{"id":"https://openalex.org/W2805686838","doi":"https://doi.org/10.1038/s41598-018-24968-x","title":"Multivalent exposure of trastuzumab on iron oxide nanoparticles improves antitumor potential and reduces resistance in HER2-positive breast cancer cells","display_name":"Multivalent exposure of trastuzumab on iron oxide nanoparticles improves antitumor potential and reduces resistance in HER2-positive breast cancer cells","publication_year":2018,"publication_date":"2018-04-20","ids":{"openalex":"https://openalex.org/W2805686838","doi":"https://doi.org/10.1038/s41598-018-24968-x","mag":"2805686838","pmid":"https://pubmed.ncbi.nlm.nih.gov/29700387","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5920071"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-24968-x","doi":"https://doi.org/10.1038/s41598-018-24968-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-24968-x","pdf_url":"https://www.nature.com/articles/s41598-018-24968-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-24968-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003506844","display_name":"Marta Truffi","orcid":"https://orcid.org/0000-0002-1095-4188","observed_orcids":["https://orcid.org/0000-0002-1095-4188"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Truffi","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011206324","display_name":"Miriam Colombo","orcid":"https://orcid.org/0000-0003-3428-5668","observed_orcids":["https://orcid.org/0000-0003-3428-5668"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Miriam Colombo","raw_affiliation_strings":["NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072371344","display_name":"Luca Sorrentino","orcid":"https://orcid.org/0000-0002-3963-2385","observed_orcids":["https://orcid.org/0000-0002-3963-2385"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Sorrentino","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088698720","display_name":"Laura Pandolfi","orcid":"https://orcid.org/0000-0003-0485-7901","observed_orcids":["https://orcid.org/0000-0003-0485-7901"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Pandolfi","raw_affiliation_strings":["NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067982846","display_name":"Serena Mazzucchelli","orcid":"https://orcid.org/0000-0001-6904-8895","observed_orcids":["https://orcid.org/0000-0001-6904-8895"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Mazzucchelli","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6904-8895","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079400676","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0002-4361-6978","observed_orcids":["https://orcid.org/0000-0002-4361-6978"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013212240","display_name":"Chiara Pacini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Pacini","raw_affiliation_strings":["NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001232860","display_name":"Raffaele Allevi","orcid":"https://orcid.org/0000-0002-9904-0947","observed_orcids":["https://orcid.org/0000-0002-9904-0947"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Allevi","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078271751","display_name":"Arianna Bonizzi","orcid":"https://orcid.org/0000-0002-5948-8747","observed_orcids":["https://orcid.org/0000-0002-5948-8747"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arianna Bonizzi","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046028029","display_name":"Fabio Corsi","orcid":"https://orcid.org/0000-0002-6469-4086","observed_orcids":["https://orcid.org/0000-0002-6469-4086"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Fabio Corsi","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy. fabio.corsi@unimi.it","Nanomedicine laboratory, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy. fabio.corsi@unimi.it","Surgery Department, Breast Unit, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy. fabio.corsi@unimi.it","Surgery Department, Breast Unit, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences \"L. Sacco\", University of Milano, via G. B. Grassi 74, 20157, Milano, Italy. fabio.corsi@unimi.it","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Nanomedicine laboratory, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy. fabio.corsi@unimi.it","institution_ids":["https://openalex.org/I4210091499"]},{"raw_affiliation_string":"Surgery Department, Breast Unit, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy. fabio.corsi@unimi.it","institution_ids":["https://openalex.org/I4210091499"]},{"raw_affiliation_string":"Surgery Department, Breast Unit, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028842822","display_name":"Davide Prosperi","orcid":"https://orcid.org/0000-0003-4577-9575","observed_orcids":["https://orcid.org/0000-0003-4577-9575"]},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Davide Prosperi","raw_affiliation_strings":["NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy. davide.prosperi@unimib.it","Nanomedicine laboratory, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy. davide.prosperi@unimib.it","NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy. davide.prosperi@unimib.it","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Nanomedicine laboratory, ICS Maugeri S.p.A. SB, via S. Maugeri 10, 27100, Pavia, Italy. davide.prosperi@unimib.it","institution_ids":["https://openalex.org/I4210091499"]},{"raw_affiliation_string":"NanoBioLab, Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028842822","https://openalex.org/A5046028029"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210091499","https://openalex.org/I66752286"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":1370,"currency":"EUR","value_usd":1477},"fwci":2.7392,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.91511565,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"6563","last_page":"6563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5849999785423279,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5849999785423279,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.4011000096797943,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.996999979019165},{"id":"https://openalex.org/keywords/iron-oxide-nanoparticles","display_name":"iron oxide nanoparticles","score":0.8330000042915344},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antibody-conjugation","display_name":"antibody conjugation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/her2-signaling","display_name":"HER2 signaling","score":0.5960000157356262},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7269999980926514},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9020000100135803},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.9679999947547913},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5820000171661377},{"id":"https://openalex.org/keywords/drug-sensitization","display_name":"drug sensitization","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.8494465351104736},{"id":"https://openalex.org/C2781164504","wikidata":"https://www.wikidata.org/wiki/Q1998021","display_name":"Pertuzumab","level":5,"score":0.7401917576789856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6476626396179199},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.6234413385391235},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.581143856048584},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5214188098907471},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49592480063438416},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4898211658000946},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.44262614846229553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4374489188194275},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.43637385964393616},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3605176508426666},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3472216725349426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33026930689811707},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3045215606689453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2250193953514099},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22069373726844788},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16012030839920044},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11784815788269043}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-018-24968-x","doi":"https://doi.org/10.1038/s41598-018-24968-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-24968-x","pdf_url":"https://www.nature.com/articles/s41598-018-24968-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4851040","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5920071","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29700387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29700387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5920071","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5920071/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:air.unimi.it:2434/588515","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/588515","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:boa.unimib.it:10281/199295","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/199295","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:bac71bef244a4969806dc3aea0ff69c9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bac71bef244a4969806dc3aea0ff69c9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-24968-x","doi":"https://doi.org/10.1038/s41598-018-24968-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-24968-x","pdf_url":"https://www.nature.com/articles/s41598-018-24968-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313475","display_name":"Universit\u00e0 degli Studi di Milano","ror":"https://ror.org/00wjc7c48"},{"id":"https://openalex.org/F4320325953","display_name":"Fondazione per la Ricerca Biomedica","ror":"https://ror.org/005w6dd37"},{"id":"https://openalex.org/F4320331789","display_name":"Fondazione Regionale per la Ricerca Biomedica","ror":"https://ror.org/01hxmsz93"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805686838.pdf","grobid_xml":"https://content.openalex.org/works/W2805686838.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1971267920","https://openalex.org/W1973544946","https://openalex.org/W1986745306","https://openalex.org/W2014836885","https://openalex.org/W2027542837","https://openalex.org/W2035004373","https://openalex.org/W2037013151","https://openalex.org/W2042599500","https://openalex.org/W2044355123","https://openalex.org/W2050584550","https://openalex.org/W2056427943","https://openalex.org/W2066258720","https://openalex.org/W2066477716","https://openalex.org/W2089696756","https://openalex.org/W2098775844","https://openalex.org/W2107022635","https://openalex.org/W2115759102","https://openalex.org/W2115847479","https://openalex.org/W2117084436","https://openalex.org/W2132537022","https://openalex.org/W2141393790","https://openalex.org/W2146390965","https://openalex.org/W2154834163","https://openalex.org/W2156115532","https://openalex.org/W2167121370","https://openalex.org/W2172265576","https://openalex.org/W2318605753","https://openalex.org/W2515812752","https://openalex.org/W2560406314","https://openalex.org/W2564108037","https://openalex.org/W2724741142","https://openalex.org/W2745482862"],"related_works":["https://openalex.org/W2792754461","https://openalex.org/W3139363653","https://openalex.org/W4300981846","https://openalex.org/W4295308681","https://openalex.org/W2033647966","https://openalex.org/W4407847651","https://openalex.org/W2275389390","https://openalex.org/W2625344545","https://openalex.org/W3209112043","https://openalex.org/W4414541606"],"abstract_inverted_index":{"Targeted":[0],"therapies":[1],"have":[2],"profoundly":[3],"changed":[4],"the":[5,20,26,30,47,99,103,155,169],"clinical":[6],"prospect":[7],"in":[8,39,86,98,115,136,175],"human":[9,88],"epidermal":[10],"growth":[11],"factor":[12],"receptor":[13,104],"2":[14],"(HER2)-positive":[15],"breast":[16,34,89,117,177],"cancer.":[17],"In":[18],"particular,":[19],"anti-HER2":[21,79],"monoclonal":[22],"antibody":[23],"trastuzumab":[24,61,165],"represents":[25],"gold":[27],"standard":[28],"for":[29,194],"treatment":[31],"of":[32,60,102,149,164,182,188],"HER2+":[33,116,176],"cancer":[35,41,90,118,178],"patients.":[36],"Its":[37],"contribution":[38],"dampening":[40],"progression":[42],"is":[43],"mainly":[44],"attributed":[45],"to":[46,70,77,124,142],"antibody-dependent":[48],"cell-mediated":[49],"cytotoxicity":[50],"(ADCC)":[51],"rather":[52],"than":[53],"HER2":[54,82,183],"blockade.":[55],"Here,":[56],"multiple":[57,162],"half":[58,166],"chains":[59],"were":[62],"conjugated":[63],"onto":[64],"magnetic":[65],"iron":[66],"oxide":[67],"nanoparticles":[68,94,128],"(MNP-HC)":[69],"develop":[71],"target-specific":[72],"and":[73,105,132],"biologically":[74],"active":[75],"nanosystems":[76],"enhance":[78],"therapeutic":[80],"potential.":[81],"targeting":[83],"was":[84],"assessed":[85],"different":[87],"cell":[91,133],"lines,":[92],"where":[93],"triggered":[95],"site-specific":[96],"phosphorylation":[97],"catalytic":[100],"domain":[101],"cellular":[106],"uptake":[107],"by":[108],"endocytosis.":[109],"MNP-HC":[110,146],"induced":[111,129],"remarkable":[112],"antiproliferative":[113],"effect":[114],"cells,":[119,151,190],"exhibiting":[120],"enhanced":[121],"activity":[122],"compared":[123],"free":[125],"drug.":[126],"Accordingly,":[127],"p27kip1":[130],"expression":[131],"cycle":[134],"arrest":[135],"G1":[137],"phase,":[138],"without":[139],"loosing":[140],"capability":[141],"prime":[143],"ADCC.":[144],"Finally,":[145],"affected":[147],"viability":[148],"trastuzumab-resistant":[150],"suggesting":[152,192],"interference":[153],"with":[154],"resistance":[156],"machinery.":[157],"Our":[158],"findings":[159],"indicate":[160],"that":[161],"arrangement":[163],"chain":[167],"on":[168],"nanoparticle":[170],"surface":[171],"enhances":[172],"anticancer":[173],"efficacy":[174],"cells.":[179],"Powerful":[180],"inhibition":[181],"signaling":[184],"could":[185],"promote":[186],"responsiveness":[187],"resistant":[189],"thus":[191],"ways":[193],"drug":[195],"sensitization.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-06-13T00:00:00"}
