{"id":"https://openalex.org/W2805987664","doi":"https://doi.org/10.18632/oncotarget.25509","title":"WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3\u2212 cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling","display_name":"WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3\u2212 cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling","publication_year":2018,"publication_date":"2018-06-04","ids":{"openalex":"https://openalex.org/W2805987664","doi":"https://doi.org/10.18632/oncotarget.25509","mag":"2805987664","pmid":"https://pubmed.ncbi.nlm.nih.gov/29930759","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6007472"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.25509","doi":"https://doi.org/10.18632/oncotarget.25509","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25509","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncotarget.25509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026135474","display_name":"Wanyin Chen","orcid":"https://orcid.org/0000-0002-2045-3854","observed_orcids":["https://orcid.org/0000-0002-2045-3854"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wanyin Chen","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001446035","display_name":"L\u00e9onel Nguekeu-Zebaze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Leonel Nguekeu Zebaze","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074575222","display_name":"Jihu Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jihu Dong","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080652627","display_name":"La\u00ebtitia Ch\u00e9zeau","orcid":"https://orcid.org/0000-0002-9147-9250","observed_orcids":["https://orcid.org/0000-0002-9147-9250"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"La\u00ebtitia Ch\u00e9zeau","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028305193","display_name":"Perrine Inquimbert","orcid":"https://orcid.org/0000-0003-2625-1468","observed_orcids":["https://orcid.org/0000-0003-2625-1468"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117903","display_name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","ror":"https://ror.org/025mhd687","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210117903","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Perrine Inquimbert","raw_affiliation_strings":["Institut des Neurosciences Cellulaires et Int\u00e9gratives, UPR3212, Centre National de la Recherche Scientifique, 67084 Strasbourg, France; Universit\u00e9 de Strasbourg, Strasbourg 67084, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Neurosciences Cellulaires et Int\u00e9gratives, UPR3212, Centre National de la Recherche Scientifique, 67084 Strasbourg, France; Universit\u00e9 de Strasbourg, Strasbourg 67084, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210117903","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071552443","display_name":"Sylvain Hugel","orcid":"https://orcid.org/0000-0003-2464-3601","observed_orcids":["https://orcid.org/0000-0003-2464-3601"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117903","display_name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","ror":"https://ror.org/025mhd687","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210117903","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Hugel","raw_affiliation_strings":["Institut des Neurosciences Cellulaires et Int\u00e9gratives, UPR3212, Centre National de la Recherche Scientifique, 67084 Strasbourg, France; Universit\u00e9 de Strasbourg, Strasbourg 67084, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Neurosciences Cellulaires et Int\u00e9gratives, UPR3212, Centre National de la Recherche Scientifique, 67084 Strasbourg, France; Universit\u00e9 de Strasbourg, Strasbourg 67084, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210117903","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064493221","display_name":"Songlin Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Songlin Niu","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030865521","display_name":"Frederic J.\u2010J. Bihel","orcid":"https://orcid.org/0000-0002-4122-0929","observed_orcids":["https://orcid.org/0000-0002-4122-0929"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9deric Bihel","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080751117","display_name":"Emmanuel Boutant","orcid":"https://orcid.org/0009-0007-6303-9892","observed_orcids":["https://orcid.org/0009-0007-6303-9892"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405257448","display_name":"Laboratoire de bioimagerie et pathologies","ror":"https://ror.org/059g0vd42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuel Boutant","raw_affiliation_strings":["Laboratoire de Bioimagerie et Pathologies - LBP, UMR7021, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Bioimagerie et Pathologies - LBP, UMR7021, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061303801","display_name":"\u00c9l\u00e9onore R\u00e9al","orcid":"https://orcid.org/0000-0002-5523-4408","observed_orcids":["https://orcid.org/0000-0002-5523-4408"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405257448","display_name":"Laboratoire de bioimagerie et pathologies","ror":"https://ror.org/059g0vd42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"El\u00e9onore R\u00e9al","raw_affiliation_strings":["Laboratoire de Bioimagerie et Pathologies - LBP, UMR7021, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Bioimagerie et Pathologies - LBP, UMR7021, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025683789","display_name":"Pascal Villa","orcid":"https://orcid.org/0000-0003-3466-4852","observed_orcids":["https://orcid.org/0000-0003-3466-4852"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387152610","display_name":"Plateforme de chimie biologique int\u00e9grative de Strasbourg","ror":"https://ror.org/052pqt102","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387152610"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Villa","raw_affiliation_strings":["Plateforme de Chimie Biologie Int\u00e9grative (PCBIS), Universit\u00e9 de Strasbourg/CNRS UMS 3286, Laboratoire d\u2019Excellence Medalis, ESBS P\u00f4le API-Bld S\u00e9bastien Brant, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plateforme de Chimie Biologie Int\u00e9grative (PCBIS), Universit\u00e9 de Strasbourg/CNRS UMS 3286, Laboratoire d\u2019Excellence Medalis, ESBS P\u00f4le API-Bld S\u00e9bastien Brant, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387152610","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018387769","display_name":"Marie\u2010Pierre Junier","orcid":"https://orcid.org/0000-0002-5731-0929","observed_orcids":["https://orcid.org/0000-0002-5731-0929"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210107326","display_name":"Institut de Biologie Paris-Seine","ror":"https://ror.org/01c2cjg59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210107326"]},{"id":"https://openalex.org/I4389425265","display_name":"Neurosciences Paris-Seine","ror":"https://ror.org/02sps6z09","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4389425265","https://openalex.org/I4405255169"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Pierre Junier","raw_affiliation_strings":["Neuroscience Paris Seine-IBPS, CNRS UMR 8246/Inserm U1130/UPMC UMCR18, Paris 75005, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Paris Seine-IBPS, CNRS UMR 8246/Inserm U1130/UPMC UMCR18, Paris 75005, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210107326","https://openalex.org/I4389425265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060230145","display_name":"Herv\u00e9 Chneiweiss","orcid":"https://orcid.org/0000-0001-7675-5061","observed_orcids":["https://orcid.org/0000-0001-7675-5061"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210107326","display_name":"Institut de Biologie Paris-Seine","ror":"https://ror.org/01c2cjg59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210107326"]},{"id":"https://openalex.org/I4389425265","display_name":"Neurosciences Paris-Seine","ror":"https://ror.org/02sps6z09","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4389425265","https://openalex.org/I4405255169"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Chneiweiss","raw_affiliation_strings":["Neuroscience Paris Seine-IBPS, CNRS UMR 8246/Inserm U1130/UPMC UMCR18, Paris 75005, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Paris Seine-IBPS, CNRS UMR 8246/Inserm U1130/UPMC UMCR18, Paris 75005, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210107326","https://openalex.org/I4389425265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061144307","display_name":"Marcel Hibert","orcid":"https://orcid.org/0000-0001-7786-7276","observed_orcids":["https://orcid.org/0000-0001-7786-7276"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marcel Hibert","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065266817","display_name":"Jacques Haiech","orcid":"https://orcid.org/0000-0003-2908-8053","observed_orcids":["https://orcid.org/0000-0003-2908-8053"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Haiech","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108698365","display_name":"Marie\u2010Claude Kilhoffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Claude Kilhoffer","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036788309","display_name":"Maria Zeniou","orcid":"https://orcid.org/0000-0002-3237-0263","observed_orcids":["https://orcid.org/0000-0002-3237-0263"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria Zeniou","raw_affiliation_strings":["Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Innovation Th\u00e9rapeutique, Centre National de la Recherche Scientifique/Universit\u00e9 de Strasbourg, UMR7200, Laboratoire d\u2019Excellence Medalis, Facult\u00e9 de Pharmacie, Illkirch 67401, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.313,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.58622734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"43","first_page":"27197","last_page":"27219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.5270000100135803},{"id":"https://openalex.org/keywords/sgk1","display_name":"SGK1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/na-hco3-cotransporter","display_name":"Na+/HCO3- cotransporter","score":0.8510000109672546},{"id":"https://openalex.org/keywords/glioblastoma-stem-cells","display_name":"glioblastoma stem cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bisacodyl","display_name":"bisacodyl","score":0.7429999709129333},{"id":"https://openalex.org/keywords/denoising-diffusion-probabilistic-models","display_name":"denoising diffusion probabilistic models","score":0.6669999957084656},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.6140000224113464},{"id":"https://openalex.org/keywords/bicarbonate-transport","display_name":"bicarbonate transport","score":0.46799999475479126},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.43299999833106995},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5797368884086609},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5620610117912292},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4921693205833435},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4827360510826111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44334882497787476},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.3206499218940735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27938762307167053},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2616475224494934},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14110907912254333}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.18632/oncotarget.25509","doi":"https://doi.org/10.18632/oncotarget.25509","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25509","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6007472","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6007472/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6007472/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:4963551","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6007472","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29930759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29930759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02349611v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02349611","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, 2018, 9 (43), pp.27197-27219. &#x27E8;10.18632/oncotarget.25509&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.25509","doi":"https://doi.org/10.18632/oncotarget.25509","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25509","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2754493927","display_name":"Medalis Drug Discovery Center","funder_award_id":"ANR-10-LABX-0034","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322147","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805987664.pdf","grobid_xml":"https://content.openalex.org/works/W2805987664.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1569513357","https://openalex.org/W1792532087","https://openalex.org/W1826862953","https://openalex.org/W1851993599","https://openalex.org/W1967230400","https://openalex.org/W1967814919","https://openalex.org/W1975016763","https://openalex.org/W1976380796","https://openalex.org/W1978324103","https://openalex.org/W1984483719","https://openalex.org/W1994541600","https://openalex.org/W2004878973","https://openalex.org/W2004970918","https://openalex.org/W2015559458","https://openalex.org/W2018569307","https://openalex.org/W2018671779","https://openalex.org/W2019759951","https://openalex.org/W2023846533","https://openalex.org/W2029860176","https://openalex.org/W2036874807","https://openalex.org/W2040121658","https://openalex.org/W2041273214","https://openalex.org/W2049263710","https://openalex.org/W2051349300","https://openalex.org/W2051588629","https://openalex.org/W2053936821","https://openalex.org/W2054532941","https://openalex.org/W2058317013","https://openalex.org/W2072543436","https://openalex.org/W2078510083","https://openalex.org/W2084554076","https://openalex.org/W2092544528","https://openalex.org/W2112638284","https://openalex.org/W2124078079","https://openalex.org/W2128158324","https://openalex.org/W2128503410","https://openalex.org/W2131398663","https://openalex.org/W2131589269","https://openalex.org/W2140153500","https://openalex.org/W2143908444","https://openalex.org/W2148931486","https://openalex.org/W2148977460","https://openalex.org/W2156647638","https://openalex.org/W2158074474","https://openalex.org/W2160120650","https://openalex.org/W2162060020","https://openalex.org/W2165874149","https://openalex.org/W2172151601","https://openalex.org/W2278244109","https://openalex.org/W2286284214","https://openalex.org/W2516723064","https://openalex.org/W2560864272","https://openalex.org/W2576755986","https://openalex.org/W2587455962","https://openalex.org/W2624969848","https://openalex.org/W2777846287","https://openalex.org/W4245392732"],"related_works":["https://openalex.org/W2622020564","https://openalex.org/W2128158324","https://openalex.org/W2576755986","https://openalex.org/W6946132604","https://openalex.org/W4413222138","https://openalex.org/W4417357840","https://openalex.org/W7128426879","https://openalex.org/W2900050466","https://openalex.org/W4307281068","https://openalex.org/W2161333480"],"abstract_inverted_index":{"//":[0],"Wanyin":[1],"Chen":[2],"1":[3,8,12,16,28,32,56,60,64,68,69],",":[4,9,13,17,21,25,29,33,37,41,45,49,53,57,61,322],"Leonel":[5],"Nguekeu":[6],"Zebaze":[7],"Jihu":[10],"Dong":[11],"La\u00ebtitia":[14],"Ch\u00e9zeau":[15],"Perrine":[18],"Inquimbert":[19],"2":[20,24,91],"Sylvain":[22],"Hugel":[23],"Songlin":[26],"Niu":[27],"Fr\u00e9deric":[30],"Bihel":[31],"Emmanuel":[34],"Boutant":[35],"3":[36,40,114],"El\u00e9onore":[38],"R\u00e9al":[39],"Pascal":[42],"Villa":[43],"4":[44,137],"Marie-Pierre":[46],"Junier":[47],"5":[48,52,160],"Herv\u00e9":[50],"Chneiweiss":[51],"Marcel":[54],"Hibert":[55],"Jacques":[58],"Haiech":[59],"Marie-Claude":[62],"Kilhoffer":[63],"and":[65,219,235,241,283,308,335,364,368],"Maria":[66,174],"Zeniou":[67],"Laboratoire":[70,82,115,149],"d\u2019Innovation":[71],"Th\u00e9rapeutique,":[72],"Centre":[73,99,123],"National":[74,100,124],"de":[75,79,86,101,109,116,125,129,132,139,145],"la":[76,102,126],"Recherche":[77,103,127],"Scientifique/Universit\u00e9":[78,128],"Strasbourg,":[80,106,110,130],"UMR7200,":[81],"d\u2019Excellence":[83,150],"Medalis,":[84,151],"Facult\u00e9":[85,131],"Pharmacie,":[87,133],"Illkirch":[88,134,157],"67401,":[89,135,158],"France":[90,113,136,159,171],"Institut":[92],"des":[93],"Neurosciences":[94],"Cellulaires":[95],"et":[96,118],"Int\u00e9gratives,":[97],"UPR3212,":[98],"Scientifique,":[104],"67084":[105],"France;":[107],"Universit\u00e9":[108,144],"Strasbourg":[111],"67084,":[112],"Bioimagerie":[117],"Pathologies":[119],"-":[120],"LBP,":[121],"UMR7021,":[122],"Plateforme":[138],"Chimie":[140],"Biologie":[141],"Int\u00e9grative":[142],"(PCBIS),":[143],"Strasbourg/CNRS":[146],"UMS":[147],"3286,":[148],"ESBS":[152],"P\u00f4le":[153],"API-Bld":[154],"S\u00e9bastien":[155],"Brant,":[156],"Neuroscience":[161],"Paris":[162,169],"Seine-IBPS,":[163],"CNRS":[164],"UMR":[165],"8246/Inserm":[166],"U1130/UPMC":[167],"UMCR18,":[168],"75005,":[170],"Correspondence":[172],"to:":[173],"Zeniou,":[175],"email:":[176],"zeniou@unistra.fr":[177],"Keywords:":[178],"Bisacodyl/DDPM;":[179],"glioblastoma":[180,289,318,395],"cancer":[181,215,228],"stem-like":[182,218,229],"cells;":[183],"WNK1;":[184],"Akt/SGK1;":[185],"NBC":[186],"Na":[187,370],"+":[188,371],"/HCO3":[189,372],"\u2212":[190,373],"cotransporters":[191,374],"Received:":[192],"December":[193],"06,":[194],"2017":[195],"Accepted:":[196],"May":[197],"10,":[198],"2018":[199,203],"Published:":[200],"June":[201],"05,":[202],"ABSTRACT":[204],"Glioblastoma":[205,227],"is":[206,397],"a":[207,254,349],"highly":[208],"heterogeneous":[209],"brain":[210],"tumor.":[211],"The":[212],"presence":[213],"of":[214,317,338,351],"cells":[216,230],"with":[217,333],"tumor":[220,281],"initiation/propagation":[221],"properties":[222],"contributes":[223],"to":[224,279,342,377],"poor":[225],"prognosis.":[226],"(GSC)":[231],"reside":[232],"in":[233,261,286,287,304,320,355,379],"hypoxic":[234],"acidic":[236,262,306],"niches":[237],"favoring":[238],"cell":[239,357],"quiescence":[240],"drug":[242],"resistance.":[243],"A":[244],"high":[245],"throughput":[246],"screening":[247],"recently":[248],"identified":[249],"the":[250,294,343,362,380],"laxative":[251],"Bisacodyl":[252,264,275,298,352],"as":[253,348],"cytotoxic":[255,299,353],"compound":[256],"targeting":[257],"quiescent":[258,302,327],"GSC":[259,303],"placed":[260],"microenvironments.":[263],"activity":[265],"requires":[266],"its":[267,271],"hydrolysis":[268],"into":[269],"DDPM,":[270],"pharmacologically":[272],"active":[273],"derivative.":[274],"was":[276],"further":[277],"shown":[278,376],"induce":[280],"shrinking":[282],"increase":[284],"survival":[285],"vivo":[288,321],"models.":[290,358],"Here":[291],"we":[292],"explored":[293],"cellular":[295],"mechanism":[296],"underlying":[297],"effects":[300],"using":[301],"an":[305,399],"microenvironment":[307],"GSC-derived":[309],"3D":[310],"macro-spheres.":[311],"These":[312],"spheres":[313],"mimic":[314],"many":[315],"aspects":[316],"tumors":[319],"including":[323,361],"hypoxic/acidic":[324],"areas":[325],"containing":[326],"cells.":[328],"Phosphokinase":[329],"protein":[330,346,366],"arrays":[331],"combined":[332],"pharmacological":[334],"genetic":[336],"modulation":[337],"signaling":[339],"pathways":[340],"point":[341],"WNK1":[344,359],"serine/threonine":[345],"kinase":[347],"mediator":[350],"effect":[354,382],"both":[356],"partners":[360],"Akt":[363],"SGK1":[365],"kinases":[367],"NBC-family":[369],"were":[375],"participate":[378],"compound\u2019s":[381],"on":[383],"GSC.":[384],"Overall,":[385],"our":[386],"findings":[387],"uncover":[388],"novel":[389],"potential":[390],"therapeutic":[391],"targets":[392],"for":[393],"combatting":[394],"which":[396],"presently":[398],"incurable":[400],"disease.":[401]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-06-13T00:00:00"}
