{"id":"https://openalex.org/W2806160661","doi":"https://doi.org/10.14336/ad.2017.0628","title":"Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence","display_name":"Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2806160661","doi":"https://doi.org/10.14336/ad.2017.0628","mag":"2806160661","pmid":"https://pubmed.ncbi.nlm.nih.gov/29896438"},"language":"en","primary_location":{"id":"doi:10.14336/ad.2017.0628","doi":"https://doi.org/10.14336/ad.2017.0628","is_oa":true,"landing_page_url":"https://doi.org/10.14336/ad.2017.0628","pdf_url":"http://www.aginganddisease.org/EN/article/downloadArticleFile.do?attachType=PDF&id=147646","source":{"id":"https://openalex.org/S2738790859","display_name":"Aging and Disease","issn_l":"2152-5250","issn":["2152-5250"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316031","host_organization_name":"Buck Institute for Research on Aging","host_organization_lineage":["https://openalex.org/P4310316031"],"host_organization_lineage_names":["Buck Institute for Research on Aging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging and disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.aginganddisease.org/EN/article/downloadArticleFile.do?attachType=PDF&id=147646","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115596378","display_name":"Zheng Zhang","orcid":"https://orcid.org/0009-0006-9558-6535","observed_orcids":["https://orcid.org/0009-0006-9558-6535","https://orcid.org/0009-0006-1628-2016","https://orcid.org/0009-0009-9117-1377"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Zhang","raw_affiliation_strings":["1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China","2Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]},{"raw_affiliation_string":"2Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071574297","display_name":"Linlei Zhang","orcid":"https://orcid.org/0000-0001-8828-8341","observed_orcids":["https://orcid.org/0000-0001-8828-8341"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlei Zhang","raw_affiliation_strings":["3Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049444390","display_name":"Yuchuan Ding","orcid":"https://orcid.org/0000-0001-5358-1660","observed_orcids":["https://orcid.org/0000-0001-5358-1660","https://orcid.org/0000-0003-0699-9807"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuchuan Ding","raw_affiliation_strings":["4Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA","Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008346473","display_name":"Zhao Han","orcid":"https://orcid.org/0000-0002-0901-9870","observed_orcids":["https://orcid.org/0000-0002-0901-9870"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhao Han","raw_affiliation_strings":["3Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041731322","display_name":"Xunming Ji","orcid":"https://orcid.org/0000-0003-0293-2744","observed_orcids":["https://orcid.org/0000-0003-0293-2744","https://orcid.org/0000-0002-0527-2852"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xunming Ji","raw_affiliation_strings":["1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China","5China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China","China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China","Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]},{"raw_affiliation_string":"5China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]},{"raw_affiliation_string":"Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210094218"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008346473"],"corresponding_institution_ids":["https://openalex.org/I27781120"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":2.267,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.88011972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"3","first_page":"507","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-hypothermia","display_name":"therapeutic hypothermia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9909999966621399},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/acute-stroke-management","display_name":"acute stroke care","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9280434846878052},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.8513436317443848},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8220623731613159},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6368812918663025},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5783284306526184},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.533038318157196},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.509849488735199},{"id":"https://openalex.org/C2911092318","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Recombinant tissue plasminogen activator","level":5,"score":0.4720512330532074},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4709252715110779},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43834373354911804},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.4282028079032898},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42268499732017517},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3636983335018158},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3436533808708191},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.288235604763031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19656702876091003},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.14336/ad.2017.0628","doi":"https://doi.org/10.14336/ad.2017.0628","is_oa":true,"landing_page_url":"https://doi.org/10.14336/ad.2017.0628","pdf_url":"http://www.aginganddisease.org/EN/article/downloadArticleFile.do?attachType=PDF&id=147646","source":{"id":"https://openalex.org/S2738790859","display_name":"Aging and Disease","issn_l":"2152-5250","issn":["2152-5250"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316031","host_organization_name":"Buck Institute for Research on Aging","host_organization_lineage":["https://openalex.org/P4310316031"],"host_organization_lineage_names":["Buck Institute for Research on Aging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging and disease","raw_type":"journal-article"},{"id":"pmid:29896438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29896438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging and disease","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4949270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5988605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5988605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5988605","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.14336/ad.2017.0628","doi":"https://doi.org/10.14336/ad.2017.0628","is_oa":true,"landing_page_url":"https://doi.org/10.14336/ad.2017.0628","pdf_url":"http://www.aginganddisease.org/EN/article/downloadArticleFile.do?attachType=PDF&id=147646","source":{"id":"https://openalex.org/S2738790859","display_name":"Aging and Disease","issn_l":"2152-5250","issn":["2152-5250"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316031","host_organization_name":"Buck Institute for Research on Aging","host_organization_lineage":["https://openalex.org/P4310316031"],"host_organization_lineage_names":["Buck Institute for Research on Aging"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging and disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6100000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4810460511","display_name":null,"funder_award_id":"81620108011","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5859654878","display_name":null,"funder_award_id":"81571114","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8982623675","display_name":null,"funder_award_id":"81325007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806160661.pdf","grobid_xml":"https://content.openalex.org/works/W2806160661.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W198844117","https://openalex.org/W890748490","https://openalex.org/W1242072092","https://openalex.org/W1485896673","https://openalex.org/W1509435978","https://openalex.org/W1512279528","https://openalex.org/W1585418384","https://openalex.org/W1963764076","https://openalex.org/W1963892835","https://openalex.org/W1968479682","https://openalex.org/W1968532657","https://openalex.org/W1968947314","https://openalex.org/W1969585993","https://openalex.org/W1972132426","https://openalex.org/W1972828294","https://openalex.org/W1974102580","https://openalex.org/W1975818024","https://openalex.org/W1976467703","https://openalex.org/W1977601515","https://openalex.org/W1978428462","https://openalex.org/W1978585021","https://openalex.org/W1978618811","https://openalex.org/W1984008216","https://openalex.org/W1985323628","https://openalex.org/W1985880493","https://openalex.org/W1988394046","https://openalex.org/W1989822988","https://openalex.org/W1990519579","https://openalex.org/W1992818475","https://openalex.org/W1994504422","https://openalex.org/W1995277420","https://openalex.org/W1995526941","https://openalex.org/W2002698220","https://openalex.org/W2002924541","https://openalex.org/W2003484955","https://openalex.org/W2003658370","https://openalex.org/W2004309874","https://openalex.org/W2006514144","https://openalex.org/W2007772363","https://openalex.org/W2008491261","https://openalex.org/W2008653692","https://openalex.org/W2009139174","https://openalex.org/W2010410884","https://openalex.org/W2010877490","https://openalex.org/W2013864444","https://openalex.org/W2016010494","https://openalex.org/W2016597337","https://openalex.org/W2016752850","https://openalex.org/W2018139629","https://openalex.org/W2021256075","https://openalex.org/W2021938872","https://openalex.org/W2022943823","https://openalex.org/W2024041225","https://openalex.org/W2024864130","https://openalex.org/W2025329734","https://openalex.org/W2025940506","https://openalex.org/W2026299432","https://openalex.org/W2027213284","https://openalex.org/W2031955562","https://openalex.org/W2034973427","https://openalex.org/W2035943184","https://openalex.org/W2036527325","https://openalex.org/W2036650593","https://openalex.org/W2036755665","https://openalex.org/W2037852973","https://openalex.org/W2041356239","https://openalex.org/W2042076314","https://openalex.org/W2044295864","https://openalex.org/W2045571206","https://openalex.org/W2046048507","https://openalex.org/W2048254285","https://openalex.org/W2048406001","https://openalex.org/W2048692124","https://openalex.org/W2051786189","https://openalex.org/W2052616951","https://openalex.org/W2053525375","https://openalex.org/W2056979092","https://openalex.org/W2058671355","https://openalex.org/W2058868308","https://openalex.org/W2059341711","https://openalex.org/W2063104200","https://openalex.org/W2063126651","https://openalex.org/W2063616597","https://openalex.org/W2068187936","https://openalex.org/W2070949944","https://openalex.org/W2072601717","https://openalex.org/W2078028637","https://openalex.org/W2078098282","https://openalex.org/W2079394559","https://openalex.org/W2079609736","https://openalex.org/W2080320582","https://openalex.org/W2082315120","https://openalex.org/W2085866871","https://openalex.org/W2085941854","https://openalex.org/W2088507875","https://openalex.org/W2093577835","https://openalex.org/W2094032990","https://openalex.org/W2094804227","https://openalex.org/W2095856656","https://openalex.org/W2096705333","https://openalex.org/W2101462280","https://openalex.org/W2103386950","https://openalex.org/W2104746669","https://openalex.org/W2106411663","https://openalex.org/W2113076817","https://openalex.org/W2113343625","https://openalex.org/W2114843994","https://openalex.org/W2116422254","https://openalex.org/W2119262748","https://openalex.org/W2121209735","https://openalex.org/W2122276247","https://openalex.org/W2122623988","https://openalex.org/W2123148481","https://openalex.org/W2126607005","https://openalex.org/W2126617386","https://openalex.org/W2127810545","https://openalex.org/W2130614261","https://openalex.org/W2131150967","https://openalex.org/W2132836263","https://openalex.org/W2137699813","https://openalex.org/W2140563166","https://openalex.org/W2141177022","https://openalex.org/W2142880742","https://openalex.org/W2145838860","https://openalex.org/W2146330634","https://openalex.org/W2151583768","https://openalex.org/W2155034622","https://openalex.org/W2155851326","https://openalex.org/W2157193686","https://openalex.org/W2161409702","https://openalex.org/W2166346391","https://openalex.org/W2171188204","https://openalex.org/W2174892681","https://openalex.org/W2192349325","https://openalex.org/W2217305404","https://openalex.org/W2231665734","https://openalex.org/W2256324412","https://openalex.org/W2264254915","https://openalex.org/W2271247184","https://openalex.org/W2300776102","https://openalex.org/W2309525264","https://openalex.org/W2324239238","https://openalex.org/W2328544024","https://openalex.org/W2333120552","https://openalex.org/W2346906340","https://openalex.org/W2401831246","https://openalex.org/W2413002084","https://openalex.org/W2470917600","https://openalex.org/W2473692091","https://openalex.org/W2559820826","https://openalex.org/W4252688237","https://openalex.org/W6939997653"],"related_works":["https://openalex.org/W3028593336","https://openalex.org/W2048612947","https://openalex.org/W2465276329","https://openalex.org/W2021344817","https://openalex.org/W2038044783","https://openalex.org/W4206801677","https://openalex.org/W1451227488","https://openalex.org/W3207550120","https://openalex.org/W2331633670","https://openalex.org/W3110973301"],"abstract_inverted_index":{"Ischemic":[0],"stroke":[1,30,94],"is":[2,14,31],"a":[3],"major":[4],"cause":[5],"of":[6,71],"death":[7],"and":[8,11,24,50,82],"disability":[9],"globally,":[10],"its":[12],"incidence":[13],"increasing.":[15],"The":[16],"only":[17],"treatment":[18,33],"approved":[19],"by":[20],"the":[21,69],"US":[22],"Food":[23],"Drug":[25],"Administration":[26],"for":[27,93],"acute":[28],"ischemic":[29],"thrombolytic":[32],"with":[34,74],"recombinant":[35],"tissue":[36],"plasminogen":[37],"activator.":[38],"As":[39],"an":[40],"alternative,":[41],"therapeutic":[42,72],"hypothermia":[43,73,92],"has":[44,56,64],"shown":[45],"excellent":[46],"potential":[47],"in":[48,59],"preclinical":[49,81],"small":[51],"clinical":[52,61,83],"studies,":[53],"but":[54],"it":[55],"largely":[57],"failed":[58],"large":[60],"studies.":[62],"This":[63,78],"led":[65],"clinicians":[66],"to":[67],"explore":[68],"combination":[70,89],"other":[75],"neuroprotective":[76],"strategies.":[77],"review":[79],"examines":[80],"progress":[84],"towards":[85],"developing":[86],"highly":[87],"effective":[88],"therapy":[90],"involving":[91],"patients.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}