{"id":"https://openalex.org/W2806299885","doi":"https://doi.org/10.1002/1878-0261.12331","title":"Dosing optimization of CCR 4 immunotoxin for improved depletion of CCR 4 + Treg in nonhuman primates","display_name":"Dosing optimization of CCR 4 immunotoxin for improved depletion of CCR 4 + Treg in nonhuman primates","publication_year":2018,"publication_date":"2018-06-06","ids":{"openalex":"https://openalex.org/W2806299885","doi":"https://doi.org/10.1002/1878-0261.12331","mag":"2806299885","pmid":"https://pubmed.ncbi.nlm.nih.gov/29873181","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6068354"},"language":"en","primary_location":{"id":"doi:10.1002/1878-0261.12331","doi":"https://doi.org/10.1002/1878-0261.12331","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.12331","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12331","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100358053","display_name":"Zhaohui Wang","orcid":"https://orcid.org/0000-0002-9035-3867","observed_orcids":["https://orcid.org/0000-0002-9035-3867"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaohui Wang","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005244272","display_name":"Nathan J. Louras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan J. Louras","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059748787","display_name":"Alexandre G. Lellouch","orcid":"https://orcid.org/0000-0001-8191-8662","observed_orcids":["https://orcid.org/0000-0001-8191-8662"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre G. Lellouch","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087240812","display_name":"Shannon G. Pratts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon G. Pratts","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huiping Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiping Zhang","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427170","display_name":"Haoyu Wang","orcid":"https://orcid.org/0000-0001-6647-598X","observed_orcids":["https://orcid.org/0000-0001-6647-598X","https://orcid.org/0000-0003-3131-8217"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoyu Wang","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056087489","display_name":"Christene A. Huang","orcid":"https://orcid.org/0000-0001-9824-5716","observed_orcids":["https://orcid.org/0000-0001-9824-5716"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christene A. Huang","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086748086","display_name":"Curtis L. Cetrulo","orcid":"https://orcid.org/0000-0001-7080-3894","observed_orcids":["https://orcid.org/0000-0001-7080-3894"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis L. Cetrulo","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084623835","display_name":"Joren C. Madsen","orcid":"https://orcid.org/0000-0003-2724-1333","observed_orcids":["https://orcid.org/0000-0003-2724-1333"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joren C. Madsen","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073338357","display_name":"David H. Sachs","orcid":"https://orcid.org/0000-0001-9588-8580","observed_orcids":["https://orcid.org/0000-0001-9588-8580"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Sachs","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","TBRC Laboratories, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"TBRC Laboratories, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108431768","display_name":"Zhirui Wang","orcid":"https://orcid.org/0000-0002-0046-2294","observed_orcids":["https://orcid.org/0000-0002-0046-2294"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhirui Wang","raw_affiliation_strings":["Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108431768"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":0.5367,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6054315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"8","first_page":"1374","last_page":"1382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diphtheria-toxin","display_name":"diphtheria toxin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/treg-depletion","display_name":"Treg depletion","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C115085202","wikidata":"https://www.wikidata.org/wiki/Q425665","display_name":"Immunotoxin","level":4,"score":0.9413983225822449},{"id":"https://openalex.org/C2775866117","wikidata":"https://www.wikidata.org/wiki/Q21102300","display_name":"CCR4","level":5,"score":0.6961165070533752},{"id":"https://openalex.org/C33057221","wikidata":"https://www.wikidata.org/wiki/Q421580","display_name":"Diphtheria toxin","level":3,"score":0.6918457746505737},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6150356531143188},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5502679944038391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45616206526756287},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4292588233947754},{"id":"https://openalex.org/C111700020","wikidata":"https://www.wikidata.org/wiki/Q5009798","display_name":"CD22","level":4,"score":0.42842021584510803},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4232776165008545},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.42005449533462524},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38191404938697815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.299002468585968},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.27607470750808716},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.2522226572036743},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17309552431106567},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.13819724321365356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09834039211273193},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.0787232518196106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000922","descriptor_name":"Immunotoxins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000922","descriptor_name":"Immunotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004167","descriptor_name":"Diphtheria Toxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004167","descriptor_name":"Diphtheria Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054398","descriptor_name":"Receptors, CCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054398","descriptor_name":"Receptors, CCR4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/1878-0261.12331","doi":"https://doi.org/10.1002/1878-0261.12331","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.12331","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12331","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5024434","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6068354","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6068354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6068354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Oncol","raw_type":"Text"},{"id":"pmid:29873181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29873181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3784c31b64f845d5a0921236bcaf6cfd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3784c31b64f845d5a0921236bcaf6cfd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Oncology, Vol 12, Iss 8, Pp 1374-1382 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/1878-0261.12331","doi":"https://doi.org/10.1002/1878-0261.12331","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.12331","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12331","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3215049708","display_name":"New Approaches to Cardiothoracic Tolerance Induction","funder_award_id":"P01HL018646","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3722486669","display_name":null,"funder_award_id":"R00000000004616","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5597993002","display_name":"Mechanisms of Kidney-Induced Cardiac Allograft Tolerance","funder_award_id":"P01AI123086","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806299885.pdf","grobid_xml":"https://content.openalex.org/works/W2806299885.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W196099822","https://openalex.org/W886293302","https://openalex.org/W2004635420","https://openalex.org/W2014608550","https://openalex.org/W2025334443","https://openalex.org/W2028166635","https://openalex.org/W2054738595","https://openalex.org/W2066553457","https://openalex.org/W2158123524","https://openalex.org/W2161547215","https://openalex.org/W2176418242","https://openalex.org/W2297581901","https://openalex.org/W2517089662","https://openalex.org/W2561926137","https://openalex.org/W2564669868","https://openalex.org/W2740495409"],"related_works":["https://openalex.org/W2176418242","https://openalex.org/W2004635420","https://openalex.org/W3137171679","https://openalex.org/W4404064463","https://openalex.org/W2092918797","https://openalex.org/W7006314064","https://openalex.org/W1998506284","https://openalex.org/W2088778486","https://openalex.org/W2018122800","https://openalex.org/W4211033466"],"abstract_inverted_index":{"Recently,":[0],"we":[1,23],"have":[2,37],"developed":[3],"a":[4,42],"diphtheria":[5],"toxin\u2010based":[6],"recombinant":[7],"anti\u2010human":[8],"CCR":[9,14,31,92],"4":[10,15,32,93],"immunotoxin":[11,94],"for":[12,29,74,105],"targeting":[13],"+":[16,33],"tumors":[17],"and":[18,47,59,86],"Tregs.":[19],"In":[20],"this":[21],"study,":[22],"further":[24,102],"optimized":[25],"the":[26,48,56,65,91],"dosing":[27],"schedule":[28],"improved":[30],"Treg":[34],"depletion.":[35],"We":[36],"demonstrated":[38],"that":[39],"up":[40],"to":[41,51],"90%":[43],"depletion":[44,49,103],"was":[45,82,95],"achieved":[46],"extended":[50],"approximately":[52,98],"2":[53,99],"weeks":[54],"in":[55,64,78],"peripheral":[57],"blood":[58],"more":[60],"than":[61],"48":[62],"days":[63,77],"lymph":[66],"node":[67],"at":[68],"25":[69],"\u03bcg\u00b7kg":[70],"\u22121":[71],",":[72],"BID":[73],"8":[75],"consecutive":[76],"cynomolgus":[79],"monkeys.":[80],"Expansion":[81],"observed":[83],"including":[84],"monocytes":[85],"NK":[87],"cells.":[88],"Antibody":[89],"against":[90],"detected":[96],"after":[97],"weeks,":[100],"affecting":[101],"efficacy":[104],"multiple":[106],"course":[107],"treatment.":[108]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}
