{"id":"https://openalex.org/W2806416237","doi":"https://doi.org/10.1016/j.sajb.2018.05.018","title":"Production of herbarin and dehydroherbarin by endophytic Chaetosphaeronema sp. (KY321184) isolated from Nepeta septemcrenata and evaluation of their bioactivities","display_name":"Production of herbarin and dehydroherbarin by endophytic Chaetosphaeronema sp. (KY321184) isolated from Nepeta septemcrenata and evaluation of their bioactivities","publication_year":2018,"publication_date":"2018-05-30","ids":{"openalex":"https://openalex.org/W2806416237","doi":"https://doi.org/10.1016/j.sajb.2018.05.018","mag":"2806416237"},"language":"en","primary_location":{"id":"doi:10.1016/j.sajb.2018.05.018","doi":"https://doi.org/10.1016/j.sajb.2018.05.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sajb.2018.05.018","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0254629918301534/pdf","source":{"id":"https://openalex.org/S31493525","display_name":"South African Journal of Botany","issn_l":"0254-6299","issn":["0254-6299","1727-9321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Journal of Botany","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0254629918301534/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018881928","display_name":"Mohamed Osman","orcid":"https://orcid.org/0000-0003-3990-6945","observed_orcids":["https://orcid.org/0000-0003-3990-6945"]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M.E. Osman","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science, Helwan University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science, Helwan University, Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002107089","display_name":"Ahmed Atef El\u2010Beih","orcid":"https://orcid.org/0000-0002-6960-027X","observed_orcids":["https://orcid.org/0000-0002-6960-027X"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A.A. El-Beih","raw_affiliation_strings":["Chemistry of Natural and Microbial Products Department, Pharmaceutical Research Industries Division, National Research Centre, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry of Natural and Microbial Products Department, Pharmaceutical Research Industries Division, National Research Centre, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047053795","display_name":"Om-Kolthoum H. Khattab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"O.-K.H. Khatab","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science, Helwan University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science, Helwan University, Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086982041","display_name":"Saad A. M. Moghannem","orcid":"https://orcid.org/0000-0002-6686-5520","observed_orcids":["https://orcid.org/0000-0002-6686-5520"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"S.A.M. Moghannem","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science, Al Azhar University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science, Al Azhar University, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080340359","display_name":"Nashwa Hamed Abdullah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"N.H. Abdullah","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science, Helwan University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science, Helwan University, Egypt","institution_ids":["https://openalex.org/I84058292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080340359"],"corresponding_institution_ids":["https://openalex.org/I84058292"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":0.3454,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.43657817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"117","issue":null,"first_page":"174","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12934","display_name":"Plant and fungal interactions","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endophytic-fungi","display_name":"endophytic fungi","score":0.984000027179718},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.7229999899864197},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hepatitis-a-virus","display_name":"hepatitis A virus","score":0.902999997138977},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.734000027179718},{"id":"https://openalex.org/keywords/heat-shock-protein-90-alpha","display_name":"heat shock protein 90 alpha","score":0.9210000038146973},{"id":"https://openalex.org/keywords/topoisomerase-i","display_name":"topoisomerase I","score":0.9829999804496765},{"id":"https://openalex.org/keywords/adme-prediction","display_name":"ADME prediction","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2776790833","wikidata":"https://www.wikidata.org/wiki/Q303820","display_name":"Nepeta","level":3,"score":0.7441024780273438},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6293618083000183},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6079311966896057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5098661184310913},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.46749603748321533},{"id":"https://openalex.org/C89638049","wikidata":"https://www.wikidata.org/wiki/Q7201546","display_name":"Plant use of endophytic fungi in defense","level":2,"score":0.46187376976013184},{"id":"https://openalex.org/C79029880","wikidata":"https://www.wikidata.org/wiki/Q901755","display_name":"GenBank","level":3,"score":0.4591675400733948},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.44720470905303955},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.41301190853118896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3256499767303467},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.30504271388053894},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.23869729042053223},{"id":"https://openalex.org/C2777143434","wikidata":"https://www.wikidata.org/wiki/Q53476","display_name":"Lamiaceae","level":2,"score":0.21445384621620178},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19937407970428467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09449049830436707},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.sajb.2018.05.018","doi":"https://doi.org/10.1016/j.sajb.2018.05.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sajb.2018.05.018","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0254629918301534/pdf","source":{"id":"https://openalex.org/S31493525","display_name":"South African Journal of Botany","issn_l":"0254-6299","issn":["0254-6299","1727-9321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Journal of Botany","raw_type":"journal-article"},{"id":"doi:10.60692/ggrm4-53078","doi":"https://doi.org/10.60692/ggrm4-53078","is_oa":true,"landing_page_url":"https://doi.org/10.60692/ggrm4-53078","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/shp5f-bfz75","doi":"https://doi.org/10.60692/shp5f-bfz75","is_oa":true,"landing_page_url":"https://doi.org/10.60692/shp5f-bfz75","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/j.sajb.2018.05.018","doi":"https://doi.org/10.1016/j.sajb.2018.05.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sajb.2018.05.018","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0254629918301534/pdf","source":{"id":"https://openalex.org/S31493525","display_name":"South African Journal of Botany","issn_l":"0254-6299","issn":["0254-6299","1727-9321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Journal of Botany","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806416237.pdf","grobid_xml":"https://content.openalex.org/works/W2806416237.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W415317890","https://openalex.org/W1537237258","https://openalex.org/W1985785625","https://openalex.org/W1985862669","https://openalex.org/W2013666629","https://openalex.org/W2034411387","https://openalex.org/W2043855224","https://openalex.org/W2046171723","https://openalex.org/W2047453476","https://openalex.org/W2049648419","https://openalex.org/W2058518669","https://openalex.org/W2061043967","https://openalex.org/W2067387519","https://openalex.org/W2069380488","https://openalex.org/W2070788764","https://openalex.org/W2082683149","https://openalex.org/W2135673702","https://openalex.org/W2136931384","https://openalex.org/W2144049681","https://openalex.org/W2162971575","https://openalex.org/W2189553837","https://openalex.org/W2308273284","https://openalex.org/W2402258526","https://openalex.org/W2536349886","https://openalex.org/W2566859523","https://openalex.org/W2585689647","https://openalex.org/W2606171297","https://openalex.org/W2952664328","https://openalex.org/W3025367164","https://openalex.org/W3129785828","https://openalex.org/W4238646163","https://openalex.org/W4285719527","https://openalex.org/W6686954036"],"related_works":["https://openalex.org/W2595976624","https://openalex.org/W3024243818","https://openalex.org/W2032397688","https://openalex.org/W2981948259","https://openalex.org/W2050260109","https://openalex.org/W2264434219","https://openalex.org/W2132844935","https://openalex.org/W2014287986","https://openalex.org/W4408542665","https://openalex.org/W2248372997"],"abstract_inverted_index":{"A":[0,158],"new":[1,41],"endophytic":[2],"fungal":[3],"isolate":[4,16,35,68],"has":[5,17,36],"been":[6,18,37,59],"isolated":[7,60],"from":[8,66],"Nepeta":[9],"septemcrenata":[10],"growing":[11],"on":[12,71,206],"Saint-Catherine-South":[13],"Sinai-Egypt.":[14],"This":[15],"identified":[19],"by":[20],"sequencing":[21],"the":[22,50,62,98,113,127,165,184,207,221],"ITS":[23],"region.":[24],"It":[25],"showed":[26,77,83,94,109,146,152],"95%":[27],"similarity":[28],"with":[29,171,190],"different":[30],"Chaetosphaeronema":[31,43],"species":[32],"thus":[33],"this":[34,67],"suggested":[38],"as":[39,61],"a":[40],"undescribed":[42],"sp.":[44],"and":[45,56,89,124,126,134,139,183],"released":[46],"in":[47],"GenBank":[48],"under":[49],"accession":[51],"number":[52],"of":[53,167,186,217,226],"KY321184.":[54],"Herbarin":[55,76],"dehydroherbarin":[57,82,138,145,168],"have":[58],"major":[63],"bioactive":[64],"compounds":[65,93,219],"when":[69],"cultivated":[70],"potato":[72],"dextrose":[73],"broth":[74],"medium.":[75],"weak":[78],"antimicrobial":[79,85],"effect":[80],"but":[81,108],"moderate":[84],"effects":[86,205],"against":[87,97],"gram-negative":[88],"gram-positive":[90],"bacteria.":[91],"Both":[92],"reduced":[95],"cytotoxicity":[96],"normal":[99],"cell":[100,116,211],"line":[101,117],"MRC":[102],"5":[103],"which":[104,200],"didn't":[105],"exceed":[106],"45.3%":[107],"higher":[110,147],"toxicity":[111,121],"towards":[112],"breast":[114,209],"cancer":[115,210],"MCF":[118],"7":[119],"where":[120,150],"reaches":[122],"95.2%":[123],"94.6%":[125],"estimated":[128],"IC":[129],"50":[130],"was":[131],"811.3":[132],"\u03bcg/ml":[133,136],"288":[135],"for":[137,156],"herbarin":[140,187,227],"respectively.":[141],"On":[142],"other":[143],"hand,":[144],"antiviral":[148],"activity":[149],"it":[151],"90%":[153],"protection":[154],"percentage":[155],"Hepatitis":[157],"virus.":[159],"In":[160,213],"silico":[161,214],"docking":[162],"study":[163],"revealed":[164,220],"affinity":[166,185],"to":[169,188],"bind":[170,189],"human":[172,191],"heat":[173],"shock":[174],"protein":[175],"90":[176],"alpha":[177],"(2K5B)":[178],"through":[179,196],"three":[180],"hydrogen":[181,198],"bonds":[182,199],"DNA":[192],"topoisomerase":[193],"I":[194],"(1A35)":[195],"five":[197],"may":[201],"explain":[202],"their":[203],"cytotoxic":[204],"tested":[208],"line.":[212],"ADME":[215],"evaluation":[216],"these":[218],"possible":[222],"good":[223],"druglike":[224],"nature":[225],"compound.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-06-13T00:00:00"}
