{"id":"https://openalex.org/W2806903799","doi":"https://doi.org/10.1038/s41598-018-19802-3","title":"Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses","display_name":"Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses","publication_year":2018,"publication_date":"2018-01-23","ids":{"openalex":"https://openalex.org/W2806903799","doi":"https://doi.org/10.1038/s41598-018-19802-3","mag":"2806903799","pmid":"https://pubmed.ncbi.nlm.nih.gov/29379112"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-19802-3","doi":"https://doi.org/10.1038/s41598-018-19802-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-19802-3","pdf_url":"https://www.nature.com/articles/s41598-018-19802-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-19802-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102714362","display_name":"Giulia Romano","orcid":"https://orcid.org/0000-0003-0356-4947","observed_orcids":["https://orcid.org/0000-0003-0356-4947"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Romano","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011352016","display_name":"Nikola Holodkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nikola Holodkov","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066513149","display_name":"Raffaella Klima","orcid":"https://orcid.org/0000-0002-0487-0658","observed_orcids":["https://orcid.org/0000-0002-0487-0658"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaella Klima","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0487-0658","affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Federica Grilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Grilli","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017943087","display_name":"Corrado Guarnaccia","orcid":"https://orcid.org/0000-0001-7013-0861","observed_orcids":["https://orcid.org/0000-0001-7013-0861"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Corrado Guarnaccia","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067890456","display_name":"Monica Nizzardo","orcid":"https://orcid.org/0000-0001-5447-0882","observed_orcids":["https://orcid.org/0000-0001-5447-0882"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Nizzardo","raw_affiliation_strings":["Department of Pathophysiology and Transplantation (DePT), Dino Ferrari Centre, University of Milan, Neuroscience Section, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5447-0882","affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Transplantation (DePT), Dino Ferrari Centre, University of Milan, Neuroscience Section, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082719787","display_name":"Federica Rizzo","orcid":"https://orcid.org/0000-0002-7677-0330","observed_orcids":["https://orcid.org/0000-0002-7677-0330"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Rizzo","raw_affiliation_strings":["Department of Pathophysiology and Transplantation (DePT), Dino Ferrari Centre, University of Milan, Neuroscience Section, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Transplantation (DePT), Dino Ferrari Centre, University of Milan, Neuroscience Section, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618071","display_name":"Rodolfo C. Garcia","orcid":"https://orcid.org/0000-0002-7618-6329","observed_orcids":["https://orcid.org/0000-0002-7618-6329"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rodolfo Garcia","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040454121","display_name":"Fabian M. Feiguin","orcid":"https://orcid.org/0000-0002-8486-7546","observed_orcids":["https://orcid.org/0000-0002-8486-7546"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Fabian Feiguin","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy. fabian.feiguin@icgeb.org","International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy. fabian.feiguin@icgeb.org","institution_ids":["https://openalex.org/I91080651"]},{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040454121"],"corresponding_institution_ids":["https://openalex.org/I91080651"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.0755,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86098332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"1809","last_page":"1809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gad1","display_name":"GAD1","score":0.7829999923706055},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neuromuscular-synapse","display_name":"neuromuscular synapse","score":0.8640000224113464},{"id":"https://openalex.org/keywords/paralysis","display_name":"paralysis","score":0.5249999761581421},{"id":"https://openalex.org/keywords/extracellular-glutamate","display_name":"extracellular glutamate","score":0.7689999938011169},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/glutamate-receptor-antagonists","display_name":"glutamate receptor antagonists","score":0.871999979019165},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gad67","display_name":"GAD67","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.6549999713897705},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.4620000123977661},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.7131128907203674},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.672439694404602},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6449624300003052},{"id":"https://openalex.org/C9497952","wikidata":"https://www.wikidata.org/wiki/Q419650","display_name":"Glutamate decarboxylase","level":3,"score":0.6435670852661133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6359184384346008},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.5889537930488586},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5692225694656372},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5532547235488892},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4400377869606018},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.43057191371917725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22962155938148499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18758192658424377},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16877493262290955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13512346148490906},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12395867705345154},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11648932099342346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08019742369651794},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-018-19802-3","doi":"https://doi.org/10.1038/s41598-018-19802-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-19802-3","pdf_url":"https://www.nature.com/articles/s41598-018-19802-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:29379112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29379112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unica.it:11584/322747","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11584/322747","pdf_url":"https://iris.unica.it/bitstream/11584/322747/1/28-Downregulation%20of%20glutamic%20acid%20decarboxylase%20in%20Drosophila%20TDP-43-null%20brains%20provokes%20paralysis%20by%20affecting%20the%20organization%20of%20the%20neuromuscular%20synapses.pdf","source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5789004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5789004","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:air.unimi.it:2434/559273","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/559273","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arts.units.it:11368/3122721","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11368/3122721","pdf_url":null,"source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:fa4043f3a1ad4afc9922f8c68ed40dfa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fa4043f3a1ad4afc9922f8c68ed40dfa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-19802-3","doi":"https://doi.org/10.1038/s41598-018-19802-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-19802-3","pdf_url":"https://www.nature.com/articles/s41598-018-19802-3.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806903799.pdf","grobid_xml":"https://content.openalex.org/works/W2806903799.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1484999790","https://openalex.org/W1851712985","https://openalex.org/W1894162067","https://openalex.org/W1970606504","https://openalex.org/W1971516308","https://openalex.org/W1978972146","https://openalex.org/W1984080658","https://openalex.org/W1984369088","https://openalex.org/W1993599371","https://openalex.org/W2001555806","https://openalex.org/W2002068275","https://openalex.org/W2002389181","https://openalex.org/W2003306914","https://openalex.org/W2003618511","https://openalex.org/W2011396520","https://openalex.org/W2012418668","https://openalex.org/W2018110972","https://openalex.org/W2020797973","https://openalex.org/W2024858047","https://openalex.org/W2027433665","https://openalex.org/W2027713051","https://openalex.org/W2029023254","https://openalex.org/W2031964319","https://openalex.org/W2036892124","https://openalex.org/W2042131974","https://openalex.org/W2042672129","https://openalex.org/W2045189928","https://openalex.org/W2047266773","https://openalex.org/W2050522409","https://openalex.org/W2052332287","https://openalex.org/W2061586477","https://openalex.org/W2069350252","https://openalex.org/W2084561728","https://openalex.org/W2088152986","https://openalex.org/W2091145925","https://openalex.org/W2107338709","https://openalex.org/W2110841847","https://openalex.org/W2122132730","https://openalex.org/W2126503719","https://openalex.org/W2126871157","https://openalex.org/W2127518646","https://openalex.org/W2127863733","https://openalex.org/W2128505255","https://openalex.org/W2151893431","https://openalex.org/W2160475742","https://openalex.org/W2199612419","https://openalex.org/W2320983896"],"related_works":["https://openalex.org/W2084167126","https://openalex.org/W2356663882","https://openalex.org/W2019659751","https://openalex.org/W1503657933","https://openalex.org/W2094849359","https://openalex.org/W3138695362","https://openalex.org/W2401562497","https://openalex.org/W2102870106","https://openalex.org/W3112221891","https://openalex.org/W2075316962"],"abstract_inverted_index":{"Amyotrophic":[0],"lateral":[1],"sclerosis":[2],"is":[3],"a":[4,48],"progressive":[5],"neurodegenerative":[6],"disease":[7],"that":[8,68,120],"affects":[9],"the":[10,31,34,41,75,133,137,165],"motor":[11],"system,":[12],"comprised":[13],"of":[14,33,74,84,89,130,135],"motoneurons":[15,153],"and":[16,44,61,81,104,125,146],"associated":[17],"glia.":[18],"Accordingly,":[19],"neuronal":[20],"or":[21,94],"glial":[22],"defects":[23],"in":[24,37,56,92,141,151,158],"TDP-43":[25,131],"function":[26],"provoke":[27],"paralysis":[28],"due":[29],"to":[30,53,98],"degeneration":[32],"neuromuscular":[35],"synapses":[36,123],"Drosophila.":[38],"To":[39],"identify":[40],"responsible":[42],"molecules":[43],"mechanisms,":[45],"we":[46],"performed":[47],"genome":[49],"wide":[50],"proteomic":[51],"analysis":[52],"determine":[54],"differences":[55],"protein":[57,140],"expression":[58],"between":[59],"wild-type":[60],"TDP-43-minus":[62],"fly":[63],"heads.":[64],"The":[65],"data":[66],"established":[67],"mutant":[69],"insects":[70],"presented":[71],"reduced":[72],"levels":[73],"enzyme":[76],"glutamic":[77],"acid":[78],"decarboxylase":[79],"(Gad1)":[80],"increased":[82],"concentrations":[83],"extracellular":[85],"glutamate.":[86],"Genetic":[87],"rescue":[88],"Gad1":[90,121,138],"activity":[91],"neurons":[93],"glia":[95],"was":[96,109],"sufficient":[97],"recuperate":[99],"flies":[100,114],"locomotion,":[101],"synaptic":[102],"organization":[103],"glutamate":[105,116],"levels.":[106],"Analogous":[107],"recovery":[108],"obtained":[110],"by":[111],"treating":[112],"TDP-43-null":[113],"with":[115],"receptor":[117],"antagonists":[118],"demonstrating":[119],"promotes":[122],"formation":[124],"prevents":[126],"excitotoxicity.":[127],"Similar":[128],"suppression":[129],"provoked":[132],"downregulation":[134],"GAD67,":[136],"homolog":[139],"human":[142],"neuroblastoma":[143],"cell":[144],"lines":[145],"analogous":[147],"modifications":[148],"were":[149],"observed":[150],"iPSC-derived":[152],"from":[154],"patients":[155],"carrying":[156],"mutations":[157],"TDP-43,":[159],"uncovering":[160],"conserved":[161],"pathological":[162],"mechanisms":[163],"behind":[164],"disease.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}