{"id":"https://openalex.org/W2806219980","doi":null,"title":"Regulation of NFkappaB-Mediated Inflammation By Green Tea in Obese Models of Nonalcoholic Steatohepatitis","display_name":"Regulation of NFkappaB-Mediated Inflammation By Green Tea in Obese Models of Nonalcoholic Steatohepatitis","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2806219980","mag":"2806219980"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1492088369370696","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jinhui Li","orcid":"https://orcid.org/0000-0002-2572-3454","observed_orcids":["https://orcid.org/0000-0002-2572-3454"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jinhui Li","raw_affiliation_strings":["the Ohio State University"],"raw_orcid":"https://orcid.org/0000-0002-2572-3454","affiliations":[{"raw_affiliation_string":"the Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28192425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.21070000529289246,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/green-tea-extract","display_name":"green tea extract","score":0.9980000257492065},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor-1","display_name":"tumor necrosis factor receptor 1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/metabolic-endotoxemia","display_name":"metabolic endotoxemia","score":0.9190000295639038},{"id":"https://openalex.org/keywords/intestinal-tight-junctions","display_name":"intestinal tight junctions","score":0.8700000047683716},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7839999794960022},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C3018708256","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic steatohepatitis","level":5,"score":0.9002547264099121},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6965948343276978},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.571792721748352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5380401611328125},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.49779796600341797},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.4303921163082123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3656683564186096},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.19534903764724731},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17982661724090576}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:osu1492088369370696","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","raw_type":"text"},{"id":"mag:2806219980","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1492088369370696","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1492088369370696","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806219980.pdf","grobid_xml":"https://content.openalex.org/works/W2806219980.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2765935443","https://openalex.org/W1979062185","https://openalex.org/W2565036592","https://openalex.org/W3172576371","https://openalex.org/W2210843203","https://openalex.org/W852546786","https://openalex.org/W3048812380","https://openalex.org/W2978689336","https://openalex.org/W1901225590","https://openalex.org/W2949275833"],"abstract_inverted_index":{"Green":[0],"tea":[1],"extract":[2],"(GTE)":[3],"protects":[4,183],"against":[5,135,184],"nuclear":[6,51],"factor":[7,52,54,73],"\u03baB":[8],"(NF\u03baB)-mediated":[9],"liver":[10],"inflammation":[11],"during":[12,25,41,98,138],"nonalcoholic":[13],"steatohepatitis":[14],"(NASH).However,":[15],"the":[16,62,82,111,122,203,244],"mechanisms":[17],"by":[18,50,109,116,169,187],"which":[19],"GTE":[20,93,104,130,161,164,182],"exerts":[21,131],"its":[22,132],"antiinflammatory":[23,90,133],"activities":[24,91,112,134],"NASH":[26,139],"are":[27,29],"unclear.There":[28],"several":[30],"potential":[31],"pathways":[32,65,86],"and":[33,70,115,174,179,209,216,228,237,240],"environmental":[34],"conditions":[35],"that":[36,47,103,129,147,163,200],"mediate":[37],"hepatic":[38,95,106],"NF\u03baB":[39,96,107,136],"activation":[40,97,108,137],"NASH,":[42],"including":[43],"intracellular":[44],"oxidative":[45],"stress":[46],"is":[48],"downregulated":[49],"E2-related":[53],"2":[55],"(Nrf2)-dependent":[56],"antioxidant":[57],"defenses,":[58],"as":[59,61],"well":[60],"extracellular":[63],"receptor-mediated":[64],"toll-like":[66],"receptor":[67,74,175],"4":[68,246],"(TLR4)":[69],"tumor":[71],"necrosis":[72],"1":[75],"(TNFR1).Therefore,":[76],"this":[77,207],"dissertation":[78],"aimed":[79],"to":[80,89,121,205,212,224,255,258],"define":[81],"involvement":[83],"of":[84,92,113,248,261],"these":[85],"in":[87,125,140,144,195],"relation":[88],"on":[94],"NASH.The":[99],"central":[100],"hypothesis":[101],"was":[102],"suppresses":[105],"increasing":[110],"Nrf2,":[114],"decreasing":[117],"TLR4-and":[118],"TNFR1-mediated":[119],"signaling.Contrary":[120],"hypothesis,":[123],"studies":[124,194],"Nrf2-knockout":[126],"mice":[127,146,198],"demonstrated":[128,162],"an":[141],"Nrf2-independent":[142],"manner.Studies":[143],"wildtype":[145],"were":[148],"fed":[149],"with":[150,218,232],"low-fat":[151],"(LF)":[152],"or":[153,159],"high-fat":[154],"(HF)":[155],"diet":[156],"containing":[157],"0":[158],"2%":[160],"lowers":[165],"NF\u03baB-dependent":[166],"inflammatory":[167],"responses":[168],"reducing":[170],"ligand":[171],"availability":[172],"for,":[173],"expression":[176],"of,":[177],"TNFR1":[178],"TLR4":[180],"pathways.Also,":[181],"metabolic":[185],"endotoxemia":[186],"restoring":[188],"intestinal":[189],"tight":[190],"junction":[191],"protein":[192],"expression.Lastly,":[193],"loss-of-function":[196],"TLR4-mutant":[197],"showed":[199],"providing":[201],"me":[202,223,231],"opportunity":[204],"conduct":[206],"research":[208],"numerous":[210],"opportunities":[211],"learn":[213],"new":[214],"skills":[215],"collaborate":[217],"other":[219,259],"researchers,":[220],"for":[221,229],"encouraging":[222],"challenge":[225],"myself":[226],"academically,":[227],"helping":[230],"fellowship":[233],"applications,":[234],"abstracts,":[235],"posters":[236],"oral":[238],"presentations,":[239],"manuscript":[241],"writing":[242],"throughout":[243],"past":[245],"years":[247],"my":[249,262],"Ph.D.":[250],"study.I":[251],"also":[252],"would":[253],"like":[254],"sincerely":[256],"thank":[257],"members":[260],"committee,":[263],"Dr.":[264]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2018-06-13T00:00:00"}