{"id":"https://openalex.org/W2806020656","doi":"https://doi.org/10.1002/adfm.201801386","title":"Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing","display_name":"Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing","publication_year":2018,"publication_date":"2018-06-06","ids":{"openalex":"https://openalex.org/W2806020656","doi":"https://doi.org/10.1002/adfm.201801386","mag":"2806020656"},"language":"en","primary_location":{"id":"doi:10.1002/adfm.201801386","doi":"https://doi.org/10.1002/adfm.201801386","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adfm.201801386","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058321727","display_name":"Guopu Chen","orcid":"https://orcid.org/0000-0001-9788-7629","observed_orcids":["https://orcid.org/0000-0001-9788-7629"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guopu Chen","raw_affiliation_strings":["Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003534434","display_name":"Yunru Yu","orcid":"https://orcid.org/0000-0003-3182-5753","observed_orcids":["https://orcid.org/0000-0003-3182-5753"]},"institutions":[{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunru Yu","raw_affiliation_strings":["State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China","institution_ids":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001666372","display_name":"Xiuwen Wu","orcid":"https://orcid.org/0000-0002-3813-3867","observed_orcids":["https://orcid.org/0000-0002-3813-3867"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuwen Wu","raw_affiliation_strings":["Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103194170","display_name":"Gefei Wang","orcid":"https://orcid.org/0000-0003-3070-3586","observed_orcids":["https://orcid.org/0000-0003-3070-3586"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gefei Wang","raw_affiliation_strings":["Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091699610","display_name":"Jianan Ren","orcid":"https://orcid.org/0000-0002-4697-4762","observed_orcids":["https://orcid.org/0000-0002-4697-4762","https://orcid.org/0000-0001-9011-3989"]},"institutions":[{"id":"https://openalex.org/I2799773085","display_name":"Nanjing General Hospital of Nanjing Military Command","ror":"https://ror.org/04kmpyd03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2799773085"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianan Ren","raw_affiliation_strings":["Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China"],"raw_orcid":"https://orcid.org/0000-0002-4697-4762","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002 China","institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086420817","display_name":"Yuanjin Zhao","orcid":"https://orcid.org/0000-0001-9242-4000","observed_orcids":["https://orcid.org/0000-0001-9242-4000"]},"institutions":[{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanjin Zhao","raw_affiliation_strings":["State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China"],"raw_orcid":"https://orcid.org/0000-0001-9242-4000","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China","institution_ids":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086420817","https://openalex.org/A5091699610"],"corresponding_institution_ids":["https://openalex.org/I2799773085","https://openalex.org/I4387154005","https://openalex.org/I76569877","https://openalex.org/I881766915"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":38.439,"has_fulltext":false,"cited_by_count":437,"citation_normalized_percentile":{"value":0.99937798,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"28","issue":"33","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.05209999904036522,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12906","display_name":"Surgical Sutures and Adhesives","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hybrid-hydrogels","display_name":"hybrid hydrogels","score":0.9350000023841858},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.7269999980926514},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.9350000023841858},{"id":"https://openalex.org/keywords/benzaldehyde","display_name":"benzaldehyde","score":0.718999981880188},{"id":"https://openalex.org/keywords/schiff-base","display_name":"Schiff base","score":0.8629999756813049},{"id":"https://openalex.org/keywords/self-healing-hydrogels","display_name":"self-healing hydrogels","score":0.8880000114440918},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tissue-adhesion","display_name":"tissue adhesion","score":0.9760000109672546},{"id":"https://openalex.org/keywords/anti-infection","display_name":"anti-infection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9399999976158142},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.6740000247955322},{"id":"https://openalex.org/keywords/full-thickness-skin-defect","display_name":"full-thickness skin defect","score":0.8270000219345093},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6639999747276306},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7385889291763306},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7271485924720764},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.6135536432266235},{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.5682412385940552},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.5319148898124695},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5026676654815674},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4779382050037384},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.44964277744293213},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.4350683093070984},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3313717842102051},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.23225590586662292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13932561874389648},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1159660816192627},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10734441876411438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10159933567047119},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0796126127243042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/adfm.201801386","doi":"https://doi.org/10.1002/adfm.201801386","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adfm.201801386","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6682000160217285,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5734136999","display_name":null,"funder_award_id":"51522302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6061150126","display_name":"\u57fa\u4e8e\u591a\u529f\u80fd\u7f16\u7801\u5fae\u8f7d\u4f53\u7684\u6db2\u76f8\u7ec6\u80de\u82af\u7247\u7814\u7a76","funder_award_id":"21473029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6720443521","display_name":null,"funder_award_id":"81571881","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W396425725","https://openalex.org/W1615617154","https://openalex.org/W1982808845","https://openalex.org/W2132124638","https://openalex.org/W2146749615","https://openalex.org/W2211541075","https://openalex.org/W2234629039","https://openalex.org/W2270890210","https://openalex.org/W2299393419","https://openalex.org/W2301044272","https://openalex.org/W2319865378","https://openalex.org/W2346668385","https://openalex.org/W2400662652","https://openalex.org/W2594482393","https://openalex.org/W2608905868","https://openalex.org/W2610784388","https://openalex.org/W2616865186","https://openalex.org/W2617378503","https://openalex.org/W2617811925","https://openalex.org/W2618245525","https://openalex.org/W2621234181","https://openalex.org/W2621934018","https://openalex.org/W2624284448","https://openalex.org/W2625319186","https://openalex.org/W2744061893","https://openalex.org/W2746680694","https://openalex.org/W2752505689","https://openalex.org/W2766408218","https://openalex.org/W4238876708"],"related_works":["https://openalex.org/W2886134754","https://openalex.org/W4306993601","https://openalex.org/W4416418874","https://openalex.org/W4385306338","https://openalex.org/W4405981799","https://openalex.org/W4200217223","https://openalex.org/W4393237150","https://openalex.org/W4205417679","https://openalex.org/W4411597606","https://openalex.org/W3081747949"],"abstract_inverted_index":{"Abstract":[0],"Inspired":[1],"by":[2,87,171],"the":[3,9,42,51,62,66,69,95,98,107,121,145,152,155],"coordinated":[4],"multiple":[5],"healing":[6],"mechanism":[7],"of":[8,65,100,120,144,151,159],"organism,":[10],"a":[11],"four\u2010armed":[12],"benzaldehyde\u2010terminated":[13],"polyethylene":[14],"glycol":[15],"and":[16,32,46,58,79,82,90,103,136,148,178],"dodecyl\u2010modified":[17],"chitosan":[18],"hybrid":[19,37,70,96,123,185],"hydrogel":[20,38,71,186],"with":[21],"vascular":[22],"endothelial":[23],"growth":[24],"factor":[25],"(VEGF)":[26],"encapsulation":[27],"are":[28],"presented":[29],"for":[30,190],"efficient":[31],"versatile":[33],"wound":[34,108],"healing.":[35],"The":[36],"is":[39,126,187],"formed":[40],"through":[41],"reversible":[43],"Schiff":[44],"base":[45],"possesses":[47],"self\u2010healing":[48],"capability.":[49],"As":[50],"dodecyl":[52],"tails":[53],"can":[54,110,139,166],"insert":[55],"themselves":[56],"into":[57],"be":[59,111,140,168],"anchored":[60],"onto":[61],"lipid":[63],"bilayer":[64],"cell":[67,77,83,101],"membrane,":[68],"has":[72],"outstanding":[73,146],"tissue":[74,104,130,180],"adhesion,":[75],"blood":[76],"coagulation":[78],"hemostasis,":[80],"anti\u2010infection,":[81],"recruitment":[84],"functions.":[85],"Moreover,":[86,154],"loading":[88],"in":[89,106,117],"controllably":[91],"releasing":[92],"VEGF":[93],"from":[94],"hydrogel,":[97,124],"processes":[99],"proliferation":[102],"remodeling":[105],"bed":[109],"significantly":[112,169],"improved.":[113],"Based":[114],"on":[115],"an":[116,160],"vivo":[118],"study":[119],"multifunctional":[122,184],"it":[125],"demonstrated":[127],"that":[128],"acute":[129],"injuries":[131],"such":[132],"as":[133],"vessel":[134],"bleeding":[135,138],"liver":[137],"repaired":[141],"immediately":[142],"because":[143],"adhesion":[147],"hemostasis":[149],"features":[150],"hydrogel.":[153],"chronic":[156],"wound\u2010healing":[157],"process":[158],"infectious":[161],"full\u2010thickness":[162],"skin":[163],"defect":[164],"model":[165],"also":[167],"enhanced":[170],"promoting":[172],"angiogenesis,":[173],"collagen":[174],"deposition,":[175],"macrophage":[176],"polarization,":[177],"granulation":[179],"formation.":[181],"Thus,":[182],"this":[183],"potentially":[188],"valuable":[189],"clinical":[191],"applications.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":53},{"year":2024,"cited_by_count":67},{"year":2023,"cited_by_count":77},{"year":2022,"cited_by_count":74},{"year":2021,"cited_by_count":72},{"year":2020,"cited_by_count":48},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-13T00:00:00"}
