{"id":"https://openalex.org/W2805729137","doi":"https://doi.org/10.1016/j.neo.2018.05.001","title":"Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2","display_name":"Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2","publication_year":2018,"publication_date":"2018-05-28","ids":{"openalex":"https://openalex.org/W2805729137","doi":"https://doi.org/10.1016/j.neo.2018.05.001","mag":"2805729137","pmid":"https://pubmed.ncbi.nlm.nih.gov/29852323","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6030392"},"language":"en","primary_location":{"id":"doi:10.1016/j.neo.2018.05.001","doi":"https://doi.org/10.1016/j.neo.2018.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2018.05.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558618301118/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1476558618301118/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039593027","display_name":"Mark C. de Gooijer","orcid":"https://orcid.org/0000-0002-2812-991X","observed_orcids":["https://orcid.org/0000-0002-2812-991X"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark C. de Gooijer","raw_affiliation_strings":["Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090821095","display_name":"Nienke A. de Vries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nienke A. de Vries","raw_affiliation_strings":["Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081033403","display_name":"Tessa Buckle","orcid":"https://orcid.org/0000-0003-2980-6895","observed_orcids":["https://orcid.org/0000-0003-2980-6895"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tessa Buckle","raw_affiliation_strings":["Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073588166","display_name":"Levi C.M. Buil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Levi C.M. Buil","raw_affiliation_strings":["Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062227574","display_name":"Jos H. Beijnen","orcid":"https://orcid.org/0000-0003-0118-561X","observed_orcids":["https://orcid.org/0000-0003-0118-561X"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos H. Beijnen","raw_affiliation_strings":["Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/MC Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands","Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/MC Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands","Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands","Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/MC Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/MC Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085298662","display_name":"Willem J. Boogerd","orcid":"https://orcid.org/0000-0003-0080-5661","observed_orcids":["https://orcid.org/0000-0003-0080-5661"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Willem Boogerd","raw_affiliation_strings":["Department of Medical Oncology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Neurology, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands","Department of Medical Oncology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","Department of Neurology, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Neurology, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Department of Medical Oncology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Hospital), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Department of Neurology, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034151807","display_name":"Olaf van Tellingen","orcid":"https://orcid.org/0000-0002-1037-6269","observed_orcids":["https://orcid.org/0000-0002-1037-6269"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Olaf van Tellingen","raw_affiliation_strings":["Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. Electronic address: o.v.tellingen@nki.nl","Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. Electronic address: o.v.tellingen@nki.nl","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034151807"],"corresponding_institution_ids":["https://openalex.org/I2898336195"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":{"value":3530,"currency":"USD","value_usd":3530},"fwci":4.6969,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":{"value":0.97015198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"20","issue":"7","first_page":"710","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":1.0},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9440000057220459},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7870000004768372},{"id":"https://openalex.org/keywords/brain-penetration","display_name":"brain penetration","score":0.9390000104904175},{"id":"https://openalex.org/keywords/elacridar","display_name":"elacridar","score":0.8550000190734863},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/intracranial-tumors","display_name":"intracranial tumors","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.9583062529563904},{"id":"https://openalex.org/C512196","wikidata":"https://www.wikidata.org/wiki/Q4650095","display_name":"Abcg2","level":5,"score":0.8356952667236328},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7283796072006226},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6064841151237488},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.5529133677482605},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5127397775650024},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49724581837654114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4485911726951599},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.43584713339805603},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4012748599052429},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3686300814151764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3226829171180725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2853035032749176},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.25486505031585693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.24295085668563843},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.2268901765346527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22599613666534424},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.19038087129592896},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.14874151349067688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05239665508270264},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.neo.2018.05.001","doi":"https://doi.org/10.1016/j.neo.2018.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2018.05.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558618301118/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4989707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6030392","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6030392","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6030392","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"Text"},{"id":"pmid:29852323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29852323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2cdc215f2d024dcda47d7a99dc431f6c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2cdc215f2d024dcda47d7a99dc431f6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 710-720 (2018)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/376145","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/376145","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/376145","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/376145","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoplasia, 20(7), 710. Elsevier","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.neo.2018.05.001","doi":"https://doi.org/10.1016/j.neo.2018.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2018.05.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558618301118/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805729137.pdf","grobid_xml":"https://content.openalex.org/works/W2805729137.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W817872913","https://openalex.org/W1483167997","https://openalex.org/W1861898234","https://openalex.org/W1966720603","https://openalex.org/W1973728983","https://openalex.org/W1977392502","https://openalex.org/W1984216868","https://openalex.org/W1995725988","https://openalex.org/W2003278476","https://openalex.org/W2006116524","https://openalex.org/W2012912125","https://openalex.org/W2031278548","https://openalex.org/W2053386771","https://openalex.org/W2067210803","https://openalex.org/W2078568774","https://openalex.org/W2079785947","https://openalex.org/W2094900768","https://openalex.org/W2101292582","https://openalex.org/W2104387616","https://openalex.org/W2105100844","https://openalex.org/W2108062634","https://openalex.org/W2111810662","https://openalex.org/W2115072974","https://openalex.org/W2118207487","https://openalex.org/W2123002505","https://openalex.org/W2125643269","https://openalex.org/W2136527161","https://openalex.org/W2136564762","https://openalex.org/W2139008103","https://openalex.org/W2142661339","https://openalex.org/W2157922236","https://openalex.org/W2158681922","https://openalex.org/W2159661815","https://openalex.org/W2159821105","https://openalex.org/W2165871546","https://openalex.org/W2166153381","https://openalex.org/W2256833355","https://openalex.org/W2264385870","https://openalex.org/W2284964360","https://openalex.org/W2512454832","https://openalex.org/W2725912298","https://openalex.org/W2752314762","https://openalex.org/W6639429464"],"related_works":["https://openalex.org/W2090078146","https://openalex.org/W2594631835","https://openalex.org/W7112136457","https://openalex.org/W4306250336","https://openalex.org/W1498275229","https://openalex.org/W1981191806","https://openalex.org/W6962812849","https://openalex.org/W2079785947","https://openalex.org/W1929868825","https://openalex.org/W2108062634"],"abstract_inverted_index":{"The":[0,151],"anticancer":[1],"drug":[2,7,127],"temozolomide":[3,113,136,155,186],"is":[4],"the":[5,21,44,49,58,65,101,109,125,130,145,192,199,204],"only":[6],"with":[8,144,189],"proven":[9],"activity":[10],"against":[11,156],"high-grade":[12],"gliomas":[13],"and":[14,30,47,62,67,82,86,94,106,167],"has":[15],"therefore":[16],"become":[17],"a":[18,74],"part":[19],"of":[20,24,52,60,69,73,77,104,112,154,185,194,201,207],"standard":[22],"treatment":[23,193],"these":[25],"tumors.":[26],"P-glycoprotein":[27],"(P-gp;":[28],"ABCB1)":[29],"breast":[31],"cancer":[32],"resistance":[33],"protein":[34],"(BCRP;":[35],"ABCG2)":[36],"are":[37,41],"transport":[38,80],"proteins,":[39],"which":[40],"present":[42],"at":[43],"blood-brain":[45],"barrier":[46],"limit":[48],"brain":[50,110],"uptake":[51],"substrate":[53],"drugs.":[54],"We":[55,97],"have":[56],"studied":[57],"effect":[59],"P-gp":[61],"BCRP":[63],"on":[64],"pharmacokinetics":[66],"pharmacodynamics":[68],"temozolomide,":[70],"making":[71],"use":[72],"comprehensive":[75],"set":[76],"in":[78,83,142,175,187],"vitro":[79],"experiments":[81,89],"vivo":[84],"pharmacokinetic":[85],"antitumor":[87,152,205],"efficacy":[88,153,206],"using":[90],"wild-type,":[91],"Abcg2\u2212/\u2212,":[92],"Abcb1a/b\u2212/\u2212,":[93],"Abcb1a/b;Abcg2\u2212/\u2212":[95],"mice.":[96,177],"here":[98],"show":[99],"that":[100],"combined":[102],"deletion":[103],"Abcb1a/b":[105,166],"Abcg2":[107,168],"increases":[108],"penetration":[111],"by":[114],"1.5-fold":[115],"compared":[116],"to":[117,139],"wild-type":[118,140],"controls":[119],"(P":[120],"<":[121],".001)":[122],"without":[123],"changing":[124],"systemic":[126],"exposure.":[128],"Moreover,":[129],"same":[131],"increase":[132],"was":[133,137,162],"achieved":[134],"when":[135,165],"given":[138],"mice":[141],"combination":[143,188],"dual":[146],"P-gp/BCRP":[147],"inhibitor":[148],"elacridar":[149,190],"(GF120918).":[150],"three":[157],"different":[158],"intracranial":[159],"tumor":[160],"models":[161],"significantly":[163],"enhanced":[164],"were":[169],"genetically":[170],"deficient":[171],"or":[172],"pharmacologically":[173],"inhibited":[174],"recipient":[176],"These":[178],"findings":[179],"call":[180],"for":[181,191],"further":[182,202],"clinical":[183],"testing":[184],"gliomas,":[195],"as":[196],"this":[197,208],"offers":[198],"perspective":[200],"improving":[203],"already":[209],"active":[210],"agent.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-13T00:00:00"}
