{"id":"https://openalex.org/W2805622227","doi":"https://doi.org/10.1038/s41598-018-27121-w","title":"Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington\u2019s Disease","display_name":"Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington\u2019s Disease","publication_year":2018,"publication_date":"2018-06-06","ids":{"openalex":"https://openalex.org/W2805622227","doi":"https://doi.org/10.1038/s41598-018-27121-w","mag":"2805622227","pmid":"https://pubmed.ncbi.nlm.nih.gov/29895889","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5997749"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-27121-w","doi":"https://doi.org/10.1038/s41598-018-27121-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27121-w","pdf_url":"https://www.nature.com/articles/s41598-018-27121-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-27121-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036846314","display_name":"Ana Isabel Duarte","orcid":"https://orcid.org/0000-0002-0223-7867","observed_orcids":["https://orcid.org/0000-0002-0223-7867"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT","SE"],"is_corresponding":true,"raw_author_name":"Ana I. Duarte","raw_affiliation_strings":["Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. ana.duarte@cnc.uc.pt","CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. ana.duarte@cnc.uc.pt","Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal. ana.duarte@cnc.uc.pt","CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-0223-7867","affiliations":[{"raw_affiliation_string":"Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. ana.duarte@cnc.uc.pt","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. ana.duarte@cnc.uc.pt","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal. ana.duarte@cnc.uc.pt","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086838264","display_name":"Marie Sj\u00f6gren","orcid":"https://orcid.org/0000-0003-3443-4539","observed_orcids":["https://orcid.org/0000-0003-3443-4539"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marie Sj\u00f6gren","raw_affiliation_strings":["Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026086117","display_name":"Maria S. Santos","orcid":"https://orcid.org/0000-0002-6881-9392","observed_orcids":["https://orcid.org/0000-0002-6881-9392"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria S. Santos","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","Life Sciences Department, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Life Sciences Department, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058867273","display_name":"Catarina Resende Oliveira","orcid":"https://orcid.org/0000-0001-6942-4328","observed_orcids":["https://orcid.org/0000-0001-6942-4328"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina R. Oliveira","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","Laboratory of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Laboratory of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053059798","display_name":"Paula Isabel Moreira","orcid":"https://orcid.org/0000-0001-5177-6747","observed_orcids":["https://orcid.org/0000-0001-5177-6747"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula I. Moreira","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","Laboratory of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5177-6747","affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Laboratory of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003327629","display_name":"Maria Bj\u00f6rkqvist","orcid":"https://orcid.org/0000-0001-8550-0431","observed_orcids":["https://orcid.org/0000-0001-8550-0431"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maria Bj\u00f6rkqvist","raw_affiliation_strings":["Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036846314"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4394709155","https://openalex.org/I76903346"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.2711,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.75979631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"8961","last_page":"8961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/dual-therapy","display_name":"dual therapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.9319999814033508},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/r6-2-mouse-model","display_name":"R6/2 mouse model","score":0.8289999961853027},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9879999756813049},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6489999890327454},{"id":"https://openalex.org/keywords/amp","display_name":"AMP","score":0.5830000042915344},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6660000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4560000002384186},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7170000076293945},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2781308992","wikidata":"https://www.wikidata.org/wiki/Q2526479","display_name":"Liraglutide","level":4,"score":0.9616923332214355},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.8866475820541382},{"id":"https://openalex.org/C2777205416","wikidata":"https://www.wikidata.org/wiki/Q433807","display_name":"Orexigenic","level":5,"score":0.8491666316986084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8161720037460327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7888894081115723},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5046995878219604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45125022530555725},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.44641247391700745},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4137406051158905},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2474350929260254},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.23330047726631165},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.15086153149604797},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.12265726923942566},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08380833268165588}],"mesh":[{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-018-27121-w","doi":"https://doi.org/10.1038/s41598-018-27121-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27121-w","pdf_url":"https://www.nature.com/articles/s41598-018-27121-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4962853","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5997749","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5997749","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5997749","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:29895889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29895889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:estudogeral.uc.pt:10316/108048","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/108048","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/108048/1/Dual-Therapy-with-Liraglutide-and-Ghrelin-Promotes-Brain-and-Peripheral-Energy-Metabolism-in-the-R62-Mouse-Model-of-Huntingtons-DiseaseScientific-Reports.pdf","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:639a238eb523436daf6b9d5fa51caa87","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/639a238eb523436daf6b9d5fa51caa87","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:a3f89bae-1783-48f2-850d-45fbf753fbf3","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/a3f89bae-1783-48f2-850d-45fbf753fbf3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2045-2322","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-27121-w","doi":"https://doi.org/10.1038/s41598-018-27121-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27121-w","pdf_url":"https://www.nature.com/articles/s41598-018-27121-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1578237752","display_name":null,"funder_award_id":"COMPETE","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2017592390","display_name":"Unravelling the neuroprotective role of peripheral co-administration of liraglutide and ghrelin on brain and cognitive function in Huntington disease - IMPACT OF PERIPHERAL EXENDIN-4 THERAPY ON THE MOLECULAR MECHANISMS UNDERLYING DIFFERENTIAL GENDER-RELATED BRAIN FUNCTION IN LONG-TERM TYPE 2 DIABETES","funder_award_id":"SFRH/BPD/84473/2012","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2616170677","display_name":"Impacto da terapia com exendina-4 nos mecanismos moleculares subjacentes \u00e0 disfun\u00e7\u00e3o cerebral associada \u00e0 diabetes tipo 2 a longo prazo","funder_award_id":"PTDC/SAU-TOX/117481/2010","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3891694003","display_name":null,"funder_award_id":"COMPETE_2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320315992","display_name":"European Huntington's Disease Network","ror":"https://ror.org/01wqpd686"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805622227.pdf","grobid_xml":"https://content.openalex.org/works/W2805622227.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1498240733","https://openalex.org/W1513688899","https://openalex.org/W1573376105","https://openalex.org/W1607364459","https://openalex.org/W1637971961","https://openalex.org/W1767153687","https://openalex.org/W1969040512","https://openalex.org/W1981108341","https://openalex.org/W1985474993","https://openalex.org/W1987732936","https://openalex.org/W1993418561","https://openalex.org/W1994995334","https://openalex.org/W1999012914","https://openalex.org/W2001573546","https://openalex.org/W2005755833","https://openalex.org/W2006568691","https://openalex.org/W2008197152","https://openalex.org/W2009115851","https://openalex.org/W2011325404","https://openalex.org/W2015788437","https://openalex.org/W2027835288","https://openalex.org/W2030270894","https://openalex.org/W2034295826","https://openalex.org/W2035027334","https://openalex.org/W2038537185","https://openalex.org/W2040678727","https://openalex.org/W2042879634","https://openalex.org/W2048277695","https://openalex.org/W2049375442","https://openalex.org/W2060571859","https://openalex.org/W2062682951","https://openalex.org/W2062867488","https://openalex.org/W2076671275","https://openalex.org/W2079124378","https://openalex.org/W2089503385","https://openalex.org/W2090644845","https://openalex.org/W2095387147","https://openalex.org/W2096944314","https://openalex.org/W2105807400","https://openalex.org/W2113455273","https://openalex.org/W2118959823","https://openalex.org/W2121642311","https://openalex.org/W2124620553","https://openalex.org/W2127294578","https://openalex.org/W2128537698","https://openalex.org/W2134304063","https://openalex.org/W2136721455","https://openalex.org/W2138677261","https://openalex.org/W2143781333","https://openalex.org/W2145196491","https://openalex.org/W2145213346","https://openalex.org/W2145924144","https://openalex.org/W2146103593","https://openalex.org/W2148970249","https://openalex.org/W2151190344","https://openalex.org/W2153012133","https://openalex.org/W2160234571","https://openalex.org/W2178372855","https://openalex.org/W2336395638","https://openalex.org/W2487019969","https://openalex.org/W2567924267","https://openalex.org/W2607031541","https://openalex.org/W2612973617","https://openalex.org/W2743474796","https://openalex.org/W2766106849","https://openalex.org/W2766437384","https://openalex.org/W4256297099"],"related_works":["https://openalex.org/W2891676595","https://openalex.org/W2560251609","https://openalex.org/W2916632467","https://openalex.org/W2766437384","https://openalex.org/W2976046304","https://openalex.org/W2560789738","https://openalex.org/W2891254648","https://openalex.org/W2888643581","https://openalex.org/W2075066102","https://openalex.org/W2347202413"],"abstract_inverted_index":{"Neuronal":[0],"loss":[1],"alongside":[2,42,174],"altered":[3,78],"energy":[4,28,86,200],"metabolism,":[5,73],"are":[6],"key":[7],"features":[8,148],"of":[9,63,94,134],"Huntington's":[10],"disease":[11],"(HD)":[12],"pathology.":[13],"The":[14,59],"orexigenic":[15,49],"gut-peptide":[16],"hormone":[17],"ghrelin":[18,51,130,180],"is":[19,31],"known":[20],"to":[21],"stimulate":[22],"appetite":[23],"and":[24,77,96,110,113,138,168,186],"affect":[25],"whole":[26],"body":[27,79,156,159],"metabolism.":[29],"Liraglutide":[30,161,178],"an":[32],"efficient":[33],"anti-type":[34],"2":[35,143],"diabetes":[36],"incretin":[37],"drug,":[38],"with":[39,47,129],"neuroprotective":[40],"effects":[41],"anorectic":[43],"properties.":[44],"Combining":[45],"liraglutide":[46,95],"the":[48,114,150],"peptide":[50],"may":[52],"potentially":[53],"promote":[54],"brain/cognitive":[55],"function":[56,118],"in":[57,88,119,149,171,189,202],"HD.":[58,120,203],"R6/2":[60,89,151,172,190],"mouse":[61],"model":[62],"HD":[64],"exhibits":[65],"progressive":[66],"central":[67],"pathology,":[68],"weight":[69,157],"loss,":[70],"deranged":[71],"glucose":[72,146],"skeletal":[74],"muscle":[75],"atrophy":[76],"composition.":[80,160],"In":[81],"this":[82],"study,":[83],"we":[84],"targeted":[85],"metabolism":[87,201],"mice":[90],"using":[91],"a":[92],"co-administration":[93],"ghrelin.":[97],"We":[98,121],"investigated":[99],"their":[100],"effect":[101],"on":[102,116],"brain":[103,164,182],"cortical":[104,165],"hormone-mediated":[105],"intracellular":[106],"signalling":[107],"pathways,":[108],"metabolic":[109],"apoptotic":[111],"markers,":[112],"impact":[115],"motor":[117],"here":[122],"demonstrate":[123],"that":[124],"liraglutide,":[125],"alone":[126,162],"or":[127,158],"together":[128],"(subcutaneous":[131],"daily":[132],"injections":[133],"150":[135],"\u00b5g/kg":[136],"(ghrelin)":[137],"0.2":[139],"mg/kg":[140],"(liraglutide),":[141],"for":[142],"weeks),":[144],"normalized":[145],"homeostatic":[147],"mouse,":[152],"without":[153],"substantially":[154],"affecting":[155],"decreased":[163,181],"active":[166],"GLP-1":[167],"IGF-1":[169],"levels":[170,188],"mice,":[173],"higher":[175],"ADP":[176],"levels.":[177],"plus":[179],"insulin,":[183],"lactate,":[184],"AMP":[185],"cholesterol":[187],"mice.":[191],"Taken":[192],"together,":[193],"our":[194],"findings":[195],"encourage":[196],"further":[197],"studies":[198],"targeting":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-13T00:00:00"}