{"id":"https://openalex.org/W2806780267","doi":null,"title":"Testing two evolutionary theories of ageing by using public genome-wide data","display_name":"Testing two evolutionary theories of ageing by using public genome-wide data","publication_year":2017,"publication_date":"2017-01-24","ids":{"openalex":"https://openalex.org/W2806780267","mag":"2806780267"},"language":"en","primary_location":{"id":"pmh:oai:dnet:tdr_________::05feb36df5c683e922bbdf1a9b52c7df","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/565860","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10803/565860","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104018538","display_name":"Rodr\u00edguez P\u00e9rez","orcid":"https://orcid.org/0000-0002-6415-440X","observed_orcids":["https://orcid.org/0000-0002-6415-440X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodr\u00edguez P\u00e9rez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112382959","display_name":"Juan Antonio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Antonio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.24040000140666962,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.597000002861023},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.968999981880188},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.7730000019073486},{"id":"https://openalex.org/keywords/replicability","display_name":"replicability","score":0.6449999809265137},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.5440000295639038},{"id":"https://openalex.org/keywords/population-aging","display_name":"population aging","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.749281644821167},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.6004754900932312}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:dnet:tdr_________::05feb36df5c683e922bbdf1a9b52c7df","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/565860","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositori-api.upf.edu:10230/34790","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/565860","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositori.upf.edu:10803/565860","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/565860","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/565860","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/565860","pdf_url":"http://hdl.handle.net/10803/565860","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2806780267","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/tesis?codigo=172208","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dnet:tdr_________::05feb36df5c683e922bbdf1a9b52c7df","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/565860","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806780267.pdf","grobid_xml":"https://content.openalex.org/works/W2806780267.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W1488124756","https://openalex.org/W1508985588","https://openalex.org/W1567333450","https://openalex.org/W1598326569","https://openalex.org/W1690786713","https://openalex.org/W1965842672","https://openalex.org/W1966040173","https://openalex.org/W1966432404","https://openalex.org/W1973042689","https://openalex.org/W1974483110","https://openalex.org/W1982733535","https://openalex.org/W1983085185","https://openalex.org/W1983481075","https://openalex.org/W1985334485","https://openalex.org/W1985849948","https://openalex.org/W1988694228","https://openalex.org/W1989539292","https://openalex.org/W1990543834","https://openalex.org/W1990758702","https://openalex.org/W1991241396","https://openalex.org/W1991415175","https://openalex.org/W1992444358","https://openalex.org/W1999230927","https://openalex.org/W2000953640","https://openalex.org/W2001040922","https://openalex.org/W2002097809","https://openalex.org/W2006369305","https://openalex.org/W2009032387","https://openalex.org/W2011781902","https://openalex.org/W2014440105","https://openalex.org/W2016113102","https://openalex.org/W2016290342","https://openalex.org/W2021489383","https://openalex.org/W2023095530","https://openalex.org/W2026353898","https://openalex.org/W2027838121","https://openalex.org/W2031493923","https://openalex.org/W2036516886","https://openalex.org/W2038018249","https://openalex.org/W2040841655","https://openalex.org/W2041467022","https://openalex.org/W2042103448","https://openalex.org/W2044430178","https://openalex.org/W2046989794","https://openalex.org/W2047072851","https://openalex.org/W2047146652","https://openalex.org/W2047330128","https://openalex.org/W2053172177","https://openalex.org/W2053900484","https://openalex.org/W2054885243","https://openalex.org/W2056319480","https://openalex.org/W2063098376","https://openalex.org/W2065435420","https://openalex.org/W2066644955","https://openalex.org/W2067308958","https://openalex.org/W2068234084","https://openalex.org/W2068889795","https://openalex.org/W2069633077","https://openalex.org/W2069863984","https://openalex.org/W2070487135","https://openalex.org/W2071348149","https://openalex.org/W2072134379","https://openalex.org/W2079501979","https://openalex.org/W2086110261","https://openalex.org/W2087546077","https://openalex.org/W2088119447","https://openalex.org/W2090809312","https://openalex.org/W2091239497","https://openalex.org/W2091438612","https://openalex.org/W2091806847","https://openalex.org/W2095107898","https://openalex.org/W2095529560","https://openalex.org/W2095829498","https://openalex.org/W2096152062","https://openalex.org/W2097757648","https://openalex.org/W2098583905","https://openalex.org/W2101033146","https://openalex.org/W2101720980","https://openalex.org/W2101861123","https://openalex.org/W2102729801","https://openalex.org/W2103027406","https://openalex.org/W2104804533","https://openalex.org/W2108482850","https://openalex.org/W2108700752","https://openalex.org/W2109195195","https://openalex.org/W2109268902","https://openalex.org/W2109750485","https://openalex.org/W2110343195","https://openalex.org/W2111037990","https://openalex.org/W2113784410","https://openalex.org/W2114912445","https://openalex.org/W2116195449","https://openalex.org/W2116868464","https://openalex.org/W2117904018","https://openalex.org/W2121642311","https://openalex.org/W2122162002","https://openalex.org/W2122740168","https://openalex.org/W2123013924","https://openalex.org/W2124277514","https://openalex.org/W2126525177","https://openalex.org/W2127839526","https://openalex.org/W2129559300","https://openalex.org/W2134783591","https://openalex.org/W2135947850","https://openalex.org/W2136404471","https://openalex.org/W2140804176","https://openalex.org/W2142435658","https://openalex.org/W2143992683","https://openalex.org/W2146940447","https://openalex.org/W2152664025","https://openalex.org/W2153039235","https://openalex.org/W2155262227","https://openalex.org/W2157470879","https://openalex.org/W2157669324","https://openalex.org/W2159139713","https://openalex.org/W2160002030","https://openalex.org/W2160429819","https://openalex.org/W2161289428","https://openalex.org/W2163924952","https://openalex.org/W2164321086","https://openalex.org/W2165469555","https://openalex.org/W2165786168","https://openalex.org/W2167638767","https://openalex.org/W2168300179","https://openalex.org/W2168909179","https://openalex.org/W2171241286","https://openalex.org/W2171481698","https://openalex.org/W2175258576","https://openalex.org/W2187949133","https://openalex.org/W2192623030","https://openalex.org/W2201499402","https://openalex.org/W2211113519","https://openalex.org/W2315512556","https://openalex.org/W2330577917","https://openalex.org/W2337055863","https://openalex.org/W2338072779","https://openalex.org/W2384506977","https://openalex.org/W2401811918","https://openalex.org/W2488609201","https://openalex.org/W2513896837","https://openalex.org/W2581012485","https://openalex.org/W2791605128","https://openalex.org/W4249447550","https://openalex.org/W4300009529"],"related_works":["https://openalex.org/W2004214366","https://openalex.org/W7120511188","https://openalex.org/W1990758702","https://openalex.org/W2144685962","https://openalex.org/W7095879763","https://openalex.org/W7099242905","https://openalex.org/W2000435897","https://openalex.org/W2002110270","https://openalex.org/W2951412168","https://openalex.org/W2580327741"],"abstract_inverted_index":{"Old":[0],"age":[1],"comes":[2],"coupled":[3],"with":[4,33,158],"frailty":[5],"and":[6,23,74,143,166,173,183],"disease":[7],"and,":[8],"thus,":[9],"the":[10,13,18,21,53,62,75,101,118,164,180,191],"ageing":[11,202],"of":[12,25,52,66,79,91,106,117,121,168,187,193],"World\u2019s":[14],"population":[15],"have":[16],"spurred":[17],"interest":[19],"on":[20,170],"causes":[22,44,48],"mechanisms":[24],"senescence.":[26,188],"Senescence":[27,67],"has":[28],"long":[29],"been":[30],"a":[31],"mystery,":[32],"no":[34],"single":[35],"universally":[36],"accepted":[37],"theory":[38],"accounting":[39],"for":[40,151,199],"its":[41],"ultimate":[42],"evolutionary":[43,56],"(if":[45],"indeed":[46],"these":[47,194],"exist).":[49],"Perhaps":[50],"two":[51],"most":[54],"popular":[55],"explanations":[57],"proposed":[58,68],"so":[59],"far":[60],"are":[61,140],"Mutation":[63,181],"Accumulation":[64,182],"Theory":[65,78],"by":[69,82],"Peter":[70],"Medawar":[71],"in":[72,86,115],"1951":[73],"Antagonistic":[76,184],"Pleiotropy":[77,185],"Senescence,":[80],"suggested":[81],"George":[83],"C.":[84],"Williams":[85],"1957.":[87],"The":[88],"large":[89],"amount":[90],"data":[92],"derived":[93],"from":[94,131],"Genome-Wide":[95],"Association":[96],"Studies":[97],"(GWAS)":[98],"obtained":[99],"over":[100],"last":[102],"decade":[103],"allows":[104],"testing":[105],"both":[107,159],"theories,":[108],"provided":[109],"that":[110,138,144,148],"they":[111,139,145],"can":[112],"make":[113],"predictions":[114],"terms":[116],"genetic":[119],"architecture":[120],"complex":[122],"disease.":[123],"However,":[124],"if":[125],"we":[126,134,161,175],"want":[127],"to":[128,136,178],"take":[129],"advantage":[130],"GWAS":[132],"data,":[133],"need":[135],"assure":[137],"sound,":[141],"replicable":[142],"contain":[146],"information":[147,169],"is":[149],"useful":[150],"our":[152],"purposes.":[153],"This":[154],"PhD":[155],"thesis":[156],"deals":[157],"goals:":[160],"first":[162],"assess":[163],"quality":[165],"replicability":[167],"genome-disease":[171],"associations":[172],"then":[174],"use":[176],"it":[177],"explore":[179],"theories":[186,195],"Knowledge":[189],"about":[190],"impact":[192],"will":[196],"be":[197],"important":[198],"an":[200],"increasingly":[201],"population.":[203]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2018-06-13T00:00:00"}