{"id":"https://openalex.org/W2805669343","doi":"https://doi.org/10.1158/1078-0432.ccr-18-0162","title":"Targeted Therapy for Premenopausal Women with HR+, HER2\u2212 Advanced Breast Cancer: Focus on Special Considerations and Latest Advances","display_name":"Targeted Therapy for Premenopausal Women with HR+, HER2\u2212 Advanced Breast Cancer: Focus on Special Considerations and Latest Advances","publication_year":2018,"publication_date":"2018-06-08","ids":{"openalex":"https://openalex.org/W2805669343","doi":"https://doi.org/10.1158/1078-0432.ccr-18-0162","mag":"2805669343","pmid":"https://pubmed.ncbi.nlm.nih.gov/29884743"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-18-0162","doi":"https://doi.org/10.1158/1078-0432.ccr-18-0162","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-18-0162","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034972183","display_name":"Aditya Bardia","orcid":"https://orcid.org/0000-0003-4885-1157","observed_orcids":["https://orcid.org/0000-0003-4885-1157"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aditya Bardia","raw_affiliation_strings":["1Massachusetts General Hospital Cancer Center/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital Cancer Center/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068059897","display_name":"Sara Alsterlind Hurvitz","orcid":"https://orcid.org/0000-0001-7808-7191","observed_orcids":["https://orcid.org/0000-0001-7808-7191"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Hurvitz","raw_affiliation_strings":["2UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034972183"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":1.2871,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.78623428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"24","issue":"21","first_page":"5206","last_page":"5218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9670000076293945},{"id":"https://openalex.org/keywords/abemaciclib","display_name":"abemaciclib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ribociclib","display_name":"ribociclib","score":1.0},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ovarian-function-suppression","display_name":"ovarian suppression","score":0.9919999837875366},{"id":"https://openalex.org/keywords/paloma-3","display_name":"PALOMA-3","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8491390347480774},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8079400062561035},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.7621588110923767},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6303331851959229},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6052030920982361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5933948159217834},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5420663356781006},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5185238122940063},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4846370816230774},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.39272457361221313},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-18-0162","doi":"https://doi.org/10.1158/1078-0432.ccr-18-0162","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-18-0162","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:29884743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29884743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1550411602","https://openalex.org/W1598892184","https://openalex.org/W1814360603","https://openalex.org/W1829247853","https://openalex.org/W1902218750","https://openalex.org/W1911641538","https://openalex.org/W1955525277","https://openalex.org/W1958561554","https://openalex.org/W1964090472","https://openalex.org/W1967894062","https://openalex.org/W1971927404","https://openalex.org/W1974836950","https://openalex.org/W1977295091","https://openalex.org/W1996133338","https://openalex.org/W2005830551","https://openalex.org/W2012194655","https://openalex.org/W2014025122","https://openalex.org/W2017433090","https://openalex.org/W2025163545","https://openalex.org/W2031131661","https://openalex.org/W2041781805","https://openalex.org/W2068699420","https://openalex.org/W2084109697","https://openalex.org/W2085481633","https://openalex.org/W2090251236","https://openalex.org/W2091640600","https://openalex.org/W2098095853","https://openalex.org/W2100808408","https://openalex.org/W2104561097","https://openalex.org/W2107292392","https://openalex.org/W2115588507","https://openalex.org/W2116188625","https://openalex.org/W2117163620","https://openalex.org/W2123820095","https://openalex.org/W2139274639","https://openalex.org/W2140095710","https://openalex.org/W2141600385","https://openalex.org/W2161226706","https://openalex.org/W2161849165","https://openalex.org/W2169649287","https://openalex.org/W2171458023","https://openalex.org/W2204394645","https://openalex.org/W2204530481","https://openalex.org/W2226294678","https://openalex.org/W2232585277","https://openalex.org/W2242165770","https://openalex.org/W2319081481","https://openalex.org/W2335969977","https://openalex.org/W2404884142","https://openalex.org/W2463633821","https://openalex.org/W2513393382","https://openalex.org/W2528767298","https://openalex.org/W2552099557","https://openalex.org/W2560635244","https://openalex.org/W2588439324","https://openalex.org/W2592496085","https://openalex.org/W2598063839","https://openalex.org/W2620993107","https://openalex.org/W2622249265","https://openalex.org/W2622352423","https://openalex.org/W2623152276","https://openalex.org/W2719623628","https://openalex.org/W2739301023","https://openalex.org/W2757511999","https://openalex.org/W2762481118","https://openalex.org/W2763875663","https://openalex.org/W2763910757","https://openalex.org/W2765167427","https://openalex.org/W2768089870","https://openalex.org/W2768583786","https://openalex.org/W2771397989","https://openalex.org/W2779584541","https://openalex.org/W2783539492","https://openalex.org/W2792094006","https://openalex.org/W2804105316","https://openalex.org/W2917837889","https://openalex.org/W4230568286","https://openalex.org/W4242670818","https://openalex.org/W4255293487","https://openalex.org/W6738875915"],"related_works":["https://openalex.org/W2971679304","https://openalex.org/W2885826477","https://openalex.org/W2890508508","https://openalex.org/W4244348889","https://openalex.org/W2803848650","https://openalex.org/W2671657713","https://openalex.org/W3095389949","https://openalex.org/W2791025732","https://openalex.org/W3011403317","https://openalex.org/W7213464202"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"incidence":[2],"of":[3,66,80,133,169,188],"advanced":[4,121,212],"breast":[5,13,29,40,81,122,172,213],"cancer":[6,14,30,41,82,173,214],"in":[7,15,31,45,51,73,83,100,115,130,136,147,166,174,208],"premenopausal":[8,53,84,101,116,134,158,176,189],"women":[9,17,35,85],"is":[10,18],"increasing,":[11],"and":[12,22,48,92,125,139,142,191,204],"younger":[16],"often":[19],"more":[20],"aggressive":[21],"has":[23,144],"a":[24,131],"worse":[25],"prognosis":[26],"compared":[27,178],"with":[28,36,63,118,179],"older":[32],"women.":[33,159],"Premenopausal":[34],"hormone":[37],"receptor\u2013positive":[38],"(HR+)":[39],"are":[42,55],"frequently":[43],"under-represented":[44],"clinical":[46,196],"trials,":[47],"treatment":[49,93,187],"strategies":[50,94],"the":[52,64,77,137,148,164,167,175,180,193,209],"setting":[54],"usually":[56],"extrapolated":[57],"from":[58,60,89,195],"data":[59],"postmenopausal":[61,90,181],"patients,":[62],"addition":[65],"ovarian":[67,205],"function":[68,206],"suppression":[69,207],"to":[70,157],"endocrine":[71,199],"therapy":[72],"HR+":[74],"disease.":[75],"However,":[76],"underlying":[78],"biology":[79,168],"can":[86],"be":[87,97],"different":[88],"women,":[91],"should":[95],"ideally":[96],"specifically":[98],"tested":[99,129,146],"patients.":[102],"Recent":[103],"phase":[104,149],"III":[105,150],"trials":[106,197],"have":[107,127],"now":[108],"investigated":[109],"cyclin-dependent":[110],"kinase":[111],"4/6":[112],"(CDK4/6)":[113],"inhibitors":[114],"patients":[117,135],"HR+,":[119,170,210],"HER2\u2212":[120,171,211],"cancer:":[123],"Palbociclib":[124],"abemaciclib":[126],"been":[128,145],"subset":[132],"PALOMA-3":[138],"MONARCH-2":[140],"studies,":[141],"ribociclib":[143],"MONALEESA-7":[151],"trial,":[152],"which":[153],"was":[154],"entirely":[155],"dedicated":[156],"This":[160],"comprehensive":[161],"review":[162],"summarizes":[163],"differences":[165],"population":[177],"population;":[182],"discusses":[183],"special":[184],"considerations":[185],"for":[186],"women;":[190],"reviews":[192],"evidence":[194],"investigating":[198],"therapy,":[200],"other":[201],"targeted":[202],"treatments,":[203],"setting.":[215],"Clin":[216],"Cancer":[217],"Res;":[218],"24(21);":[219],"5206\u201318.":[220],"\u00a92018":[221],"AACR.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}
