{"id":"https://openalex.org/W2807119864","doi":null,"title":"Evaluation of targeting schemes for complement-modulating, strain-selective antimicrobial microparticles","display_name":"Evaluation of targeting schemes for complement-modulating, strain-selective antimicrobial microparticles","publication_year":2018,"publication_date":"2018-04-30","ids":{"openalex":"https://openalex.org/W2807119864","mag":"2807119864"},"language":"en","primary_location":{"id":"pmh:oai:smartech.gatech.edu:1853/59955","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/59955","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044146596","display_name":"Michael C. Bellavia","orcid":"https://orcid.org/0000-0001-5500-1594","observed_orcids":["https://orcid.org/0000-0001-5500-1594"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael C. Bellavia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5500-1594","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044146596"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8119999766349792},{"id":"https://openalex.org/keywords/escherichia-coli-o157-h7","display_name":"Escherichia coli O157:H7","score":0.8809999823570251},{"id":"https://openalex.org/keywords/polystyrene-microparticles","display_name":"polystyrene microparticles","score":0.8420000076293945},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.6579999923706055},{"id":"https://openalex.org/keywords/igg-adsorption","display_name":"IgG adsorption","score":0.6579999923706055},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.734000027179718},{"id":"https://openalex.org/keywords/bacterial-cytotoxicity","display_name":"bacterial cytotoxicity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.5419999957084656},{"id":"https://openalex.org/keywords/candidiasis","display_name":"candidiasis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antibiotic-sensitization","display_name":"antibiotic sensitization","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6451308131217957},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4990267753601074},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.4740217328071594},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3589194416999817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3197326064109802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2674436569213867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11058682203292847},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.10686984658241272},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:smartech.gatech.edu:1853/59955","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/59955","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2807119864","doi":null,"is_oa":false,"landing_page_url":"https://smartech.gatech.edu/handle/1853/59955","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W33953625","https://openalex.org/W93590824","https://openalex.org/W340610577","https://openalex.org/W580464475","https://openalex.org/W1485519026","https://openalex.org/W1531268983","https://openalex.org/W1544892070","https://openalex.org/W1577886506","https://openalex.org/W1637988114","https://openalex.org/W1670134091","https://openalex.org/W1855555556","https://openalex.org/W1907898035","https://openalex.org/W1969951819","https://openalex.org/W1971018628","https://openalex.org/W1971422062","https://openalex.org/W1973114669","https://openalex.org/W1974951926","https://openalex.org/W1976228191","https://openalex.org/W1977446721","https://openalex.org/W1981904613","https://openalex.org/W1984162012","https://openalex.org/W1985960971","https://openalex.org/W1988418627","https://openalex.org/W1988943863","https://openalex.org/W1989924708","https://openalex.org/W1991081822","https://openalex.org/W1991656907","https://openalex.org/W1992294675","https://openalex.org/W1996397096","https://openalex.org/W1997284049","https://openalex.org/W1997408488","https://openalex.org/W1998620676","https://openalex.org/W1999027251","https://openalex.org/W2006709508","https://openalex.org/W2007857508","https://openalex.org/W2010197849","https://openalex.org/W2010717419","https://openalex.org/W2018513502","https://openalex.org/W2020963636","https://openalex.org/W2023355522","https://openalex.org/W2025846249","https://openalex.org/W2027374210","https://openalex.org/W2030822319","https://openalex.org/W2031852128","https://openalex.org/W2034554356","https://openalex.org/W2038181025","https://openalex.org/W2043529001","https://openalex.org/W2044252447","https://openalex.org/W2047043751","https://openalex.org/W2054550086","https://openalex.org/W2055443357","https://openalex.org/W2057657739","https://openalex.org/W2057760381","https://openalex.org/W2060338272","https://openalex.org/W2062412467","https://openalex.org/W2063911444","https://openalex.org/W2064452752","https://openalex.org/W2072652504","https://openalex.org/W2074880818","https://openalex.org/W2082661031","https://openalex.org/W2083233394","https://openalex.org/W2086775219","https://openalex.org/W2087032263","https://openalex.org/W2087108989","https://openalex.org/W2089430367","https://openalex.org/W2090109532","https://openalex.org/W2090538273","https://openalex.org/W2091577149","https://openalex.org/W2091579496","https://openalex.org/W2091591930","https://openalex.org/W2091814579","https://openalex.org/W2094031027","https://openalex.org/W2094490061","https://openalex.org/W2096376610","https://openalex.org/W2099471877","https://openalex.org/W2102809922","https://openalex.org/W2104662464","https://openalex.org/W2106523804","https://openalex.org/W2107975574","https://openalex.org/W2110555587","https://openalex.org/W2114245966","https://openalex.org/W2118392314","https://openalex.org/W2120177610","https://openalex.org/W2120227455","https://openalex.org/W2122921940","https://openalex.org/W2123238891","https://openalex.org/W2125033177","https://openalex.org/W2125123295","https://openalex.org/W2125453929","https://openalex.org/W2125945066","https://openalex.org/W2127952905","https://openalex.org/W2127999800","https://openalex.org/W2136648677","https://openalex.org/W2136790131","https://openalex.org/W2137863756","https://openalex.org/W2138648278","https://openalex.org/W2139912385","https://openalex.org/W2140465229","https://openalex.org/W2142343447","https://openalex.org/W2145723948","https://openalex.org/W2148067809","https://openalex.org/W2148928984","https://openalex.org/W2149470780","https://openalex.org/W2154683188","https://openalex.org/W2163970869","https://openalex.org/W2165954341","https://openalex.org/W2167194776","https://openalex.org/W2167896930","https://openalex.org/W2169656611","https://openalex.org/W2170658957","https://openalex.org/W2179036997","https://openalex.org/W2185119698","https://openalex.org/W2210504891","https://openalex.org/W2247713917","https://openalex.org/W2297086543","https://openalex.org/W2317729965","https://openalex.org/W2318493458","https://openalex.org/W2318509744","https://openalex.org/W2324397673","https://openalex.org/W2326849645","https://openalex.org/W2336121886","https://openalex.org/W2336504073","https://openalex.org/W2402171825","https://openalex.org/W2404544016","https://openalex.org/W2410386337","https://openalex.org/W2440269597","https://openalex.org/W2473625848","https://openalex.org/W2481379384","https://openalex.org/W2495382381","https://openalex.org/W2551570567","https://openalex.org/W2571164552","https://openalex.org/W2594214281","https://openalex.org/W2597828438","https://openalex.org/W2611797318","https://openalex.org/W2735947590","https://openalex.org/W2739660851","https://openalex.org/W2783785722","https://openalex.org/W4295850018"],"related_works":["https://openalex.org/W2571164552","https://openalex.org/W4383723084","https://openalex.org/W4388126551","https://openalex.org/W1971018628","https://openalex.org/W4401213591","https://openalex.org/W4297249877","https://openalex.org/W7165021385","https://openalex.org/W1602933202","https://openalex.org/W1908309513","https://openalex.org/W2794164274"],"abstract_inverted_index":{"Here":[0],"we":[1],"present":[2],"bifunctional":[3],"microparticles":[4,26],"that":[5,94],"bind":[6],"Escherichia":[7],"coli":[8,117,123],"(E.":[9],"coli)":[10],"bacteria":[11],"via":[12],"a":[13,41,55,195,226,237],"cell":[14],"membrane":[15],"constituent":[16],"while":[17],"also":[18],"activating":[19],"the":[20,68,80,95,144,151,158,162,177,201,216],"classical":[21],"complement":[22,53,223],"pathway.":[23],"Carboxylated":[24],"polystyrene":[25],"1":[27],"\u00b5m":[28],"in":[29,77],"diameter":[30],"were":[31,147,173],"functionalized":[32],"through":[33],"several":[34],"means":[35],"with":[36,79,161,242],"nonspecific":[37],"polyclonal":[38,61],"IgG":[39,204],"and/or":[40],"monoclonal":[42],"E.":[43,116,122],"coli-binding":[44],"antibody":[45,62,82,90,96],"to":[46,51,54,66,109,176,187,215,219,239],"compare":[47],"different":[48],"targeting":[49,81,129,159],"schemes":[50],"localize":[52],"particular":[56],"bacterial":[57],"strain.":[58],"The":[59],"complement-prompting":[60],"was":[63,125,128,184,194,209],"either":[64,112,168],"adsorbed":[65,73],"saturate":[67],"particle":[69,107],"nonspecifically":[70,74],"(Untargeted,":[71],"UT),":[72],"at":[75],"half-saturation":[76],"combination":[78],"(Mixed":[83],"Untargeted,":[84],"MUT),":[85],"or":[86,250],"interspersed":[87],"amongst":[88],"crosslinker-monoclonal":[89],"pairs":[91],"formed":[92],"such":[93,247],"Fab":[97],"regions":[98],"project":[99],"outward":[100],"(MT,":[101],"Mixed":[102],"Targeted).":[103],"Cytotoxicity":[104],"of":[105,203],"each":[106],"type":[108,139],"its":[110,234],"cognate,":[111],"complement-sensitive":[113],"non-pathogenic":[114],"mutant":[115],"J5":[118,135,180,183],"and":[119,134,153,170,200,225],"wild-type":[120],"pathogenic":[121],"O157:H7":[124],"evaluated,":[126],"as":[127,236,248],"affinity":[130],"for":[131,179,230,244],"anti-J5":[132],"particles":[133,146],"bacteria.":[136,181],"Although":[137],"no":[138,165],"provided":[140,164],"clinically-relevant":[141],"cytotoxicity,":[142],"notably":[143],"MUT":[145,178,217],"somewhat":[148],"effective":[149],"against":[150,167],"virulent":[152],"otherwise":[154],"complement-resistant":[155],"O157.":[156],"Orienting":[157],"moiety":[160],"MT":[163],"benefit":[166],"strain,":[169],"binding":[171],"frequencies":[172],"attenuated":[174],"relative":[175],"Complement-sensitive":[182],"most":[185,191],"vulnerable":[186],"UT":[188],"particles.":[189],"In":[190],"cases,":[192],"there":[193],"correlation":[196],"between":[197],"increased":[198],"cytotoxicity":[199],"extent":[202],"coverage,":[205],"but":[206],"this":[207],"effect":[208],"generally":[210],"not":[211],"pronounced.":[212],"Additional":[213],"modifications":[214],"platform":[218],"more":[220],"potently":[221],"stimulate":[222],"activation":[224],"new":[227],"base":[228],"material":[229],"biocompatibility":[231],"could":[232],"enable":[233],"use":[235],"sensitizer":[238],"be":[240],"paired":[241],"antibiotics":[243],"systemic":[245],"diseases":[246],"sepsis":[249],"candidiasis.":[251]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2018-06-13T00:00:00"}