{"id":"https://openalex.org/W2806247170","doi":"https://doi.org/10.1128/jvi.02131-17","title":"The Murine Polyomavirus MicroRNA Locus Is Required To Promote Viruria during the Acute Phase of Infection","display_name":"The Murine Polyomavirus MicroRNA Locus Is Required To Promote Viruria during the Acute Phase of Infection","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2806247170","doi":"https://doi.org/10.1128/jvi.02131-17","mag":"2806247170","pmid":"https://pubmed.ncbi.nlm.nih.gov/29875236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6069185"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.02131-17","doi":"https://doi.org/10.1128/jvi.02131-17","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.02131-17","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6069185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054250864","display_name":"James M. Burke","orcid":"https://orcid.org/0000-0002-5525-3641","observed_orcids":["https://orcid.org/0000-0002-5525-3641"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Burke","raw_affiliation_strings":["The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060942241","display_name":"Clovis R. Bass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clovis R. Bass","raw_affiliation_strings":["The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001824985","display_name":"Rodney P. Kincaid","orcid":"https://orcid.org/0000-0002-5318-3934","observed_orcids":["https://orcid.org/0000-0002-5318-3934"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodney P. Kincaid","raw_affiliation_strings":["The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020165813","display_name":"Emin T. Ulug","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emin T. Ulug","raw_affiliation_strings":["The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039061944","display_name":"Christopher S. Sullivan","orcid":"https://orcid.org/0000-0002-1739-7417","observed_orcids":["https://orcid.org/0000-0002-1739-7417"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Sullivan","raw_affiliation_strings":["The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Center for Systems and Synthetic Biology, Center for Infectious Disease and Department of Molecular Biosciences, Austin, Texas, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":0.6565,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.71821024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"92","issue":"16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murine-polyomavirus","display_name":"murine polyomavirus","score":0.9449999928474426},{"id":"https://openalex.org/keywords/viral-micrornas","display_name":"viral microRNAs","score":0.7649999856948853},{"id":"https://openalex.org/keywords/viruria","display_name":"viruria","score":0.7950000166893005},{"id":"https://openalex.org/keywords/viral-shedding","display_name":"viral shedding","score":0.7070000171661377},{"id":"https://openalex.org/keywords/acute-infection","display_name":"acute infection","score":0.828000009059906},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.8999999761581421},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.824999988079071},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9145928621292114},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6996088624000549},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6838412284851074},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5571197271347046},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5521973371505737},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.551236629486084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44322314858436584},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4398082196712494},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4367785155773163},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.42228570580482483},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33967554569244385},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.33470115065574646}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011120","descriptor_name":"Polyomavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011120","descriptor_name":"Polyomavirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027601","descriptor_name":"Polyomavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D027601","descriptor_name":"Polyomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.02131-17","doi":"https://doi.org/10.1128/jvi.02131-17","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.02131-17","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5331015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6069185","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6069185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6069185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:29875236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29875236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5331015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6069185","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4597196943","display_name":"Determining the Functional Role of microRNAs in Viral Tumorigenesis","funder_award_id":"RP140842","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1011582955","https://openalex.org/W1574568281","https://openalex.org/W1599023610","https://openalex.org/W1752775867","https://openalex.org/W1851420930","https://openalex.org/W1900954440","https://openalex.org/W1968487820","https://openalex.org/W1977215565","https://openalex.org/W1992080507","https://openalex.org/W2000423452","https://openalex.org/W2011182277","https://openalex.org/W2036897871","https://openalex.org/W2045756360","https://openalex.org/W2047414491","https://openalex.org/W2057652506","https://openalex.org/W2057682509","https://openalex.org/W2060308073","https://openalex.org/W2068596636","https://openalex.org/W2078686416","https://openalex.org/W2079093296","https://openalex.org/W2090325126","https://openalex.org/W2093247811","https://openalex.org/W2106720906","https://openalex.org/W2108321019","https://openalex.org/W2110615349","https://openalex.org/W2114715544","https://openalex.org/W2117145331","https://openalex.org/W2142769285","https://openalex.org/W2153527981","https://openalex.org/W2154945580","https://openalex.org/W2159647376","https://openalex.org/W2159921941","https://openalex.org/W2169297347","https://openalex.org/W2170551349","https://openalex.org/W2416065760"],"related_works":["https://openalex.org/W2786423024","https://openalex.org/W2169297347","https://openalex.org/W1968487820","https://openalex.org/W2094553997","https://openalex.org/W2193202133","https://openalex.org/W2139998197","https://openalex.org/W2765300793","https://openalex.org/W3142822746","https://openalex.org/W7118184414","https://openalex.org/W2012154526"],"abstract_inverted_index":{"MicroRNAs":[0],"are":[1],"expressed":[2],"by":[3,91],"diverse":[4],"viruses,":[5],"but":[6],"for":[7,50,68],"only":[8],"a":[9,47,51],"few":[10],"is":[11,40,89,121],"there":[12],"any":[13,66],"understanding":[14],"of":[15,31,41,93,108],"their":[16],"in":[17,25,55,63,73,105,125,146],"vivo":[18,106],"function.":[19],"PyVs":[20,139],"can":[21],"cause":[22],"serious":[23],"disease":[24,120],"immunocompromised":[26],"hosts.":[27],"Therefore,":[28],"increased":[29],"knowledge":[30],"how":[32,135],"these":[33],"viruses":[34],"interact":[35],"with":[36,123],"the":[37,69,82,104,109,114,126,136,141],"immune":[38,98,115,127,142],"response":[39,143],"clinical":[42],"relevance.":[43],"Here":[44],"we":[45],"show":[46],"novel":[48],"activity":[49,80,107],"viral":[52],"miRNA":[53,71,111],"locus":[54,72,112],"promoting":[56],"virus":[57],"shedding.":[58],"This":[59],"work":[60,101],"indicates":[61],"that":[62,118],"addition":[64],"to":[65,113,132],"role":[67],"PyV":[70,110],"long-term":[74],"persistence,":[75],"it":[76],"also":[77,102],"has":[78],"biological":[79],"during":[81],"acute":[83],"phase.":[84],"As":[85],"this":[86],"mutant":[87],"phenotype":[88],"alleviated":[90],"infection":[92],"mice":[94],"lacking":[95],"an":[96],"adaptive":[97],"response,":[99,128],"our":[100,129],"connects":[103],"response.":[116],"Given":[117],"PyV-associated":[119],"associated":[122],"alterations":[124],"findings":[130],"help":[131],"better":[133],"understand":[134],"balance":[137],"between":[138],"and":[140],"becomes":[144],"altered":[145],"pathogenic":[147],"states.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}