{"id":"https://openalex.org/W2805655504","doi":"https://doi.org/10.1136/esmoopen-2018-000329","title":"Clonal evolution of colorectal cancer in a patient with serially resected metastases and liquid biopsies: a case report and discussion of the literature","display_name":"Clonal evolution of colorectal cancer in a patient with serially resected metastases and liquid biopsies: a case report and discussion of the literature","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2805655504","doi":"https://doi.org/10.1136/esmoopen-2018-000329","mag":"2805655504","pmid":"https://pubmed.ncbi.nlm.nih.gov/29942663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6012565"},"language":"en","primary_location":{"id":"doi:10.1136/esmoopen-2018-000329","doi":"https://doi.org/10.1136/esmoopen-2018-000329","is_oa":true,"landing_page_url":"https://doi.org/10.1136/esmoopen-2018-000329","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1136/esmoopen-2018-000329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007523105","display_name":"Myrto Kastrisiou","orcid":"https://orcid.org/0000-0003-3261-0228","observed_orcids":["https://orcid.org/0000-0003-3261-0228"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Myrto Kastrisiou","raw_affiliation_strings":["Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece","Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060334897","display_name":"George Zarkavelis","orcid":"https://orcid.org/0000-0001-5961-2237","observed_orcids":["https://orcid.org/0000-0001-5961-2237"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Zarkavelis","raw_affiliation_strings":["Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece","Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062721938","display_name":"Eleftherios O. Kampletsas","orcid":"https://orcid.org/0009-0002-6865-7255","observed_orcids":["https://orcid.org/0009-0002-6865-7255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleftherios Kampletsas","raw_affiliation_strings":["Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eleni Panopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Panopoulou","raw_affiliation_strings":["Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034989963","display_name":"ANNA C. GOUSSIA","orcid":"https://orcid.org/0000-0002-4134-6177","observed_orcids":["https://orcid.org/0000-0002-4134-6177"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anna Goussia","raw_affiliation_strings":["Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023140801","display_name":"George Nasioulas","orcid":"https://orcid.org/0009-0002-9891-1883","observed_orcids":["https://orcid.org/0009-0002-9891-1883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Nasioulas","raw_affiliation_strings":["GeneKor Medical SA, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneKor Medical SA, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052598","display_name":"Eirini Papadopoulou","orcid":"https://orcid.org/0000-0001-5519-5325","observed_orcids":["https://orcid.org/0000-0001-5519-5325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eirini Papadopoulou","raw_affiliation_strings":["GeneKor Medical SA, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneKor Medical SA, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033307302","display_name":"Christina Tsaousi","orcid":"https://orcid.org/0000-0003-3135-1586","observed_orcids":["https://orcid.org/0000-0003-3135-1586"]},"institutions":[{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christina Tsaousi","raw_affiliation_strings":["Haematology Laboratory, Ioannina University Hospital, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology Laboratory, Ioannina University Hospital, Ioannina, Greece","institution_ids":["https://openalex.org/I4210141877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015437737","display_name":"George E. Pentheroudakis","orcid":"https://orcid.org/0000-0002-6632-2462","observed_orcids":["https://orcid.org/0000-0002-6632-2462"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"George Pentheroudakis","raw_affiliation_strings":["Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece","Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Ioannina, Greece","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015437737"],"corresponding_institution_ids":["https://openalex.org/I194019607"],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":{"value":3910,"currency":"USD","value_usd":3910},"fwci":0.0756,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34580389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"4","first_page":"e000329","last_page":"e000329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8669999837875366},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.8460000157356262},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7117201685905457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5712777972221375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5202102065086365},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.4754445552825928},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.47483736276626587},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3856014907360077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3020966649055481}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1136/esmoopen-2018-000329","doi":"https://doi.org/10.1136/esmoopen-2018-000329","is_oa":true,"landing_page_url":"https://doi.org/10.1136/esmoopen-2018-000329","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4966670","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6012565","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6012565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6012565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"Text"},{"id":"pmid:29942663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29942663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO open","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/esmoopen-2018-000329","doi":"https://doi.org/10.1136/esmoopen-2018-000329","is_oa":true,"landing_page_url":"https://doi.org/10.1136/esmoopen-2018-000329","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1914351667","https://openalex.org/W2027735722","https://openalex.org/W2035022458","https://openalex.org/W2041142042","https://openalex.org/W2079551052","https://openalex.org/W2116716449","https://openalex.org/W2135129362","https://openalex.org/W2135449254","https://openalex.org/W2272438203","https://openalex.org/W2534249763","https://openalex.org/W2580761361","https://openalex.org/W2587988233","https://openalex.org/W2752462502","https://openalex.org/W4235642752","https://openalex.org/W4235857807"],"related_works":["https://openalex.org/W3135896458","https://openalex.org/W2787270690","https://openalex.org/W3212770426","https://openalex.org/W3040733624","https://openalex.org/W2724624620","https://openalex.org/W4252283243","https://openalex.org/W2580761361","https://openalex.org/W3179400249","https://openalex.org/W2977320472","https://openalex.org/W3033925901"],"abstract_inverted_index":{"BACKGROUND:":[0],"Metastatic":[1],"colorectal":[2,49],"cancer":[3,50],"represents":[4],"a":[5,43,46],"striking":[6],"example":[7],"of":[8,26,36,45,54,77,92,99,108],"clonal":[9,27],"heterogeneity":[10,28],"and":[11,51,61,88,112],"tumour":[12,72,111],"evolution,":[13],"which":[14,57],"generates":[15],"acquired":[16],"resistance":[17],"to":[18,22,117,134,145],"therapy.":[19],"Once":[20],"hard":[21],"perform,":[23],"the":[24,34,70,78,86,89,100,106,109,127],"study":[25],"is":[29],"now":[30],"significantly":[31],"aided":[32],"by":[33],"use":[35],"liquid":[37,95,119,136],"biopsies.":[38,96],"METHOD:":[39],"We":[40],"herein":[41],"report":[42],"case":[44,125],"patient":[47,124],"with":[48,139],"serial":[52],"development":[53],"multiple":[55],"metastases":[56],"were":[58],"all":[59],"resected":[60],"genotyped.":[62],"A":[63],"rare":[64],"point":[65],"mutation":[66],"was":[67],"identified":[68],"in":[69,75,85,105,143,151],"primary":[71],"(but":[73],"not":[74],"any":[76],"organ":[79],"metastatic":[80],"sites),":[81],"as":[82,84],"well":[83],"first":[87],"last":[90],"out":[91],"three":[93],"consecutive":[94],"The":[97],"review":[98],"literature":[101],"offered":[102],"some":[103],"insight":[104],"evolution":[107],"patient's":[110],"general":[113],"directions":[114],"on":[115],"how":[116],"interpret":[118],"biopsy":[120,137],"results.":[121],"CONCLUSIONS:":[122],"This":[123],"emphasises":[126],"need":[128],"for":[129],"large":[130],"prospective":[131],"studies":[132],"designed":[133],"bridge":[135],"data":[138],"useful":[140],"clinical":[141],"endpoints,":[142],"order":[144],"optimally":[146],"integrate":[147],"this":[148],"revolutionary":[149],"tool":[150],"everyday":[152],"practice.":[153]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-06-13T00:00:00"}