{"id":"https://openalex.org/W2806435840","doi":"https://doi.org/10.1038/s41467-018-04708-5","title":"Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth","display_name":"Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth","publication_year":2018,"publication_date":"2018-06-05","ids":{"openalex":"https://openalex.org/W2806435840","doi":"https://doi.org/10.1038/s41467-018-04708-5","mag":"2806435840","pmid":"https://pubmed.ncbi.nlm.nih.gov/29891932","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5995930"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-04708-5","doi":"https://doi.org/10.1038/s41467-018-04708-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-04708-5","pdf_url":"https://www.nature.com/articles/s41467-018-04708-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-04708-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018132581","display_name":"Jishan Jiang","orcid":"https://orcid.org/0000-0002-0262-9967","observed_orcids":["https://orcid.org/0000-0002-0262-9967"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I4405278674","display_name":"Institute for Integrative Genome Biology","ror":"https://ror.org/00cpdm633","country_code":"US","type":"facility","lineage":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jishan Jiang","raw_affiliation_strings":["Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016301912","display_name":"Cecilia Rodr\u00edguez-Furl\u00e1n","orcid":"https://orcid.org/0000-0002-3453-4719","observed_orcids":["https://orcid.org/0000-0002-3453-4719"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I4405278674","display_name":"Institute for Integrative Genome Biology","ror":"https://ror.org/00cpdm633","country_code":"US","type":"facility","lineage":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia Rodriguez-Furlan","raw_affiliation_strings":["Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA"],"raw_orcid":"https://orcid.org/0000-0002-3453-4719","affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014018321","display_name":"Jinzheng Wang","orcid":"https://orcid.org/0000-0002-5575-7815","observed_orcids":["https://orcid.org/0000-0002-5575-7815"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I4405278674","display_name":"Institute for Integrative Genome Biology","ror":"https://ror.org/00cpdm633","country_code":"US","type":"facility","lineage":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Zheng Wang","raw_affiliation_strings":["Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070484672","display_name":"Amancio Jos\u00e9 de Souza","orcid":"https://orcid.org/0000-0001-6447-3905","observed_orcids":["https://orcid.org/0000-0001-6447-3905"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I4405278674","display_name":"Institute for Integrative Genome Biology","ror":"https://ror.org/00cpdm633","country_code":"US","type":"facility","lineage":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amancio de Souza","raw_affiliation_strings":["Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071616966","display_name":"Haiyan Ke","orcid":"https://orcid.org/0000-0001-9365-7922","observed_orcids":["https://orcid.org/0000-0001-9365-7922"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I4405278674","display_name":"Institute for Integrative Genome Biology","ror":"https://ror.org/00cpdm633","country_code":"US","type":"facility","lineage":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyan Ke","raw_affiliation_strings":["Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037389310","display_name":"Taras P. Pasternak","orcid":"https://orcid.org/0000-0001-5061-4076","observed_orcids":["https://orcid.org/0000-0001-5061-4076"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Taras Pasternak","raw_affiliation_strings":["University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","University of Freiburg, Faculty of Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"University of Freiburg, Faculty of Biology","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027455857","display_name":"Hanna Lasok","orcid":"https://orcid.org/0000-0002-1719-4636","observed_orcids":["https://orcid.org/0000-0002-1719-4636"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanna Lasok","raw_affiliation_strings":["University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","University of Freiburg, Faculty of Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"University of Freiburg, Faculty of Biology","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058112460","display_name":"Franck Anicet Ditengou","orcid":"https://orcid.org/0000-0001-5355-0282","observed_orcids":["https://orcid.org/0000-0001-5355-0282"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franck A. Ditengou","raw_affiliation_strings":["University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","University of Freiburg, Faculty of Biology"],"raw_orcid":"https://orcid.org/0000-0001-5355-0282","affiliations":[{"raw_affiliation_string":"University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"University of Freiburg, Faculty of Biology","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078652050","display_name":"Klaus J. Palme","orcid":"https://orcid.org/0000-0002-2728-3835","observed_orcids":["https://orcid.org/0000-0002-2728-3835"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Palme","raw_affiliation_strings":["University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","University of Freiburg, Faculty of Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies, Sch\u00e4nzlestr. 1, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"University of Freiburg, Faculty of Biology","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064155641","display_name":"Katayoon Dehesh","orcid":"https://orcid.org/0000-0002-9312-8032","observed_orcids":["https://orcid.org/0000-0002-9312-8032"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I4405278674","display_name":"Institute for Integrative Genome Biology","ror":"https://ror.org/00cpdm633","country_code":"US","type":"facility","lineage":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katayoon Dehesh","raw_affiliation_strings":["Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA. kdehesh@ucr.edu","Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA. kdehesh@ucr.edu","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]},{"raw_affiliation_string":"Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA, 92506, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064155641"],"corresponding_institution_ids":["https://openalex.org/I103635307","https://openalex.org/I4405278674"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":2.9566,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.9033094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"2262","last_page":"2262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/auxin","display_name":"auxin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mono-2-ethyl-5-carboxypentyl-phthalate","display_name":"MECPP","score":0.8360000252723694},{"id":"https://openalex.org/keywords/auxin-homeostasis","display_name":"auxin homeostasis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/auxin-distribution","display_name":"auxin distribution","score":0.7070000171661377},{"id":"https://openalex.org/keywords/pin1","display_name":"Pin1","score":0.6610000133514404},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/plant-stress-response","display_name":"plant stress response","score":0.656000018119812},{"id":"https://openalex.org/keywords/adaptive-growth","display_name":"adaptive growth","score":0.9229999780654907},{"id":"https://openalex.org/keywords/auxin-efflux-carriers","display_name":"auxin efflux carriers","score":0.6140000224113464},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C207778908","wikidata":"https://www.wikidata.org/wiki/Q190022","display_name":"Auxin","level":3,"score":0.9119422435760498},{"id":"https://openalex.org/C154472170","wikidata":"https://www.wikidata.org/wiki/Q18030556","display_name":"PIN1","level":4,"score":0.7813811302185059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7005085945129395},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.5568286180496216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5450064539909363},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4419136047363281},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4377746880054474},{"id":"https://openalex.org/C194082555","wikidata":"https://www.wikidata.org/wiki/Q7317034","display_name":"Retrograde signaling","level":3,"score":0.4245303273200989},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3118157982826233},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.234730064868927},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16719970107078552},{"id":"https://openalex.org/C2781264208","wikidata":"https://www.wikidata.org/wiki/Q118026","display_name":"Isomerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002966","descriptor_name":"Clathrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004896","descriptor_name":"Erythritol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004896","descriptor_name":"Erythritol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007210","descriptor_name":"Indoleacetic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010937","descriptor_name":"Plant Growth Regulators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1038/s41467-018-04708-5","doi":"https://doi.org/10.1038/s41467-018-04708-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-04708-5","pdf_url":"https://www.nature.com/articles/s41467-018-04708-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4951184","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5995930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5995930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5995930","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:29891932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29891932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0086d3vh","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0086d3vh","pdf_url":"https://escholarship.org/content/qt0086d3vh/qt0086d3vh.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, vol 9, iss 1","raw_type":"article"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04708-5","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-04708-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:69894e722e7b41cd9573de020d2f70b5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/69894e722e7b41cd9573de020d2f70b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a5a5b9f2d91b48489e520b1168b97083","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a5a5b9f2d91b48489e520b1168b97083","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0086d3vh","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0086d3vh","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature communications, vol 9, iss 1","raw_type":"article"},{"id":"pmh:oai:freidok.uni-freiburg.de:269327","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/269327","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature communications. - 9, 1 (2018) , 2262, ISSN: 2041-1723","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-04708-5","doi":"https://doi.org/10.1038/s41467-018-04708-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-04708-5","pdf_url":"https://www.nature.com/articles/s41467-018-04708-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1135511128","display_name":null,"funder_award_id":"R01GM107311","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3142890886","display_name":null,"funder_award_id":"DFG SFB 746","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4942225502","display_name":"Defining the Retrograde Plastid-to-Nucleus Stress Signaling Pathway","funder_award_id":"R01GM107311","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5181716343","display_name":"Defining transcriptional and post-translational regulatory networks in retrogradw stress signaling","funder_award_id":"1352478","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G550493830","display_name":null,"funder_award_id":"SFB-746","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7095202346","display_name":null,"funder_award_id":"INST 39/839","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7897619189","display_name":"HPL-Pathway Mediated Stress Signaling Networks in Plants","funder_award_id":"1036491","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806435840.pdf","grobid_xml":"https://content.openalex.org/works/W2806435840.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1503248546","https://openalex.org/W1844799245","https://openalex.org/W1964803931","https://openalex.org/W1968079819","https://openalex.org/W1969189009","https://openalex.org/W1979047527","https://openalex.org/W1979902100","https://openalex.org/W1984256365","https://openalex.org/W1989637267","https://openalex.org/W1989716780","https://openalex.org/W1989989789","https://openalex.org/W2004608542","https://openalex.org/W2004899620","https://openalex.org/W2009849705","https://openalex.org/W2011820514","https://openalex.org/W2012352145","https://openalex.org/W2013078771","https://openalex.org/W2013874546","https://openalex.org/W2014207396","https://openalex.org/W2018051749","https://openalex.org/W2018811826","https://openalex.org/W2022268403","https://openalex.org/W2037618053","https://openalex.org/W2038818582","https://openalex.org/W2042838204","https://openalex.org/W2053087257","https://openalex.org/W2055323344","https://openalex.org/W2062336656","https://openalex.org/W2066833492","https://openalex.org/W2077549321","https://openalex.org/W2086491289","https://openalex.org/W2091902645","https://openalex.org/W2096630683","https://openalex.org/W2099692433","https://openalex.org/W2099980098","https://openalex.org/W2103000773","https://openalex.org/W2105136620","https://openalex.org/W2109800411","https://openalex.org/W2110103595","https://openalex.org/W2110915711","https://openalex.org/W2116723626","https://openalex.org/W2130107661","https://openalex.org/W2133817939","https://openalex.org/W2135087570","https://openalex.org/W2137737959","https://openalex.org/W2143958191","https://openalex.org/W2147228753","https://openalex.org/W2148740279","https://openalex.org/W2149536871","https://openalex.org/W2149548109","https://openalex.org/W2164185725","https://openalex.org/W2166878800","https://openalex.org/W2167898577","https://openalex.org/W2168575960","https://openalex.org/W2169471008","https://openalex.org/W2169918138","https://openalex.org/W2171358926","https://openalex.org/W2281834070","https://openalex.org/W2394705589","https://openalex.org/W2505272467","https://openalex.org/W2547939082","https://openalex.org/W2601477564","https://openalex.org/W2728439857","https://openalex.org/W2758799530","https://openalex.org/W7099285589"],"related_works":["https://openalex.org/W3026269605","https://openalex.org/W4408160309","https://openalex.org/W2758799530","https://openalex.org/W2955811519","https://openalex.org/W3216901609","https://openalex.org/W1989716780","https://openalex.org/W4385190975","https://openalex.org/W2913393717","https://openalex.org/W4401055423","https://openalex.org/W4390959174"],"abstract_inverted_index":{"The":[0],"ancient":[1],"morphoregulatory":[2],"hormone":[3],"auxin":[4,26,56,81,132],"dynamically":[5],"realigns":[6],"dedicated":[7],"cellular":[8],"processes":[9],"that":[10,33,54,67],"shape":[11],"plant":[12],"growth":[13,46],"under":[14],"prevailing":[15],"environmental":[16],"conditions.":[17],"However,":[18,100],"the":[19,22,34,77,88,91,97,107,115,125,141],"nature":[20],"of":[21,74,79,90,127,144],"stress-responsive":[23],"signal":[24],"altering":[25,131],"homeostasis":[27],"remains":[28],"elusive.":[29],"Here":[30],"we":[31],"establish":[32],"evolutionarily":[35],"conserved":[36],"plastidial":[37,138],"retrograde":[38],"signaling":[39,121],"metabolite":[40],"methylerythritol":[41],"cyclodiphosphate":[42],"(MEcPP)":[43],"controls":[44],"adaptive":[45,145],"by":[47,123],"dual":[48],"transcriptional":[49],"and":[50,58,84,86,134],"post-translational":[51],"regulatory":[52],"inputs":[53],"modulate":[55],"levels":[57],"distribution":[59],"patterns":[60],"in":[61,68,130],"response":[62],"to":[63],"stress.":[64],"We":[65],"demonstrate":[66],"vivo":[69],"accumulation":[70],"or":[71],"exogenous":[72],"application":[73],"MEcPP":[75,128],"alters":[76],"expression":[78],"two":[80,119],"reporters,":[82],"DR5:GFP":[83],"DII-VENUS,":[85],"reduces":[87],"abundance":[89],"auxin-efflux":[92],"carrier":[93],"PIN-FORMED1":[94],"(PIN1)":[95],"at":[96],"plasma":[98],"membrane.":[99],"pharmacological":[101],"intervention":[102],"with":[103],"clathrin-mediated":[104],"endocytosis":[105],"blocks":[106],"PIN1":[108],"reduction.":[109],"This":[110],"study":[111],"provides":[112],"insight":[113],"into":[114],"interplay":[116],"between":[117],"these":[118],"indispensable":[120],"metabolites":[122],"establishing":[124],"mode":[126],"action":[129],"homeostasis,":[133],"as":[135,140],"such,":[136],"positioning":[137],"function":[139],"primary":[142],"driver":[143],"growth.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}