{"id":"https://openalex.org/W2805670949","doi":"https://doi.org/10.3389/fphar.2018.00555","title":"Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice","display_name":"Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice","publication_year":2018,"publication_date":"2018-05-30","ids":{"openalex":"https://openalex.org/W2805670949","doi":"https://doi.org/10.3389/fphar.2018.00555","mag":"2805670949","pmid":"https://pubmed.ncbi.nlm.nih.gov/29899699","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5988854"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2018.00555","doi":"https://doi.org/10.3389/fphar.2018.00555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.00555","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00555/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00555/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100375083","display_name":"Jing Liu","orcid":"https://orcid.org/0000-0002-9728-8893","observed_orcids":["https://orcid.org/0000-0002-9728-8893"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036263674","display_name":"Wencai Li","orcid":"https://orcid.org/0000-0002-5185-6218","observed_orcids":["https://orcid.org/0000-0002-5185-6218"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wencai Li","raw_affiliation_strings":["Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066045845","display_name":"Manoj Hang Limbu","orcid":"https://orcid.org/0000-0003-4713-0710","observed_orcids":["https://orcid.org/0000-0003-4713-0710"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manoj H. Limbu","raw_affiliation_strings":["Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628285","display_name":"Yiping Li","orcid":"https://orcid.org/0000-0001-5611-9877","observed_orcids":["https://orcid.org/0000-0001-5611-9877"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiping Li","raw_affiliation_strings":["Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376398","display_name":"Zhi Wang","orcid":"https://orcid.org/0000-0002-5276-1413","observed_orcids":["https://orcid.org/0000-0002-5276-1413"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Wang","raw_affiliation_strings":["Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016893632","display_name":"Zhengyuan Cheng","orcid":"https://orcid.org/0000-0002-6829-6544","observed_orcids":["https://orcid.org/0000-0002-6829-6544"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengyuan Cheng","raw_affiliation_strings":["Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357469","display_name":"Xiaoyi Zhang","orcid":"https://orcid.org/0000-0002-7185-0470","observed_orcids":["https://orcid.org/0000-0002-7185-0470"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyi Zhang","raw_affiliation_strings":["Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077975945","display_name":"Pingsheng Chen","orcid":"https://orcid.org/0000-0002-3876-1994","observed_orcids":["https://orcid.org/0000-0002-3876-1994"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pingsheng Chen","raw_affiliation_strings":["Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077975945"],"corresponding_institution_ids":["https://openalex.org/I76569877"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.47,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64840955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"9","issue":null,"first_page":"555","last_page":"555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/phd1","display_name":"PHD1","score":0.949999988079071},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.6359999775886536},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hydrodynamic-gene-delivery","display_name":"hydrodynamic gene delivery","score":0.7670000195503235},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.5989999771118164},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6050000190734863},{"id":"https://openalex.org/keywords/fibrosis-prevention","display_name":"fibrosis prevention","score":0.6510000228881836},{"id":"https://openalex.org/keywords/fibrosis-reversal","display_name":"fibrosis reversal","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7346904277801514},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6933636665344238},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.625463604927063},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6182651519775391},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.6153566837310791},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.6032276153564453},{"id":"https://openalex.org/C2779770810","wikidata":"https://www.wikidata.org/wiki/Q23069155","display_name":"Sirius Red","level":3,"score":0.5670852661132812},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5424597263336182},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5256306529045105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5219430327415466},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.48516541719436646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47854453325271606},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4598584473133087},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3831613063812256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2977294921875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27311599254608154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20537617802619934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13690346479415894},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1073918342590332},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06949663162231445},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.047230303287506104},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphar.2018.00555","doi":"https://doi.org/10.3389/fphar.2018.00555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.00555","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00555/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4950794","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5988854","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5988854","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5988854","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:29899699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29899699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6a3d269bef9f42f99a6b717ca193229f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6a3d269bef9f42f99a6b717ca193229f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2018.00555","doi":"https://doi.org/10.3389/fphar.2018.00555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2018.00555","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2018.00555/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4582177636","display_name":"\u80be\u5c0f\u7ba1\u57fa\u5e95\u819c\u589e\u539a\u7684\u65b0\u673a\u5236--\u7f3a\u6c27\u5bf9MMP-2\u6d3b\u6027\u8c03\u63a7\u5f71\u54cd\u7684\u673a\u5236\u63a2\u8ba8","funder_award_id":"81370868","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805670949.pdf","grobid_xml":"https://content.openalex.org/works/W2805670949.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W43008910","https://openalex.org/W1793314829","https://openalex.org/W1963648622","https://openalex.org/W1974303227","https://openalex.org/W1996163490","https://openalex.org/W1999758742","https://openalex.org/W2000105955","https://openalex.org/W2012924032","https://openalex.org/W2014559623","https://openalex.org/W2030672230","https://openalex.org/W2035970470","https://openalex.org/W2039533485","https://openalex.org/W2046697349","https://openalex.org/W2052356187","https://openalex.org/W2066761745","https://openalex.org/W2079084782","https://openalex.org/W2081914643","https://openalex.org/W2084538362","https://openalex.org/W2086477144","https://openalex.org/W2087577841","https://openalex.org/W2087661748","https://openalex.org/W2120049903","https://openalex.org/W2150480269","https://openalex.org/W2155510029","https://openalex.org/W2172643117","https://openalex.org/W2224592141","https://openalex.org/W2320147764","https://openalex.org/W2606880963","https://openalex.org/W2613104427"],"related_works":["https://openalex.org/W4404504775","https://openalex.org/W3112833100","https://openalex.org/W4406358406","https://openalex.org/W2102081625","https://openalex.org/W7212152958","https://openalex.org/W3144290433","https://openalex.org/W2897557441","https://openalex.org/W4399355091","https://openalex.org/W2015752678","https://openalex.org/W2899615762"],"abstract_inverted_index":{"Background":[0],"and":[1,9,49,100,117,122,147,154,158,172,179,200,208,222],"Aims:":[2],"To":[3],"investigate":[4],"whether":[5],"double-knockdown":[6],"of":[7,17,28,35,60,78,95,115,130,140,145,156,170,195,206,220],"PHD1":[8,116,157,171,199,207],"Keap1":[10,159,173,201,209],"in":[11,38,105,152,161,174,186,211],"mice":[12,29,175],"could":[13,214],"enhance":[14],"the":[15,58,61,65,72,93,113,127,138,180,187,212],"resolution":[16],"carbon":[18],"tetrachloride":[19],"(CCl4)-induced":[20],"liver":[21,25,162,177,213,225],"fibrosis.":[22,131,226],"Methods:":[23],"The":[24,143],"fibrosis":[26],"model":[27],"was":[30,90,109,163,182],"established":[31],"by":[32,165],"intraperitoneal":[33],"injection":[34,80,219],"25%":[36],"CCl4":[37,79],"olive":[39],"oil":[40],"(4ul/g)":[41],"twice":[42],"a":[43],"week":[44,63,67,74,77],"for":[45,111,125],"8":[46],"weeks.":[47],"PHD1shRNA":[48,221],"Keap1shRNA":[50],"eukaryotic":[51],"expression":[52,94,114,139,160,194,210],"plasmids":[53],"were":[54,134,149,202],"simultaneously":[55],"administered":[56],"from":[57,71],"beginning":[59],"first":[62],"to":[64,75,136],"fourth":[66],"(preventive":[68],"group)":[69,82],"or":[70],"fifth":[73],"eighth":[76],"(therapeutic":[81],"via":[83,217],"hydrodynamic-based":[84],"tail":[85],"vein":[86],"injection.":[87],"Successful":[88],"transfection":[89],"confirmed":[91],"with":[92],"red":[96,121,146],"fluorescent":[97,102],"protein":[98,103],"(RFP)":[99],"green":[101,148],"(GFP)":[104],"hepatocytes.":[106],"Western":[107],"blot":[108],"used":[110],"determining":[112],"Keap1,":[118],"HE,":[119],"Sirius":[120],"Masson":[123],"staining":[124,191],"evaluating":[126],"histopathological":[128],"stages":[129],"Immunohistochemical":[132],"technique":[133],"applied":[135],"evaluate":[137],"\uf061-SMA.":[141],"Results:":[142],"fluorescence":[144],"observed":[150],"mainly":[151],"hepatocytes,":[153],"downregulation":[155],"detected":[164],"western":[166],"blot.":[167],"Meanwhile,":[168],"Double-knockdown":[169],"alleviated":[176],"fibrosis,":[178],"effect":[181],"further":[183],"enhanced":[184],"especially":[185],"preventive":[188],"group.":[189],"Immunocytochemical":[190],"showed":[192],"decreased":[193],"\uf061-SMA":[196],"when":[197],"both":[198],"knockdown.":[203],"Conclusions:":[204],"Downregulation":[205],"be":[215],"achieved":[216],"hydrodynamic":[218],"Keap1shRNA,":[223],"thereby,preventing":[224]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-06-13T00:00:00"}