W2032518018","https://openalex.org/W2040149948","https://openalex.org/W2065340354","https://openalex.org/W2067151470","https://openalex.org/W2070339716","https://openalex.org/W2073358150","https://openalex.org/W2074247829","https://openalex.org/W2081726111","https://openalex.org/W2082239705","https://openalex.org/W2088942535","https://openalex.org/W2090461073","https://openalex.org/W2092390808","https://openalex.org/W2099292393","https://openalex.org/W2099343472","https://openalex.org/W2099698839","https://openalex.org/W2106391833","https://openalex.org/W2110735634","https://openalex.org/W2112138633","https://openalex.org/W2117757143","https://openalex.org/W2118503070","https://openalex.org/W2119764457","https://openalex.org/W2120227082","https://openalex.org/W2121690903","https://openalex.org/W2129288227","https://openalex.org/W2129795133","https://openalex.org/W2138665978","https://openalex.org/W2139979927","https://openalex.org/W2149309158","https://openalex.org/W2150322923","https://openalex.org/W2152393981","https://openalex.org/W2156858440","https://openalex.org/W2157923000","https://openalex.org/W2161661776","https://openalex.org/W2167105834","https://openalex.org/W2168645747","https://openalex.org/W2174049393","https://openalex.org/W2198371822","https://openalex.org/W2210604951","https://openalex.org/W2222000795","https://openalex.org/W2282095422","https://openalex.org/W2286667211","https://openalex.org/W2305228807","https://openalex.org/W2331800864","https://openalex.org/W2340182364","https://openalex.org/W2411203921","https://openalex.org/W2411304278","https://openalex.org/W2411962548","https://openalex.org/W2461038129","https://openalex.org/W2487426829","https://openalex.org/W2512004978","https://openalex.org/W2554974048","https://openalex.org/W2568481627","https://openalex.org/W2586644020","https://openalex.org/W2587598568","https://openalex.org/W2597274540","https://openalex.org/W2618389271","https://openalex.org/W2768302346","https://openalex.org/W2768684165","https://openalex.org/W2769248706","https://openalex.org/W2781608882","https://openalex.org/W2788743957","https://openalex.org/W2949074346","https://openalex.org/W2949740511","https://openalex.org/W4255872716"],"related_works":["https://openalex.org/W2980628747","https://openalex.org/W2781345608","https://openalex.org/W2968416001","https://openalex.org/W2290431143","https://openalex.org/W3111828641","https://openalex.org/W2176823996","https://openalex.org/W4412790731","https://openalex.org/W3193417673","https://openalex.org/W2065709676","https://openalex.org/W4207077659"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}