{"id":"https://openalex.org/W2805631273","doi":"https://doi.org/10.1016/j.cct.2018.06.001","title":"Methylene blue MMX\u00ae tablets for chromoendoscopy. Bioavailability, colon staining and safety in healthy volunteers undergoing a full colonoscopy","display_name":"Methylene blue MMX\u00ae tablets for chromoendoscopy. Bioavailability, colon staining and safety in healthy volunteers undergoing a full colonoscopy","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2805631273","doi":"https://doi.org/10.1016/j.cct.2018.06.001","mag":"2805631273","pmid":"https://pubmed.ncbi.nlm.nih.gov/29864547"},"language":"en","primary_location":{"id":"doi:10.1016/j.cct.2018.06.001","doi":"https://doi.org/10.1016/j.cct.2018.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cct.2018.06.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1551714418300302/pdf","source":{"id":"https://openalex.org/S63040059","display_name":"Contemporary Clinical Trials","issn_l":"1551-7144","issn":["1551-7144","1559-2030"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary Clinical Trials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1551714418300302/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039418277","display_name":"Andrea F. D. Di Stefano","orcid":"https://orcid.org/0000-0002-4316-9039","observed_orcids":["https://orcid.org/0000-0002-4316-9039"]},"institutions":[{"id":"https://openalex.org/I4405267631","display_name":"CROSS Research SA (Switzerland)","ror":"https://ror.org/03nqjwm69","country_code":"CH","type":"company","lineage":["https://openalex.org/I4405267631"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"A.F.D. Di Stefano","raw_affiliation_strings":["Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland. Electronic address: andrea.distefano@croalliance.com","Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-4316-9039","affiliations":[{"raw_affiliation_string":"Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland. Electronic address: andrea.distefano@croalliance.com","institution_ids":["https://openalex.org/I4405267631"]},{"raw_affiliation_string":"Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland","institution_ids":["https://openalex.org/I4405267631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027823359","display_name":"Milko Massimiliano Radicioni","orcid":"https://orcid.org/0000-0002-3940-8375","observed_orcids":["https://orcid.org/0000-0002-3940-8375"]},"institutions":[{"id":"https://openalex.org/I4405267631","display_name":"CROSS Research SA (Switzerland)","ror":"https://ror.org/03nqjwm69","country_code":"CH","type":"company","lineage":["https://openalex.org/I4405267631"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M.M. Radicioni","raw_affiliation_strings":["Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland","institution_ids":["https://openalex.org/I4405267631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063647537","display_name":"Angelo Vaccani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267631","display_name":"CROSS Research SA (Switzerland)","ror":"https://ror.org/03nqjwm69","country_code":"CH","type":"company","lineage":["https://openalex.org/I4405267631"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A. Vaccani","raw_affiliation_strings":["Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cross Research S.A., Via F. A. Giorgioli, 14, Arzo CH-6864, Switzerland","institution_ids":["https://openalex.org/I4405267631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067419326","display_name":"A. Fransioli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119562","display_name":"Ospedale Regionale di Bellinzona e Valli","ror":"https://ror.org/02s61w335","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210119562"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A. Fransioli","raw_affiliation_strings":["Department of Gastreonterology, Regional Hospital, Bellinzona, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastreonterology, Regional Hospital, Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4210119562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046211909","display_name":"Luigi Maria Longo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Longo","raw_affiliation_strings":["Cosmo Technologies Ltd., Riverside II, Sir John Rogerson's Quay, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmo Technologies Ltd., Riverside II, Sir John Rogerson's Quay, Dublin 2, Ireland","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Moro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Moro","raw_affiliation_strings":["Cosmo Technologies Ltd., Riverside II, Sir John Rogerson's Quay, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmo Technologies Ltd., Riverside II, Sir John Rogerson's Quay, Dublin 2, Ireland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020927144","display_name":"Alessandro Repici","orcid":"https://orcid.org/0000-0002-1621-6450","observed_orcids":["https://orcid.org/0000-0002-1621-6450"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Repici","raw_affiliation_strings":["Department of Gastreonterology, IRCCS Istituto Clinico Humanitas, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastreonterology, IRCCS Istituto Clinico Humanitas, Milan, Italy","institution_ids":["https://openalex.org/I4210163047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039418277"],"corresponding_institution_ids":["https://openalex.org/I4405267631"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":{"value":3140,"currency":"USD","value_usd":3140},"fwci":0.7306,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.72689517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"71","issue":null,"first_page":"96","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13921","display_name":"Biological Stains and Phytochemicals","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromoendoscopy","display_name":"chromoendoscopy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/colonoscopy","display_name":"colonoscopy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9240000247955322},{"id":"https://openalex.org/keywords/bowel-preparation","display_name":"bowel preparation","score":0.5479999780654907},{"id":"https://openalex.org/keywords/colorectal-adenoma-detection","display_name":"colorectal adenoma detection","score":0.7409999966621399},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.4690000116825104},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5740000009536743},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8926877975463867},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.7294439077377319},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6883826851844788},{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.6598079204559326},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5723108053207397},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5391817688941956},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5324678421020508},{"id":"https://openalex.org/C2777068960","wikidata":"https://www.wikidata.org/wiki/Q417874","display_name":"Bisacodyl","level":5,"score":0.5022091865539551},{"id":"https://openalex.org/C2777490804","wikidata":"https://www.wikidata.org/wiki/Q5113878","display_name":"Chromoendoscopy","level":5,"score":0.48062199354171753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4278663694858551},{"id":"https://openalex.org/C71527416","wikidata":"https://www.wikidata.org/wiki/Q3774852","display_name":"Cathartic","level":2,"score":0.422305703163147},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.2954736351966858},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23015645146369934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09068751335144043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002400","descriptor_name":"Cathartics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058996","descriptor_name":"Quality Improvement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065667","descriptor_name":"Renal Elimination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cct.2018.06.001","doi":"https://doi.org/10.1016/j.cct.2018.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cct.2018.06.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1551714418300302/pdf","source":{"id":"https://openalex.org/S63040059","display_name":"Contemporary Clinical Trials","issn_l":"1551-7144","issn":["1551-7144","1559-2030"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary Clinical Trials","raw_type":"journal-article"},{"id":"pmid:29864547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29864547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary clinical trials","raw_type":"Journal Article"},{"id":"pmh:oai:zenodo.org:83453","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/83453","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.cct.2018.06.001","doi":"https://doi.org/10.1016/j.cct.2018.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cct.2018.06.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1551714418300302/pdf","source":{"id":"https://openalex.org/S63040059","display_name":"Contemporary Clinical Trials","issn_l":"1551-7144","issn":["1551-7144","1559-2030"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary Clinical Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805631273.pdf","grobid_xml":"https://content.openalex.org/works/W2805631273.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W112662023","https://openalex.org/W1972080095","https://openalex.org/W1994928667","https://openalex.org/W1994935402","https://openalex.org/W2023558210","https://openalex.org/W2057146183","https://openalex.org/W2059198233","https://openalex.org/W2062641303","https://openalex.org/W2066229398","https://openalex.org/W2085444179","https://openalex.org/W2094207612","https://openalex.org/W2098733700","https://openalex.org/W2142821946","https://openalex.org/W4242755597"],"related_works":["https://openalex.org/W1972080095","https://openalex.org/W2002114527","https://openalex.org/W1992483207","https://openalex.org/W1994935402","https://openalex.org/W2945108208","https://openalex.org/W7217276931","https://openalex.org/W2327800482","https://openalex.org/W2913899589","https://openalex.org/W2805433088","https://openalex.org/W2332768154"],"abstract_inverted_index":{"Methylene":[0,138],"blue-MMX\u00ae":[1],"tablets":[2,73],"are":[3],"proposed":[4],"as":[5,84],"an":[6],"aid":[7],"for":[8,119],"detection":[9,23],"and":[10,14,25,39,52,66,89,98,105,157,172,184,191,194,211,277,279],"visualisation":[11],"of":[12,29,37,63,87,113,123,151,225,231],"adenomas":[13],"carcinomas":[15],"in":[16,94,125,132,146],"patients":[17],"undergoing":[18,47],"colonoscopy,":[19],"by":[20],"improving":[21],"their":[22],"rate":[24],"highlighting":[26],"the":[27,30,58,67,72,80,85,95,103,106,133,188,198,232,250,272,283],"presence":[28],"intestinal":[31],"dysplastic":[32],"lesions.":[33],"Single":[34],"total":[35],"doses":[36],"100":[38,134,155,170,209],"200":[40,78,161,178,215],"mg":[41,135,156,171,210,216],"were":[42,74,117,130],"administered":[43,235],"to":[44,56,71,218,249,274,286,296],"healthy":[45],"volunteers":[46],"a":[48,53,143,147,238,261],"bowel":[49,239],"cleansing":[50,240],"preparation":[51,241],"full":[54],"colonoscopy":[55],"investigate":[57],"colonic":[59,121],"staining.":[60],"The":[61,201,222,255],"pharmacokinetics":[62],"methylene":[64,297],"blue":[65,139],"safety":[68],"after":[69,169,177,187,197,208,214,228],"exposure":[70],"also":[75],"investigated.":[76],"With":[77],"mg,":[79],"best":[81],"staining,":[82,91],"assessed":[83],"sum":[86],"acceptable":[88],"good":[90],"was":[92,164,205,242,247,260,293],"achieved":[93],"ascending":[96],"colon":[97,108],"rectosigmoid":[99],"(75%":[100],"subjects":[101],"each),":[102],"transverse":[104],"descending":[107],"(approximately":[109],"63%":[110],"each).":[111],"Absence":[112],"staining":[114],"or":[115],"overstaining":[116],"reported":[118],"no":[120],"region":[122],"interest":[124],"any":[126],"subject.":[127],"Similar":[128],"results":[129],"observed":[131],"dose":[136,190,230],"group.":[137],"blood":[140],"concentrations":[141],"reached":[142],"peak":[144],"(Cmax)":[145],"median":[148],"time":[149],"(Tmax)":[150],"12":[152],"h":[153,159,186,196,220],"with":[154,160,237],"16":[158],"mg.":[162,179],"AUC0-t":[163],"10.7":[165],"\u00b1":[166,174],"6.7":[167],"\u03bcg/mLxh":[168,176],"25.2":[173],"7.4":[175],"Half-life":[180],"ranged":[181],"between":[182,192],"9":[183],"22":[185],"lower":[189],"6":[193],"26":[195],"higher":[199],"dose.":[200],"cumulative":[202],"urinary":[203],"excretion":[204],"about":[206,212],"28%":[207],"39%":[213],"up":[217],"60":[219],"post-dose.":[221],"overall":[223],"frequency":[224],"adverse":[226,258,267,288],"events":[227],"single":[229],"test":[233,251],"product":[234],"along":[236],"39%,":[243],"but":[244],"only":[245],"one":[246,287],"related":[248,295],"product:":[252],"abnormal":[253],"transaminases.":[254],"most":[256],"frequent":[257],"event":[259,268,289,292],"transient":[262],"polyuria":[263],"(17%).":[264],"One":[265],"serious":[266],"(gastrointestinal":[269],"haemorrhage)":[270],"led":[271],"subject":[273,281],"study":[275,284],"discontinuation":[276],"hospitalisation":[278],"another":[280],"withdrew":[282],"due":[285],"(haematemesis).":[290],"Either":[291],"not":[294],"blue.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}
