{"id":"https://openalex.org/W280565635","doi":null,"title":"Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo","display_name":"Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo","publication_year":2012,"publication_date":"2012-11-19","ids":{"openalex":"https://openalex.org/W280565635","mag":"280565635"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/31366","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/31366","pdf_url":"http://hdl.handle.net/2077/31366","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/31366","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Fredrik Pettersson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fredrik Pettersson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.24959999322891235,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1923999935388565,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopaminergic-neurotransmission","display_name":"dopamine signaling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dopamine-d2-receptor-antagonists","display_name":"dopamine D2 receptor antagonists","score":0.6970000267028809},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.765999972820282},{"id":"https://openalex.org/keywords/mao-a-inhibition","display_name":"MAO-A inhibition","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.7200000286102295},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7889999747276306},{"id":"https://openalex.org/keywords/qsar-modeling","display_name":"QSAR models","score":0.5040000081062317},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7260000109672546},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.734000027179718},{"id":"https://openalex.org/keywords/dopamine-receptor-ligands","display_name":"dopamine receptor ligands","score":0.45899999141693115},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.675000011920929},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6890000104904175},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7773330211639404},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.6369280219078064},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5952577590942383},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5911392569541931},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.5508267879486084},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.5046993494033813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5046862363815308},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4775010943412781},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.4767204821109772},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47424548864364624},{"id":"https://openalex.org/C14200731","wikidata":"https://www.wikidata.org/wiki/Q1752866","display_name":"D2-like receptor","level":5,"score":0.4657239615917206},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.4580773711204529},{"id":"https://openalex.org/C160262196","wikidata":"https://www.wikidata.org/wiki/Q5376331","display_name":"Endogenous agonist","level":5,"score":0.4463490843772888},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42129790782928467},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.4050198197364807},{"id":"https://openalex.org/C120750228","wikidata":"https://www.wikidata.org/wiki/Q2035393","display_name":"Dopamine receptor D1","level":4,"score":0.38090288639068604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31847894191741943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2423173487186432}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/31366","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/31366","pdf_url":"http://hdl.handle.net/2077/31366","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:280565635","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/31366/8/gupea_2077_31366_8.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/31366","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/31366","pdf_url":"http://hdl.handle.net/2077/31366","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W280565635.pdf"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W45776812","https://openalex.org/W175006040","https://openalex.org/W206085204","https://openalex.org/W595606452","https://openalex.org/W1039353764","https://openalex.org/W1502799818","https://openalex.org/W1522302812","https://openalex.org/W1523570821","https://openalex.org/W1526393440","https://openalex.org/W1546116904","https://openalex.org/W1567767515","https://openalex.org/W1736189198","https://openalex.org/W1925492557","https://openalex.org/W1966092598","https://openalex.org/W1968257988","https://openalex.org/W1971179661","https://openalex.org/W1971417227","https://openalex.org/W1972159732","https://openalex.org/W1972931244","https://openalex.org/W1973079091","https://openalex.org/W1973251131","https://openalex.org/W1973739813","https://openalex.org/W1975897272","https://openalex.org/W1975957542","https://openalex.org/W1977869470","https://openalex.org/W1978890358","https://openalex.org/W1980097507","https://openalex.org/W1980962873","https://openalex.org/W1982901809","https://openalex.org/W1982916435","https://openalex.org/W1985533494","https://openalex.org/W1985560386","https://openalex.org/W1985760248","https://openalex.org/W1990862724","https://openalex.org/W1991177440","https://openalex.org/W1993737776","https://openalex.org/W1997784657","https://openalex.org/W1998454579","https://openalex.org/W2001406669","https://openalex.org/W2001862693","https://openalex.org/W2003534327","https://openalex.org/W2004124667","https://openalex.org/W2005051528","https://openalex.org/W2006087162","https://openalex.org/W2007487695","https://openalex.org/W2011908659","https://openalex.org/W2012919466","https://openalex.org/W2017578012","https://openalex.org/W2018215998","https://openalex.org/W2021784043","https://openalex.org/W2022012830","https://openalex.org/W2026180033","https://openalex.org/W2026750936","https://openalex.org/W2027144452","https://openalex.org/W2027189331","https://openalex.org/W2027698033","https://openalex.org/W2028730857","https://openalex.org/W2030049861","https://openalex.org/W2030905853","https://openalex.org/W2031051908","https://openalex.org/W2031165805","https://openalex.org/W2032819792","https://openalex.org/W2033579865","https://openalex.org/W2034629571","https://openalex.org/W2034941411","https://openalex.org/W2038763233","https://openalex.org/W2040883320","https://openalex.org/W2041068326","https://openalex.org/W2042170152","https://openalex.org/W2042349428","https://openalex.org/W2042570040","https://openalex.org/W2042961961","https://openalex.org/W2043583025","https://openalex.org/W2046073894","https://openalex.org/W2046204255","https://openalex.org/W2047034694","https://openalex.org/W2048631643","https://openalex.org/W2048785930","https://openalex.org/W2048866978","https://openalex.org/W2054253103","https://openalex.org/W2057491831","https://openalex.org/W2058543411","https://openalex.org/W2061343703","https://openalex.org/W2063779505","https://openalex.org/W2064730371","https://openalex.org/W2065342329","https://openalex.org/W2066569368","https://openalex.org/W2068007833","https://openalex.org/W2070639484","https://openalex.org/W2070950079","https://openalex.org/W2071579644","https://openalex.org/W2071634031","https://openalex.org/W2072486526","https://openalex.org/W2073089037","https://openalex.org/W2073503722","https://openalex.org/W2079463706","https://openalex.org/W2085518524","https://openalex.org/W2087688448","https://openalex.org/W2089934994","https://openalex.org/W2089996359","https://openalex.org/W2090096265","https://openalex.org/W2090891087","https://openalex.org/W2092695053","https://openalex.org/W2094186244","https://openalex.org/W2097744565","https://openalex.org/W2099576957","https://openalex.org/W2104755990","https://openalex.org/W2104961861","https://openalex.org/W2108364115","https://openalex.org/W2109518858","https://openalex.org/W2117569373","https://openalex.org/W2117771667","https://openalex.org/W2124137436","https://openalex.org/W2125249259","https://openalex.org/W2134996660","https://openalex.org/W2138067285","https://openalex.org/W2151789070","https://openalex.org/W2153663490","https://openalex.org/W2153763527","https://openalex.org/W2155208284","https://openalex.org/W2157499002","https://openalex.org/W2163111199","https://openalex.org/W2163553768","https://openalex.org/W2166604754","https://openalex.org/W2168555516","https://openalex.org/W2168966210","https://openalex.org/W2177479668","https://openalex.org/W2206687388","https://openalex.org/W2262288602","https://openalex.org/W2322296010","https://openalex.org/W2324472445","https://openalex.org/W2324736321","https://openalex.org/W2334783452","https://openalex.org/W2342710700","https://openalex.org/W2396714115","https://openalex.org/W2402410749","https://openalex.org/W2463999367","https://openalex.org/W2504418975","https://openalex.org/W2949794922","https://openalex.org/W2953195743","https://openalex.org/W4242005644","https://openalex.org/W4406066377"],"related_works":["https://openalex.org/W2015132588","https://openalex.org/W1986333603","https://openalex.org/W2949836043","https://openalex.org/W2000863189","https://openalex.org/W312057142","https://openalex.org/W2091797845","https://openalex.org/W2057346966","https://openalex.org/W2469562486","https://openalex.org/W2331153762","https://openalex.org/W2112488667"],"abstract_inverted_index":{"The":[0,48,88,294],"endogenous":[1],"neurotransmitter":[2],"dopamine":[3,49],"(DA)":[4],"is":[5,98,372],"involved":[6,207],"in":[7,142,144,147,281,289,292,333,359,383],"several":[8],"functions":[9],"that":[10,199,214,297,370,379],"are":[11,59,232],"controlled":[12],"from":[13,183],"the":[14,53,72,81,101,121,152,175,184,192,195,203,235,267,286,301,307,313,330,342,345,353,356,368,382],"central":[15],"nervous":[16],"system":[17],"(CNS),":[18],"for":[19,96,123,172,329,387],"example":[20],"behaviour,":[21],"memory,":[22],"cognition":[23],"and":[24,58,104,112,131,136,146,179,208,266,291,303,348,352],"reward.":[25],"A":[26,221,351],"disturbed":[27],"dopaminergic":[28,91,125],"neurotransmission":[29],"may":[30],"lead":[31,380],"to":[32,52,174,226,234,326,344,349,367,381],"many":[33],"severe":[34],"conditions,":[35],"such":[36],"as":[37,94,107,310,312],"schizophrenia,":[38],"attention":[39],"deficit":[40],"hyperactivity":[41],"disorder":[42],"(ADHD)":[43],"or":[44,74,318],"Parkinson's":[45],"disease":[46],"(PD).":[47],"receptors":[50,56],"belong":[51],"G-protein":[54],"coupled":[55],"(GPCRs)":[57],"divided":[60],"into":[61],"five":[62],"distinct":[63],"subtypes":[64,67],"(D1-D5).":[65],"These":[66],"can":[68],"be":[69,327],"either":[70],"of":[71,83,129,160,191,194,216,253,269,277,306,355,390],"D1-":[73],"D2-types":[75],"based":[76],"on":[77,80],"their":[78,137],"effect":[79],"production":[82],"cyclic":[84],"adenosine":[85],"monophosphate":[86],"(cAMP).":[87],"most":[89],"common":[90],"receptor":[92,103,116,205,347],"used":[93],"target":[95],"pharmaceuticals":[97],"by":[99,251],"far":[100],"D2":[102,165,204,346],"drugs":[105],"acting":[106],"full":[108],"agonists,":[109],"partial":[110,154,254],"agonists":[111],"antagonists":[113,166],"at":[114],"this":[115,282,388],"have":[117,133,139],"been":[118,134,140,362],"developed.":[119],"\\nIn":[120],"search":[122],"new":[124],"ligands,":[126],"a":[127,169,316,319,338],"set":[128,244],"4-phenylpiperidines":[130],"4-phenylpiperazines":[132],"synthesized":[135],"effects":[138],"tested":[141],"both":[143,288],"vivo":[145,290,384],"vitro":[148],"assays.":[149],"Starting":[150],"with":[151,168,241,260,375],"known":[153],"agonist":[155,176],"3-(1-benzylpiperidin-4-yl)phenol,":[156],"stepwise":[157],"structural":[158,230,279,295],"modifications":[159,280],"functional":[161],"groups":[162],"afforded":[163],"mainly":[164],"but":[167],"conserved":[170],"preference":[171],"binding":[173,177,209],"site":[178],"fast":[180],"dissociation":[181],"rates":[182],"receptor.":[185],"However,":[186],"further":[187],"modifications,":[188],"including":[189],"changes":[190],"position":[193,302],"aromatic":[196,308],"substituent,":[197],"indicated":[198],"other":[200],"targets":[201,378],"than":[202],"was":[206],"affinity":[210],"studies":[211],"later":[212],"concluded":[213],"some":[215,334],"these":[217,270,322,376],"compounds":[218],"had":[219],"MAO":[220,350],"inhibiting":[222],"properties.":[223],"In":[224,336],"order":[225],"fully":[227],"elucidate":[228],"what":[229],"properties":[231,305,323],"related":[233],"different":[236,331],"pharmacological":[237],"responses,":[238],"QSAR":[239],"models":[240,271],"physicochemical":[242,304],"descriptors":[243],"against":[245],"each":[246],"respective":[247],"response":[248,287,385],"were":[249,264,298],"acquired":[250],"means":[252],"least":[255],"square":[256],"(PLS)":[257],"regression.":[258],"Models":[259],"high":[261],"predictivity":[262],"(Q2>0.53)":[263],"obtained":[265],"interpretation":[268],"has":[272,361],"provided":[273],"an":[274],"improved":[275],"understanding":[276],"how":[278],"chemical":[283],"class":[284,389],"affect":[285],"vitro.":[293],"motifs":[296],"investigated":[299],"included":[300],"substituent":[309],"well":[311],"heterocycle":[314],"being":[315],"piperazine":[317],"piperidine.":[320],"All":[321],"turned":[324],"out":[325],"significant":[328],"responses":[332],"aspect.":[335],"addition,":[337],"strong":[339],"correlation":[340],"between":[341],"affinities":[343],"levels":[354],"metabolite":[357],"DOPAC":[358],"striatum":[360],"established.":[363],"This":[364],"led":[365],"us":[366],"conclusion":[369],"it":[371],"primarily":[373],"interactions":[374],"two":[377],"observed":[386],"compounds.":[391]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}