{"id":"https://openalex.org/W2806557186","doi":"https://doi.org/10.1038/s41467-018-04343-0","title":"Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide","display_name":"Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide","publication_year":2018,"publication_date":"2018-05-08","ids":{"openalex":"https://openalex.org/W2806557186","doi":"https://doi.org/10.1038/s41467-018-04343-0","mag":"2806557186","pmid":"https://pubmed.ncbi.nlm.nih.gov/29760386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5951806"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-04343-0","doi":"https://doi.org/10.1038/s41467-018-04343-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-04343-0","pdf_url":"https://www.nature.com/articles/s41467-018-04343-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-04343-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022941329","display_name":"Tomonori Tamura","orcid":"https://orcid.org/0000-0003-1648-9296","observed_orcids":["https://orcid.org/0000-0003-1648-9296"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Tamura","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1648-9296","affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tsuyoshi Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Ueda","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Taiki Goto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiki Goto","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076055383","display_name":"Taku Tsukidate","orcid":"https://orcid.org/0000-0003-3158-3635","observed_orcids":["https://orcid.org/0000-0003-3158-3635"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taku Tsukidate","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002279870","display_name":"Yonatan Shapira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yonatan Shapira","raw_affiliation_strings":["Feinberg Graduate School, Weizmann Institute of Science, Rehovot, 7610001, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feinberg Graduate School, Weizmann Institute of Science, Rehovot, 7610001, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110597127","display_name":"Yuki Nishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Nishikawa","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064346966","display_name":"Alma Fujisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Alma Fujisawa","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021730310","display_name":"Itaru Hamachi","orcid":"https://orcid.org/0000-0002-3327-3916","observed_orcids":["https://orcid.org/0000-0002-3327-3916"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Itaru Hamachi","raw_affiliation_strings":["CREST (Core Research for Evolutional Science and Technology, JST), Sanbancho, Chiyodaku, Tokyo, 102-0075, Japan. ihamachi@sbchem.kyoto-u.ac.jp","Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan. ihamachi@sbchem.kyoto-u.ac.jp","CREST (Core Research for Evolutional Science and Technology, JST), Sanbancho, Chiyodaku, Tokyo, 102-0075, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST (Core Research for Evolutional Science and Technology, JST), Sanbancho, Chiyodaku, Tokyo, 102-0075, Japan. ihamachi@sbchem.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan. ihamachi@sbchem.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"CREST (Core Research for Evolutional Science and Technology, JST), Sanbancho, Chiyodaku, Tokyo, 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021730310"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210086780"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":7.5441,"has_fulltext":true,"cited_by_count":247,"citation_normalized_percentile":{"value":0.98843341,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"1870","last_page":"1870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioorthogonal-labeling","display_name":"bioorthogonal labeling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/covalent-inhibition","display_name":"covalent inhibition","score":0.7549999952316284},{"id":"https://openalex.org/keywords/lysine-modification","display_name":"lysine modification","score":0.7250000238418579},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.5830000042915344},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.578000009059906},{"id":"https://openalex.org/keywords/covalent-inhibitors","display_name":"covalent inhibitors","score":0.6759999990463257},{"id":"https://openalex.org/keywords/reaction-kinetics","display_name":"reaction kinetics","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C930959","wikidata":"https://www.wikidata.org/wiki/Q4086920","display_name":"Bioorthogonal chemistry","level":3,"score":0.8791347742080688},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.8059968948364258},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6242002248764038},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6193743944168091},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5990030169487},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5760366320610046},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.5307818651199341},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.48205122351646423},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.4789224863052368},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.46130993962287903},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4035698473453522},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38867151737213135},{"id":"https://openalex.org/C69610077","wikidata":"https://www.wikidata.org/wiki/Q912270","display_name":"Click chemistry","level":2,"score":0.15402474999427795},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.14738884568214417},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1289801299571991},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1256585717201233}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002623","descriptor_name":"Chemistry Techniques, Analytical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013424","descriptor_name":"Sulfanilamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013424","descriptor_name":"Sulfanilamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41467-018-04343-0","doi":"https://doi.org/10.1038/s41467-018-04343-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-04343-0","pdf_url":"https://www.nature.com/articles/s41467-018-04343-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4873117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5951806","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5951806","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5951806","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:29760386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29760386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0000185988","doi":null,"is_oa":true,"landing_page_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/ee11ca79-3c23-447e-8fc4-58f46cbca03c/download","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/ee11ca79-3c23-447e-8fc4-58f46cbca03c/download","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications","raw_type":"journal article"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04343-0","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-04343-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7cb4a42cb77f46bb9985a6f970724a6a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7cb4a42cb77f46bb9985a6f970724a6a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c5bf9853b58246d194cfd15f07718f54","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c5bf9853b58246d194cfd15f07718f54","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/231114","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/231114","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-04343-0","doi":"https://doi.org/10.1038/s41467-018-04343-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-04343-0","pdf_url":"https://www.nature.com/articles/s41467-018-04343-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2521286739","display_name":null,"funder_award_id":"CREST","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G2728280745","display_name":null,"funder_award_id":"17H06348","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G5330664741","display_name":"Development of novel protein chemical modification method for imaging analysis of endogenous protein-protein interaction in live cells","funder_award_id":"15K17884","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5462475690","display_name":null,"funder_award_id":"17H06348","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G6395368013","display_name":"\u7d30\u80de\u5185\uff28\uff53\uff50\uff19\uff10\u306e\uff26\uff32\uff25\uff34\u578b\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u306e\u69cb\u7bc9\u3068\u305d\u306e\u963b\u5bb3\u5264\u63a2\u7d22\u3078\u306e\u5fdc\u7528","funder_award_id":"18J14502","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6561169077","display_name":"\u5185\u5728\u6027\u6838\u5185\u53d7\u5bb9\u4f53\u306e\u30b1\u30df\u30ab\u30eb\u30e9\u30d9\u30ea\u30f3\u30b0\u306b\u3088\u308b\u52d5\u614b\u30fb\u6a5f\u80fd\u89e3\u6790","funder_award_id":"16J10316","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6718509927","display_name":null,"funder_award_id":"CREST","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7732427646","display_name":null,"funder_award_id":"17H06348","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320316984","display_name":"Kyoto University Foundation","ror":null},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806557186.pdf","grobid_xml":"https://content.openalex.org/works/W2806557186.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W823219258","https://openalex.org/W1526377515","https://openalex.org/W1550877969","https://openalex.org/W1965001079","https://openalex.org/W1978513278","https://openalex.org/W1995754625","https://openalex.org/W2008358764","https://openalex.org/W2010993054","https://openalex.org/W2011092143","https://openalex.org/W2016036293","https://openalex.org/W2029680398","https://openalex.org/W2038074501","https://openalex.org/W2039589883","https://openalex.org/W2039944716","https://openalex.org/W2041806467","https://openalex.org/W2047951064","https://openalex.org/W2053281570","https://openalex.org/W2056693633","https://openalex.org/W2057141116","https://openalex.org/W2070160448","https://openalex.org/W2076035508","https://openalex.org/W2076402046","https://openalex.org/W2088497317","https://openalex.org/W2090084506","https://openalex.org/W2092014932","https://openalex.org/W2093859044","https://openalex.org/W2102979750","https://openalex.org/W2114869204","https://openalex.org/W2136966549","https://openalex.org/W2150028503","https://openalex.org/W2151709132","https://openalex.org/W2163471519","https://openalex.org/W2165823708","https://openalex.org/W2167854315","https://openalex.org/W2274015824","https://openalex.org/W2283105825","https://openalex.org/W2285767004","https://openalex.org/W2322836762","https://openalex.org/W2325156674","https://openalex.org/W2332024781","https://openalex.org/W2516370098","https://openalex.org/W2517282085","https://openalex.org/W2517550655","https://openalex.org/W2589889942","https://openalex.org/W2604646706","https://openalex.org/W2605481346","https://openalex.org/W2606824156","https://openalex.org/W2731987565","https://openalex.org/W2742118221","https://openalex.org/W2752520345","https://openalex.org/W2754323855"],"related_works":["https://openalex.org/W4405275560","https://openalex.org/W2946671596","https://openalex.org/W3003182738","https://openalex.org/W2771015442","https://openalex.org/W2143109504","https://openalex.org/W2897597758","https://openalex.org/W4205262481","https://openalex.org/W2790553494","https://openalex.org/W173375673","https://openalex.org/W2044677774"],"abstract_inverted_index":{"Abstract":[0],"Selective":[1],"modification":[2,60],"of":[3,11,61,71,79,108,115,124,127],"native":[4],"proteins":[5],"in":[6,15,129,147],"live":[7],"cells":[8],"is":[9,143],"one":[10],"the":[12,29,67,85,105,112,125,138],"central":[13],"challenges":[14],"recent":[16],"chemical":[17],"biology.":[18],"As":[19],"a":[20,45,62,72,76,116],"unique":[21,106],"bioorthogonal":[22,87],"approach,":[23],"ligand-directed":[24,53],"chemistry":[25,56],"recently":[26],"emerged,":[27],"but":[28],"slow":[30],"kinetics":[31],"limits":[32],"its":[33],"scope.":[34],"Here":[35],"we":[36],"successfully":[37],"overcome":[38],"this":[39,93],"obstacle":[40],"using":[41],"N-acyl-N-alkyl":[42,54,109],"sulfonamide":[43,55,110],"as":[44],"reactive":[46],"group.":[47],"Quantitative":[48],"kinetic":[49],"analyses":[50],"reveal":[51],"that":[52,120,142],"allows":[57],"for":[58],"rapid":[59],"lysine":[63],"residue":[64],"proximal":[65],"to":[66,84,136],"ligand":[68],"binding":[69],"site":[70],"target":[73],"protein,":[74],"with":[75],"rate":[77],"constant":[78],"~104":[80],"M\u22121":[81],"s\u22121,":[82],"comparable":[83],"fastest":[86],"chemistry.":[88],"Despite":[89],"some":[90],"off-target":[91],"reactions,":[92],"method":[94],"can":[95],"selectively":[96],"label":[97],"both":[98],"intracellular":[99],"and":[100],"membrane-bound":[101],"endogenous":[102],"proteins.":[103],"Moreover,":[104],"reactivity":[107],"enables":[111],"rational":[113],"design":[114],"lysine-targeted":[117],"covalent":[118,139],"inhibitor":[119],"shows":[121],"durable":[122],"suppression":[123],"activity":[126],"Hsp90":[128],"cancer":[130],"cells.":[131],"This":[132],"work":[133],"provides":[134],"possibilities":[135],"extend":[137],"inhibition":[140],"approach":[141],"currently":[144],"being":[145],"reassessed":[146],"drug":[148],"discovery.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":52},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-13T00:00:00"}
