{"id":"https://openalex.org/W2806688958","doi":null,"title":"The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor","display_name":"The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor","publication_year":2016,"publication_date":"2016-05-09","ids":{"openalex":"https://openalex.org/W2806688958","mag":"2806688958"},"language":"en","primary_location":{"id":"pmh:oai:bora.uib.no:1956/17729","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/17729","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1956/17729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112369423","display_name":"Fanny A. Pelissier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fanny A. Pelissier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112369423"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.08630000054836273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9520000219345093},{"id":"https://openalex.org/keywords/breast-cancer-susceptibility","display_name":"breast cancer susceptibility","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/axl","display_name":"AXL","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.6919999718666077},{"id":"https://openalex.org/keywords/yap-taz","display_name":"YAP/TAZ","score":0.949999988079071},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/luminal-cells","display_name":"luminal cells","score":0.6769999861717224},{"id":"https://openalex.org/keywords/epithelial-progenitors","display_name":"epithelial progenitors","score":0.6539999842643738},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mass-cytometry","display_name":"mass cytometry","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5504640936851501},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46581247448921204},{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.44724833965301514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3660467267036438},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3647875189781189},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3407799303531647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1863493025302887},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14572927355766296},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bora.uib.no:1956/17729","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/17729","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2806688958","doi":null,"is_oa":false,"landing_page_url":"https://bora.uib.no/handle/1956/17729","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bora.uib.no:1956/17729","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/17729","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2490826292","https://openalex.org/W2072384133","https://openalex.org/W2114369115","https://openalex.org/W2954609687","https://openalex.org/W4317104762","https://openalex.org/W6987856614","https://openalex.org/W4317104880","https://openalex.org/W2317868013","https://openalex.org/W4387895254","https://openalex.org/W4404699593"],"abstract_inverted_index":{"Aging":[0],"is":[1,32,68,101],"the":[2,13,22,33,60,75,117,120,124,153,172,219,233,242],"critical":[3],"risk":[4,35],"factor":[5,36],"for":[6,37,52,221],"many":[7],"forms":[8],"of":[9,24,66,104,107,123,141,163,191,195],"cancer.":[10,38],"We":[11,58,77,97,126],"used":[12],"mammary":[14,84,180],"gland":[15],"as":[16,80],"a":[17,63,69,81,102,105,192,200,227,247],"model":[18,228],"system":[19],"to":[20,150,160,246,260],"study":[21],"impact":[23],"age":[25,31],"on":[26],"human":[27,179],"epithelia":[28],"in":[29,89,131,143,147,152,177,215,249,255],"which":[30],"greatest":[34],"Dysfunctional":[39],"progenitor":[40],"and":[41,93,204,235,253,258],"luminal":[42,196],"cells":[43,197],"with":[44,136,206],"acquired":[45,199],"basal":[46,202],"cell":[47,72,86],"properties":[48,122],"accumulate":[49,205],"during":[50,241],"aging":[51,67,142,243],"reasons":[53],"that":[54,62,99,128,158,198],"are":[55,113,134,239],"not":[56],"understood.":[57],"evaluated":[59],"hypothesis":[61],"novel":[64],"effect":[65],"defective":[70],"stem":[71,85],"regulation":[73],"by":[74,116],"microenvironment.":[76],"identified":[78,189],"Axl":[79,100],"previously":[82],"unappreciated":[83],"marker":[87,103],"involved":[88],"breast":[90,94,144,222,236,250],"epithelial":[91,109,181,237],"homeostasis":[92],"cancer":[95],"progression.":[96],"showed":[98],"subpopulation":[106],"cKit":[108,132],"progenitors.":[110],"These":[111],"progenitors":[112,133,238],"tightly":[114],"regulated":[115],"microenvironment,":[118],"specifically":[119],"mechanical":[121],"niche.":[125],"observed":[127],"mechano-response":[129],"mechanisms":[130],"altered":[135],"age.":[137,207],"Thus,":[138],"tissue-level":[139],"phenotypes":[140],"may":[145],"arise":[146],"part":[148],"due":[149],"alterations":[151],"Hippo":[154],"mechano-signal":[155],"transduction":[156],"pathway":[157],"lead":[159],"reduced":[161],"efficiency":[162],"YAP/TAZ":[164],"activation.":[165],"Finally,":[166],"using":[167,185],"mass":[168],"cytometry,":[169],"we":[170,225],"described":[171],"first":[173],"high-dimensional":[174],"phenotypic":[175,211,256],"heterogeneity":[176],"normal":[178],"cells.":[182],"Computational":[183],"analysis":[184],"unsupervised":[186],"population":[187],"partitioning":[188],"clusters":[190],"specific":[193],"subset":[194],"more":[201],"phenotype":[203],"Moreover,":[208],"distinct":[209],"age-related":[210],"signatures":[212],"were":[213],"detectable":[214],"cKit-progenitor":[216],"cells,":[217],"considered":[218],"cell-of-origin":[220],"cancers.":[223],"Here,":[224],"propose":[226],"where":[229],"reciprocal":[230],"interactions":[231],"between":[232],"microenvironment":[234],"skewed":[240],"process,":[244],"leading":[245],"decrease":[248],"tissue":[251],"integrity,":[252],"increase":[254],"divergence":[257],"susceptibility":[259],"tumorigenesis.":[261]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}