{"id":"https://openalex.org/W2806489140","doi":"https://doi.org/10.1186/s12885-018-4519-y","title":"Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial","display_name":"Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial","publication_year":2018,"publication_date":"2018-06-04","ids":{"openalex":"https://openalex.org/W2806489140","doi":"https://doi.org/10.1186/s12885-018-4519-y","mag":"2806489140","pmid":"https://pubmed.ncbi.nlm.nih.gov/29866075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5987491"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-018-4519-y","doi":"https://doi.org/10.1186/s12885-018-4519-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-018-4519-y","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-018-4519-y","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-018-4519-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081646000","display_name":"Masahiro Hatooka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Hatooka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031469873","display_name":"Tomokazu Kawaoka","orcid":"https://orcid.org/0000-0002-1887-1096","observed_orcids":["https://orcid.org/0000-0002-1887-1096"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomokazu Kawaoka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037963685","display_name":"Hiroshi Aikata","orcid":"https://orcid.org/0000-0002-3409-2156","observed_orcids":["https://orcid.org/0000-0002-3409-2156"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Aikata","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan. aikata@hiroshima-u.ac.jp","Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan. aikata@hiroshima-u.ac.jp","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007696404","display_name":"Yuki Inagaki","orcid":"https://orcid.org/0000-0002-6681-386X","observed_orcids":["https://orcid.org/0000-0002-6681-386X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Inagaki","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074699709","display_name":"Kei Morio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Morio","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112313285","display_name":"Takashi Nakahara","orcid":"https://orcid.org/0000-0001-7762-4629","observed_orcids":["https://orcid.org/0000-0001-7762-4629"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakahara","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024813969","display_name":"Eisuke Murakami","orcid":"https://orcid.org/0000-0003-0357-2795","observed_orcids":["https://orcid.org/0000-0003-0357-2795"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eisuke Murakami","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027695992","display_name":"Masataka Tsuge","orcid":"https://orcid.org/0000-0001-7591-8287","observed_orcids":["https://orcid.org/0000-0001-7591-8287"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Tsuge","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018431544","display_name":"Akira Hiramatsu","orcid":"https://orcid.org/0000-0003-0011-3243","observed_orcids":["https://orcid.org/0000-0003-0011-3243"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Hiramatsu","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022484621","display_name":"Michio Imamura","orcid":"https://orcid.org/0000-0002-0745-991X","observed_orcids":["https://orcid.org/0000-0002-0745-991X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Imamura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113824353","display_name":"Yoshiiku Kawakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiiku Kawakami","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102958504","display_name":"Kazuo Awai","orcid":"https://orcid.org/0000-0002-5039-2546","observed_orcids":["https://orcid.org/0000-0002-5039-2546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuo Awai","raw_affiliation_strings":["Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima, 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima, 734-8551, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101016388","display_name":"Keiichi Masaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104416","display_name":"Hiroshima City Asa Citizens Hospital","ror":"https://ror.org/01hkncq81","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104416","https://openalex.org/I4405283728"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Masaki","raw_affiliation_strings":["Hiroshima City Asa Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hiroshima City Asa Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210104416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016882648","display_name":"Koji Waki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104416","display_name":"Hiroshima City Asa Citizens Hospital","ror":"https://ror.org/01hkncq81","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104416","https://openalex.org/I4405283728"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Waki","raw_affiliation_strings":["Hiroshima City Asa Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hiroshima City Asa Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210104416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040593295","display_name":"Hirotaka Kohno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160686","display_name":"Kure Medical Center","ror":"https://ror.org/05te51965","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210160686"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Kohno","raw_affiliation_strings":["Kure Medical Center, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kure Medical Center, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210160686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114247882","display_name":"Hiroshi Kohno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160686","display_name":"Kure Medical Center","ror":"https://ror.org/05te51965","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210160686"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kohno","raw_affiliation_strings":["Kure Medical Center, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kure Medical Center, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210160686"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takashi Moriya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134687","display_name":"Chugoku Rosai Hospital","ror":"https://ror.org/03vwxd822","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210134687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Moriya","raw_affiliation_strings":["Chugoku Rousai Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chugoku Rousai Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210134687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004807660","display_name":"Yuko Nagaoki","orcid":"https://orcid.org/0000-0002-5065-2205","observed_orcids":["https://orcid.org/0000-0002-5065-2205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuko Nagaoki","raw_affiliation_strings":["Mazda Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazda Hospital, Hiroshima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toru Tamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toru Tamura","raw_affiliation_strings":["Mazda Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazda Hospital, Hiroshima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108245105","display_name":"Hajime Amano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164854","display_name":"Onomichi General Hospital","ror":"https://ror.org/05nr3de46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210164854"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Amano","raw_affiliation_strings":["Onomichi General Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onomichi General Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210164854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112103915","display_name":"Yoshio Katamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164854","display_name":"Onomichi General Hospital","ror":"https://ror.org/05nr3de46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210164854"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Katamura","raw_affiliation_strings":["Onomichi General Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onomichi General Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210164854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023958825","display_name":"Kazuaki Chayama","orcid":"https://orcid.org/0000-0002-5530-5341","observed_orcids":["https://orcid.org/0000-0002-5530-5341"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuaki Chayama","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan","Liver Research Project Center, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210150921"]},{"raw_affiliation_string":"Liver Research Project Center, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5037963685"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.9957,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.748461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"633","last_page":"633"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion-chemotherapy","display_name":"hepatic arterial infusion chemotherapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/advanced-liver-cancer","display_name":"advanced liver cancer","score":0.7409999966621399},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5370000004768372},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6600000262260437},{"id":"https://openalex.org/keywords/des-gamma-carboxy-prothrombin","display_name":"PIVKA-II","score":0.9520000219345093},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8029999732971191},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8880716562271118},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.8768502473831177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7495162487030029},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7140359878540039},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6613436341285706},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.582536518573761},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.48247697949409485},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.462078332901001},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.4550413489341736},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45334693789482117},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4515383541584015},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.45121175050735474},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4227890074253082},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.42200374603271484},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.36696097254753113},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.26619425415992737},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/s12885-018-4519-y","doi":"https://doi.org/10.1186/s12885-018-4519-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-018-4519-y","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-018-4519-y","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4990796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5987491","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29866075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29866075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:irdb.nii.ac.jp:01372:0006660092","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2006505","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5987491","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5987491/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b7ffc53bb2d54631a09725a7151575b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b7ffc53bb2d54631a09725a7151575b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)","raw_type":"article"},{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02006505","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2006505","pdf_url":null,"source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:ir.lib.hiroshima-u.ac.jp:00047069","doi":null,"is_oa":true,"landing_page_url":"http://ir.lib.hiroshima-u.ac.jp/00047069","pdf_url":null,"source":{"id":"https://openalex.org/S4377196292","display_name":"Hiroshima University Acedemic Information Repository (Hiroshima University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I113306721","host_organization_name":"Hiroshima University","host_organization_lineage":["https://openalex.org/I113306721"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1186/s12885-018-4519-y","doi":"https://doi.org/10.1186/s12885-018-4519-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-018-4519-y","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-018-4519-y","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806489140.pdf","grobid_xml":"https://content.openalex.org/works/W2806489140.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1483980368","https://openalex.org/W1967543010","https://openalex.org/W1971837077","https://openalex.org/W1981989535","https://openalex.org/W1983436991","https://openalex.org/W1983775525","https://openalex.org/W1994193851","https://openalex.org/W2000298215","https://openalex.org/W2009257495","https://openalex.org/W2009435220","https://openalex.org/W2022671815","https://openalex.org/W2024126773","https://openalex.org/W2024802373","https://openalex.org/W2032084645","https://openalex.org/W2058887247","https://openalex.org/W2075942495","https://openalex.org/W2096797256","https://openalex.org/W2103723243","https://openalex.org/W2108835065","https://openalex.org/W2113789021","https://openalex.org/W2116597887","https://openalex.org/W2122590547","https://openalex.org/W2131597845","https://openalex.org/W2161920425","https://openalex.org/W2461541060","https://openalex.org/W3139763557","https://openalex.org/W4324262440"],"related_works":["https://openalex.org/W2981257152","https://openalex.org/W1598022021","https://openalex.org/W1511734497","https://openalex.org/W2565364873","https://openalex.org/W1614752494","https://openalex.org/W2802278855","https://openalex.org/W7143702502","https://openalex.org/W3045447168","https://openalex.org/W2127590295","https://openalex.org/W2943931626"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,223],"patients":[2,44,137,177,182,212,248],"with":[3,35,66,91,186,201,249],"advanced":[4,250],"hepatocellular":[5],"carcinoma":[6],"(HCC),":[7],"evidence":[8],"is":[9,21],"unclear":[10],"as":[11,51],"to":[12,32,40,85,221,261],"whether":[13],"hepatic":[14],"arterial":[15],"infusion":[16],"chemotherapy":[17],"(HAIC)":[18],"or":[19,37,62,74,103,191],"sorafenib":[20,86],"superior.":[22],"We":[23],"performed":[24],"a":[25,52,75,98],"prospective,":[26],"open-label,":[27],"non-comparative":[28],"phase":[29],"II":[30],"study":[31],"assess":[33],"survival":[34,112,119,123,146,229],"HAIC":[36,38,50,121,126],"converted":[39],"sorafenib.":[41],"METHODS:":[42],"Fifty-five":[43],"were":[45,83,116,148,214,219,231],"prospectively":[46,256],"enrolled.":[47],"Patients":[48,82],"received":[49],"second":[53],"course":[54,156],"if":[55,87],"they":[56,88],"had":[57,89,172,178,184,199],"complete":[58,163],"response,":[59,61,122,164,169],"partial":[60,168],"stable":[63],"disease":[64,104],"(SD)":[65],"an":[67,92],"alpha":[68],"fetoprotein":[69],"(AFP)":[70],"ratio":[71,79,94,100],"<":[72,80,189,194],"1":[73,96,102,190,205],"des-\u03b3-carboxy":[76],"prothrombin":[77],"(DCP)":[78],"1.":[81,210,263],"switched":[84],"SD":[90,185,200],"AFP":[93,187,202],">":[95,101,204,209],"and":[97,130,144,150,174,196,206,216,227,233],"DCP":[99,192,207],"progression.":[105],"The":[106],"primary":[107],"endpoint":[108],"was":[109,254],"the":[110,117,135,139,142,154,225,238],"1-year":[111,143,226],"rate.":[113],"Secondary":[114],"endpoints":[115],"2-year":[118,145,228],"rate,":[120],"rate":[124],"among":[125],"responders,":[127,224],"progression-free":[128],"survival,":[129],"adverse":[131],"events.":[132],"RESULTS:":[133],"Of":[134],"55":[136],"in":[138],"intent-to-treat":[140],"population,":[141],"rates":[147,230],"64.0":[149],"48.3%,":[151],"respectively.":[152,235],"After":[153],"first":[155],"of":[157,240],"HAIC,":[158],"one":[159],"(1.8%)":[160],"patient":[161],"showed":[162,167],"13":[165],"(23.6%)":[166],"30":[170],"(54.5%)":[171],"SD,":[173],"10":[175],"(18.1%)":[176],"progressive":[179],"disease.":[180],"Twenty-three":[181],"(41.8%)":[183],"ratios":[188,193,203,208],"1,":[195],"7":[197],"(12.7%)":[198],"Thirty-seven":[211],"(68.5%)":[213],"responders":[215],"17":[217],"(30.9%)":[218],"non-responders":[220],"HAIC.":[222],"78":[232],"62%,":[234],"CONCLUSION:":[236],"Given":[237],"results":[239],"this":[241,243],"study,":[242],"protocol":[244],"deserves":[245],"consideration":[246],"for":[247],"HCC.":[251],"This":[252],"trial":[253],"registered":[255],"from":[257],"December":[258],"12.":[259],"2012":[260],"September":[262],"2016.":[264]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}
