{"id":"https://openalex.org/W2806033435","doi":"https://doi.org/10.1021/acsbiomaterials.8b00617","title":"An Injectable Decellularized Matrix That Improves Mesenchymal Stem Cell Engraftment for Therapeutic Angiogenesis","display_name":"An Injectable Decellularized Matrix That Improves Mesenchymal Stem Cell Engraftment for Therapeutic Angiogenesis","publication_year":2018,"publication_date":"2018-06-07","ids":{"openalex":"https://openalex.org/W2806033435","doi":"https://doi.org/10.1021/acsbiomaterials.8b00617","mag":"2806033435","pmid":"https://pubmed.ncbi.nlm.nih.gov/33435120"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.8b00617","doi":"https://doi.org/10.1021/acsbiomaterials.8b00617","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b00617","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053871036","display_name":"Gun\u2010Jae Jeong","orcid":"https://orcid.org/0000-0002-0106-0078","observed_orcids":["https://orcid.org/0000-0002-0106-0078"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gun-Jae Jeong","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074758500","display_name":"Seuk Young Song","orcid":"https://orcid.org/0000-0003-4679-6334","observed_orcids":["https://orcid.org/0000-0003-4679-6334"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seuk Young Song","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044550389","display_name":"Mikyung Kang","orcid":"https://orcid.org/0000-0002-0592-1648","observed_orcids":["https://orcid.org/0000-0002-0592-1648"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mikyung Kang","raw_affiliation_strings":["Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079172054","display_name":"Seokhyeong Go","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seokhyeong Go","raw_affiliation_strings":["Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076505324","display_name":"Hee Su Sohn","orcid":"https://orcid.org/0000-0002-1889-1206","observed_orcids":["https://orcid.org/0000-0002-1889-1206"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Su Sohn","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100642851","display_name":"Byung\u2010Soo Kim","orcid":"https://orcid.org/0000-0001-5210-7430","observed_orcids":["https://orcid.org/0000-0001-5210-7430"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung-Soo Kim","raw_affiliation_strings":["School of Chemical and Biological Engineering \u00a0and\u00a0 Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5210-7430","affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering \u00a0and\u00a0 Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100642851"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.2852,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77492963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"7","first_page":"2571","last_page":"2581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decellularized-extracellular-matrix","display_name":"decellularized extracellular matrix","score":0.8410000205039978},{"id":"https://openalex.org/keywords/injectable-scaffolds","display_name":"injectable scaffolds","score":0.722000002861023},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/stem-cell-engraftment","display_name":"stem cell engraftment","score":0.8820000290870667},{"id":"https://openalex.org/keywords/therapeutic-angiogenesis","display_name":"therapeutic angiogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ischemic-tissue","display_name":"ischemic tissue","score":0.7160000205039978},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hindlimb-ischemia","display_name":"hindlimb ischemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/microvessel-formation","display_name":"microvessel formation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/blood-perfusion","display_name":"blood perfusion","score":0.7279999852180481},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.9108890891075134},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8263638019561768},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7146558165550232},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5683348774909973},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5637935996055603},{"id":"https://openalex.org/C2781188250","wikidata":"https://www.wikidata.org/wiki/Q4455440","display_name":"Therapeutic angiogenesis","level":4,"score":0.5584906339645386},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.5152156949043274},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.48438459634780884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45129674673080444},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4283076524734497},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.426675945520401},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3592239022254944},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3561566472053528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3111598491668701},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2746523916721344},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1936238706111908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18798980116844177}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsbiomaterials.8b00617","doi":"https://doi.org/10.1021/acsbiomaterials.8b00617","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b00617","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},{"id":"pmid:33435120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33435120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/204251","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/204251","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3162219560","display_name":null,"funder_award_id":"2017R1A2B3005842","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1600024584","https://openalex.org/W1782017176","https://openalex.org/W1906542005","https://openalex.org/W1966433278","https://openalex.org/W1969015369","https://openalex.org/W1983733906","https://openalex.org/W1999408698","https://openalex.org/W2002230244","https://openalex.org/W2002898375","https://openalex.org/W2015136076","https://openalex.org/W2019205502","https://openalex.org/W2027205270","https://openalex.org/W2030338665","https://openalex.org/W2030637965","https://openalex.org/W2036061724","https://openalex.org/W2037810763","https://openalex.org/W2045218007","https://openalex.org/W2056046349","https://openalex.org/W2083123206","https://openalex.org/W2090985907","https://openalex.org/W2094457676","https://openalex.org/W2095998404","https://openalex.org/W2101228997","https://openalex.org/W2109188048","https://openalex.org/W2112267683","https://openalex.org/W2119792393","https://openalex.org/W2123163588","https://openalex.org/W2125086964","https://openalex.org/W2131705281","https://openalex.org/W2132461606","https://openalex.org/W2134244003","https://openalex.org/W2151367313","https://openalex.org/W2165162226","https://openalex.org/W2166582490","https://openalex.org/W2168725031","https://openalex.org/W2169293420","https://openalex.org/W2184359604","https://openalex.org/W2221267861","https://openalex.org/W2252815101","https://openalex.org/W2298852992","https://openalex.org/W2301051006","https://openalex.org/W2313165248","https://openalex.org/W2341385919","https://openalex.org/W2395249393","https://openalex.org/W2416791545","https://openalex.org/W2668361924","https://openalex.org/W2724488549","https://openalex.org/W2759535657","https://openalex.org/W4243385699"],"related_works":["https://openalex.org/W2015136076","https://openalex.org/W2096622000","https://openalex.org/W2218099079","https://openalex.org/W2883603270","https://openalex.org/W2566934185","https://openalex.org/W1497803689","https://openalex.org/W2111711916","https://openalex.org/W2041831348","https://openalex.org/W2002027997","https://openalex.org/W4403481913"],"abstract_inverted_index":{"Stem":[0],"cell":[1,70,80,160],"therapy":[2,161],"has":[3],"great":[4],"potential":[5],"for":[6,162],"the":[7,20,36,45,48,66,69,88,103,124,135],"treatment":[8],"of":[9,15,39,47,58,90,126,142,158],"ischemic":[10,55,91,110,136,163],"diseases,":[11],"but":[12],"poor":[13],"engraftment":[14,46],"implanted":[16,51],"stem":[17,41,49,62,159],"cells":[18,42,50,63],"limits":[19],"therapeutic":[21,156],"efficacy.":[22],"Here,":[23],"we":[24],"developed":[25],"an":[26,54,109,149],"approximately":[27],"80":[28],"\u03bcm":[29],"injectable":[30],"decellularized":[31],"matrix":[32],"(IDM)":[33],"to":[34,53,65,102,140],"increase":[35],"angiogenic":[37,74,116],"efficacy":[38,157],"mesenchymal":[40],"by":[43],"improving":[44],"in":[52,76,134],"tissue.":[56],"Adhesion":[57],"human":[59],"adipose":[60],"tissue-derived":[61],"(hADSCs)":[64],"IDM":[67,104,146],"enhanced":[68],"viability":[71],"and":[72,105,115,130],"upregulated":[73],"factors":[75],"vitro":[77],"under":[78],"either":[79],"adhesion-suppressive":[81],"conditions":[82],"or":[83],"hypoxic":[84],"conditions,":[85],"which":[86],"simulated":[87],"microenvironment":[89],"tissues.":[92],"In":[93],"a":[94],"murine":[95],"ischemic-hindlimb":[96],"model,":[97],"hADSCs":[98,143],"that":[99,153],"were":[100],"attached":[101],"subsequently":[106,122],"injected":[107],"into":[108],"region":[111],"showed":[112],"better":[113],"grafting":[114],"factor":[117],"expression.":[118],"The":[119,145],"hADSC-IDM":[120],"implantation":[121,141],"promoted":[123],"formation":[125],"microvessels,":[127],"attenuated":[128],"fibrosis,":[129],"increased":[131],"blood":[132],"perfusion":[133],"region,":[137],"as":[138],"compared":[139],"only.":[144],"may":[147],"be":[148],"effective":[150],"off-the-shelf":[151],"material":[152],"can":[154],"enhance":[155],"diseases.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
