{"id":"https://openalex.org/W2806937873","doi":"https://doi.org/10.1038/s41598-018-21621-5","title":"Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury","display_name":"Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury","publication_year":2018,"publication_date":"2018-02-12","ids":{"openalex":"https://openalex.org/W2806937873","doi":"https://doi.org/10.1038/s41598-018-21621-5","mag":"2806937873","pmid":"https://pubmed.ncbi.nlm.nih.gov/29453346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5816629"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-21621-5","doi":"https://doi.org/10.1038/s41598-018-21621-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-21621-5","pdf_url":"https://www.nature.com/articles/s41598-018-21621-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-21621-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077700350","display_name":"Seong\u2010Jun Kim","orcid":"https://orcid.org/0000-0001-8504-2872","observed_orcids":["https://orcid.org/0000-0001-8504-2872"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Jun Kim","raw_affiliation_strings":["Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020895444","display_name":"Wan\u2010Kyu Ko","orcid":"https://orcid.org/0000-0003-2400-2740","observed_orcids":["https://orcid.org/0000-0003-2400-2740"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wan-Kyu Ko","raw_affiliation_strings":["Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077627627","display_name":"Min\u2010Jae Jo","orcid":"https://orcid.org/0000-0002-5694-1972","observed_orcids":["https://orcid.org/0000-0002-5694-1972"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Jae Jo","raw_affiliation_strings":["Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067788767","display_name":"Yoshie Arai","orcid":"https://orcid.org/0000-0003-1055-3357","observed_orcids":["https://orcid.org/0000-0003-1055-3357"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoshie Arai","raw_affiliation_strings":["Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054777834","display_name":"Hyemin Choi","orcid":"https://orcid.org/0000-0002-6058-236X","observed_orcids":["https://orcid.org/0000-0002-6058-236X"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyemin Choi","raw_affiliation_strings":["Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037192790","display_name":"Hemant Kumar","orcid":"https://orcid.org/0000-0002-6434-0245","observed_orcids":["https://orcid.org/0000-0002-6434-0245"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hemant Kumar","raw_affiliation_strings":["Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007647504","display_name":"Inbo Han","orcid":"https://orcid.org/0000-0002-0834-9325","observed_orcids":["https://orcid.org/0000-0002-0834-9325"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"In-Bo Han","raw_affiliation_strings":["Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea. hanib@cha.ac.kr","Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea. hanib@cha.ac.kr","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046237315","display_name":"Seil Sohn","orcid":"https://orcid.org/0000-0001-5724-8099","observed_orcids":["https://orcid.org/0000-0001-5724-8099"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seil Sohn","raw_affiliation_strings":["Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea. sisohn@cha.ac.kr","Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5724-8099","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea. sisohn@cha.ac.kr","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007647504","https://openalex.org/A5046237315"],"corresponding_institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":4.2718,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95232155,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"3176","last_page":"3176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tauroursodeoxycholic-acid","display_name":"tauroursodeoxycholic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8659999966621399},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.968999981880188},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2777422422","wikidata":"https://www.wikidata.org/wiki/Q7688907","display_name":"Tauroursodeoxycholic acid","level":4,"score":0.9128172397613525},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5513772368431091},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5437520742416382},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5317731499671936},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5289490222930908},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5188518762588501},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4869343042373657},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4833809733390808},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45377758145332336},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44670966267585754},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.410678505897522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2853064239025116},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26198074221611023},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19386205077171326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1561276614665985},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.06690323352813721},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013655","descriptor_name":"Taurochenodeoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013655","descriptor_name":"Taurochenodeoxycholic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-018-21621-5","doi":"https://doi.org/10.1038/s41598-018-21621-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-21621-5","pdf_url":"https://www.nature.com/articles/s41598-018-21621-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:29453346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29453346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5816629","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5816629/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4b778520a80f4b9d99628fb841a70ebf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4b778520a80f4b9d99628fb841a70ebf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-21621-5","doi":"https://doi.org/10.1038/s41598-018-21621-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-21621-5","pdf_url":"https://www.nature.com/articles/s41598-018-21621-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2836585387","display_name":null,"funder_award_id":"2016M3A9E8941668","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4392560668","display_name":null,"funder_award_id":"NRF-2016M3A9E8941668","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G6693677939","display_name":null,"funder_award_id":"NRF-2016M3A9E8941668","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806937873.pdf","grobid_xml":"https://content.openalex.org/works/W2806937873.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W85194748","https://openalex.org/W1771352729","https://openalex.org/W1778627337","https://openalex.org/W1864497115","https://openalex.org/W1967965268","https://openalex.org/W1970024238","https://openalex.org/W1982979794","https://openalex.org/W1995270458","https://openalex.org/W2003438800","https://openalex.org/W2019449356","https://openalex.org/W2025416757","https://openalex.org/W2049241173","https://openalex.org/W2054714741","https://openalex.org/W2057818411","https://openalex.org/W2070995184","https://openalex.org/W2081515380","https://openalex.org/W2082414362","https://openalex.org/W2086790402","https://openalex.org/W2088068912","https://openalex.org/W2102436686","https://openalex.org/W2105156184","https://openalex.org/W2109017124","https://openalex.org/W2119521536","https://openalex.org/W2130529018","https://openalex.org/W2132822330","https://openalex.org/W2136722399","https://openalex.org/W2142269737","https://openalex.org/W2161456562","https://openalex.org/W2277490066","https://openalex.org/W2320560993","https://openalex.org/W2354324780","https://openalex.org/W2416456431","https://openalex.org/W2538899501","https://openalex.org/W2565880658","https://openalex.org/W2580879223","https://openalex.org/W3165521705"],"related_works":["https://openalex.org/W4283453988","https://openalex.org/W3153298114","https://openalex.org/W2791735760","https://openalex.org/W3158718410","https://openalex.org/W4409331776","https://openalex.org/W4205430517","https://openalex.org/W1982979794","https://openalex.org/W6901847368","https://openalex.org/W4411153468","https://openalex.org/W2531320950"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"study":[2],"aimed":[3],"to":[4],"investigate":[5],"the":[6,79,100,143,146,151,166],"anti-inflammatory":[7,41,169],"effects":[8,42],"of":[9,43,78,110,145,153,168],"tauroursodeoxycholic":[10],"acid":[11],"(TUDCA)":[12],"after":[13],"spinal":[14,80],"cord":[15,81],"injury":[16,147],"(SCI)":[17],"in":[18,25,76,126,178],"rats.":[19],"We":[20],"induced":[21,165],"an":[22],"inflammatory":[23,102,154,176],"process":[24],"RAW":[26,47,179],"264.7":[27,48,180],"macrophages,":[28,49,181],"BV2":[29,50,182],"microglial":[30,51,183],"cells,":[31,52,184],"and":[32,53,68,95,120,129,149,160,185],"bone":[33],"marrow-derived":[34],"macrophages":[35],"(BMM)":[36],"using":[37,57],"lipopolysaccharide":[38],"(LPS).":[39],"The":[40,73],"TUDCA":[44,98,134,141,164,174,187],"on":[45],"LPS-stimulated":[46,101],"BMMs":[54],"were":[55,83],"analyzed":[56],"nitric":[58,122],"oxide":[59,123],"(NO)":[60],"assays,":[61],"quantitative":[62],"real-time":[63],"polymerase":[64],"chain":[65],"reactions":[66],"(qRT-PCR),":[67],"enzyme-linked":[69],"immunosorbent":[70],"assays":[71],"(ELISA).":[72],"pathological":[74],"changes":[75],"lesions":[77],"tissue":[82],"evaluated":[84],"by":[85],"hematoxylin":[86],"&":[87],"eosin":[88],"(H&E)":[89],"staining,":[90],"luxol":[91],"fast":[92],"blue/cresyl":[93],"violet-staining":[94],"immunofluorescent":[96],"staining.":[97],"decreased":[99,135],"mediator,":[103],"NO.":[104],"It":[105],"also":[106],"suppressed":[107,150],"pro-inflammatory":[108],"cytokines":[109,155],"tumor":[111],"necrosis":[112],"factor-\u03b1":[113],"(TNF-\u03b1),":[114],"interleukin":[115],"1-\u03b2":[116],"(IL-1\u03b2),":[117],"cyclooxygenase-2":[118],"(COX-2),":[119],"inducible":[121],"synthase":[124],"(iNOS)":[125],"both":[127],"mRNA":[128],"protein":[130],"levels.":[131],"In":[132,162,172],"addition,":[133,163],"prostaglandin":[136],"E2":[137],"(PGE2).":[138],"After":[139],"SCI,":[140],"supported":[142],"recovery":[144],"site":[148],"expression":[152,167],"such":[156],"as":[157],"iNOS,":[158],"CD68":[159],"CD86.":[161],"cytokine,":[170],"Arg-1.":[171],"conclusion,":[173],"inhibits":[175],"responses":[177],"BMMs.":[186],"can":[188],"be":[189],"a":[190],"potential":[191],"alternative":[192],"drug":[193],"for":[194],"SCI.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}