{"id":"https://openalex.org/W2806836498","doi":"https://doi.org/10.1038/s41598-018-23109-8","title":"Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation","display_name":"Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation","publication_year":2018,"publication_date":"2018-03-15","ids":{"openalex":"https://openalex.org/W2806836498","doi":"https://doi.org/10.1038/s41598-018-23109-8","mag":"2806836498","pmid":"https://pubmed.ncbi.nlm.nih.gov/29563576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5862878"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-23109-8","doi":"https://doi.org/10.1038/s41598-018-23109-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-23109-8","pdf_url":"https://www.nature.com/articles/s41598-018-23109-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-23109-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064842876","display_name":"Nassima Chouaki Benmansour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nassima Chouaki Benmansour","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059055143","display_name":"Kilian Ruminski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kilian Ruminski","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067390484","display_name":"Anne-Marie Sartre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Marie Sartre","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046450913","display_name":"Marie-Claire Ph\u00e9lipot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Claire Phelipot","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001756969","display_name":"Audrey Salles","orcid":"https://orcid.org/0000-0002-1890-6957","observed_orcids":["https://orcid.org/0000-0002-1890-6957"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Audrey Salles","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","UTechS Photonic BioImaging (Imagopole) Citech, Institut Pasteur, Paris, 75724, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]},{"raw_affiliation_string":"UTechS Photonic BioImaging (Imagopole) Citech, Institut Pasteur, Paris, 75724, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027776998","display_name":"Elise Bergot","orcid":"https://orcid.org/0000-0003-1425-6560","observed_orcids":["https://orcid.org/0000-0003-1425-6560"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elise Bergot","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087203944","display_name":"Ambroise Wu","orcid":"https://orcid.org/0000-0001-8568-8331","observed_orcids":["https://orcid.org/0000-0001-8568-8331"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ambroise Wu","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044464476","display_name":"Ga\u00ebtan Chicanne","orcid":"https://orcid.org/0000-0002-7081-2595","observed_orcids":["https://orcid.org/0000-0002-7081-2595"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ga\u00ebtan Chicanne","raw_affiliation_strings":["Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm U1048, Universit\u00e9 Toulouse 3, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm U1048, Universit\u00e9 Toulouse 3, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018261814","display_name":"Mathieu Fallet","orcid":"https://orcid.org/0000-0001-8144-6159","observed_orcids":["https://orcid.org/0000-0001-8144-6159"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathieu Fallet","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071182713","display_name":"Sophie Brustlein","orcid":"https://orcid.org/0009-0008-8719-1159","observed_orcids":["https://orcid.org/0009-0008-8719-1159"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Brustlein","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027581647","display_name":"Cyrille Billaudeau","orcid":"https://orcid.org/0000-0002-6161-4968","observed_orcids":["https://orcid.org/0000-0002-6161-4968"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I3017594750","display_name":"Microbiologie de l\u2019alimentation au service de la sant\u00e9","ror":"https://ror.org/0471cyx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyrille Billaudeau","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, 78350, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]},{"raw_affiliation_string":"Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, 78350, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024392488","display_name":"Anthony Formisano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anthony Formisano","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021310198","display_name":"S\u00e9bastien Mailfert","orcid":"https://orcid.org/0000-0002-0409-0432","observed_orcids":["https://orcid.org/0000-0002-0409-0432"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Mailfert","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081552914","display_name":"Bernard Payrastre","orcid":"https://orcid.org/0000-0002-8693-0190","observed_orcids":["https://orcid.org/0000-0002-8693-0190"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Payrastre","raw_affiliation_strings":["Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm U1048, Universit\u00e9 Toulouse 3, Toulouse, France","Laboratoire d'H\u00e9matologie, Centre Hospitalier Universitaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm U1048, Universit\u00e9 Toulouse 3, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Laboratoire d'H\u00e9matologie, Centre Hospitalier Universitaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079495747","display_name":"Didier Marguet","orcid":"https://orcid.org/0000-0003-3198-5095","observed_orcids":["https://orcid.org/0000-0003-3198-5095"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Marguet","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0003-3198-5095","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023076774","display_name":"Sophie Brasselet","orcid":"https://orcid.org/0000-0002-6766-9273","observed_orcids":["https://orcid.org/0000-0002-6766-9273"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210125985","display_name":"Institut Fresnel","ror":"https://ror.org/03br1wy20","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210095849","https://openalex.org/I4210125985","https://openalex.org/I4210142724"]},{"id":"https://openalex.org/I4210142724","display_name":"Centrale M\u00e9diterran\u00e9e","ror":"https://ror.org/040baw385","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210142724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Brasselet","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, UMR 7249, 13397, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-6766-9273","affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, UMR 7249, 13397, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210125985","https://openalex.org/I4210142724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036455958","display_name":"Yannick Hamon","orcid":"https://orcid.org/0000-0002-7636-2310","observed_orcids":["https://orcid.org/0000-0002-7636-2310"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Yannick Hamon","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France. hamon@ciml.univ-mrs.fr","Aix Marseille Univ, CNRS, INSERM, CIML, Centre d\u2019Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France. hamon@ciml.univ-mrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]},{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d\u2019Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000443642","display_name":"Hai\u2010Tao He","orcid":"https://orcid.org/0000-0002-6594-290X","observed_orcids":["https://orcid.org/0000-0002-6594-290X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Hai-Tao He","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France. he@ciml.univ-mrs.fr","Aix Marseille Univ, CNRS, INSERM, CIML, Centre d\u2019Immunologie de Marseille-Luminy, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-6594-290X","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France. he@ciml.univ-mrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]},{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, CIML, Centre d\u2019Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5000443642","https://openalex.org/A5036455958"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":1370,"currency":"EUR","value_usd":1477},"fwci":1.653,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.80101448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"4966","last_page":"4966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.328900009393692,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.328900009393692,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.13510000705718994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphoinositides","display_name":"phosphoinositides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tcr-cd3-complex","display_name":"TCR/CD3 complex","score":0.9010000228881836},{"id":"https://openalex.org/keywords/membrane-dynamics","display_name":"membrane dynamics","score":0.8180000185966492},{"id":"https://openalex.org/keywords/inositol-polyphosphate-5-phosphatase","display_name":"inositol polyphosphate 5-phosphatase","score":0.925000011920929},{"id":"https://openalex.org/keywords/lck-kinase","display_name":"Lck kinase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-hybridomas","display_name":"T cell hybridomas","score":0.6830000281333923},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.8637869358062744},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.8169286847114563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7064735293388367},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.650959312915802},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6348446607589722},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.60993492603302},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5123251676559448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4321097433567047},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41545435786247253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3874703049659729},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2813361883163452},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13854506611824036},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.09177368879318237},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.09007710218429565}],"mesh":[{"descriptor_ui":"D000099182","descriptor_name":"Phosphoinositide 5-Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-23109-8","doi":"https://doi.org/10.1038/s41598-018-23109-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-23109-8","pdf_url":"https://www.nature.com/articles/s41598-018-23109-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4773794","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5862878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29563576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29563576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5862878","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5862878/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01920092v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-01920092","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, 2018, 8 (1), pp.4966. ⟨10.1038/s41598-018-23109-8⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:961cc4c296364db68b43653b3c0412de","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/961cc4c296364db68b43653b3c0412de","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-23109-8","doi":"https://doi.org/10.1038/s41598-018-23109-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-23109-8","pdf_url":"https://www.nature.com/articles/s41598-018-23109-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2441619162","display_name":null,"funder_award_id":"ANR-10-INBS-04-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2450198060","display_name":null,"funder_award_id":"10-INBS-04","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G262592543","display_name":null,"funder_award_id":"10-INBS-04-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G381665449","display_name":null,"funder_award_id":"ANR\u201010_INBS\u201004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5297999932","display_name":"Observing the T cell receptor (TCR) activation in real time: monitoring the intracellular domain orientation dynamics of the receptor complex in live cells with polarized time-resolved fluorescence imaging","funder_award_id":"ANR-10-BLAN-1509","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6545385182","display_name":null,"funder_award_id":"ANR-10-INBS-04","funder_id":"https://openalex.org/F4320322890","funder_display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche"},{"id":"https://openalex.org/G703701052","display_name":null,"funder_award_id":"INBS-04-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7777646733","display_name":null,"funder_award_id":"ANR-10-INBS-04","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"},{"id":"https://openalex.org/G8234668411","display_name":null,"funder_award_id":"ANR-10-INBS-04","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G8447172698","display_name":"D\u00e9veloppment d'une infrastructure fran\u00e7aise distribu\u00e9e coordonn\u00e9e","funder_award_id":"ANR-10-INBS-0004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8916787474","display_name":null,"funder_award_id":"ANR-10-INBS-04","funder_id":"https://openalex.org/F4320322361","funder_display_name":"Fondation ARC pour la Recherche sur le Cancer"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320322890","display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche","ror":"https://ror.org/03sjk9a61"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806836498.pdf","grobid_xml":"https://content.openalex.org/works/W2806836498.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W569951484","https://openalex.org/W1513958154","https://openalex.org/W1546930353","https://openalex.org/W1585450293","https://openalex.org/W1604544257","https://openalex.org/W1802980406","https://openalex.org/W1922099438","https://openalex.org/W1934867783","https://openalex.org/W1950543250","https://openalex.org/W1964754567","https://openalex.org/W1965613574","https://openalex.org/W1967359088","https://openalex.org/W1988549572","https://openalex.org/W1989488426","https://openalex.org/W1992196706","https://openalex.org/W1998000396","https://openalex.org/W2008636329","https://openalex.org/W2010519082","https://openalex.org/W2011756793","https://openalex.org/W2012886666","https://openalex.org/W2013348437","https://openalex.org/W2022204362","https://openalex.org/W2025116006","https://openalex.org/W2039987826","https://openalex.org/W2041748354","https://openalex.org/W2043597075","https://openalex.org/W2049029186","https://openalex.org/W2049701773","https://openalex.org/W2054799935","https://openalex.org/W2055567106","https://openalex.org/W2065490663","https://openalex.org/W2065681262","https://openalex.org/W2070732456","https://openalex.org/W2076601151","https://openalex.org/W2084388859","https://openalex.org/W2085035388","https://openalex.org/W2086149271","https://openalex.org/W2089003221","https://openalex.org/W2091884933","https://openalex.org/W2092722000","https://openalex.org/W2093621953","https://openalex.org/W2100412095","https://openalex.org/W2102530636","https://openalex.org/W2103944364","https://openalex.org/W2107290681","https://openalex.org/W2116033277","https://openalex.org/W2119806797","https://openalex.org/W2122236783","https://openalex.org/W2125337252","https://openalex.org/W2127566892","https://openalex.org/W2128783251","https://openalex.org/W2130826825","https://openalex.org/W2142084587","https://openalex.org/W2144935474","https://openalex.org/W2150293212","https://openalex.org/W2152807226","https://openalex.org/W2156393136","https://openalex.org/W2163623676","https://openalex.org/W2166227072","https://openalex.org/W2181821326","https://openalex.org/W2303327195","https://openalex.org/W2404634384","https://openalex.org/W2464616750","https://openalex.org/W2472262249","https://openalex.org/W2476984584","https://openalex.org/W2479324451","https://openalex.org/W2507273126","https://openalex.org/W2531213272","https://openalex.org/W2575292366","https://openalex.org/W2592634893","https://openalex.org/W2595399666","https://openalex.org/W2599088423","https://openalex.org/W2608759419","https://openalex.org/W2732928415"],"related_works":["https://openalex.org/W7071267653","https://openalex.org/W2126470675","https://openalex.org/W2095210861","https://openalex.org/W1618856863","https://openalex.org/W11480356","https://openalex.org/W3185195276","https://openalex.org/W4313380768","https://openalex.org/W2102530636","https://openalex.org/W2075587546","https://openalex.org/W2086149271"],"abstract_inverted_index":{"Phosphoinositides":[0],"(PIs)":[1],"play":[2,166],"important":[3],"roles":[4],"in":[5,13,37,44,50,103,130,135,170],"numerous":[6],"membrane-based":[7],"cellular":[8],"activities.":[9],"However,":[10],"their":[11,34],"involvement":[12],"the":[14,24,71,74,91,106,120,126,150,157,171,174,181],"mechanism":[15],"of":[16,40,58,68,153,173],"T":[17],"cell":[18],"receptor":[19],"(TCR)":[20],"signal":[21],"transduction":[22],"across":[23],"plasma":[25],"membrane":[26],"(PM)":[27],"is":[28],"poorly":[29],"defined.":[30],"Here,":[31],"we":[32,112],"investigate":[33],"role,":[35],"and":[36,48,84,178],"particular":[38],"that":[39,66,115,164],"phosphatidylinositol":[41],"4,5-bisphosphate":[42],"[PI(4,5)P2]":[43],"TCR":[45],"PM":[46,77,127],"dynamics":[47,177],"activity":[49],"a":[51,59,167],"mouse":[52],"T-cell":[53],"hybridoma":[54],"upon":[55],"ectopic":[56],"expression":[57],"PM-localized":[60],"inositol":[61],"polyphosphate-5-phosphatase":[62],"(Inp54p).":[63],"We":[64],"observed":[65,151],"dephosphorylation":[67,117,155],"PI(4,5)P2":[69,116,154],"by":[70],"phosphatase":[72],"increased":[73,137],"TCR/CD3":[75,175],"complex":[76,176],"lateral":[78],"mobility":[79],"prior":[80],"stimulation.":[81],"The":[82],"constitutive":[83],"antigen-elicited":[85],"CD3":[86,138,158],"phosphorylation":[87],"as":[88,90],"well":[89],"antigen-stimulated":[92],"early":[93],"signaling":[94],"pathways":[95],"were":[96],"all":[97],"found":[98],"to":[99],"be":[100],"significantly":[101,147],"augmented":[102],"cells":[104],"expressing":[105],"phosphatase.":[107],"Using":[108],"state-of-the-art":[109],"biophotonic":[110],"approaches,":[111],"further":[113],"showed":[114],"strongly":[118],"promoted":[119],"CD3\u03b5":[121],"cytoplasmic":[122],"domain":[123],"unbinding":[124],"from":[125],"inner":[128],"leaflet":[129],"living":[131],"cells,":[132],"thus":[133,162],"resulting":[134],"an":[136],"availability":[139],"for":[140,149],"interactions":[141],"with":[142],"Lck":[143],"kinase.":[144],"This":[145],"could":[146],"account":[148],"effects":[152],"on":[156],"phosphorylation.":[159],"Our":[160],"data":[161],"suggest":[163],"PIs":[165],"key":[168],"role":[169],"regulation":[172],"activation":[179],"at":[180],"PM.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-06-13T00:00:00"}