{"id":"https://openalex.org/W2806848747","doi":"https://doi.org/10.1038/s41598-018-22191-2","title":"The pharmacokinetic advantage of 5-methyltetrahydrofolate for minimization of the risk for birth defects","display_name":"The pharmacokinetic advantage of 5-methyltetrahydrofolate for minimization of the risk for birth defects","publication_year":2018,"publication_date":"2018-02-28","ids":{"openalex":"https://openalex.org/W2806848747","doi":"https://doi.org/10.1038/s41598-018-22191-2","mag":"2806848747","pmid":"https://pubmed.ncbi.nlm.nih.gov/29511242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840174"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-22191-2","doi":"https://doi.org/10.1038/s41598-018-22191-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-22191-2","pdf_url":"https://www.nature.com/articles/s41598-018-22191-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-22191-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Steven W. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven W. Bailey","raw_affiliation_strings":["Department of Pharmacology, University of South Alabama, Rm 3370 MSB, Mobile, AL, 36688, USA. sbailey@southalabama.edu","Department of Pharmacology, University of South Alabama, Rm 3370 MSB, Mobile, AL, 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Rm 3370 MSB, Mobile, AL, 36688, USA. sbailey@southalabama.edu","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Rm 3370 MSB, Mobile, AL, 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085725014","display_name":"June E. Ayling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June E. Ayling","raw_affiliation_strings":["Department of Pharmacology, University of South Alabama, Rm 3370 MSB, Mobile, AL, 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Rm 3370 MSB, Mobile, AL, 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83809506"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.131,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.85663517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"4096","last_page":"4096"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-methyltetrahydrofolate","display_name":"5-methyltetrahydrofolate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.968999981880188},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.6190000176429749},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.7440000176429749},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cleft-lip-and-palate","display_name":"cleft lip and palate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/birth-defect-prevention","display_name":"birth defects prevention","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6449999809265137},{"id":"https://openalex.org/keywords/unmetabolized-folic-acid","display_name":"unmetabolized folic acid","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.7633881568908691},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6875641942024231},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5873963236808777},{"id":"https://openalex.org/C2779804826","wikidata":"https://www.wikidata.org/wiki/Q45435667","display_name":"Folinic acid","level":4,"score":0.5686602592468262},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.537172257900238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5209758877754211},{"id":"https://openalex.org/C198211336","wikidata":"https://www.wikidata.org/wiki/Q57821","display_name":"Fortification","level":2,"score":0.44462504982948303},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42618048191070557},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4237549304962158},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3461073637008667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2580319046974182},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.14893928170204163},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.12240329384803772},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11787724494934082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08094114065170288},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013763","descriptor_name":"Tetrahydrofolates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013763","descriptor_name":"Tetrahydrofolates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-018-22191-2","doi":"https://doi.org/10.1038/s41598-018-22191-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-22191-2","pdf_url":"https://www.nature.com/articles/s41598-018-22191-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4753296","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840174","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5840174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:29511242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29511242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:03911df1bca24e268bc22fec5d31791c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/03911df1bca24e268bc22fec5d31791c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-22191-2","doi":"https://doi.org/10.1038/s41598-018-22191-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-22191-2","pdf_url":"https://www.nature.com/articles/s41598-018-22191-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806848747.pdf","grobid_xml":"https://content.openalex.org/works/W2806848747.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1727893992","https://openalex.org/W1778851167","https://openalex.org/W1860664133","https://openalex.org/W1873864710","https://openalex.org/W1921110349","https://openalex.org/W1974282685","https://openalex.org/W1995877613","https://openalex.org/W1996917184","https://openalex.org/W1997917571","https://openalex.org/W2018163418","https://openalex.org/W2019038011","https://openalex.org/W2039806274","https://openalex.org/W2048151432","https://openalex.org/W2050651040","https://openalex.org/W2082514717","https://openalex.org/W2096019735","https://openalex.org/W2110016941","https://openalex.org/W2113314534","https://openalex.org/W2115081805","https://openalex.org/W2118405820","https://openalex.org/W2123445784","https://openalex.org/W2157747858","https://openalex.org/W2293647902","https://openalex.org/W2326564641","https://openalex.org/W2466651294","https://openalex.org/W2527279288","https://openalex.org/W2556879523","https://openalex.org/W2601068201","https://openalex.org/W4206832593","https://openalex.org/W4237533794"],"related_works":["https://openalex.org/W6960612250","https://openalex.org/W3174761574","https://openalex.org/W1978073234","https://openalex.org/W4385724082","https://openalex.org/W2157747858","https://openalex.org/W1558063368","https://openalex.org/W7212019238","https://openalex.org/W7140914116","https://openalex.org/W2161978857","https://openalex.org/W148419630"],"abstract_inverted_index":{"Despite":[0],"efforts":[1],"to":[2,22,43,56,145],"increase":[3],"folic":[4,127],"acid":[5],"(FA)":[6],"intake,":[7],"even":[8],"within":[9],"countries":[10],"mandating":[11],"FA":[12,37,88,141],"fortification,":[13],"there":[14],"remain":[15],"pregnant":[16],"women":[17,76,95],"with":[18],"folate":[19,53,64,134],"levels":[20],"inadequate":[21],"minimize":[23],"congenital":[24],"disorders":[25],"(e.g.,":[26],"of":[27,36,59,81,87,123,126,133],"the":[28,70,84],"neural":[29],"tube,":[30],"heart,":[31],"and":[32,38,47,138,142],"lip/palate).":[33],"The":[34],"pharmacokinetics":[35],"[6S]-5-methyltetrahydrofolate":[39],"(5-MTHF)":[40],"were":[41],"examined":[42],"find":[44],"a":[45],"reliable":[46],"minimal":[48],"dose":[49],"for":[50,90],"rapidly":[51,68],"rescuing":[52],"status":[54],"prior":[55],"critical":[57],"periods":[58],"embryonic":[60],"development.":[61],"Serum":[62],"total":[63,112],"increased":[65],"much":[66],"more":[67,136],"over":[69],"first":[71],"four":[72],"days":[73],"in":[74],"insufficient":[75],"given":[77,96],"7.5":[78,97],"mg":[79,98],"doses":[80,104],"5-MTHF":[82,99,130],"than":[83,140],"same":[85],"regimen":[86],"(P":[89],"trend":[91],"<0.0001).":[92],"Nearly":[93],"all":[94],"(every":[100],"12":[101],"hours,":[102],"five":[103],"total)":[105],"almost":[106],"immediately":[107],"reached":[108],"50":[109],"nM":[110],"serum":[111],"folate.":[113],"Moreover,":[114],"this":[115],"level":[116],"could":[117],"be":[118],"maintained":[119],"by":[120],"subsequent":[121],"administration":[122],"0.4":[124],"mg/d":[125],"acid.":[128],"Thus,":[129],"enables":[131],"repletion":[132],"stores":[135],"quickly":[137],"uniformly":[139],"without":[143],"exposure":[144],"unmetabolized":[146],"FA.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}