{"id":"https://openalex.org/W2806208316","doi":"https://doi.org/10.1111/acel.12791","title":"Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease","display_name":"Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease","publication_year":2018,"publication_date":"2018-06-06","ids":{"openalex":"https://openalex.org/W2806208316","doi":"https://doi.org/10.1111/acel.12791","mag":"2806208316","pmid":"https://pubmed.ncbi.nlm.nih.gov/29877034","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6052400"},"language":"en","primary_location":{"id":"doi:10.1111/acel.12791","doi":"https://doi.org/10.1111/acel.12791","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.12791","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/acel.12791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006306026","display_name":"David Baglietto\u2010Vargas","orcid":"https://orcid.org/0000-0003-1441-3175","observed_orcids":["https://orcid.org/0000-0003-1441-3175"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"David Baglietto\u2010Vargas","raw_affiliation_strings":["Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain","Department of Neurobiology and Behavior, University of California, Irvine, California","Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210164724","https://openalex.org/I82767444"]},{"raw_affiliation_string":"Department of Neurobiology and Behavior, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gilberto Aleph Prieto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilberto Aleph Prieto","raw_affiliation_strings":["Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090575202","display_name":"Agenor Lim\u00f3n","orcid":"https://orcid.org/0000-0002-6613-770X","observed_orcids":["https://orcid.org/0000-0002-6613-770X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agenor Limon","raw_affiliation_strings":["Department of Psychiatry and Human Behavior, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Human Behavior, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046841109","display_name":"Stef\u00e2nia Forner","orcid":"https://orcid.org/0000-0001-7977-4866","observed_orcids":["https://orcid.org/0000-0001-7977-4866"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefania Forner","raw_affiliation_strings":["Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078725664","display_name":"Carlos J. Rodr\u00edguez\u2010Ortiz","orcid":"https://orcid.org/0000-0003-2688-947X","observed_orcids":["https://orcid.org/0000-0003-2688-947X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos J. Rodriguez\u2010Ortiz","raw_affiliation_strings":["Division of Occupational and Environmental Medicine, Department of Medicine, Center for Occupational and Environmental Health (COEH), University of California, Irvine, California","Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Occupational and Environmental Medicine, Department of Medicine, Center for Occupational and Environmental Health (COEH), University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035905820","display_name":"Kenji Ikemura","orcid":"https://orcid.org/0000-0002-0799-4242","observed_orcids":["https://orcid.org/0000-0002-0799-4242"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenji Ikemura","raw_affiliation_strings":["Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050794917","display_name":"Rahasson R. Ager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahasson R. Ager","raw_affiliation_strings":["Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037612690","display_name":"Rodrigo Medeiros","orcid":"https://orcid.org/0000-0002-9399-7852","observed_orcids":["https://orcid.org/0000-0002-9399-7852"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Rodrigo Medeiros","raw_affiliation_strings":["Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia","Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035625971","display_name":"Laura Trujillo\u2010Estrada","orcid":"https://orcid.org/0000-0001-6696-4505","observed_orcids":["https://orcid.org/0000-0001-6696-4505"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Laura Trujillo\u2010Estrada","raw_affiliation_strings":["Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain","Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210164724","https://openalex.org/I82767444"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028981440","display_name":"Alessandra Cadete Martini","orcid":"https://orcid.org/0000-0002-8447-6756","observed_orcids":["https://orcid.org/0000-0002-8447-6756"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandra C. Martini","raw_affiliation_strings":["Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009317100","display_name":"Masashi Kitazawa","orcid":"https://orcid.org/0000-0003-2165-8197","observed_orcids":["https://orcid.org/0000-0003-2165-8197"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masashi Kitazawa","raw_affiliation_strings":["Division of Occupational and Environmental Medicine, Department of Medicine, Center for Occupational and Environmental Health (COEH), University of California, Irvine, California","Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Occupational and Environmental Medicine, Department of Medicine, Center for Occupational and Environmental Health (COEH), University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017246570","display_name":"Jos\u00e9 Carlos D\u00e1vila","orcid":"https://orcid.org/0000-0001-7016-288X","observed_orcids":["https://orcid.org/0000-0001-7016-288X"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose C. Davila","raw_affiliation_strings":["Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210164724","https://openalex.org/I82767444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109127771","display_name":"Carl W. Cotman","orcid":"https://orcid.org/0000-0001-6533-9062","observed_orcids":["https://orcid.org/0000-0001-6533-9062"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl W. Cotman","raw_affiliation_strings":["Department of Neurobiology and Behavior, University of California, Irvine, California","Department of Neurology, University of California, Irvine, California","Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Neurology, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084561391","display_name":"Antonia Guti\u00e9rrez","orcid":"https://orcid.org/0000-0002-6264-6152","observed_orcids":["https://orcid.org/0000-0002-6264-6152"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonia Gutierrez","raw_affiliation_strings":["Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210164724","https://openalex.org/I82767444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026487650","display_name":"Frank M. LaFerla","orcid":"https://orcid.org/0000-0003-2324-6911","observed_orcids":["https://orcid.org/0000-0003-2324-6911"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank M. LaFerla","raw_affiliation_strings":["Department of Neurobiology and Behavior, University of California, Irvine, California","Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5026487650"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":7.5473,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.98152355,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"17","issue":"4","first_page":"e12791","last_page":"e12791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.8199999928474426},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9929999709129333},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9340000152587891},{"id":"https://openalex.org/keywords/soluble-amyloid-beta","display_name":"soluble amyloid-beta","score":0.7160000205039978},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.7418999671936035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7328637838363647},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.6042810082435608},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.582960844039917},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5279340147972107},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5030838847160339},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.41320058703422546},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.2610695958137512},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22940754890441895},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19503846764564514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16580641269683838},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10233581066131592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09091004729270935}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018350","descriptor_name":"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1111/acel.12791","doi":"https://doi.org/10.1111/acel.12791","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.12791","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5021474","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6052400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6052400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6052400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"Text"},{"id":"pmid:29877034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29877034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9gb6s52z","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9gb6s52z","pdf_url":"https://escholarship.org/content/qt9gb6s52z/qt9gb6s52z.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging Cell, vol 17, iss 4","raw_type":"article"},{"id":"pmh:oai:www.repositoriosalud.es:10668/12558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052400/pdf","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12791","source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9gb6s52z","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9gb6s52z","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging cell, vol 17, iss 4","raw_type":"article"},{"id":"pmh:oai:riuma.uma.es:10630/33793","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10630/33793","pdf_url":null,"source":{"id":"https://openalex.org/S4306401385","display_name":"Repositorio Institucional de la Universidad de M\u00e1laga (University of M\u00e1laga)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82767444","host_organization_name":"Universidad de M\u00e1laga","host_organization_lineage":["https://openalex.org/I82767444"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1111/acel.12791","doi":"https://doi.org/10.1111/acel.12791","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.12791","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1220092839","display_name":"Behavioral and Neural Plasticity in the Aged","funder_award_id":"P01AG000538","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1818098274","display_name":"A Neurolucida and Stereo Investigator Imaging System with MicroLucida","funder_award_id":"1s10od010420-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1883455192","display_name":null,"funder_award_id":"AG00538","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G2080535851","display_name":"Molecular mechanisms of synaptic degeneration in Alzheimer\u2019s disease","funder_award_id":"NIRG-15-363477","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G2546058270","display_name":null,"funder_award_id":"AG027544","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2652371871","display_name":"Synaptic imbalance in mild cognitive impairment and Alzheimer's Disease","funder_award_id":"R21AG053740","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G315073359","display_name":null,"funder_award_id":"CN\u201013\u2010613","funder_id":"https://openalex.org/F4320308590","funder_display_name":"University of California"},{"id":"https://openalex.org/G3759868739","display_name":null,"funder_award_id":"AG 00538","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4759224646","display_name":"Impact of the actin cytoskeleton and its regulators in Alzheimer\u2019s disease","funder_award_id":"AARF-16-440760","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G517339504","display_name":"Impact of diabetes on tau pathology and cognition in AD transgenic mice","funder_award_id":"A2015535S","funder_id":"https://openalex.org/F4320308990","funder_display_name":"BrightFocus Foundation"},{"id":"https://openalex.org/G551826375","display_name":null,"funder_award_id":"2013-A-016-FEL","funder_id":"https://openalex.org/F4320306380","funder_display_name":"Larry L. Hillblom Foundation"},{"id":"https://openalex.org/G5725603674","display_name":"Astrocyte-enriched miR181 impact on neuronal plasticity and memory in Alzheimer's Disease","funder_award_id":"MNIRGD-15-363229","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G6241287090","display_name":null,"funder_award_id":"2016-A-016-FEL","funder_id":"https://openalex.org/F4320306380","funder_display_name":"Larry L. Hillblom Foundation"},{"id":"https://openalex.org/G6893618707","display_name":"Learning and Memory Impairments in Transgenic AD Models","funder_award_id":"R01AG027544","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7058818363","display_name":"A Novel Approach to Study Synaptic Plasticity in Isolated Synaptosomes using Flow Cytometry","funder_award_id":"R21AG048506","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G741062372","display_name":null,"funder_award_id":"CN-16-170","funder_id":"https://openalex.org/F4320308590","funder_display_name":"University of California"},{"id":"https://openalex.org/G8090362730","display_name":"Evaluando la disfunci\u00f3n microglial y astroglial como base del proceso neurodegenerativo y la demencia en la enfermedad de Alzheimer: nuevas aproximaciones terap\u00e9uticas","funder_award_id":"PI15/00796","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G819710145","display_name":null,"funder_award_id":"NIH/NIA AG027544","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000119970","display_name":null,"funder_award_id":"AG00538","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G922941218","display_name":null,"funder_award_id":"AG053740","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320306380","display_name":"Larry L. Hillblom Foundation","ror":"https://ror.org/00br6vq85"},{"id":"https://openalex.org/F4320308590","display_name":"University of California","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320308990","display_name":"BrightFocus Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321595","display_name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","ror":"https://ror.org/0348bpk17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W17728281","https://openalex.org/W1520903105","https://openalex.org/W1891861366","https://openalex.org/W1967464880","https://openalex.org/W1973514051","https://openalex.org/W1974117578","https://openalex.org/W1980750700","https://openalex.org/W1984652813","https://openalex.org/W1985086842","https://openalex.org/W1991587407","https://openalex.org/W2001428953","https://openalex.org/W2008767130","https://openalex.org/W2018643157","https://openalex.org/W2025563134","https://openalex.org/W2038739322","https://openalex.org/W2040268226","https://openalex.org/W2040787372","https://openalex.org/W2040907585","https://openalex.org/W2043006474","https://openalex.org/W2055275688","https://openalex.org/W2061123524","https://openalex.org/W2061387301","https://openalex.org/W2062575000","https://openalex.org/W2068883870","https://openalex.org/W2072193814","https://openalex.org/W2079952612","https://openalex.org/W2083606437","https://openalex.org/W2091712128","https://openalex.org/W2093852116","https://openalex.org/W2109727228","https://openalex.org/W2114129553","https://openalex.org/W2116456562","https://openalex.org/W2121448546","https://openalex.org/W2127441616","https://openalex.org/W2128401893","https://openalex.org/W2133103790","https://openalex.org/W2133623572","https://openalex.org/W2134486111","https://openalex.org/W2136623897","https://openalex.org/W2136901555","https://openalex.org/W2142367912","https://openalex.org/W2145976523","https://openalex.org/W2147561535","https://openalex.org/W2148846435","https://openalex.org/W2166406463","https://openalex.org/W2168334242","https://openalex.org/W2208177230","https://openalex.org/W2228598504","https://openalex.org/W2301943443","https://openalex.org/W2473669150","https://openalex.org/W2492959600","https://openalex.org/W2611965998","https://openalex.org/W2725208026"],"related_works":["https://openalex.org/W3024317714","https://openalex.org/W7204604322","https://openalex.org/W2133103790","https://openalex.org/W3083913562","https://openalex.org/W2107235804","https://openalex.org/W2003591201","https://openalex.org/W1997203285","https://openalex.org/W2097568912","https://openalex.org/W2921012261","https://openalex.org/W2158567732"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,26,61,98],"(AD)":[2],"is":[3,22,53,93,110],"a":[4,25],"devastating":[5],"neurodegenerative":[6],"disorder":[7],"that":[8,20,78,150,164,186],"impairs":[9],"memory":[10],"and":[11,14,33,46,62,73,122,130,143,169],"causes":[12],"cognitive":[13],"psychiatric":[15],"deficits.":[16],"New":[17],"evidences":[18],"indicate":[19],"AD":[21,102],"conceptualized":[23],"as":[24],"of":[27,48,59,125,137],"synaptic":[28,51,85,152],"failure,":[29],"although":[30],"the":[31,44,49,57,60,88,97,120,123,135],"molecular":[32],"cellular":[34],"mechanisms":[35],"underlying":[36],"these":[37,151,178],"defects":[38],"remain":[39],"to":[40],"be":[41,155],"elucidated.":[42],"Determining":[43],"timing":[45],"nature":[47],"early":[50,95,173],"deficits":[52,179],"critical":[54],"for":[55,63,67],"understanding":[56],"progression":[58],"identifying":[64],"effective":[65],"targets":[66],"therapeutic":[68],"intervention.":[69],"Using":[70],"single-synapse":[71],"functional":[72,194],"morphological":[74],"analyses,":[75],"we":[76,148],"find":[77],"AMPA":[79,108,128,167],"signaling,":[80],"which":[81,118],"mediates":[82],"fast":[83],"glutamatergic":[84],"transmission":[86],"in":[87,96,100,107,114,166,174],"central":[89],"nervous":[90],"system":[91],"(CNS),":[92],"compromised":[94],"course":[99],"an":[101],"mouse":[103],"model.":[104],"The":[105],"decline":[106],"signaling":[109,168],"associated":[111],"with":[112,134],"changes":[113],"actin":[115],"cytoskeleton":[116],"integrity,":[117],"alters":[119],"number":[121],"structure":[124],"dendritic":[126],"spines.":[127],"dysfunction":[129],"spine":[131],"alteration":[132],"correlate":[133],"presence":[136],"soluble":[138],"but":[139],"not":[140],"insoluble":[141],"A\u03b2":[142,158,183],"tau":[144],"species.":[145],"In":[146],"particular,":[147],"demonstrate":[149],"impairments":[153],"can":[154],"mitigated":[156],"by":[157,182],"immunotherapy.":[159],"Together,":[160],"our":[161],"data":[162],"suggest":[163],"alterations":[165],"cytoskeletal":[170],"processes":[171],"occur":[172],"AD.":[175],"Most":[176],"important,":[177],"are":[180],"prevented":[181],"immunotherapy,":[184],"suggesting":[185],"existing":[187],"therapies,":[188],"if":[189],"administered":[190],"earlier,":[191],"could":[192],"confer":[193],"benefits.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}