{"id":"https://openalex.org/W280552647","doi":null,"title":"Does the expression of BCL2 have prognostic significance in malignant peritoneal mesothelioma?","display_name":"Does the expression of BCL2 have prognostic significance in malignant peritoneal mesothelioma?","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W280552647","mag":"280552647","pmid":"https://pubmed.ncbi.nlm.nih.gov/23841030","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696537"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2700472","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3696537","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3696537","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113091248","display_name":"Krishna Pillai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210123059","display_name":"St George Hospital","ror":"https://ror.org/02pk13h45","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210123059"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Krishna Pillai","raw_affiliation_strings":["Department of Surgery, St. George Hospital, University of New South Wales Kogarah, NSW 2217, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. George Hospital, University of New South Wales Kogarah, NSW 2217, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210123059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062094407","display_name":"Mohammad H. Pourgholami","orcid":"https://orcid.org/0000-0002-1158-801X","observed_orcids":["https://orcid.org/0000-0002-1158-801X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad H Pourgholami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061945795","display_name":"Terence C. Chua","orcid":"https://orcid.org/0000-0002-4263-1017","observed_orcids":["https://orcid.org/0000-0002-4263-1017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terence C Chua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083810235","display_name":"David Lawson Morris","orcid":"https://orcid.org/0000-0001-9377-8521","observed_orcids":["https://orcid.org/0000-0001-9377-8521"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L Morris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5934,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.81385712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"3","first_page":"312","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-peritoneal-mesothelioma","display_name":"malignant peritoneal mesothelioma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8320000171661377},{"id":"https://openalex.org/keywords/anti-apoptotic-proteins","display_name":"anti-apoptotic proteins","score":0.7400000095367432},{"id":"https://openalex.org/keywords/asbestos-exposure","display_name":"asbestos exposure","score":0.7049999833106995},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5460000038146973},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.7039999961853027},{"id":"https://openalex.org/keywords/sarcomatoid-histology","display_name":"sarcomatoid histology","score":0.8859999775886536},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7785246968269348},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.667154848575592},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6621131896972656},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.5737738013267517},{"id":"https://openalex.org/C2778995398","wikidata":"https://www.wikidata.org/wiki/Q7168876","display_name":"Peritoneal mesothelioma","level":3,"score":0.5602373480796814},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5534708499908447},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.5212098360061646},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.49938011169433594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4774209260940552},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4559805989265442},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45146444439888},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41979289054870605},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4101332128047943}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2700472","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3696537","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3696537","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696537","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:23841030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23841030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:280552647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23841030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2700472","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3696537","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W43675158","https://openalex.org/W1867879258","https://openalex.org/W1892496998","https://openalex.org/W1962741441","https://openalex.org/W1965686174","https://openalex.org/W1967354499","https://openalex.org/W1969761720","https://openalex.org/W1977258127","https://openalex.org/W1984985329","https://openalex.org/W1995775226","https://openalex.org/W2007431287","https://openalex.org/W2008945391","https://openalex.org/W2017605778","https://openalex.org/W2020001674","https://openalex.org/W2020402295","https://openalex.org/W2021125112","https://openalex.org/W2025390494","https://openalex.org/W2028162650","https://openalex.org/W2044129652","https://openalex.org/W2046839020","https://openalex.org/W2056020287","https://openalex.org/W2057257609","https://openalex.org/W2065721692","https://openalex.org/W2070794718","https://openalex.org/W2071450046","https://openalex.org/W2072998066","https://openalex.org/W2082803176","https://openalex.org/W2087877138","https://openalex.org/W2099302662","https://openalex.org/W2101798074","https://openalex.org/W2108081829","https://openalex.org/W2117046140","https://openalex.org/W2140420106","https://openalex.org/W2143209174","https://openalex.org/W2152990698","https://openalex.org/W2163003999","https://openalex.org/W2163039827","https://openalex.org/W2164878282","https://openalex.org/W2166116307","https://openalex.org/W2168362647","https://openalex.org/W2169403679","https://openalex.org/W2186526646","https://openalex.org/W2231000545","https://openalex.org/W2396428164","https://openalex.org/W2399288709","https://openalex.org/W2427228670"],"related_works":["https://openalex.org/W304802472","https://openalex.org/W4375861467","https://openalex.org/W1995762079","https://openalex.org/W1991220557","https://openalex.org/W2070794718","https://openalex.org/W2979107099","https://openalex.org/W2075807789","https://openalex.org/W3015090461","https://openalex.org/W2800488808","https://openalex.org/W3112520497"],"abstract_inverted_index":{"UNLABELLED:":[0],"Background":[1],"Malignant":[2],"peritoneal":[3,12],"mesothelioma":[4],"(MPM)":[5],"is":[6,15,24,67,220,240],"a":[7,68,165],"rare":[8],"neoplasm":[9],"of":[10,56,81,132,169,214,227],"the":[11,39,54,79,138,235],"membrane":[13],"that":[14,153,176,197],"causally":[16],"related":[17],"to":[18,77,102,104,142,164,231],"asbestos":[19],"exposure.":[20],"Survival":[21],"after":[22],"treatment":[23],"poor.":[25],"Current":[26],"therapy":[27],"involving":[28],"hyperthermic":[29],"intraperitoneal":[30],"chemotherapy":[31],"has":[32,52],"improved":[33],"survival":[34,147],"in":[35,47,72,83,95,137,154,245],"selective":[36],"patients.":[37],"In":[38],"past,":[40],"several":[41],"prognostic":[42,70,223],"factors":[43],"have":[44],"been":[45],"identified":[46],"MPM":[48],"patients":[49,163],"and":[50,59,86,100,110,117,183,202,249],"this":[51],"prompted":[53],"development":[55],"new":[57],"therapies":[58],"patient":[60,91],"management.":[61],"Since":[62],"BCL2,":[63,215],"an":[64,221,242],"antiapoptotic":[65],"oncoprotein,":[66],"favourable":[69,166],"factor":[71],"breast":[73],"cancer,":[74],"we":[75],"investigated":[76],"determine":[78,143],"significance":[80],"BCL2":[82,133,160,170,205,228,239],"MPM.":[84],"Materials":[85],"Methods":[87],"Forty":[88],"two":[89,120],"archival":[90],"tumour":[92],"sections":[93],"embedded":[94],"paraffin":[96],"blocks":[97],"were":[98,190],"sectioned":[99],"subjected":[101],"immunohistochemistry":[103],"detect":[105],"BCL2.":[106],"The":[107,130],"staining":[108],"intensity":[109],"abundance":[111],"was":[112,135,207],"classified":[113,118],"using":[114,145],"standard":[115],"procedures":[116],"into":[119],"groups":[121,134],"(0-4":[122],"=":[123,127],"low":[124],"&":[125],"5-8":[126],"high":[128,159,181,204,252],"expression).":[129],"distribution":[131],"examined":[136],"different":[139],"clinicopathological":[140,157,237],"categories":[141],"prognosis":[144,233],"Kaplan-Meier":[146],"analysis.":[148],"RESULTS:":[149],"Univariate":[150],"analysis":[151,173,195],"revealed":[152],"almost":[155],"all":[156,199,246],"categories,":[158],"expression":[161,206,253],"predisposed":[162],"prognosis.":[167,193,211,258],"Independent":[168],"expression,":[171],"univariate":[172],"also":[174,241],"showed":[175],"male":[177],"gender,":[178],"sarcomatoid":[179],"histology,":[180],"PCI":[182],"age":[184,216],"at":[185],"diagnosis":[186],"\u2265":[187,217],"60":[188,218],"years":[189,219],"associated":[191,208,255],"poor":[192],"Multivariate":[194],"indicated":[196],"for":[198],"tumours,":[200,247],"males":[201,248],"females,":[203,250],"with":[209,251,256],"good":[210,257],"Further,":[212],"independent":[213,243],"unfavourable":[222],"factor.":[224],"CONCLUSION:":[225],"Expression":[226],"may":[229],"serve":[230],"distinguish":[232],"within":[234],"individual":[236],"categories.":[238],"variable":[244],"being":[254]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
