{"id":"https://openalex.org/W2805597488","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","title":"Re-Expression of Bone Marrow Proteoglycan-2 by 5-Azacytidine is associated with STAT3 Inactivation and Sensitivity Response to Imatinib in Resistant CML Cells","display_name":"Re-Expression of Bone Marrow Proteoglycan-2 by 5-Azacytidine is associated with STAT3 Inactivation and Sensitivity Response to Imatinib in Resistant CML Cells","publication_year":2018,"publication_date":"2018-06-25","ids":{"openalex":"https://openalex.org/W2805597488","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","mag":"2805597488","pmid":"https://pubmed.ncbi.nlm.nih.gov/29936783","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6103584"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5054303","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6103584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6103584","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003100188","display_name":"Hamid Ali Nagi Al\u2010Jamal","orcid":"https://orcid.org/0000-0001-6194-2729","observed_orcids":["https://orcid.org/0000-0001-6194-2729"]},"institutions":[{"id":"https://openalex.org/I51569856","display_name":"Sultan Zainal Abidin University","ror":"https://ror.org/00bnk2e50","country_code":"MY","type":"education","lineage":["https://openalex.org/I51569856"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Hamid Ali Nagi Al-Jamal","raw_affiliation_strings":["Diagnostic and Biomedicine, Faculty of Health Science, Universiti Sultan Zainal Abidin, Gong Badak Compus, Kuala Nerus, Terengganu, Malaysia. Email: aljamalhamid@unisza.edu.my"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diagnostic and Biomedicine, Faculty of Health Science, Universiti Sultan Zainal Abidin, Gong Badak Compus, Kuala Nerus, Terengganu, Malaysia. Email: aljamalhamid@unisza.edu.my","institution_ids":["https://openalex.org/I51569856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064396637","display_name":"Muhammad Farid Johan","orcid":"https://orcid.org/0000-0001-6344-0220","observed_orcids":["https://orcid.org/0000-0001-6344-0220"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Muhammad Farid Johan","raw_affiliation_strings":["Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia,Kubang Kerian, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia,Kubang Kerian, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058943535","display_name":"Siti Asmaa Mat Jusoh","orcid":"https://orcid.org/0000-0003-3827-7112","observed_orcids":["https://orcid.org/0000-0003-3827-7112"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Siti Asmaa Mat Jusoh","raw_affiliation_strings":["Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia,Kubang Kerian, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia,Kubang Kerian, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050871114","display_name":"Imilia Ismail","orcid":"https://orcid.org/0000-0002-3701-4006","observed_orcids":["https://orcid.org/0000-0002-3701-4006"]},"institutions":[{"id":"https://openalex.org/I51569856","display_name":"Sultan Zainal Abidin University","ror":"https://ror.org/00bnk2e50","country_code":"MY","type":"education","lineage":["https://openalex.org/I51569856"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Imilia Ismail","raw_affiliation_strings":["Diagnostic and Biomedicine, Faculty of Health Science, Universiti Sultan Zainal Abidin, Gong Badak Compus, Kuala Nerus, Terengganu, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diagnostic and Biomedicine, Faculty of Health Science, Universiti Sultan Zainal Abidin, Gong Badak Compus, Kuala Nerus, Terengganu, Malaysia","institution_ids":["https://openalex.org/I51569856"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063746643","display_name":"Wan Rohani Wan Taib","orcid":"https://orcid.org/0000-0001-9455-5768","observed_orcids":["https://orcid.org/0000-0001-9455-5768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wan Rohani Wan Taib","raw_affiliation_strings":["Institute for Community Health Development, Gong Badak Compus, Kuala Nerus, Terengganu, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Community Health Development, Gong Badak Compus, Kuala Nerus, Terengganu, Malaysia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8959,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74520534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"6","first_page":"1585","last_page":"1590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.640999972820282},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.7070000171661377},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/demethylation","display_name":"demethylation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.8185815811157227},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.684035062789917},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6835838556289673},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.5681886076927185},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.567088782787323},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5071310997009277},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.504332423210144},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4475984573364258},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4471490681171417},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.4375343322753906},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.433278352022171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4318326711654663},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4234890043735504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3309628367424011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32010209560394287},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3126777708530426},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2757665514945984},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.25338077545166016},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23921272158622742},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1928454041481018},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09018144011497498},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08465862274169922},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047093","descriptor_name":"Eosinophil Major Basic Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047093","descriptor_name":"Eosinophil Major Basic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5054303","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6103584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6103584","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6103584","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pac J Cancer Prev","raw_type":"Text"},{"id":"pmid:29936783","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29936783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"mag:2805597488","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29936783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5054303","doi":"https://doi.org/10.22034/apjcp.2018.19.6.1585","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6103584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W53373746","https://openalex.org/W135868982","https://openalex.org/W1968975746","https://openalex.org/W1970308473","https://openalex.org/W1974315755","https://openalex.org/W1976665551","https://openalex.org/W1980531181","https://openalex.org/W1986716910","https://openalex.org/W1986995673","https://openalex.org/W2004945687","https://openalex.org/W2016656445","https://openalex.org/W2020801853","https://openalex.org/W2039193356","https://openalex.org/W2044268362","https://openalex.org/W2047610364","https://openalex.org/W2052265257","https://openalex.org/W2055203083","https://openalex.org/W2059223797","https://openalex.org/W2069931679","https://openalex.org/W2080411938","https://openalex.org/W2082233303","https://openalex.org/W2082580993","https://openalex.org/W2083967825","https://openalex.org/W2091660633","https://openalex.org/W2096604601","https://openalex.org/W2103177765","https://openalex.org/W2106515248","https://openalex.org/W2107268345","https://openalex.org/W2108215899","https://openalex.org/W2113169665","https://openalex.org/W2114210071","https://openalex.org/W2114867684","https://openalex.org/W2138807703","https://openalex.org/W2140587516","https://openalex.org/W2145872889","https://openalex.org/W2153515209","https://openalex.org/W2167579899","https://openalex.org/W2182336002"],"related_works":["https://openalex.org/W2887774952","https://openalex.org/W2896585739","https://openalex.org/W2167579899","https://openalex.org/W2035655534","https://openalex.org/W2091447363","https://openalex.org/W4381597207","https://openalex.org/W2086773784","https://openalex.org/W271935301","https://openalex.org/W2479408098","https://openalex.org/W3013956679"],"abstract_inverted_index":{"Background:":[0],"Epigenetic":[1],"silencing":[2],"of":[3,14,17,27,35,40,71,95,123,132,147,197],"tumor":[4],"suppressor":[5],"genes":[6],"(TSG)":[7],"is":[8,19,50,176],"involved":[9],"in":[10,33,46,63,66,137,153,164],"development":[11],"and":[12,93,97,103,120,143,179],"progression":[13],"cancers.":[15],"Re-expression":[16],"TSG":[18,178],"inversely":[20],"proportionate":[21],"with":[22,75,91],"STAT3":[23,161,200],"signaling":[24],"pathways.":[25],"Demethylation":[26],"DNA":[28],"by":[29,42,101,111,127],"5-Azacytidine":[30],"(5-Aza)":[31],"results":[32],"re-expression":[34],"silenced":[36],"TSG.":[37],"Forced":[38],"expression":[39,107],"PRG2":[41,124,133,148,174,198],"5-Aza":[43,92],"induced":[44],"apoptosis":[45,98],"cancer":[47],"cells.":[48],"Imatinib":[49],"a":[51,177],"tyrosine":[52,60],"kinase":[53,61],"inhibitor":[54],"that":[55],"potently":[56],"inhibits":[57],"BCR/":[58],"ABL":[59],"resulting":[62],"hematological":[64],"remission":[65],"CML":[67,72,84],"patients.":[68],"However,":[69,187],"majority":[70],"patients":[73],"treated":[74,90],"imatinib":[76,88,96],"would":[77],"develop":[78],"resistance":[79],"under":[80],"prolonged":[81],"therapy.":[82],"Methods:":[83],"cells":[85,139,155,159,166],"resistant":[86],"to":[87,141,157,171,185,192],"were":[89,99],"cytotoxicity":[94],"determined":[100,126],"MTS":[102],"annexin-V,":[104],"respectively.":[105],"Gene":[106],"analysis":[108],"was":[109,125,134,150,162],"detected":[110],"real":[112],"time-PCR,":[113],"STATs":[114],"activity":[115],"examined":[116],"using":[117],"Western":[118],"blot":[119],"methylation":[121],"status":[122],"pyrosequencing":[128],"analysis.":[129],"Result:":[130],"Expression":[131],"significantly":[135,151],"higher":[136,169],"K562-R+5-Aza":[138,154,165],"compared":[140,156],"K562":[142],"K562-R":[144],"(p=0.001).":[145],"Methylation":[146],"gene":[149,175],"decreased":[152],"other":[158],"(p=0.021).":[160],"inactivated":[163],"which":[167],"showed":[168],"sensitivity":[170,184],"imatinib.":[172,186],"Conclusion:":[173],"its":[180],"overexpression":[181],"might":[182],"induce":[183],"further":[188],"studies":[189],"are":[190],"required":[191],"evaluate":[193],"the":[194],"negative":[195],"regulations":[196],"on":[199],"signaling.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}
