{"id":"https://openalex.org/W2805910700","doi":"https://doi.org/10.1016/j.chest.2018.05.015","title":"Comparative Effectiveness of Proton Pump Inhibitors vs Histamine Type 2 Receptor Blockers for Preventing Clinically Important Gastrointestinal Bleeding During Intensive Care","display_name":"Comparative Effectiveness of Proton Pump Inhibitors vs Histamine Type 2 Receptor Blockers for Preventing Clinically Important Gastrointestinal Bleeding During Intensive Care","publication_year":2018,"publication_date":"2018-05-29","ids":{"openalex":"https://openalex.org/W2805910700","doi":"https://doi.org/10.1016/j.chest.2018.05.015","mag":"2805910700","pmid":"https://pubmed.ncbi.nlm.nih.gov/29856970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6689080"},"language":"en","primary_location":{"id":"doi:10.1016/j.chest.2018.05.015","doi":"https://doi.org/10.1016/j.chest.2018.05.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chest.2018.05.015","pdf_url":"http://journal.chestnet.org/article/S0012369218307955/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://journal.chestnet.org/article/S0012369218307955/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103210780","display_name":"Craig M. Lilly","orcid":"https://orcid.org/0000-0002-1600-0510","observed_orcids":["https://orcid.org/0000-0002-1600-0510"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig M. Lilly","raw_affiliation_strings":["Departments of Medicine, Anesthesiology, and Surgery, University of Massachusetts Medical School, Clinical and Population Health Research Program, Graduate School of Biomedical Sciences, Worcester, MA. Electronic address: craig.lilly@umassmed.edu","Departments of Medicine, Anesthesiology, and Surgery, University of Massachusetts Medical School, Clinical and Population Health Research Program, Graduate School of Biomedical Sciences, Worcester, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Anesthesiology, and Surgery, University of Massachusetts Medical School, Clinical and Population Health Research Program, Graduate School of Biomedical Sciences, Worcester, MA. Electronic address: craig.lilly@umassmed.edu","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Departments of Medicine, Anesthesiology, and Surgery, University of Massachusetts Medical School, Clinical and Population Health Research Program, Graduate School of Biomedical Sciences, Worcester, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075532940","display_name":"Mohammad H. Aljawadi","orcid":"https://orcid.org/0000-0002-5114-1343","observed_orcids":["https://orcid.org/0000-0002-5114-1343"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA","US"],"is_corresponding":false,"raw_author_name":"Mohammad Aljawadi","raw_affiliation_strings":["University of Maryland School of Pharmacy, Baltimore, MD; King Saud University, Riyadh, Saudi Arabia","King Saud University, Riyadh, Saudi Arabia","University of Maryland School of Pharmacy, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland School of Pharmacy, Baltimore, MD; King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I28022161"]},{"raw_affiliation_string":"King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"University of Maryland School of Pharmacy, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000657987","display_name":"Omar Badawi","orcid":"https://orcid.org/0000-0001-8518-9006","observed_orcids":["https://orcid.org/0000-0001-8518-9006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omar Badawi","raw_affiliation_strings":["Philips Healthcare, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philips Healthcare, Baltimore, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067844331","display_name":"E. Onukwugha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ebere Onukwugha","raw_affiliation_strings":["University of Maryland School of Pharmacy, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland School of Pharmacy, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024637473","display_name":"Sarah E. Tom","orcid":"https://orcid.org/0000-0003-0094-5138","observed_orcids":["https://orcid.org/0000-0003-0094-5138"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Tom","raw_affiliation_strings":["University of Maryland School of Pharmacy, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland School of Pharmacy, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079843231","display_name":"Laurence S. Magder","orcid":"https://orcid.org/0000-0001-9297-1952","observed_orcids":["https://orcid.org/0000-0001-9297-1952"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence S. Magder","raw_affiliation_strings":["University of Maryland School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000066395","display_name":"Ilene Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155539","display_name":"Impaq International (United States)","ror":"https://ror.org/04kb0nk47","country_code":"US","type":"company","lineage":["https://openalex.org/I1293631320","https://openalex.org/I4210155539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilene Harris","raw_affiliation_strings":["IMPAQ International, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMPAQ International, Baltimore, MD","institution_ids":["https://openalex.org/I4210155539"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103210780"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":5.2423,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.96030108,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"154","issue":"3","first_page":"557","last_page":"566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stress-ulcer-prophylaxis","display_name":"stress ulcer prophylaxis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.949999988079071},{"id":"https://openalex.org/keywords/critically-ill-adults","display_name":"critically ill adults","score":0.8610000014305115},{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.921999990940094},{"id":"https://openalex.org/keywords/acid-suppression","display_name":"acid suppression","score":0.9039999842643738},{"id":"https://openalex.org/keywords/comparative-effectiveness","display_name":"comparative effectiveness","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9362779855728149},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6596171855926514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6292768120765686},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5292921662330627},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.5189242362976074},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4917762577533722},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4628550112247467},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4542333781719208},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.4464068114757538},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.44017618894577026},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.14063745737075806},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006635","descriptor_name":"Histamine H2 Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017891","descriptor_name":"Pharmacoepidemiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D057216","descriptor_name":"Propensity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.chest.2018.05.015","doi":"https://doi.org/10.1016/j.chest.2018.05.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chest.2018.05.015","pdf_url":"http://journal.chestnet.org/article/S0012369218307955/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5678709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6689080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6689080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6689080","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Text"},{"id":"pmid:29856970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29856970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/j.chest.2018.05.015","doi":"https://doi.org/10.1016/j.chest.2018.05.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chest.2018.05.015","pdf_url":"http://journal.chestnet.org/article/S0012369218307955/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000870616","display_name":"University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)","funder_award_id":"P30AG028747","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805910700.pdf","grobid_xml":"https://content.openalex.org/works/W2805910700.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W15925677","https://openalex.org/W108992697","https://openalex.org/W1971937817","https://openalex.org/W1980869256","https://openalex.org/W1981748372","https://openalex.org/W1985959276","https://openalex.org/W1991861591","https://openalex.org/W1995410581","https://openalex.org/W2010339935","https://openalex.org/W2014799253","https://openalex.org/W2036193982","https://openalex.org/W2048548077","https://openalex.org/W2053838472","https://openalex.org/W2069432084","https://openalex.org/W2072130577","https://openalex.org/W2072238544","https://openalex.org/W2086771308","https://openalex.org/W2089973354","https://openalex.org/W2116770308","https://openalex.org/W2126056171","https://openalex.org/W2133073213","https://openalex.org/W2319207481","https://openalex.org/W2324679286","https://openalex.org/W2546700110","https://openalex.org/W2742190403","https://openalex.org/W2803743745","https://openalex.org/W6604366558"],"related_works":["https://openalex.org/W3199206997","https://openalex.org/W3174835192","https://openalex.org/W3197238431","https://openalex.org/W7140167683","https://openalex.org/W2089973354","https://openalex.org/W2346892182","https://openalex.org/W4417162731","https://openalex.org/W3164159648","https://openalex.org/W4417532273","https://openalex.org/W2571467407"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}
