{"id":"https://openalex.org/W2806904932","doi":"https://doi.org/10.1590/s1678-9946201860023","title":"Pathology and pathogenesis of human leptospirosis: a commented review","display_name":"Pathology and pathogenesis of human leptospirosis: a commented review","publication_year":2018,"publication_date":"2018-05-28","ids":{"openalex":"https://openalex.org/W2806904932","doi":"https://doi.org/10.1590/s1678-9946201860023","mag":"2806904932","pmid":"https://pubmed.ncbi.nlm.nih.gov/29846473"},"language":"en","primary_location":{"id":"doi:10.1590/s1678-9946201860023","doi":"https://doi.org/10.1590/s1678-9946201860023","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1678-9946201860023","pdf_url":"http://www.scielo.br/pdf/rimtsp/v60/1678-9946-rimtsp-60-S1678-9946201860023.pdf","source":{"id":"https://openalex.org/S182450478","display_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","issn_l":"0036-4665","issn":["0036-4665","1678-9946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","latindex","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scielo.br/pdf/rimtsp/v60/1678-9946-rimtsp-60-S1678-9946201860023.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110268202","display_name":"Thales de Brito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thales De Brito","raw_affiliation_strings":["Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil","Universidade de Sao Paulo, Instituto de Medicina Tropical de Sao Paulo, LIM 06, Sao Paulo, BrazilUniversidade de Sao Paulo, Faculdade de Medicina, Departamento de Patologia, Sao Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Universidade de Sao Paulo, Instituto de Medicina Tropical de Sao Paulo, LIM 06, Sao Paulo, BrazilUniversidade de Sao Paulo, Faculdade de Medicina, Departamento de Patologia, Sao Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034573617","display_name":"Ana Maria Gon\u00e7alves da Silva","orcid":"https://orcid.org/0000-0001-7554-0894","observed_orcids":["https://orcid.org/0000-0001-7554-0894","https://orcid.org/0000-0002-3300-6025"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Maria Gon\u00e7alves da Silva","raw_affiliation_strings":["Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil","Universidade de Sao Paulo, Instituto de Medicina Tropical de Sao Paulo, LIM 06, Sao Paulo, BrazilUniversidade de Sao Paulo, Faculdade de Medicina, Departamento de Patologia, Sao Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Universidade de Sao Paulo, Instituto de Medicina Tropical de Sao Paulo, LIM 06, Sao Paulo, BrazilUniversidade de Sao Paulo, Faculdade de Medicina, Departamento de Patologia, Sao Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051823324","display_name":"Patr\u00edcia Ant\u00f4nia Estima Abreu","orcid":"https://orcid.org/0000-0002-7541-0341","observed_orcids":["https://orcid.org/0000-0002-7541-0341"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patr\u00edcia Antonia Estima Abreu","raw_affiliation_strings":["Instituto Butantan,  Brazil","Instituto Butantan, Laboratorio de Bacteriologia, Sao Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Butantan,  Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Instituto Butantan, Laboratorio de Bacteriologia, Sao Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.55,"has_fulltext":true,"cited_by_count":135,"citation_normalized_percentile":{"value":0.98927477,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"60","issue":"0","first_page":"e23","last_page":"e23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptospirosis","display_name":"leptospirosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pathogenic-leptospires","display_name":"pathogenic leptospires","score":0.7889999747276306},{"id":"https://openalex.org/keywords/zoonotic-transmission","display_name":"zoonotic transmission","score":0.8980000019073486},{"id":"https://openalex.org/keywords/severe-leptospirosis","display_name":"severe leptospirosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.8410000205039978},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pulmonary-hemorrhage","display_name":"pulmonary hemorrhage","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-membrane-damage","display_name":"cell membrane damage","score":0.7429999709129333},{"id":"https://openalex.org/keywords/leptospiral-antigens","display_name":"leptospiral antigens","score":0.7680000066757202},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2778033228","wikidata":"https://www.wikidata.org/wiki/Q155098","display_name":"Leptospirosis","level":2,"score":0.8607532978057861},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7952720522880554},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.629300594329834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6092124581336975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4700787365436554},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.44362491369247437},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4350094795227051},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1590/s1678-9946201860023","doi":"https://doi.org/10.1590/s1678-9946201860023","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1678-9946201860023","pdf_url":"http://www.scielo.br/pdf/rimtsp/v60/1678-9946-rimtsp-60-S1678-9946201860023.pdf","source":{"id":"https://openalex.org/S182450478","display_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","issn_l":"0036-4665","issn":["0036-4665","1678-9946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","latindex","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","raw_type":"journal-article"},{"id":"pmid:29846473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29846473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de Sao Paulo","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S0036-46652018005000400","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000400","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo v.60 2018","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:4940177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5975557","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5975557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5975557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rev Inst Med Trop Sao Paulo","raw_type":"Text"},{"id":"pmh:oai:americanae.aecid.es:2531729","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2531729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo v.60 2018","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1809c39906d240cabc185894670194d3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1809c39906d240cabc185894670194d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo, Vol 60, Iss 0 (2018)","raw_type":"article"},{"id":"pmh:oai:revistas.usp.br:article/146975","doi":null,"is_oa":false,"landing_page_url":"https://www.revistas.usp.br/rimtsp/article/view/146975","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:IMT","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:revistas.usp.br:article/151565","doi":null,"is_oa":false,"landing_page_url":"https://www.revistas.usp.br/rimtsp/article/view/151565","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:IMT","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1590/s1678-9946201860023","doi":"https://doi.org/10.1590/s1678-9946201860023","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1678-9946201860023","pdf_url":"http://www.scielo.br/pdf/rimtsp/v60/1678-9946-rimtsp-60-S1678-9946201860023.pdf","source":{"id":"https://openalex.org/S182450478","display_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","issn_l":"0036-4665","issn":["0036-4665","1678-9946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","latindex","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806904932.pdf","grobid_xml":"https://content.openalex.org/works/W2806904932.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W9066891","https://openalex.org/W75505851","https://openalex.org/W175780719","https://openalex.org/W298259253","https://openalex.org/W1451690978","https://openalex.org/W1948094720","https://openalex.org/W1967980984","https://openalex.org/W1978308594","https://openalex.org/W1991389657","https://openalex.org/W1994195884","https://openalex.org/W2006717074","https://openalex.org/W2018043642","https://openalex.org/W2018355252","https://openalex.org/W2020101086","https://openalex.org/W2020472054","https://openalex.org/W2029801078","https://openalex.org/W2036482161","https://openalex.org/W2040593473","https://openalex.org/W2051622300","https://openalex.org/W2062734474","https://openalex.org/W2070093265","https://openalex.org/W2076674872","https://openalex.org/W2081384390","https://openalex.org/W2090163045","https://openalex.org/W2135900330","https://openalex.org/W2144586591","https://openalex.org/W2144691829","https://openalex.org/W2144916185","https://openalex.org/W2147412846","https://openalex.org/W2148957392","https://openalex.org/W2157801459","https://openalex.org/W2161132377","https://openalex.org/W2163356825","https://openalex.org/W2164498067","https://openalex.org/W2170313716","https://openalex.org/W2234240508","https://openalex.org/W2299170223","https://openalex.org/W2402033826","https://openalex.org/W2410190692","https://openalex.org/W2412750249","https://openalex.org/W2428557485","https://openalex.org/W2442713952","https://openalex.org/W2485168470","https://openalex.org/W2615918849","https://openalex.org/W2618906471","https://openalex.org/W2741650785","https://openalex.org/W4211105424","https://openalex.org/W4229595388","https://openalex.org/W4301017902","https://openalex.org/W6845457673"],"related_works":["https://openalex.org/W3153799911","https://openalex.org/W2417842367","https://openalex.org/W2190249206","https://openalex.org/W2036172755","https://openalex.org/W1893171985","https://openalex.org/W2415557774","https://openalex.org/W2377500394","https://openalex.org/W4385463330","https://openalex.org/W2098912119","https://openalex.org/W4401369041"],"abstract_inverted_index":{"Leptospirosis":[0],"is":[1],"an":[2],"acute":[3],"bacterial":[4],"septicemic":[5,86],"febrile":[6],"disease":[7,97,129],"caused":[8],"by":[9,26,52,89],"pathogenic":[10],"leptospires,":[11],"which":[12,82,137],"affect":[13],"humans":[14],"and":[15,59,114,122,130],"animals":[16,31],"in":[17,149],"all":[18],"parts":[19],"of":[20,73,95,126,133,144],"the":[21,50,62,85,96,124,127,131,142,150],"world.":[22],"Transmission":[23],"can":[24],"occur":[25,138],"direct":[27],"contact":[28,37],"with":[29,38,43,84,102],"infected":[30,46],"or,":[32],"more":[33],"commonly,":[34],"through":[35,61],"indirect":[36],"water":[39],"or":[40,56],"soil":[41],"contaminated":[42],"urine":[44],"from":[45],"animals.":[47],"Leptospires":[48],"enter":[49],"body":[51],"penetrating":[53],"mucous":[54],"membranes":[55],"skin":[57],"abrasions":[58],"disseminate":[60],"hematogenic":[63],"route.":[64],"In":[65,117],"humans,":[66],"leptospirosis":[67],"may":[68,98],"cause":[69],"a":[70,78],"wide":[71],"spectrum":[72],"symptoms.":[74],"Most":[75],"cases":[76],"have":[77],"biphasic":[79],"clinical":[80],"presentation,":[81],"begins":[83],"phase":[87],"followed":[88],"immune":[90],"manifestations.":[91],"The":[92],"severe":[93],"forms":[94],"be":[99],"life":[100],"threatening":[101],"multisystem":[103],"damage":[104],"including":[105],"renal":[106],"failure,":[107],"hepatic":[108],"dysfunction,":[109],"vascular":[110],"damage,":[111],"pulmonary":[112],"hemorrhage":[113],"muscle":[115],"lesions.":[116],"this":[118],"review,":[119],"we":[120],"present":[121],"discuss":[123],"pathogenesis":[125],"human":[128],"mechanisms":[132],"cell":[134],"membrane":[135],"injuries,":[136],"mainly":[139],"due":[140],"to":[141],"presence":[143],"leptospires":[145],"and/or":[146],"their":[147],"antigen/s":[148],"host":[151],"tissues.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}