{"id":"https://openalex.org/W2806135547","doi":"https://doi.org/10.1002/jlcr.3629","title":"Synthesis and characterization of a deuterium labeled stercobilin: A potential biomarker for autism","display_name":"Synthesis and characterization of a deuterium labeled stercobilin: A potential biomarker for autism","publication_year":2018,"publication_date":"2018-05-14","ids":{"openalex":"https://openalex.org/W2806135547","doi":"https://doi.org/10.1002/jlcr.3629","mag":"2806135547","pmid":"https://pubmed.ncbi.nlm.nih.gov/29761558"},"language":"en","primary_location":{"id":"doi:10.1002/jlcr.3629","doi":"https://doi.org/10.1002/jlcr.3629","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.3629","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022390076","display_name":"Jordan M. Coffey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27559774","display_name":"SUNY Geneseo","ror":"https://ror.org/03g1q6c06","country_code":"US","type":"education","lineage":["https://openalex.org/I27559774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan M. Coffey","raw_affiliation_strings":["Department of Chemistry, State University of New York at Geneseo, Geneseo, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, State University of New York at Geneseo, Geneseo, New York, USA","institution_ids":["https://openalex.org/I27559774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001351517","display_name":"Andrew J. Vadas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27559774","display_name":"SUNY Geneseo","ror":"https://ror.org/03g1q6c06","country_code":"US","type":"education","lineage":["https://openalex.org/I27559774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Vadas","raw_affiliation_strings":["Department of Biology, State University of New York at Geneseo, Geneseo, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, State University of New York at Geneseo, Geneseo, New York, USA","institution_ids":["https://openalex.org/I27559774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014104515","display_name":"Thomas R. Puleo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Puleo","raw_affiliation_strings":["Department of Chemistry, Colorado State University, Fort Collins, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Colorado State University, Fort Collins, Colorado, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015183357","display_name":"Katelyn P. Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32907511","display_name":"Fairleigh Dickinson University","ror":"https://ror.org/04wkzvc75","country_code":"US","type":"education","lineage":["https://openalex.org/I32907511"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn P. Lewis","raw_affiliation_strings":["Fairleigh Dickinson University School of Pharmacy & Health Sciences  Florham Park New Jersey USA","Fairleigh Dickinson University, School of Pharmacy & Health Sciences, Florham Park, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fairleigh Dickinson University School of Pharmacy & Health Sciences  Florham Park New Jersey USA","institution_ids":["https://openalex.org/I32907511"]},{"raw_affiliation_string":"Fairleigh Dickinson University, School of Pharmacy & Health Sciences, Florham Park, New Jersey, USA","institution_ids":["https://openalex.org/I32907511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056667413","display_name":"Gregory F. Pirrone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory F. Pirrone","raw_affiliation_strings":["Process Research and Development MRL, Merck & Co., Inc.  Rahway New Jersey USA","Process Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development MRL, Merck & Co., Inc.  Rahway New Jersey USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Process Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000048016","display_name":"Heather L. Rudolph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142480","display_name":"Thermo Fisher Scientific (United States)","ror":"https://ror.org/03x1ewr52","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142480"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather L. Rudolph","raw_affiliation_strings":["Thermo Fisher Scientific, Grand Island, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thermo Fisher Scientific, Grand Island, New York, USA","institution_ids":["https://openalex.org/I4210142480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069182721","display_name":"Eric D. Helms","orcid":"https://orcid.org/0000-0003-0072-8889","observed_orcids":["https://orcid.org/0000-0003-0072-8889"]},"institutions":[{"id":"https://openalex.org/I27559774","display_name":"SUNY Geneseo","ror":"https://ror.org/03g1q6c06","country_code":"US","type":"education","lineage":["https://openalex.org/I27559774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Helms","raw_affiliation_strings":["Department of Chemistry, State University of New York at Geneseo, Geneseo, New York, USA"],"raw_orcid":"https://orcid.org/0000-0003-0072-8889","affiliations":[{"raw_affiliation_string":"Department of Chemistry, State University of New York at Geneseo, Geneseo, New York, USA","institution_ids":["https://openalex.org/I27559774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076358242","display_name":"Troy D. Wood","orcid":"https://orcid.org/0000-0002-2556-8511","observed_orcids":["https://orcid.org/0000-0002-2556-8511"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy D. Wood","raw_affiliation_strings":["University at Buffalo, Department of Chemistry, Buffalo, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-2556-8511","affiliations":[{"raw_affiliation_string":"University at Buffalo, Department of Chemistry, Buffalo, New York, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":null,"display_name":"Amber Flynn\u2010Charlebois","orcid":"https://orcid.org/0000-0002-8448-6380","observed_orcids":["https://orcid.org/0000-0002-8448-6380"]},"institutions":[{"id":"https://openalex.org/I27559774","display_name":"SUNY Geneseo","ror":"https://ror.org/03g1q6c06","country_code":"US","type":"education","lineage":["https://openalex.org/I27559774"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amber Flynn\u2010Charlebois","raw_affiliation_strings":["Department of Chemistry, State University of New York at Geneseo, Geneseo, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-8448-6380","affiliations":[{"raw_affiliation_string":"Department of Chemistry, State University of New York at Geneseo, Geneseo, New York, USA","institution_ids":["https://openalex.org/I27559774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27559774"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.2343,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43411878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"61","issue":"10","first_page":"742","last_page":"748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stercobilin","display_name":"stercobilin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/deuterium-labeling","display_name":"deuterium labeling","score":0.9750000238418579},{"id":"https://openalex.org/keywords/isotopologues","display_name":"isotopologues","score":0.7049999833106995},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.875},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bilirubin-reduction","display_name":"bilirubin reduction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/deuterium-incorporation","display_name":"deuterium incorporation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/mass-spectrometry-fragmentation","display_name":"mass spectral fragmentation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/nmr-spectroscopy","display_name":"NMR spectroscopy","score":0.5080000162124634},{"id":"https://openalex.org/keywords/diagnostic-probes","display_name":"diagnostic probes","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.7715592384338379},{"id":"https://openalex.org/C13934619","wikidata":"https://www.wikidata.org/wiki/Q2198720","display_name":"Isotopologue","level":3,"score":0.7152490019798279},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6962246298789978},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.48981520533561707},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.48840564489364624},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.4111723005771637},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.34365314245224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19847136735916138},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10719525814056396},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.09967014193534851},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jlcr.3629","doi":"https://doi.org/10.1002/jlcr.3629","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.3629","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"},{"id":"pmid:29761558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29761558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of labelled compounds & radiopharmaceuticals","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6810687280","display_name":"High Field Electrospray/MALDI Fourier Transform Mass Spectrometer","funder_award_id":"S10RR029517","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W17822169","https://openalex.org/W33496347","https://openalex.org/W1533677192","https://openalex.org/W2032844472","https://openalex.org/W2060233777","https://openalex.org/W2112109116","https://openalex.org/W2140970074","https://openalex.org/W2145550766","https://openalex.org/W2160053525","https://openalex.org/W2417068663","https://openalex.org/W2899353575"],"related_works":["https://openalex.org/W3096641847","https://openalex.org/W1995348999","https://openalex.org/W2329024258","https://openalex.org/W4399550287","https://openalex.org/W2030137103","https://openalex.org/W2170400629","https://openalex.org/W2125687801","https://openalex.org/W2056547369","https://openalex.org/W17822169","https://openalex.org/W4281698183"],"abstract_inverted_index":{"Stercobilin":[0],"is":[1,19,156],"an":[2,58],"end-stage":[3],"metabolite":[4],"of":[5,9,24,29,82,98,115,119,132,143,154],"hemoglobin,":[6],"a":[7,20,40,53,96,136,169],"component":[8],"red":[10],"blood":[11],"cells.":[12],"It":[13],"has":[14],"been":[15],"found":[16],"that":[17,142],"there":[18],"significantly":[21],"lower":[22],"concentration":[23],"stercobilin":[25,47,68,85,91,155],"in":[26,100,112,138],"the":[27,67,80,83,89,101,113,116,120],"urine":[28],"people":[30],"diagnosed":[31],"with":[32,70],"autism":[33,177],"spectrum":[34,178],"disorders,":[35],"suggesting":[36],"potential":[37,147,172],"use":[38,167],"as":[39,168],"biomarker.":[41],"In":[42,61],"vitro,":[43],"we":[44,63],"have":[45,64],"synthesized":[46],"from":[48],"its":[49,166],"precursor":[50],"bilirubin":[51],"through":[52],"reduction":[54],"reaction":[55],"proceeded":[56],"by":[57],"oxidation":[59],"reaction.":[60],"addition,":[62],"isotopically":[65],"labeled":[66],"product":[69],"deuterium":[71,127,150],"using":[72],"this":[73],"protocol.":[74],"Nuclear":[75],"magnetic":[76,123],"resonance":[77,124],"investigations":[78],"show":[79,135],"products":[81],"unlabeled":[84],"(Rxn":[86,92],"1)":[87],"and":[88,160,171],"deuterated":[90],"2)":[93],"both":[94],"had":[95],"loss":[97],"signals":[99],"5.0-":[102],"to":[103,109],"7.0-ppm":[104],"range":[105],"indicating":[106],"proper":[107,126],"conversion":[108],"stercobilin.":[110],"Changes":[111],"multiplicity":[114],"sp3":[117],"region":[118],"proton":[121],"nuclear":[122],"suggest":[125],"incorporation.":[128,151],"Mass":[129],"spectrometry":[130],"studies":[131],"Rxn":[133,144],"1":[134],"difference":[137],"fragmentation":[139],"patterns":[140],"than":[141],"2":[145],"proposing":[146],"locations":[148],"for":[149,165,176],"This":[152],"isotopologue":[153],"stable":[157],"(>6":[158],"mo),":[159],"further":[161],"analysis":[162],"permits":[163],"investigation":[164],"biomarker":[170],"quantitative":[173],"diagnostic":[174],"probe":[175],"disorders.":[179]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-13T00:00:00"}