{"id":"https://openalex.org/W2806457627","doi":"https://doi.org/10.2174/1573395514666180605091240","title":"Use of Monoclonal Antibodies to Prevent the Sexual Transmission of Human Immunodeficiency Virus Type 1","display_name":"Use of Monoclonal Antibodies to Prevent the Sexual Transmission of Human Immunodeficiency Virus Type 1","publication_year":2018,"publication_date":"2018-06-05","ids":{"openalex":"https://openalex.org/W2806457627","doi":"https://doi.org/10.2174/1573395514666180605091240","mag":"2806457627"},"language":"en","primary_location":{"id":"doi:10.2174/1573395514666180605091240","doi":"https://doi.org/10.2174/1573395514666180605091240","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573395514666180605091240","pdf_url":null,"source":{"id":"https://openalex.org/S175109673","display_name":"Current Immunology Reviews","issn_l":"1573-3955","issn":["1573-3955","1875-631X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Immunology Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079140140","display_name":"Deborah Jean Anderson","orcid":"https://orcid.org/0000-0002-2848-7290","observed_orcids":["https://orcid.org/0000-0002-2848-7290","https://orcid.org/0000-0002-6944-8634"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deborah J. Anderson","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060237704","display_name":"Joseph A. Politch","orcid":"https://orcid.org/0000-0002-7022-0135","observed_orcids":["https://orcid.org/0000-0002-7022-0135"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Politch","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024417940","display_name":"Gabriela Baldeon Vaca","orcid":"https://orcid.org/0000-0003-2465-7157","observed_orcids":["https://orcid.org/0000-0003-2465-7157"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela B. Vaca","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006322528","display_name":"Kadryn Kadasia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kadryn Kadasia","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025746769","display_name":"Kevin J. Whaley","orcid":"https://orcid.org/0000-0003-3856-6803","observed_orcids":["https://orcid.org/0000-0003-3856-6803"]},"institutions":[{"id":"https://openalex.org/I4210104471","display_name":"Mapp Biopharmaceutical (United States)","ror":"https://ror.org/01e47qp55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104471"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Whaley","raw_affiliation_strings":["Mapp Biopharmaceutical, San Diego, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mapp Biopharmaceutical, San Diego, CA, United States","institution_ids":["https://openalex.org/I4210104471"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079140140"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":null,"apc_paid":null,"fwci":0.1315,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42607004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"1","first_page":"123","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/broadly-neutralizing-antibodies","display_name":"broadly neutralizing antibodies","score":0.8600000143051147},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sexual-transmission-prevention","display_name":"sexual transmission prevention","score":0.7770000100135803},{"id":"https://openalex.org/keywords/passive-immunization","display_name":"passive immunization","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mucosal-hiv-transmission","display_name":"mucosal HIV transmission","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hiv-prophylaxis","display_name":"HIV prophylaxis","score":0.781000018119812},{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.6869999766349792},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.6589999794960022},{"id":"https://openalex.org/keywords/macaque","display_name":"macaque","score":0.7850000262260437},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7958605289459229},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.666205883026123},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6330811381340027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6304740905761719},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.6010480523109436},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5769626498222351},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5697530508041382},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.53424471616745},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5168960094451904},{"id":"https://openalex.org/C3019340110","wikidata":"https://www.wikidata.org/wiki/Q525512","display_name":"Sexual transmission","level":4,"score":0.5046676397323608},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4239300489425659},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.10502374172210693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0831398069858551},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.05603954195976257},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1573395514666180605091240","doi":"https://doi.org/10.2174/1573395514666180605091240","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573395514666180605091240","pdf_url":null,"source":{"id":"https://openalex.org/S175109673","display_name":"Current Immunology Reviews","issn_l":"1573-3955","issn":["1573-3955","1875-631X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Immunology Reviews","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W630338634","https://openalex.org/W1528520360","https://openalex.org/W1529373421","https://openalex.org/W1568188620","https://openalex.org/W1866523548","https://openalex.org/W1878923342","https://openalex.org/W1909824893","https://openalex.org/W1913035032","https://openalex.org/W1915519529","https://openalex.org/W1924338894","https://openalex.org/W1964828486","https://openalex.org/W1965439127","https://openalex.org/W1973873487","https://openalex.org/W1976160240","https://openalex.org/W1988019069","https://openalex.org/W1990615139","https://openalex.org/W1990745725","https://openalex.org/W1992968022","https://openalex.org/W1993675648","https://openalex.org/W1996707604","https://openalex.org/W2000115462","https://openalex.org/W2002116187","https://openalex.org/W2005320015","https://openalex.org/W2005499852","https://openalex.org/W2006925543","https://openalex.org/W2008737440","https://openalex.org/W2011136801","https://openalex.org/W2011261569","https://openalex.org/W2015567053","https://openalex.org/W2016364569","https://openalex.org/W2017098129","https://openalex.org/W2020549361","https://openalex.org/W2022564159","https://openalex.org/W2022988643","https://openalex.org/W2025988335","https://openalex.org/W2027763245","https://openalex.org/W2028289363","https://openalex.org/W2030129290","https://openalex.org/W2030522563","https://openalex.org/W2034996626","https://openalex.org/W2036908588","https://openalex.org/W2038110764","https://openalex.org/W2039062327","https://openalex.org/W2041483436","https://openalex.org/W2042411936","https://openalex.org/W2044326018","https://openalex.org/W2044410500","https://openalex.org/W2045873166","https://openalex.org/W2048414431","https://openalex.org/W2050405684","https://openalex.org/W2054099123","https://openalex.org/W2056045953","https://openalex.org/W2057961805","https://openalex.org/W2063245379","https://openalex.org/W2063789804","https://openalex.org/W2063825303","https://openalex.org/W2065329551","https://openalex.org/W2065458595","https://openalex.org/W2068838995","https://openalex.org/W2071843728","https://openalex.org/W2075684046","https://openalex.org/W2078161421","https://openalex.org/W2082994110","https://openalex.org/W2083726777","https://openalex.org/W2085577978","https://openalex.org/W2087565826","https://openalex.org/W2090538642","https://openalex.org/W2093797128","https://openalex.org/W2094052190","https://openalex.org/W2094459622","https://openalex.org/W2098324528","https://openalex.org/W2101931208","https://openalex.org/W2105021800","https://openalex.org/W2105350254","https://openalex.org/W2108692663","https://openalex.org/W2109065191","https://openalex.org/W2109368056","https://openalex.org/W2110233649","https://openalex.org/W2113822425","https://openalex.org/W2118540273","https://openalex.org/W2121558572","https://openalex.org/W2123297188","https://openalex.org/W2137354517","https://openalex.org/W2140157151","https://openalex.org/W2143036112","https://openalex.org/W2144023036","https://openalex.org/W2145699153","https://openalex.org/W2146981871","https://openalex.org/W2152048324","https://openalex.org/W2152314372","https://openalex.org/W2152399881","https://openalex.org/W2155379930","https://openalex.org/W2159515958","https://openalex.org/W2172224306","https://openalex.org/W2175262016","https://openalex.org/W2200798239","https://openalex.org/W2256769101","https://openalex.org/W2270775403","https://openalex.org/W2274486873","https://openalex.org/W2289965054","https://openalex.org/W2295803553","https://openalex.org/W2314178424","https://openalex.org/W2329273646","https://openalex.org/W2331126300","https://openalex.org/W2338025722","https://openalex.org/W2347047438","https://openalex.org/W2359605300","https://openalex.org/W2410322058","https://openalex.org/W2426635085","https://openalex.org/W2462486714","https://openalex.org/W2467571498","https://openalex.org/W2581575342","https://openalex.org/W2611116815","https://openalex.org/W2998115530","https://openalex.org/W7073976023"],"related_works":["https://openalex.org/W2611116815","https://openalex.org/W4387406169","https://openalex.org/W2945631985","https://openalex.org/W2768170182","https://openalex.org/W3039215568","https://openalex.org/W2802188588","https://openalex.org/W3186505124","https://openalex.org/W3217021952","https://openalex.org/W2938231046","https://openalex.org/W2467571498"],"abstract_inverted_index":{"Passive":[0],"immunization":[1],"has":[2,24],"been":[3],"used":[4],"since":[5],"the":[6,28,100,110,116,137],"late":[7],"1800\u2019s":[8],"to":[9,27,108,135],"prevent":[10,109],"and":[11,21,37,52,60,73,77,89,103,129,139],"treat":[12],"human":[13,22,106],"infectious":[14],"diseases.":[15],"Administration":[16],"of":[17,30,63,105,113,141],"animal":[18,118],"immune":[19],"sera":[20],"immunoglobulin":[23],"given":[25],"way":[26],"use":[29],"monoclonal":[31],"antibodies":[32,43],"(mAbs)":[33],"for":[34,49,87,99],"passive":[35],"immunization,":[36],"highly":[38],"potent":[39],"broadly":[40],"neutralizing":[41],"anti-HIV":[42],"(bNAbs)":[44],"are":[45,80],"now":[46],"being":[47,82],"considered":[48],"HIV":[50,127,143],"therapy":[51],"prophylaxis.":[53],"Recent":[54],"studies":[55,119],"have":[56,121],"shown":[57],"that":[58,120],"systemic":[59],"topical":[61],"administration":[62],"bNAbs":[64,79,107],"can":[65],"effectively":[66],"inhibit":[67],"HIV/SHIV":[68],"mucosal":[69,126],"transmission":[70,112],"in":[71,74,84,91,145],"macaques":[72],"humanized":[75],"mice,":[76],"selected":[78],"currently":[81,133],"tested":[83],"clinical":[85,131],"trials":[86,132],"safety":[88,138],"efficacy":[90,140],"humans.":[92,146],"In":[93],"this":[94],"review,":[95],"we":[96],"outline":[97],"strategies":[98],"selection,":[101],"engineering":[102],"manufacture":[104],"sexual":[111],"HIV,":[114],"describe":[115],"proof-of-concept":[117],"demonstrated":[122],"mAb-mediated":[123],"protection":[124],"against":[125],"transmission,":[128],"review":[130],"underway":[134],"test":[136],"mAb-based":[142],"prevention":[144]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2018-06-13T00:00:00"}
