{"id":"https://openalex.org/W2806841577","doi":"https://doi.org/10.1186/s12944-018-0775-8","title":"LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia","display_name":"LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia","publication_year":2018,"publication_date":"2018-05-24","ids":{"openalex":"https://openalex.org/W2806841577","doi":"https://doi.org/10.1186/s12944-018-0775-8","mag":"2806841577","pmid":"https://pubmed.ncbi.nlm.nih.gov/29793488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5968477"},"language":"en","primary_location":{"id":"doi:10.1186/s12944-018-0775-8","doi":"https://doi.org/10.1186/s12944-018-0775-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-018-0775-8","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-018-0775-8","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-018-0775-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078929375","display_name":"Silvia Magno","orcid":"https://orcid.org/0000-0002-8705-6554","observed_orcids":["https://orcid.org/0000-0002-8705-6554"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Magno","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050207678","display_name":"Giovanni Ceccarini","orcid":"https://orcid.org/0000-0003-0701-642X","observed_orcids":["https://orcid.org/0000-0003-0701-642X"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Ceccarini","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034601687","display_name":"Caterina Pelosini","orcid":"https://orcid.org/0000-0001-8322-6205","observed_orcids":["https://orcid.org/0000-0001-8322-6205"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Pelosini","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036694135","display_name":"Roberta Jaccheri","orcid":"https://orcid.org/0009-0003-6063-4830","observed_orcids":["https://orcid.org/0009-0003-6063-4830"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Jaccheri","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009892172","display_name":"Jacopo Vitti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"J. Vitti","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039563460","display_name":"Paola Fierabracci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Fierabracci","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113340543","display_name":"G. Salvetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Salvetti","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048074145","display_name":"G. Airoldi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Airoldi","raw_affiliation_strings":["Studio Associato Airoldi Cicogna Ghirri, Via Manzoni 40, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Studio Associato Airoldi Cicogna Ghirri, Via Manzoni 40, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028512257","display_name":"Massimiliano Minale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Minale","raw_affiliation_strings":["ISPharm srl, Via Oberdan 43, Lucca, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISPharm srl, Via Oberdan 43, Lucca, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021480070","display_name":"Giorgio Saponati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Saponati","raw_affiliation_strings":["ISPharm srl, Via Oberdan 43, Lucca, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISPharm srl, Via Oberdan 43, Lucca, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041749393","display_name":"Ferruccio Santini","orcid":"https://orcid.org/0000-0002-1706-0822","observed_orcids":["https://orcid.org/0000-0002-1706-0822"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"F. Santini","raw_affiliation_strings":["Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy. ferruccio.santini@med.unipi.it","Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy. ferruccio.santini@med.unipi.it","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]},{"raw_affiliation_string":"Obesity Center at the Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041749393"],"corresponding_institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":2.0372,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.85685451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"124","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.9179999828338623},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8610000014305115},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.5910000205039978},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.5950000286102295},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.3149999976158142},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.5509999990463257},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7617137432098389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6560178995132446},{"id":"https://openalex.org/C22894154","wikidata":"https://www.wikidata.org/wiki/Q15483409","display_name":"Lipidology","level":3,"score":0.6352151036262512},{"id":"https://openalex.org/C2779384338","wikidata":"https://www.wikidata.org/wiki/Q321285","display_name":"Coenzyme Q10","level":2,"score":0.6299231052398682},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5973500609397888},{"id":"https://openalex.org/C148257392","wikidata":"https://www.wikidata.org/wiki/Q2358629","display_name":"Clinical nutrition","level":2,"score":0.5742271542549133},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5158650279045105},{"id":"https://openalex.org/C382228","wikidata":"https://www.wikidata.org/wiki/Q849994","display_name":"Clinical chemistry","level":2,"score":0.5099111795425415},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4985806941986084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46723562479019165},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.41053080558776855},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3737322688102722}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12944-018-0775-8","doi":"https://doi.org/10.1186/s12944-018-0775-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-018-0775-8","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-018-0775-8","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4925308","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5968477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5968477","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5968477","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids Health Dis","raw_type":"Text"},{"id":"pmid:29793488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29793488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in health and disease","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/942646","doi":null,"is_oa":true,"landing_page_url":"https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0775-8","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:92de42cbe1df457cac1035a5932eb8ee","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/92de42cbe1df457cac1035a5932eb8ee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-8 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12944-018-0775-8","doi":"https://doi.org/10.1186/s12944-018-0775-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12944-018-0775-8","pdf_url":"https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-018-0775-8","source":{"id":"https://openalex.org/S188748365","display_name":"Lipids in Health and Disease","issn_l":"1476-511X","issn":["1476-511X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids in Health and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806841577.pdf","grobid_xml":"https://content.openalex.org/works/W2806841577.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1887537657","https://openalex.org/W1967026165","https://openalex.org/W1984531810","https://openalex.org/W1999094249","https://openalex.org/W1999627506","https://openalex.org/W2003677326","https://openalex.org/W2018636372","https://openalex.org/W2019071303","https://openalex.org/W2021529471","https://openalex.org/W2023013255","https://openalex.org/W2025162232","https://openalex.org/W2026547857","https://openalex.org/W2029932977","https://openalex.org/W2036062936","https://openalex.org/W2047061085","https://openalex.org/W2050518716","https://openalex.org/W2060346221","https://openalex.org/W2066320566","https://openalex.org/W2067614264","https://openalex.org/W2071654814","https://openalex.org/W2074005494","https://openalex.org/W2092620816","https://openalex.org/W2102839002","https://openalex.org/W2108838752","https://openalex.org/W2117274684","https://openalex.org/W2147649126","https://openalex.org/W2155903397","https://openalex.org/W2168356010","https://openalex.org/W2247997571","https://openalex.org/W2278860456","https://openalex.org/W2305741915","https://openalex.org/W2402599050","https://openalex.org/W2561047698","https://openalex.org/W2593271859","https://openalex.org/W3021842026","https://openalex.org/W4236673002"],"related_works":["https://openalex.org/W4312174101","https://openalex.org/W4380083904","https://openalex.org/W4280506874","https://openalex.org/W4404399492","https://openalex.org/W1812348863","https://openalex.org/W4402232656","https://openalex.org/W4309232462","https://openalex.org/W1983997443","https://openalex.org/W4292763871","https://openalex.org/W2165060403"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypercholesterolemia":[1],"is":[2],"a":[3,70,87,103,148,316,339],"major":[4],"risk":[5],"factor":[6],"for":[7,142,287],"cardiovascular":[8],"disorders":[9],"and":[10,19,67,79,94,124,134,182,189,215,238,274,334],"requires":[11],"specific":[12],"intervention":[13],"through":[14,50,200],"an":[15,25],"adequate":[16],"lifestyle":[17],"(diet":[18],"physical":[20],"exercise)":[21],"and,":[22],"if":[23],"necessary,":[24],"appropriate":[26],"drug":[27],"treatment.":[28,246],"Lipid-lowering":[29],"drugs,":[30],"although":[31],"generally":[32],"efficacious,":[33],"may":[34],"sometimes":[35],"cause":[36],"adverse":[37,294],"events.":[38],"A":[39,221,245,262,273],"growing":[40],"attention":[41],"has":[42],"been":[43],"devoted":[44],"to":[45,62,86],"the":[46,51,64,187,191,201,225,298,304,320,323],"correction":[47],"of":[48,53,58,69,193,310,327,342],"dyslipidemias":[49],"use":[52],"dietary":[54,71,131],"supplements.":[55],"The":[56,279],"aim":[57],"this":[59],"study":[60,111],"was":[61,102,198,229,259,265,283],"assess":[63],"lipid-lowering":[65],"activity":[66],"safety":[68],"supplement":[72,317],"containing":[73,91,137],"monacolin":[74,92,138,311,328],"K,":[75],"L-arginine,":[76,331],"coenzyme":[77,95],"Q10":[78,333],"ascorbic":[80,335],"acid,":[81],"named":[82],"Argicolina":[83],"(A),":[84],"compared":[85],"commercially":[88],"available":[89],"product":[90],"K":[93,139,329],"Q10,":[96],"Normolip":[97],"5":[98],"(N).":[99],"METHODS:":[100],"This":[101],"single":[104],"center,":[105],"controlled,":[106],"randomized,":[107],"open-label,":[108],"cross-over":[109],"clinical":[110],"enrolling":[112],"20":[113],"Caucasian":[114],"outpatients":[115],"aged":[116],"18-75":[117],"years":[118],"with":[119,210,220,315,330],"serum":[120],"LDL-C":[121,204,226,307],"between":[122,281],"130":[123],"180":[125],"mg/dL.":[126],"Patients":[127],"assumed":[128],"two":[129],"different":[130],"supplements":[132],"(A":[133],"N)":[135],"both":[136],"10":[140],"mg":[141],"8":[143],"weeks":[144],"each,":[145],"separated":[146],"by":[147,206,216],"4-week":[149],"wash-out":[150],"period.":[151,196,256],"Evaluated":[152],"parameters":[153],"were:":[154],"Total":[155],"cholesterol":[156,161,166],"(Tot-C),":[157],"low":[158],"density":[159,164],"lipoprotein":[160,165],"(LDL-C),":[162],"high":[163],"(HDL-C),":[167],"triglycerides":[168,343],"(TG),":[169],"fasting":[170],"blood":[171],"glucose,":[172],"aspartate":[173],"aminotransferase,":[174,176],"alanine":[175],"creatinekinase,":[177],"gamma-glutamyl-transpeptidase,":[178],"brachial":[179],"arterial":[180],"pressure":[181],"heart":[183],"rate,":[184],"measured":[185],"at":[186,190],"start":[188],"end":[192],"each":[194,254],"treatment":[195,209,219,237,255],"Safety":[197],"monitored":[199],"study.":[202,299],"RESULTS:":[203],"decreased":[205,248],"23.3%":[207],"during":[208,218,235,244,261,267,272,277,297],"N":[211,236],"(p":[212,222,250],"<":[213,223,251],"0.0001)":[214,252],"25.6%":[217],"0.0001);":[224],"mean":[227],"reduction":[228,341],"36.4":[230],"(95%":[231,240],"CI:":[232,241],"45,6-27,1)":[233],"mg/dL":[234,243],"40.1":[239],"49.2-30,9)":[242],"Tot-C":[247],"significantly":[249,276],"within":[253],"HDL-C":[257],"increase":[258],"negligible":[260],"whereas":[263],"it":[264],"significant":[266,286,340,345],"N.":[268,278],"TG":[269],"diminished":[270],"markedly":[271],"not":[275,284],"difference":[280],"treatments":[282],"statistically":[285],"all":[288],"variables.":[289],"No":[290],"serious":[291],"or":[292],"severe":[293],"events":[295],"occurred":[296],"CONCLUSIONS:":[300],"Our":[301],"results":[302],"confirm":[303],"clinically":[305],"meaningful":[306],"lowering":[308],"properties":[309],"K.":[312],"At":[313],"variance":[314],"already":[318],"in":[319],"market":[321],"(N),":[322],"novel":[324],"association":[325],"(A)":[326],"coenzime":[332],"acid":[336],"also":[337],"produces":[338],"without":[344],"effects":[346],"on":[347],"HDL.":[348],"TRIAL":[349],"REGISTRATION:":[350],"ClinicalTrials.gov":[351],"ID:":[352],"NCT03425630":[353],".":[354]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
