{"id":"https://openalex.org/W2806801901","doi":null,"title":"The multicenter THALAMOSS cellular Biobank for \u03b2-Thalassemia","display_name":"The multicenter THALAMOSS cellular Biobank for \u03b2-Thalassemia","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2806801901","mag":"2806801901"},"language":"en","primary_location":{"id":"pmh:oai:sfera.unife.it:11392/2369751","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/2369751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068509156","display_name":"Lucia Carmela Cosenza","orcid":"https://orcid.org/0000-0002-2949-7191","observed_orcids":["https://orcid.org/0000-0002-2949-7191","https://orcid.org/0000-0002-0221-7102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucia Carmela Cosenza","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2949-7191","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069433670","display_name":"Laura Breda","orcid":"https://orcid.org/0000-0003-2133-4432","observed_orcids":["https://orcid.org/0000-0003-2133-4432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Breda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2133-4432","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045022292","display_name":"Giulia Breveglieri","orcid":"https://orcid.org/0000-0002-9013-1738","observed_orcids":["https://orcid.org/0000-0002-9013-1738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulia Breveglieri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9013-1738","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107462983","display_name":"Cristina Zuccato","orcid":"https://orcid.org/0000-0002-1380-0539","observed_orcids":["https://orcid.org/0000-0002-1380-0539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Zuccato","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1380-0539","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030568464","display_name":"Alessia Finotti","orcid":"https://orcid.org/0000-0002-7638-515X","observed_orcids":["https://orcid.org/0000-0002-7638-515X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessia Finotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004138315","display_name":"Ilaria Lampronti","orcid":"https://orcid.org/0000-0002-1972-7766","observed_orcids":["https://orcid.org/0000-0002-1972-7766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilaria Lampronti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1972-7766","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110220760","display_name":"Stefania Satta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefania Satta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026299357","display_name":"Laura Manunza","orcid":"https://orcid.org/0000-0002-1800-5139","observed_orcids":["https://orcid.org/0000-0002-1800-5139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Manunza","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1800-5139","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089618257","display_name":"Franca Rosa Demartis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franca Rosa De Martis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030084867","display_name":"Paolo Moi","orcid":"https://orcid.org/0000-0001-7879-8057","observed_orcids":["https://orcid.org/0000-0001-7879-8057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Moi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076081716","display_name":"Swee Lay Thein","orcid":"https://orcid.org/0000-0002-9835-6501","observed_orcids":["https://orcid.org/0000-0002-9835-6501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swee Lay Thein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9835-6501","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061822217","display_name":"Stephan Menzel","orcid":"https://orcid.org/0000-0002-1590-9108","observed_orcids":["https://orcid.org/0000-0002-1590-9108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan Menzel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1590-9108","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086784163","display_name":"Amandine Breton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amandine Breton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085216609","display_name":"Carsten Werner Lederer","orcid":"https://orcid.org/0000-0003-3920-9584","observed_orcids":["https://orcid.org/0000-0003-3920-9584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten W. Lederer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3920-9584","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057667251","display_name":"Monica Borgatti","orcid":"https://orcid.org/0000-0001-8470-2496","observed_orcids":["https://orcid.org/0000-0001-8470-2496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Borgatti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8470-2496","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025564778","display_name":"Marina Kleanthous","orcid":"https://orcid.org/0000-0003-0064-7034","observed_orcids":["https://orcid.org/0000-0003-0064-7034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Kleanthous","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046499318","display_name":"Stefano Rivella","orcid":"https://orcid.org/0000-0002-0938-6558","observed_orcids":["https://orcid.org/0000-0002-0938-6558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Rivella","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0938-6558","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070584148","display_name":"Roberto Gambari","orcid":"https://orcid.org/0000-0001-9205-6033","observed_orcids":["https://orcid.org/0000-0001-9205-6033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Gambari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9205-6033","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013472145","display_name":"Nicoletta Bianchi","orcid":"https://orcid.org/0000-0001-9280-6017","observed_orcids":["https://orcid.org/0000-0001-9280-6017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicoletta Bianchi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9280-6017","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":null,"first_page":"69","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.953000009059906},{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mithramycin","display_name":"mithramycin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.9990000128746033},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.9200000166893005},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.9562992453575134},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.7877435684204102},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.545873761177063},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5232683420181274},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.46080660820007324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43280255794525146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41590559482574463},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3868544101715088},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27884459495544434}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:sfera.unife.it:11392/2369751","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/2369751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"mag:2806801901","doi":null,"is_oa":false,"landing_page_url":"https://iris.unife.it/handle/11392/2369751","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3210032439","https://openalex.org/W2513071654","https://openalex.org/W1054555628","https://openalex.org/W6958572098","https://openalex.org/W6939985508","https://openalex.org/W1973934721","https://openalex.org/W2990375746","https://openalex.org/W4254449590","https://openalex.org/W4242139672","https://openalex.org/W1554364555"],"abstract_inverted_index":{"The":[0,26,42,102,188],"production":[1],"and":[2,40,61,78,95,112,145,176,202,226],"validation":[3,103],"of":[4,24,44,71,76,80,91,183,222],"a":[5,181],"cellular":[6,27,105,166],"thalassemia":[7],"Biobank":[8,28,106,167],"was":[9,107],"conducted":[10],"within":[11],"the":[12,35,67,72,84,92,104,114,118,128,136,148,164,219,223,227],"multicenter":[13],"European":[14],"Project":[15],"THALAMOSS":[16,165],"(THalassemia":[17],"MOdular":[18],"Stratification":[19],"System":[20],"for":[21,134,180],"personalized":[22],"therapy":[23,160],"\u03b2-thalassemia).":[25],"contains":[29],"hematopoietic":[30],"stem":[31],"cells":[32,73,85,116,130,150],"isolated":[33],"from":[34,87,117,172],"peripheral":[36],"blood,":[37],"expanded,":[38],"freezed":[39],"cryopreserved.":[41],"use":[43],"biobanked":[45,89,129,149],"samples":[46,55,171],"allows":[47],"to":[48,138,154,158,229],"compare":[49],"potentially":[50],"therapeutic":[51,231],"treatments":[52],"on":[53],"several":[54,100],"growing":[56],"in":[57,74,121],"parallel.":[58],"Freezing,":[59],"cryopreservation":[60],"thawing":[62],"steps":[63],"do":[64],"not":[65],"affect":[66],"erythroid":[68],"differentiation":[69],"potential":[70,230],"terms":[75],"kinetics":[77],"types":[79],"hemoglobin":[81],"produced":[82],"by":[83,110,170],"obtained":[86],"different":[88,122,139],"cryovials":[90],"same":[93,119],"patient":[94],"thawed":[96],"with":[97],"intervals":[98],"reaching":[99],"months.":[101],"further":[108],"performed":[109],"sending":[111],"culturing":[113],"crypreserved":[115],"patients":[120,175,213],"laboratories.":[123],"Finally,":[124],"we":[125],"demonstrated":[126],"that":[127],"can":[131,151],"be":[132,152],"used":[133,153],"determining":[135],"response":[137,157,228],"inducers,":[140],"such":[141],"as":[142],"mithramycin,":[143],"hydroxyurea":[144],"resveratrol.":[146],"Moreover,":[147],"test":[155],"their":[156],"gene":[159],"protocols.":[161],"At":[162],"present,":[163],"is":[168],"composed":[169],"135":[173],"\u03b2-thalassemia":[174],"19":[177],"healthy":[178],"donors":[179],"totale":[182],"more":[184],"than":[185],"750":[186],"cryovials.":[187],"most":[189],"represented":[190],"genotypes":[191],"are":[192],"\u03b2039/\u03b2039":[193],"(51":[194],"patients),":[195,198],"\u03b2+IVSI-6/\u03b2+IVSI-110":[196],"(31":[197],"\u03b2039/\u03b2+IVSI-110":[199],"(21":[200],"patients)":[201],"\u03b2+IVSI-110/\u03b2+IVSI-110":[203],"(9":[204],"patients).":[205],"In":[206],"conclusion,":[207],"this":[208],"research":[209],"activity":[210],"will":[211],"allow":[212],"stratification":[214],"taking":[215],"into":[216],"account":[217],"all":[218],"phenotypic/genotypic":[220],"characteristics":[221],"single":[224],"individual,":[225],"treatments.":[232]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}