{"id":"https://openalex.org/W2806460700","doi":"https://doi.org/10.1038/s41589-018-0061-0","title":"Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme","display_name":"Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2806460700","doi":"https://doi.org/10.1038/s41589-018-0061-0","mag":"2806460700","pmid":"https://pubmed.ncbi.nlm.nih.gov/29867143","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008203"},"language":"en","primary_location":{"id":"doi:10.1038/s41589-018-0061-0","doi":"https://doi.org/10.1038/s41589-018-0061-0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41589-018-0061-0","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008203","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100332778","display_name":"Nan Wang","orcid":"https://orcid.org/0000-0003-0330-8636","observed_orcids":["https://orcid.org/0000-0003-0330-8636","https://orcid.org/0009-0002-7120-752X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Wang","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032968619","display_name":"Jeffrey D. Rudolf","orcid":"https://orcid.org/0000-0003-2718-9651","observed_orcids":["https://orcid.org/0000-0003-2718-9651"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Rudolf","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-2718-9651","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048844381","display_name":"Liao\u2010Bin Dong","orcid":"https://orcid.org/0000-0002-2943-1299","observed_orcids":["https://orcid.org/0000-0002-2943-1299"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liao-Bin Dong","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-2943-1299","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085159378","display_name":"J. Osipiuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerzy Osipiuk","raw_affiliation_strings":["Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061000297","display_name":"Catherine Hatzos-Skintges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Hatzos-Skintges","raw_affiliation_strings":["Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075078265","display_name":"Michael J Endres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Endres","raw_affiliation_strings":["Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014911571","display_name":"Chin\u2010Yuan Chang","orcid":"https://orcid.org/0000-0001-7314-3967","observed_orcids":["https://orcid.org/0000-0001-7314-3967"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin-Yuan Chang","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049505423","display_name":"G. Babnigg","orcid":"https://orcid.org/0000-0002-9838-1803","observed_orcids":["https://orcid.org/0000-0002-9838-1803"]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gyorgy Babnigg","raw_affiliation_strings":["Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015893701","display_name":"A. Joachimiak","orcid":"https://orcid.org/0000-0003-2535-6209","observed_orcids":["https://orcid.org/0000-0003-2535-6209"]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrzej Joachimiak","raw_affiliation_strings":["Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":null,"display_name":"George N. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George N. Phillips","raw_affiliation_strings":["Department of Biosciences, Rice University, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, Rice University, Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087514362","display_name":"Ben Shen","orcid":"https://orcid.org/0000-0002-9750-5982","observed_orcids":["https://orcid.org/0000-0002-9750-5982"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ben Shen","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA. shenb@scripps.edu","Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA. shenb@scripps.edu","Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute, Jupiter, FL, USA. shenb@scripps.edu","Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-9750-5982","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA. shenb@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA. shenb@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute, Jupiter, FL, USA. shenb@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087514362"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":2.502,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.88100284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"7","first_page":"730","last_page":"737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-coa-synthetase","display_name":"acyl-CoA synthetase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/adenylation","display_name":"adenylylation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/thioesterification","display_name":"thioesterification","score":0.9959999918937683},{"id":"https://openalex.org/keywords/platencin","display_name":"platencin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/carboxylic-acid-activation","display_name":"carboxylic acid activation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.753000020980835},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.7371845841407776},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6337999105453491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5821461081504822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4815264344215393},{"id":"https://openalex.org/C3018256011","wikidata":"https://www.wikidata.org/wiki/Q898987","display_name":"Separation method","level":2,"score":0.42084643244743347},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4131395220756531},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3187497854232788},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.10625326633453369},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41589-018-0061-0","doi":"https://doi.org/10.1038/s41589-018-0061-0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41589-018-0061-0","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},{"id":"pmid:29867143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29867143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5241327","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008203","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6008203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008203","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Chem Biol","raw_type":"Text"},{"id":"pmh:oai:repository.rice.edu:1911/107723","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41589-018-0061-0.","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:osti.gov:1466308","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1466308","pdf_url":"https://www.osti.gov/servlets/purl/1466308","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5241327","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008203","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G102163711","display_name":null,"funder_award_id":"DE\u2010 AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2240095462","display_name":"Enzyme Discovery for Natural Product Biosynthesis","funder_award_id":"U01GM098248","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G262962599","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2857925935","display_name":null,"funder_award_id":"DEAC0206CH11357","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G409777406","display_name":null,"funder_award_id":"DE-AC02-06CH11357","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4239711504","display_name":null,"funder_award_id":"GM114353","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4759281571","display_name":null,"funder_award_id":"GM098248","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5291573843","display_name":"Discovery and biosynthesis of diterpenoid natural products in actinomycetals","funder_award_id":"R01GM114353","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5431085921","display_name":"Midwest Center for Structural Genomics","funder_award_id":"U54GM094585","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5607048534","display_name":null,"funder_award_id":"DE-AC02\u201306CH11357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6848031779","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7379127318","display_name":null,"funder_award_id":"GM094585","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8571893692","display_name":null,"funder_award_id":"GM109456","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8816403436","display_name":"Rigidity and flexibility of large bio-molecular assemblies","funder_award_id":"R01GM109456","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000019905","display_name":null,"funder_award_id":"GM094585","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320336399","display_name":"Institute of Applied Ecology, Chinese Academy of Sciences","ror":"https://ror.org/01thb7525"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806460700.pdf","grobid_xml":"https://content.openalex.org/works/W2806460700.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1535893202","https://openalex.org/W1853437253","https://openalex.org/W1912085754","https://openalex.org/W1966524255","https://openalex.org/W1977910429","https://openalex.org/W1979656018","https://openalex.org/W1980776509","https://openalex.org/W1992336064","https://openalex.org/W2005159632","https://openalex.org/W2009883823","https://openalex.org/W2011589439","https://openalex.org/W2017472057","https://openalex.org/W2018063919","https://openalex.org/W2018990299","https://openalex.org/W2023950913","https://openalex.org/W2025168003","https://openalex.org/W2027813939","https://openalex.org/W2035503835","https://openalex.org/W2043054174","https://openalex.org/W2050544107","https://openalex.org/W2052642718","https://openalex.org/W2055043387","https://openalex.org/W2075747312","https://openalex.org/W2077913471","https://openalex.org/W2088860725","https://openalex.org/W2092211067","https://openalex.org/W2103503400","https://openalex.org/W2105110220","https://openalex.org/W2108921801","https://openalex.org/W2127130852","https://openalex.org/W2127322768","https://openalex.org/W2132632499","https://openalex.org/W2140885472","https://openalex.org/W2144495216","https://openalex.org/W2146080841","https://openalex.org/W2154714625","https://openalex.org/W2155612513","https://openalex.org/W2160054006","https://openalex.org/W2180229411","https://openalex.org/W2327745821","https://openalex.org/W2338341418","https://openalex.org/W2344293454","https://openalex.org/W2550070588","https://openalex.org/W2553198434","https://openalex.org/W2560710801","https://openalex.org/W2587992070","https://openalex.org/W2607043745","https://openalex.org/W4234175205"],"related_works":["https://openalex.org/W2020471978","https://openalex.org/W1994262832","https://openalex.org/W2105110220","https://openalex.org/W4412483441","https://openalex.org/W2077913471","https://openalex.org/W2072326030","https://openalex.org/W2167132864","https://openalex.org/W4392362479","https://openalex.org/W2607043745","https://openalex.org/W3174354617"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
