{"id":"https://openalex.org/W2807159595","doi":"https://doi.org/10.1111/edt.12411","title":"Effect of propolis on preserving human periodontal ligament cells and regulating pro\u2010inflammatory cytokines","display_name":"Effect of propolis on preserving human periodontal ligament cells and regulating pro\u2010inflammatory cytokines","publication_year":2018,"publication_date":"2018-05-28","ids":{"openalex":"https://openalex.org/W2807159595","doi":"https://doi.org/10.1111/edt.12411","mag":"2807159595","pmid":"https://pubmed.ncbi.nlm.nih.gov/29806101"},"language":"en","primary_location":{"id":"doi:10.1111/edt.12411","doi":"https://doi.org/10.1111/edt.12411","is_oa":false,"landing_page_url":"https://doi.org/10.1111/edt.12411","pdf_url":null,"source":{"id":"https://openalex.org/S113867935","display_name":"Dental Traumatology","issn_l":"1600-4469","issn":["1600-4469","1600-9657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dental Traumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101801490","display_name":"Xiaojing Yuan","orcid":"https://orcid.org/0000-0003-0483-6916","observed_orcids":["https://orcid.org/0000-0003-0483-6916"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojing Yuan","raw_affiliation_strings":["Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-0483-6916","affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]},{"raw_affiliation_string":"Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059474491","display_name":"Yuanyuan Wang","orcid":"https://orcid.org/0000-0003-1126-1639","observed_orcids":["https://orcid.org/0000-0003-1126-1639"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Wang","raw_affiliation_strings":["Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]},{"raw_affiliation_string":"Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069521418","display_name":"Bingqing Shi","orcid":"https://orcid.org/0000-0002-2349-4504","observed_orcids":["https://orcid.org/0000-0002-2349-4504"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingqing Shi","raw_affiliation_strings":["Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]},{"raw_affiliation_string":"Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100599479","display_name":"Yuming Zhao","orcid":"https://orcid.org/0000-0002-2395-6254","observed_orcids":["https://orcid.org/0000-0002-2395-6254"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210095659","display_name":"Peking University School and Hospital of Stomatology","ror":"https://ror.org/00s2xkh70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuming Zhao","raw_affiliation_strings":["Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry Hospital of Stomatology Peking University  Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"]},{"raw_affiliation_string":"Department of Pediatric Dentistry, Hospital of Stomatology, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100599479"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210095659"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":2.9467,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.89968652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"4","first_page":"245","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12367","display_name":"Dental Trauma and Treatments","score":0.24549999833106995,"subfield":{"id":"https://openalex.org/subfields/3604","display_name":"Emergency Medical Services"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propolis","display_name":"propolis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/periodontal-ligament-cells","display_name":"periodontal ligament cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tooth-avulsion","display_name":"tooth avulsion","score":0.6800000071525574},{"id":"https://openalex.org/keywords/tooth-storage-media","display_name":"tooth storage media","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hanks-solution","display_name":"Hank's solution","score":0.9359999895095825},{"id":"https://openalex.org/keywords/milk","display_name":"milk","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8019999861717224},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7820000052452087},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8080000281333923},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.6610000133514404},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C2780488879","wikidata":"https://www.wikidata.org/wiki/Q184398","display_name":"Propolis","level":2,"score":0.9280276298522949},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.7598778605461121},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7244131565093994},{"id":"https://openalex.org/C41868710","wikidata":"https://www.wikidata.org/wiki/Q540092","display_name":"Periodontal fiber","level":2,"score":0.6983728408813477},{"id":"https://openalex.org/C2778996431","wikidata":"https://www.wikidata.org/wiki/Q4849997","display_name":"Balanced salt solution","level":2,"score":0.672753632068634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.511489748954773},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47466209530830383},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.44550621509552},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.41185128688812256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34457892179489136},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.31159090995788574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2853560149669647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26888102293014526},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24517413973808289},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.24106359481811523},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14245742559432983},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/edt.12411","doi":"https://doi.org/10.1111/edt.12411","is_oa":false,"landing_page_url":"https://doi.org/10.1111/edt.12411","pdf_url":null,"source":{"id":"https://openalex.org/S113867935","display_name":"Dental Traumatology","issn_l":"1600-4469","issn":["1600-4469","1600-9657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dental Traumatology","raw_type":"journal-article"},{"id":"pmid:29806101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29806101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dental traumatology : official publication of International Association for Dental Traumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6998452700","display_name":null,"funder_award_id":"Z151100004015093","funder_id":"https://openalex.org/F4320325902","funder_display_name":"Beijing Municipal Science and Technology Commission"}],"funders":[{"id":"https://openalex.org/F4320325902","display_name":"Beijing Municipal Science and Technology Commission","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1536693212","https://openalex.org/W1835822022","https://openalex.org/W1855813882","https://openalex.org/W1979220883","https://openalex.org/W1984131792","https://openalex.org/W1999802831","https://openalex.org/W2000547009","https://openalex.org/W2003636304","https://openalex.org/W2007015692","https://openalex.org/W2010525783","https://openalex.org/W2036619030","https://openalex.org/W2039098355","https://openalex.org/W2047978393","https://openalex.org/W2057964798","https://openalex.org/W2061036506","https://openalex.org/W2084999822","https://openalex.org/W2093892019","https://openalex.org/W2100234692","https://openalex.org/W2103453995","https://openalex.org/W2116971444","https://openalex.org/W2123195938","https://openalex.org/W2125792099","https://openalex.org/W2130178759","https://openalex.org/W2169563040","https://openalex.org/W2197775693","https://openalex.org/W2262257734","https://openalex.org/W2401544667","https://openalex.org/W2464702812","https://openalex.org/W2471419548","https://openalex.org/W2561272213","https://openalex.org/W2564822836","https://openalex.org/W2597927652","https://openalex.org/W2617236721","https://openalex.org/W2619309185","https://openalex.org/W2664947310","https://openalex.org/W2793587369","https://openalex.org/W4297900236","https://openalex.org/W4321000922","https://openalex.org/W4390776153"],"related_works":["https://openalex.org/W2341333145","https://openalex.org/W2103248188","https://openalex.org/W2121107088","https://openalex.org/W3030667680","https://openalex.org/W574198516","https://openalex.org/W2321931350","https://openalex.org/W2095984224","https://openalex.org/W60177492","https://openalex.org/W2085571087","https://openalex.org/W2389310297"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"Propolis":[1],"has":[2],"been":[3],"suggested":[4],"as":[5],"a":[6,262],"storage":[7,68],"medium":[8],"for":[9],"avulsed":[10],"teeth.":[11],"The":[12,70,119,185],"aim":[13],"of":[14,22,36,93,191,246],"this":[15],"study":[16],"was":[17,76,96,111],"to":[18,59],"compare":[19],"the":[20,34,123,158,171,211,218,225,244],"effectiveness":[21],"Brazilian":[23,106,127,159,201,226,235,259],"propolis":[24,107,128,160,227,260],"with":[25,200],"Hank's":[26,130,162,229,237],"balanced":[27,131,163,230,238],"salt":[28,132,164,231,239],"solution":[29,133,165,232],"and":[30,45,82,89,101,129,142,151,161,177,187,194,228,241,251],"milk":[31,120,172,219,242],"in":[32,66,146,157,170,182,217,224],"maintaining":[33],"viability":[35,65,245],"human":[37,61,115,247],"periodontal":[38,62,116,248],"ligament":[39,63,117,249],"cells,":[40],"their":[41,253],"osteogenic":[42,74,254],"differentiation":[43,75,255],"potential,":[44],"pro-inflammatory":[46,94],"cytokine":[47,215],"expression.":[48],"MATERIAL":[49],"AND":[50],"METHODS:":[51],"Cell":[52],"Counting":[53],"Kit":[54],"8":[55],"assays":[56],"were":[57,144,155,168,180,221],"performed":[58,97],"test":[60],"cell":[64,125,137],"different":[67],"media.":[69],"preservative":[71],"effect":[72],"on":[73],"evaluated":[77],"using":[78,98],"alkaline":[79],"phosphatase":[80,140],"staining":[81,141],"activity":[83,143],"assays,":[84],"Alizarin":[85],"Red":[86],"S":[87],"staining,":[88],"western":[90],"blotting.":[91],"Quantification":[92],"cytokines":[95],"real-time":[99],"PCR":[100],"enzyme-linked":[102],"immunosorbent":[103],"assays.":[104],"RESULTS:":[105],"at":[108],"10":[109],"\u03bcg/ml":[110],"not":[112],"cytotoxic":[113],"toward":[114],"cells.":[118],"group":[121,220],"showed":[122,135,206,261],"highest":[124],"viability.":[126],"groups":[134],"similar":[136,145,156,181],"viabilities.":[138],"Alkaline":[139],"all":[147,183],"groups.":[148,184,213,233],"Calcium":[149],"deposition":[150],"mineralization":[152],"nodule":[153],"formation":[154],"groups,":[166],"but":[167],"higher":[169,222],"group.":[173],"Osteogenic":[174],"marker":[175],"gene":[176],"protein":[178,188],"levels":[179,190,216],"genes":[186],"expression":[189,205],"IL1\u03b2,":[192],"IL6,":[193],"IL8":[195],"decreased":[196],"significantly":[197],"after":[198],"treatment":[199],"propolis.":[202],"TNF\u03b1":[203],"mRNA":[204],"no":[207],"significant":[208],"difference":[209],"among":[210],"experimental":[212],"Pro-inflammatory":[214],"than":[223],"CONCLUSIONS:":[234],"propolis,":[236],"solution,":[240],"maintained":[243],"cells":[250],"preserved":[252],"ability":[256],"similarly.":[257],"However,":[258],"better":[263],"anti-inflammatory":[264],"effect.":[265],"This":[266],"article":[267],"is":[268],"protected":[269],"by":[270],"copyright.":[271],"All":[272],"rights":[273],"reserved.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}