{"id":"https://openalex.org/W2805605813","doi":"https://doi.org/10.7490/f1000research.1115528.1","title":"Is there a role for combined use of Gabapentin and Pregabalin in pain control? Too good to be true?","display_name":"Is there a role for combined use of Gabapentin and Pregabalin in pain control? Too good to be true?","publication_year":2018,"publication_date":"2018-06-07","ids":{"openalex":"https://openalex.org/W2805605813","doi":"https://doi.org/10.7490/f1000research.1115528.1","mag":"2805605813"},"language":"en","primary_location":{"id":"doi:10.7490/f1000research.1115528.1","doi":"https://doi.org/10.7490/f1000research.1115528.1","is_oa":true,"landing_page_url":"https://doi.org/10.7490/f1000research.1115528.1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7490/f1000research.1115528.1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052056735","display_name":"Helen Senderovich","orcid":"https://orcid.org/0000-0003-0449-7029","observed_orcids":["https://orcid.org/0000-0003-0449-7029"]},"institutions":[{"id":"https://openalex.org/I4405258058","display_name":"Baycrest Academy for Research and Education","ror":"https://ror.org/001fxzj49","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4405258058"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Helen Senderovich","raw_affiliation_strings":["Baycrest Health Sciences System, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baycrest Health Sciences System, Canada","institution_ids":["https://openalex.org/I4405258058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036601480","display_name":"Geetha Jeyapragasan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geetha Jeyapragasan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061155472","display_name":"Michal Moshkovich","orcid":"https://orcid.org/0009-0001-7612-3950","observed_orcids":["https://orcid.org/0009-0001-7612-3950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Moshkovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082588518","display_name":"Shaira Wignarajah","orcid":"https://orcid.org/0000-0001-7324-9104","observed_orcids":["https://orcid.org/0000-0001-7324-9104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaira Wignarajah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052056735"],"corresponding_institution_ids":["https://openalex.org/I4405258058"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":1.0},{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6320000290870667},{"id":"https://openalex.org/keywords/gabapentinoids","display_name":"gabapentinoids","score":0.824999988079071},{"id":"https://openalex.org/keywords/synergistic-analgesic-effect","display_name":"synergistic analgesic effect","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.9279999732971191},{"id":"https://openalex.org/keywords/adjuvant-analgesia","display_name":"adjuvant analgesia","score":0.7080000042915344},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.9821096658706665},{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.9762067794799805},{"id":"https://openalex.org/C2983643791","wikidata":"https://www.wikidata.org/wiki/Q1999993","display_name":"Open peer review","level":3,"score":0.9396215677261353},{"id":"https://openalex.org/C2991742891","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain control","level":2,"score":0.7187833786010742},{"id":"https://openalex.org/C2992936677","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Plant biology","level":2,"score":0.6847622394561768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6455028057098389},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.5374565124511719},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.490548312664032},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4088793992996216},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3663683235645294},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2612972855567932},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.20601066946983337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13550454378128052},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06719636917114258},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7490/f1000research.1115528.1","doi":"https://doi.org/10.7490/f1000research.1115528.1","is_oa":true,"landing_page_url":"https://doi.org/10.7490/f1000research.1115528.1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.7490/f1000research.1115528.1","doi":"https://doi.org/10.7490/f1000research.1115528.1","is_oa":true,"landing_page_url":"https://doi.org/10.7490/f1000research.1115528.1","pdf_url":null,"source":{"id":"https://openalex.org/S7407050752","display_name":"Faculty of 1000 Research Ltd","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"},{"id":"mag:2805605813","doi":null,"is_oa":true,"landing_page_url":"https://f1000research.com/posters/7-712","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"F1000Research","raw_type":null}],"best_oa_location":{"id":"doi:10.7490/f1000research.1115528.1","doi":"https://doi.org/10.7490/f1000research.1115528.1","is_oa":true,"landing_page_url":"https://doi.org/10.7490/f1000research.1115528.1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4311325658","https://openalex.org/W4392345380","https://openalex.org/W1565733093","https://openalex.org/W7214115259","https://openalex.org/W2139106120","https://openalex.org/W2411442671","https://openalex.org/W7214172527","https://openalex.org/W4294163185","https://openalex.org/W4411065905","https://openalex.org/W7165791271"],"abstract_inverted_index":{"Gabapentin":[0],"(Neurontin)":[1],"and":[2,7,12,51,54,92],"Pregabalin":[3],"(Lyrica)":[4],"are":[5,13],"first":[6],"second-generation":[8],"\u03b12delta":[9],"ligands,":[10],"respectively,":[11],"both":[14,49],"approved":[15],"for":[16,68],"use":[17],"as":[18],"adjunctive":[19],"therapy":[20],"in":[21,46,48,63,79,102],"pain":[22,64,80],"control.":[23],"Their":[24],"mechanism":[25],"of":[26,86],"action":[27],"is":[28],"not":[29],"yet":[30],"fully":[31],"understood,":[32],"but":[33],"research":[34,52],"has":[35],"demonstrated":[36],"promising":[37],"results.":[38],"Despite":[39],"their":[40],"similarities,":[41],"they":[42],"have":[43,55,59],"been":[44,56],"used":[45],"combination":[47],"clinical":[50],"settings,":[53],"noted":[57],"to":[58,93,98],"a":[60,99],"synergistic":[61],"effect":[62],"control":[65],"without":[66],"concern":[67],"clinically":[69],"significant":[70],"pharmacokinetic":[71],"interactions.":[72],"This":[73],"combined":[74],"approach":[75],"can":[76],"be":[77],"valuable":[78],"management":[81],"by":[82],"reducing":[83],"the":[84],"dose":[85],"individual":[87],"agent,":[88],"its":[89],"side":[90],"effects,":[91],"enhance":[94],"therapeutic":[95],"response":[96],"compared":[97],"single":[100],"agent":[101],"resistant":[103],"cases.":[104]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2018-06-13T00:00:00"}