{"id":"https://openalex.org/W2806587416","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1053.13","title":"Phrenic long\u2010term facilitation (pLTF) following acute intermittent hypoxia (AIH) is TrkB and PI3K/Akt dependent in rats with motor neuron death from intrapleural CTB\u2010saporin injections","display_name":"Phrenic long\u2010term facilitation (pLTF) following acute intermittent hypoxia (AIH) is TrkB and PI3K/Akt dependent in rats with motor neuron death from intrapleural CTB\u2010saporin injections","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2806587416","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1053.13","mag":"2806587416"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.1053.13","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1053.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.1053.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050229766","display_name":"Nicole Louise Nichols","orcid":"https://orcid.org/0000-0003-3837-0069","observed_orcids":["https://orcid.org/0000-0003-3837-0069"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole L. Nichols","raw_affiliation_strings":["Biomedical Sciences University of Missouri\u2010Columbia Columbia MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences University of Missouri\u2010Columbia Columbia MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021566859","display_name":"Miles A. Tanner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miles Tanner","raw_affiliation_strings":["Biomedical Sciences University of Missouri\u2010Columbia Columbia MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences University of Missouri\u2010Columbia Columbia MO","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19261459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phrenic-long-term-facilitation","display_name":"phrenic long-term facilitation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acute-intermittent-hypoxia","display_name":"acute intermittent hypoxia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/trkb","display_name":"TrkB","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.8529999852180481},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6620000004768372},{"id":"https://openalex.org/keywords/u0126","display_name":"U0126","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2781260279","wikidata":"https://www.wikidata.org/wiki/Q2224066","display_name":"Saporin","level":5,"score":0.932711124420166},{"id":"https://openalex.org/C2777099253","wikidata":"https://www.wikidata.org/wiki/Q737313","display_name":"Phrenic nerve","level":3,"score":0.6711938381195068},{"id":"https://openalex.org/C2780796939","wikidata":"https://www.wikidata.org/wiki/Q25326656","display_name":"Intermittent hypoxia","level":3,"score":0.6389580368995667},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.6247573494911194},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.540706217288971},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.4769805371761322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46303969621658325},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.42967358231544495},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4234466254711151},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40060189366340637},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.39205676317214966},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.386797159910202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36787861585617065},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34190964698791504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.239300936460495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15771687030792236},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.1483546495437622},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13151097297668457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10251656174659729},{"id":"https://openalex.org/C115085202","wikidata":"https://www.wikidata.org/wiki/Q425665","display_name":"Immunotoxin","level":4,"score":0.0},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.1053.13","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1053.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.1053.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000064911","display_name":null,"funder_award_id":"K99/R00 HL119606","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3084034523","https://openalex.org/W2748890195","https://openalex.org/W1551441278","https://openalex.org/W3175824215","https://openalex.org/W3184653525","https://openalex.org/W4405082194","https://openalex.org/W4398165856","https://openalex.org/W3171644728","https://openalex.org/W3205321930","https://openalex.org/W2518376368"],"abstract_inverted_index":{"Intrapleural":[0],"injections":[1,210],"of":[2,42,66,79,106,127,146,196,334,375],"cholera":[3],"toxin":[4],"B":[5],"fragment":[6],"conjugated":[7],"to":[8,38,53,58],"saporin":[9],"(CTB\u2010SAP)":[10],"selectively":[11],"kills":[12],"respiratory":[13,43,376],"motor":[14,18,44,68,144,384],"neurons,":[15],"and":[16,55,71,108,129,174,178,184,219,308,336,339,351,378],"mimics":[17],"neuron":[19,45,385],"death":[20,46],"observed":[21],"in":[22,95,141,181,253,270,289,297,302,355],"rats":[23,97,149,158,256,305,321,358],"with":[24],"amyotrophic":[25],"lateral":[26],"sclerosis":[27],"(ALS)":[28],"(Nichols":[29],"et":[30,151],"al.,":[31,152],"2015).":[32],"This":[33,316,370],"CTB\u2010SAP":[34,80,147,157,213,254,303,319,356],"model":[35],"allows":[36],"us":[37],"study":[39],"the":[40,86,103,124,142,160,168,331],"impact":[41],"on":[47,347],"breathing":[48,382],"without":[49],"many":[50],"complications":[51],"attendant":[52],"ALS,":[54],"is":[56,92,113,172,257,272,359],"sufficient":[57],"enhance":[59],"phrenic":[60,67,143],"long\u2010term":[61],"facilitation":[62],"(pLTF,":[63],"a":[64],"form":[65],"facilitation;":[69],"Nichols":[70],"Mitchell,":[72],"ibid":[73,153],",":[74],"2014)":[75],"after":[76],"7":[77,205],"days":[78,206],"(CTB\u2010SAP":[81],"145\u00b122%;":[82],"control":[83],"54\u00b15%).":[84],"However,":[85],"mechanism":[87,116,162,328],"responsible":[88],"for":[89,117,163,381],"this":[90,349],"enhancement":[91],"unknown.":[93],"pLTF":[94,118,171,202,252,269,288,299,323,354],"na\u00efve":[96],"predominately":[98],"requires":[99,120,330],"5HT":[100],"2":[101,199],"receptors,":[102,123],"new":[104,125,332],"synthesis":[105,126,333],"BDNF,":[107],"MEK/ERK":[109,338],"signaling;":[110],"however,":[111],"there":[112],"an":[114,326],"alternative":[115,161,327],"that":[119,135,156,170,232,251,318,329],"A":[121,136,365],"2A":[122,137,366],"TrkB,":[128],"PI3K/Akt":[130,340],"signaling.":[131,341],"Preliminary":[132],"data":[133,249],"suggest":[134,250],"receptors":[138],"are":[139],"increased":[140],"nucleus":[145],"treated":[148,255,304,320,357],"(Craig":[150],")":[154,200],"suggesting":[155],"utilize":[159],"pLTF.":[164],"Here,":[165],"we":[166],"tested":[167],"hypothesis":[169],"TrkB":[173,236,258,335],"PI3K/Akt,":[175],"not":[176,284],"BDNF":[177,234,273],"MEK/ERK,":[179],"dependent":[180,259,274],"anesthetized,":[182],"paralyzed":[183],"ventilated":[185],"adult":[186],"Sprague":[187],"Dawley":[188],"rats.":[189],"Specifically,":[190],"AIH":[191],"(3,":[192],"5":[193],"min":[194],"bouts":[195],"10.5%":[197],"O":[198],"induced":[201],"was":[203,300],"studied":[204],"following":[207,306,361,383],"bilateral,":[208],"intrapleural":[209],"of:":[211],"1)":[212,228],"(25\u03bcg),":[214],"or":[215,235,242,388],"2)":[216,238],"un\u2010conjugated":[217],"CTB":[218],"SAP":[220],"(control).":[221],"Intrathecal":[222],"C":[223,362],"4":[224,363],"delivery":[225],"included":[226],"either:":[227],"small":[229],"interfering":[230],"RNA":[231],"targeted":[233],"mRNA;":[237],"U0126":[239,307],"(MEK/ERK":[240],"inhibitor);":[241],"3)":[243],"PI828":[244,309],"(PI3K/Akt":[245],"inhibitor).":[246],"Our":[247],"preliminary":[248],"(siTrkB:":[260,275],"1%,":[261],"n":[262,277],"=":[263,278],"1;":[264,279],"siBDNF:":[265,280],"127%,":[266],"n=1),":[267],"whereas":[268],"controls":[271,290],"35%,":[276],"11%,":[281],"n=1).":[282],"U0126,":[283],"PI828,":[285],"nearly":[286],"abolished":[287,360],"(U0126:":[291,310],"13%,":[292],"n=2;":[293,312],"PI828:":[294,313],"52%,":[295],"n=2);":[296],"contrast,":[298],"attenuated":[301],"71%,":[311],"85%,":[314],"n=2).":[315],"suggests":[317],"express":[322],"primarily":[324],"via":[325],"both":[337],"Future":[342],"studies":[343],"will":[344],"be":[345],"focused":[346],"completing":[348],"analysis":[350],"testing":[352],"whether":[353],"intrathecal,":[364],"receptor":[367],"antagonist":[368],"treatment.":[369],"project":[371],"increases":[372],"our":[373],"understanding":[374],"plasticity":[377],"its":[379],"implications":[380],"death.":[386],"Support":[387],"Funding":[389],"Information":[390],"Supported":[391],"by":[392],"NIH":[393],"K99/R00":[394],"HL119606":[395]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-06-13T00:00:00"}