{"id":"https://openalex.org/W2806541585","doi":"https://doi.org/10.1186/s12931-018-0786-z","title":"Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation","display_name":"Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation","publication_year":2018,"publication_date":"2018-05-25","ids":{"openalex":"https://openalex.org/W2806541585","doi":"https://doi.org/10.1186/s12931-018-0786-z","mag":"2806541585","pmid":"https://pubmed.ncbi.nlm.nih.gov/29801490"},"language":"en","primary_location":{"id":"doi:10.1186/s12931-018-0786-z","doi":"https://doi.org/10.1186/s12931-018-0786-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0786-z","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0786-z","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0786-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057493219","display_name":"Liran Levy","orcid":"https://orcid.org/0000-0001-6368-8015","observed_orcids":["https://orcid.org/0000-0001-6368-8015"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Liran Levy","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041148635","display_name":"S. Juvet","orcid":"https://orcid.org/0000-0002-7243-556X","observed_orcids":["https://orcid.org/0000-0002-7243-556X"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephen C. Juvet","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064375243","display_name":"Kristen M. Boonstra","orcid":"https://orcid.org/0000-0002-6337-4419","observed_orcids":["https://orcid.org/0000-0002-6337-4419"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kristen Boonstra","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033864764","display_name":"Lianne Gail Singer","orcid":"https://orcid.org/0000-0002-2693-8676","observed_orcids":["https://orcid.org/0000-0002-2693-8676"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lianne G. Singer","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109962179","display_name":"Sassan Azad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sassan Azad","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015320258","display_name":"Betty Joe","orcid":"https://orcid.org/0009-0009-3634-9208","observed_orcids":["https://orcid.org/0009-0009-3634-9208"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Betty Joe","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091225330","display_name":"Marcelo Cypel","orcid":"https://orcid.org/0000-0001-5652-1938","observed_orcids":["https://orcid.org/0000-0001-5652-1938"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marcelo Cypel","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086297813","display_name":"Shaf H Keshavjee","orcid":"https://orcid.org/0000-0003-4547-8094","observed_orcids":["https://orcid.org/0000-0003-4547-8094"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shaf Keshavjee","raw_affiliation_strings":["Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020400867","display_name":"Tereza Martinu","orcid":"https://orcid.org/0000-0001-9234-6807","observed_orcids":["https://orcid.org/0000-0001-9234-6807"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Tereza Martinu","raw_affiliation_strings":["Toronto General Hospital, 585 University Ave, PMB 11-128, Toronto, ON, M5G 2N2, Canada. tereza.martinu@uhn.ca","Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada. tereza.martinu@uhn.ca","Toronto General Hospital, 585 University Ave, PMB 11-128, Toronto, ON, M5G 2N2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toronto General Hospital, 585 University Ave, PMB 11-128, Toronto, ON, M5G 2N2, Canada. tereza.martinu@uhn.ca","institution_ids":["https://openalex.org/I2801845744"]},{"raw_affiliation_string":"Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada. tereza.martinu@uhn.ca","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Toronto General Hospital, 585 University Ave, PMB 11-128, Toronto, ON, M5G 2N2, Canada","institution_ids":["https://openalex.org/I2801845744"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020400867"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2801845744"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":1.4188,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80658442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"1","first_page":"102","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lung-allograft-rejection","display_name":"lung allograft rejection","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lung-allograft-dysfunction","display_name":"lung allograft dysfunction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6320000290870667},{"id":"https://openalex.org/keywords/surfactant-protein-d","display_name":"surfactant protein D","score":0.8489999771118164},{"id":"https://openalex.org/keywords/club-cell-secretory-protein","display_name":"club cell secretory protein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.7279999852180481},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7239999771118164},{"id":"https://openalex.org/keywords/sample-collection-standardization","display_name":"sample collection standardization","score":0.6230000257492065},{"id":"https://openalex.org/keywords/lung-compartments","display_name":"lung compartments","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7790289521217346},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.667572557926178},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.6661884784698486},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5749027132987976},{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.5514428019523621},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.535579264163971},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4588954448699951},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.4521000385284424},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.41965654492378235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3382207751274109},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3376721739768982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17095965147018433},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14891815185546875}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018893","descriptor_name":"Bronchoalveolar Lavage","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018893","descriptor_name":"Bronchoalveolar Lavage","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018893","descriptor_name":"Bronchoalveolar Lavage","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12931-018-0786-z","doi":"https://doi.org/10.1186/s12931-018-0786-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0786-z","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0786-z","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},{"id":"pmid:29801490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29801490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory research","raw_type":"Journal Article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/88042","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/88042","pdf_url":"https://utoronto.scholaris.ca/bitstreams/7d36f860-29ec-4923-b8ba-eb56357ed8c4/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:4925785","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5970521","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5970521","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5970521","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respir Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8c3aa9e3471f44ea978acad2098f38a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c3aa9e3471f44ea978acad2098f38a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, Vol 19, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12931-018-0786-z","doi":"https://doi.org/10.1186/s12931-018-0786-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-018-0786-z","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-018-0786-z","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313552","display_name":"Toronto General and Western Hospital Foundation","ror":"https://ror.org/00tfsm290"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806541585.pdf","grobid_xml":"https://content.openalex.org/works/W2806541585.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1484923899","https://openalex.org/W1648944350","https://openalex.org/W1657764750","https://openalex.org/W1840330473","https://openalex.org/W1841597983","https://openalex.org/W1852846816","https://openalex.org/W1971802598","https://openalex.org/W1984651873","https://openalex.org/W1996235718","https://openalex.org/W2003851888","https://openalex.org/W2004876902","https://openalex.org/W2006024835","https://openalex.org/W2011668096","https://openalex.org/W2014658578","https://openalex.org/W2024955939","https://openalex.org/W2029031348","https://openalex.org/W2033884349","https://openalex.org/W2034383024","https://openalex.org/W2044586780","https://openalex.org/W2055953496","https://openalex.org/W2059344598","https://openalex.org/W2062708238","https://openalex.org/W2071916461","https://openalex.org/W2079252343","https://openalex.org/W2082987800","https://openalex.org/W2087701330","https://openalex.org/W2100966360","https://openalex.org/W2109042898","https://openalex.org/W2110401438","https://openalex.org/W2112421342","https://openalex.org/W2138379611","https://openalex.org/W2139000046","https://openalex.org/W2142973230","https://openalex.org/W2156910598","https://openalex.org/W2165787419","https://openalex.org/W2460043851","https://openalex.org/W2621144224"],"related_works":["https://openalex.org/W4232339815","https://openalex.org/W2579366076","https://openalex.org/W1990451192","https://openalex.org/W4293536409","https://openalex.org/W1989951239","https://openalex.org/W3216129341","https://openalex.org/W2952855332","https://openalex.org/W2020069346","https://openalex.org/W4313359034","https://openalex.org/W2279445397"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bronchoalveolar":[1],"lavage":[2],"(BAL)":[3],"has":[4],"proven":[5],"to":[6,10,19,70,159,187],"be":[7],"very":[8],"useful":[9],"monitor":[11],"the":[12,213,228,243,255],"lung":[13,34,81,195,205],"allograft":[14,35],"after":[15],"transplantation.":[16],"In":[17,190],"addition":[18],"allowing":[20],"detection":[21],"of":[22,33,55,76,104,126,172,184,245],"infections,":[23],"multiple":[24],"BAL":[25,40,49,71,246,265],"analytes":[26],"have":[27,208],"been":[28],"proposed":[29],"as":[30],"potential":[31],"biomarkers":[32],"rejection":[36],"or":[37],"dysfunction.":[38],"However,":[39],"collection":[41,50,247],"is":[42],"not":[43,151],"well":[44],"standardized":[45,259],"and":[46,88,100,114,124,138,144,155,169,176,207,221,236,252],"differences":[47,63],"in":[48,80,92,194,261],"represent":[51,203],"an":[52],"important":[53],"source":[54],"variation.":[56],"We":[57],"hypothesized":[58],"that":[59,67,200],"there":[60],"are":[61,68],"systematic":[62],"between":[64,142,153],"sequential":[65,85,201],"BALs":[66,86,202],"relevant":[69],"analysis.":[72],"METHODS:":[73],"As":[74],"part":[75],"126":[77],"consecutive":[78],"bronchoscopies":[79],"transplant":[82,196],"recipients,":[83,197],"two":[84],"(BAL1":[87],"BAL2)":[89],"were":[90,140],"performed":[91,193],"one":[93],"location":[94],"during":[95],"each":[96],"bronchoscopy":[97],"by":[98],"instilling":[99],"suctioning":[101],"50":[102],"ml":[103],"normal":[105],"saline":[106],"twice":[107],"into":[108],"separate":[109],"containers.":[110],"Cell":[111,120],"concentration,":[112],"viability":[113,235],"differentials,":[115],"Surfactant":[116],"Protein-D":[117],"(SP-D),":[118],"Club":[119],"Secretory":[121],"Protein":[122],"(CCSP),":[123],"levels":[125],"CXCL10,":[127],"IL-10,":[128],"CCL2,":[129],"CCL5,":[130],"VEGF-C,":[131],"RAGE,":[132],"CXCL9,":[133],"CXCL1,":[134],"IL-17A,":[135],"IL-21,":[136],"PDGF,":[137],"GCSF":[139],"compared":[141,158,186],"BAL1":[143,154,161,211],"BAL2.":[145],"RESULTS:":[146],"Total":[147],"cell":[148,234],"concentration":[149,183],"did":[150],"differ":[152],"BAL2;":[156],"however,":[157],"BAL2,":[160],"had":[162,180],"more":[163,217],"dead":[164],"cells,":[165,167,219],"epithelial":[166,218],"neutrophils,":[168,220],"higher":[170,182,237],"concentrations":[171,251],"airway":[173,214],"epithelium-derived":[174,222],"CCSP":[175],"inflammatory":[177],"markers.":[178],"BAL2":[179,225],"a":[181,258],"SP-D":[185],"BAL1.":[188],"CONCLUSION:":[189],"this":[191],"study":[192],"we":[198],"show":[199],"different":[204],"compartments":[206],"distinct":[209],"compositions.":[210],"represents":[212],"compartment":[215],"with":[216,232],"CCSP.":[223],"Conversely,":[224],"samples":[226],"preferentially":[227],"distal":[229],"bronchoalveolar":[230],"space":[231],"greater":[233],"SP-D.":[238],"Our":[239],"findings":[240],"illustrate":[241],"how":[242],"method":[244],"can":[248],"influence":[249],"analyte":[250],"further":[253],"emphasize":[254],"need":[256],"for":[257],"approach":[260],"translational":[262],"research":[263],"involving":[264],"samples.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
