{"id":"https://openalex.org/W2805586956","doi":"https://doi.org/10.1055/s-0038-1655768","title":"Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy of the Neonatal Bowel: Novel, Bedside, Noninvasive, and Radiation-Free Imaging for Early Detection of Necrotizing Enterocolitis","display_name":"Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy of the Neonatal Bowel: Novel, Bedside, Noninvasive, and Radiation-Free Imaging for Early Detection of Necrotizing Enterocolitis","publication_year":2018,"publication_date":"2018-05-31","ids":{"openalex":"https://openalex.org/W2805586956","doi":"https://doi.org/10.1055/s-0038-1655768","mag":"2805586956","pmid":"https://pubmed.ncbi.nlm.nih.gov/29852509"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1655768","doi":"https://doi.org/10.1055/s-0038-1655768","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1655768","pdf_url":null,"source":{"id":"https://openalex.org/S82239980","display_name":"American Journal of Perinatology","issn_l":"0735-1631","issn":["0735-1631","1098-8785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Perinatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052893967","display_name":"Suzanne Al-Hamad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Al-Hamad","raw_affiliation_strings":["Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083298871","display_name":"David Joel Hackam","orcid":"https://orcid.org/0000-0001-5195-8807","observed_orcids":["https://orcid.org/0000-0001-5195-8807"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hackam","raw_affiliation_strings":["Division of Pediatric Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091871828","display_name":"Seth D. Goldstein","orcid":"https://orcid.org/0000-0001-7806-4109","observed_orcids":["https://orcid.org/0000-0001-7806-4109"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Goldstein","raw_affiliation_strings":["Division of Pediatric Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074269614","display_name":"Thierry A.G.M. Huisman","orcid":"https://orcid.org/0000-0003-2302-6724","observed_orcids":["https://orcid.org/0000-0003-2302-6724"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thierry Huisman","raw_affiliation_strings":["Division of Pediatric Radiology and Pediatric Neuroradiology, Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Radiology and Pediatric Neuroradiology, Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034326186","display_name":"Kassa Darge","orcid":"https://orcid.org/0000-0002-8989-6485","observed_orcids":["https://orcid.org/0000-0002-8989-6485"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kassa Darge","raw_affiliation_strings":["Division of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026999160","display_name":"Misun Hwang","orcid":"https://orcid.org/0000-0002-0125-2686","observed_orcids":["https://orcid.org/0000-0002-0125-2686"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Misun Hwang","raw_affiliation_strings":["Division of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9858,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.89765055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"35","issue":"14","first_page":"1358","last_page":"1365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/contrast-enhanced-ultrasound","display_name":"contrast-enhanced ultrasound","score":0.9710000157356262},{"id":"https://openalex.org/keywords/near-infrared-spectroscopy","display_name":"near-infrared spectroscopy","score":1.0},{"id":"https://openalex.org/keywords/bowel-perfusion","display_name":"bowel perfusion","score":0.9229999780654907},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.5799999833106995},{"id":"https://openalex.org/keywords/ischemic-bowel","display_name":"ischemic bowel","score":0.4959999918937683},{"id":"https://openalex.org/keywords/abdominal-ultrasound","display_name":"abdominal ultrasound","score":0.5770000219345093},{"id":"https://openalex.org/keywords/radiation-free-imaging","display_name":"radiation-free imaging","score":0.8309999704360962},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9550530910491943},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.861923098564148},{"id":"https://openalex.org/C2779585989","wikidata":"https://www.wikidata.org/wiki/Q500458","display_name":"Contrast-enhanced ultrasound","level":3,"score":0.7074737548828125},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5906373858451843},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5612298250198364},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.487710565328598},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3949497938156128},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21952733397483826}],"mesh":[{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0038-1655768","doi":"https://doi.org/10.1055/s-0038-1655768","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1655768","pdf_url":null,"source":{"id":"https://openalex.org/S82239980","display_name":"American Journal of Perinatology","issn_l":"0735-1631","issn":["0735-1631","1098-8785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Perinatology","raw_type":"journal-article"},{"id":"pmid:29852509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29852509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of perinatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W103067337","https://openalex.org/W121181338","https://openalex.org/W1510513224","https://openalex.org/W1539576925","https://openalex.org/W1611516688","https://openalex.org/W1964986858","https://openalex.org/W1975608290","https://openalex.org/W1978958068","https://openalex.org/W1979464227","https://openalex.org/W2007136466","https://openalex.org/W2015331068","https://openalex.org/W2019210168","https://openalex.org/W2022980575","https://openalex.org/W2031499328","https://openalex.org/W2032865283","https://openalex.org/W2037108148","https://openalex.org/W2040138419","https://openalex.org/W2040652733","https://openalex.org/W2073248141","https://openalex.org/W2076683726","https://openalex.org/W2087469005","https://openalex.org/W2095755613","https://openalex.org/W2115916838","https://openalex.org/W2119207044","https://openalex.org/W2155127918","https://openalex.org/W2157716742","https://openalex.org/W2167989433","https://openalex.org/W2214734410","https://openalex.org/W2315136101","https://openalex.org/W2419639934","https://openalex.org/W2508979238","https://openalex.org/W2512327724","https://openalex.org/W2549347129","https://openalex.org/W2586581711","https://openalex.org/W2593710527"],"related_works":["https://openalex.org/W4221038890","https://openalex.org/W7163868786","https://openalex.org/W7152957226","https://openalex.org/W4405316951","https://openalex.org/W3205635820","https://openalex.org/W2549347129","https://openalex.org/W1979464227","https://openalex.org/W4223894591","https://openalex.org/W4220677653","https://openalex.org/W4297520071"],"abstract_inverted_index":{"Despite":[0],"extensive":[1],"research":[2],"and":[3,13,32,40,49,57,88,92,153,160,166,178],"improvements":[4],"in":[5,37,64,120,139,142,150,174],"the":[6,11,24,86,134,145,156,164,175],"field":[7],"of":[8,30,85,90,109,124,128,137,147,158,169,180],"neonatal":[9],"care,":[10],"morbidity":[12,39],"mortality":[14,41],"associated":[15,42],"with":[16,43],"necrotizing":[17],"enterocolitis":[18],"(NEC)":[19],"have":[20,67],"remained":[21],"unchanged":[22],"over":[23,76],"past":[25],"three":[26],"decades.":[27],"Early":[28],"detection":[29,123,168],"ischemia":[31],"necrotic":[33],"bowel":[34,140,171],"is":[35,112,131],"vital":[36],"improving":[38,121],"NEC;":[44],"however,":[45],"strategies":[46],"for":[47,106],"predicting":[48],"preventing":[50],"NEC":[51],"are":[52,61],"lacking.":[53],"Contrast-enhanced":[54],"ultrasound":[55,78],"(CEUS)":[56],"near-infrared":[58],"spectroscopy":[59],"(NIRS)":[60],"novel":[62],"techniques":[63],"pediatrics":[65],"that":[66,116],"been":[68,98],"proven":[69],"as":[70,100],"safe":[71],"modalities.":[72],"CEUS":[73,159],"has":[74,97,117],"benefits":[75],"conventional":[77],"(US)":[79],"by":[80],"its":[81],"improved":[82],"real-time":[83],"evaluation":[84,108],"micro-":[87],"macrovascularities":[89],"normally":[91],"abnormally":[93],"perfused":[94],"tissue.":[95],"US":[96,149],"implemented":[99],"a":[101],"useful":[102],"adjunct":[103],"to":[104,132],"X-ray":[105],"earlier":[107],"NEC.":[110,125,181],"NIRS":[111,161],"another":[113],"noninvasive":[114],"technique":[115],"shown":[118],"promise":[119],"early":[122,167],"The":[126],"purpose":[127],"this":[129],"article":[130],"review":[133],"current":[135],"understanding":[136],"changes":[138],"perfusion":[141,173],"NEC,":[143,152],"discuss":[144],"accuracy":[146],"abdominal":[148],"detecting":[151],"explain":[154],"how":[155],"use":[157],"will":[162],"enhance":[163],"precise":[165],"altered/pathological":[170],"wall":[172],"initial":[176],"development":[177],"course":[179]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}