{"id":"https://openalex.org/W2805484014","doi":"https://doi.org/10.1038/s41413-018-0013-z","title":"SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity","display_name":"SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity","publication_year":2018,"publication_date":"2018-04-06","ids":{"openalex":"https://openalex.org/W2805484014","doi":"https://doi.org/10.1038/s41413-018-0013-z","mag":"2805484014","pmid":"https://pubmed.ncbi.nlm.nih.gov/29644115","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5886981"},"language":"en","primary_location":{"id":"doi:10.1038/s41413-018-0013-z","doi":"https://doi.org/10.1038/s41413-018-0013-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-018-0013-z","pdf_url":"https://www.nature.com/articles/s41413-018-0013-z.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41413-018-0013-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chunlin Zuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Chunlin Zuo","raw_affiliation_strings":["1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","9Present Address: Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022 China","Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"9Present Address: Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022 China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318868","display_name":"Lijun Wang","orcid":"https://orcid.org/0000-0002-0462-7033","observed_orcids":["https://orcid.org/0000-0002-0462-7033","https://orcid.org/0000-0001-6200-868X"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijun Wang","raw_affiliation_strings":["1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027534178","display_name":"Raghavendra M. Kamalesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghavendra M. Kamalesh","raw_affiliation_strings":["1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040083748","display_name":"Margot E. Bowen","orcid":"https://orcid.org/0000-0001-6391-5775","observed_orcids":["https://orcid.org/0000-0001-6391-5775"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margot E. Bowen","raw_affiliation_strings":["2Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115 USA","Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022646522","display_name":"Douglas C. Moore","orcid":"https://orcid.org/0000-0002-7649-695X","observed_orcids":["https://orcid.org/0000-0002-7649-695X"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas C. Moore","raw_affiliation_strings":["1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051277880","display_name":"Mark S. Dooner","orcid":"https://orcid.org/0000-0003-0653-6562","observed_orcids":["https://orcid.org/0000-0003-0653-6562"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Dooner","raw_affiliation_strings":["3Division of Hematology and Oncology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","Division of Hematology and Oncology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Hematology and Oncology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Division of Hematology and Oncology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029317871","display_name":"Anthony M. Reginato","orcid":"https://orcid.org/0000-0003-4658-4163","observed_orcids":["https://orcid.org/0000-0003-4658-4163"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony M. Reginato","raw_affiliation_strings":["4Division of Rheumatology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","Division of Rheumatology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Rheumatology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Division of Rheumatology, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035093874","display_name":"Qian Wu","orcid":"https://orcid.org/0000-0001-7815-522X","observed_orcids":["https://orcid.org/0000-0001-7815-522X"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Wu","raw_affiliation_strings":["5Department of Pathology and Laboratory Medicine, University of Connecticut Health Center, Farmington, CT 06030 USA","Department of Pathology and Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Pathology and Laboratory Medicine, University of Connecticut Health Center, Farmington, CT 06030 USA","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026630563","display_name":"Christoph Schorl","orcid":"https://orcid.org/0000-0001-6132-3581","observed_orcids":["https://orcid.org/0000-0001-6132-3581"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Schorl","raw_affiliation_strings":["6Department of Molecular and Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI 02912 USA","Department of Molecular and Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI, 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Molecular and Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI 02912 USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Molecular and Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI, 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039921012","display_name":"Yueming Song","orcid":"https://orcid.org/0000-0002-2377-0740","observed_orcids":["https://orcid.org/0000-0002-2377-0740"]},"institutions":[{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueming Song","raw_affiliation_strings":["7Department of Orthopedic Surgery, West China Hospital of Sichuan University, Chengdu, 610041 China","Department of Orthopedic Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Orthopedic Surgery, West China Hospital of Sichuan University, Chengdu, 610041 China","institution_ids":["https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054511395","display_name":"Matthew L. Warman","orcid":"https://orcid.org/0000-0003-2020-3449","observed_orcids":["https://orcid.org/0000-0003-2020-3449"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Warman","raw_affiliation_strings":["2Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115 USA","Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Orthopaedic Research Laboratories and Howard Hughes Medical Institute, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061899406","display_name":"Benjamin G. Neel","orcid":"https://orcid.org/0000-0002-9589-585X","observed_orcids":["https://orcid.org/0000-0002-9589-585X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin G. Neel","raw_affiliation_strings":["8Laura and Issac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016 USA","Laura and Issac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Laura and Issac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016 USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"raw_affiliation_string":"Laura and Issac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113213238","display_name":"Michael G. Ehrlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Ehrlich","raw_affiliation_strings":["1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071869928","display_name":"Wentian Yang","orcid":"https://orcid.org/0000-0002-2127-6239","observed_orcids":["https://orcid.org/0000-0002-2127-6239"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wentian Yang","raw_affiliation_strings":["1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903 USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI, 02903, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5071869928"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"],"apc_list":{"value":3405,"currency":"USD","value_usd":3405},"apc_paid":{"value":3405,"currency":"USD","value_usd":3405},"fwci":3.6168,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.92771182,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ptpn11","display_name":"PTPN11","score":0.9049999713897705},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pka-signaling","display_name":"PKA signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ossification","display_name":"ossification","score":0.6669999957084656},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.597000002861023},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2778486617","wikidata":"https://www.wikidata.org/wiki/Q18031654","display_name":"SOX9","level":4,"score":0.7257483005523682},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.6967534422874451},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.573479413986206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5637657046318054},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.534774124622345},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5340577363967896},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.501044511795044},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.48662886023521423},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.4686310291290283},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.4532639682292938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2849099040031433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2565072178840637},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15977239608764648}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/s41413-018-0013-z","doi":"https://doi.org/10.1038/s41413-018-0013-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-018-0013-z","pdf_url":"https://www.nature.com/articles/s41413-018-0013-z.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4823555","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5886981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5886981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5886981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Res","raw_type":"Text"},{"id":"pmid:29644115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29644115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone research","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/37067764","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37067764","pdf_url":"https://dash.harvard.edu/bitstreams/7312037e-b972-6bd4-e053-0100007fdf3b/download","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b2198d03bc674edcbc24d583ba66a159","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b2198d03bc674edcbc24d583ba66a159","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bone Research, Vol 6, Iss 1, Pp 1-13 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41413-018-0013-z","doi":"https://doi.org/10.1038/s41413-018-0013-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-018-0013-z","pdf_url":"https://www.nature.com/articles/s41413-018-0013-z.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1659864852","display_name":"COBRE for Skeletal Health and Repair","funder_award_id":"P20GM104937","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2205996562","display_name":"COBRE for Skeletal Health & Repair","funder_award_id":"P30GM122732","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2627839964","display_name":"Shp2 in Osteoclastogenesis and Bone Remodeling","funder_award_id":"R21AR057156","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2865270541","display_name":"Stem Cell Biology: New Directions in Clinical and Basic Research","funder_award_id":"P20RR025179","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2905029277","display_name":"Stem Cell Biology: New Directions in Clinical and Basic Research","funder_award_id":"P20GM103468","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3168195300","display_name":null,"funder_award_id":"NIAMS RO1AR066746","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G326027437","display_name":"Signal Transduction by Non-transmembrane PTPs","funder_award_id":"R37CA049152","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5911270718","display_name":null,"funder_award_id":"RO1AR066746","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6294532276","display_name":"Role of PTPN11 in Cartilage Stem Cells and Tumorigenesis","funder_award_id":"R01AR066746","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000258897","display_name":null,"funder_award_id":"CA49152","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320312470","display_name":"Pediatric Orthopaedic Society of North America","ror":"https://ror.org/05jf1d077"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805484014.pdf","grobid_xml":"https://content.openalex.org/works/W2805484014.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W18760785","https://openalex.org/W1488372279","https://openalex.org/W1521920146","https://openalex.org/W1542773988","https://openalex.org/W1574722884","https://openalex.org/W1611399137","https://openalex.org/W1963742875","https://openalex.org/W1963807629","https://openalex.org/W1979275431","https://openalex.org/W1980947337","https://openalex.org/W1982557817","https://openalex.org/W1989073601","https://openalex.org/W1990665236","https://openalex.org/W1993592731","https://openalex.org/W2000975356","https://openalex.org/W2003621498","https://openalex.org/W2011576192","https://openalex.org/W2011864853","https://openalex.org/W2014362480","https://openalex.org/W2014680491","https://openalex.org/W2015714994","https://openalex.org/W2019196925","https://openalex.org/W2019744993","https://openalex.org/W2022771831","https://openalex.org/W2023002592","https://openalex.org/W2023070796","https://openalex.org/W2026254620","https://openalex.org/W2027764467","https://openalex.org/W2029160837","https://openalex.org/W2034866998","https://openalex.org/W2037358338","https://openalex.org/W2037499635","https://openalex.org/W2039385299","https://openalex.org/W2040278668","https://openalex.org/W2042932723","https://openalex.org/W2051166632","https://openalex.org/W2062656093","https://openalex.org/W2068696415","https://openalex.org/W2069475583","https://openalex.org/W2071069669","https://openalex.org/W2071343874","https://openalex.org/W2072288858","https://openalex.org/W2086339368","https://openalex.org/W2087834037","https://openalex.org/W2088044493","https://openalex.org/W2088537912","https://openalex.org/W2091450174","https://openalex.org/W2091906478","https://openalex.org/W2100039503","https://openalex.org/W2104010513","https://openalex.org/W2104135721","https://openalex.org/W2108447730","https://openalex.org/W2108578539","https://openalex.org/W2110150849","https://openalex.org/W2112441454","https://openalex.org/W2116074901","https://openalex.org/W2120909571","https://openalex.org/W2122193693","https://openalex.org/W2127012014","https://openalex.org/W2129089132","https://openalex.org/W2136970568","https://openalex.org/W2138090110","https://openalex.org/W2138697615","https://openalex.org/W2139043745","https://openalex.org/W2140963908","https://openalex.org/W2143848166","https://openalex.org/W2147083273","https://openalex.org/W2150134228","https://openalex.org/W2154967508","https://openalex.org/W2155907836","https://openalex.org/W2156726032","https://openalex.org/W2167536088","https://openalex.org/W2171560127","https://openalex.org/W2323655309","https://openalex.org/W2468923062","https://openalex.org/W4210436031","https://openalex.org/W4211007637"],"related_works":["https://openalex.org/W2758808877","https://openalex.org/W4402194679","https://openalex.org/W2069475583","https://openalex.org/W3126078366","https://openalex.org/W2108578539","https://openalex.org/W2085017200","https://openalex.org/W4200161032","https://openalex.org/W2138895339","https://openalex.org/W2900923606","https://openalex.org/W3204309615"],"abstract_inverted_index":{"Abstract":[0],"Chondrocytes":[1],"and":[2,13,51,64,73,89,109,123,149,158],"osteoblasts":[3],"differentiate":[4],"from":[5],"a":[6,153],"common":[7],"mesenchymal":[8],"precursor,":[9],"the":[10,16,34,80,83,121,133],"osteochondroprogenitor":[11],"(OCP),":[12],"help":[14],"build":[15],"vertebrate":[17],"skeleton.":[18],"The":[19],"signaling":[20,135],"pathways":[21],"that":[22,68,114,140],"control":[23],"lineage":[24,44,147],"commitment":[25,45],"for":[26,144,156],"OCPs":[27,70],"are":[28],"incompletely":[29],"understood.":[30],"We":[31],"asked":[32],"whether":[33],"ubiquitously":[35],"expressed":[36],"protein-tyrosine":[37],"phosphatase":[38],"SHP2":[39,115,141],"(encoded":[40],"byPtpn11)":[41],"affects":[42],"skeletal":[43,145],"by":[46,101],"conditionally":[47],"deletingPtpn11in":[48],"mouse":[49],"limb":[50],"head":[52],"mesenchyme":[53],"using":[54],"\u201cCre-loxP\u201d-mediated":[55],"gene":[56,102],"excision.":[57],"SHP2-deficient":[58,69,97],"mice":[59],"have":[60],"increased":[61,95],"cartilage":[62,159],"mass":[63],"deficient":[65],"ossification,":[66],"suggesting":[67],"become":[71],"chondrocytes":[72],"not":[74],"osteoblasts.":[75],"Consistent":[76],"with":[77],"these":[78],"observations,":[79],"expression":[81,103],"of":[82,125],"master":[84],"chondrogenic":[85],"transcription":[86],"factor":[87],"SOX9":[88],"its":[90],"target":[91,155],"genesAcan,":[92],"Col2a1,":[93],"andCol10a1were":[94],"in":[96,106,130],"chondrocytes,":[98],"as":[99],"revealed":[100],"arrays,":[104],"qRT-PCR,":[105],"situ":[107],"hybridization,":[108],"immunostaining.":[110],"Mechanistic":[111],"studies":[112],"demonstrate":[113],"regulates":[116],"OCP":[117],"fate":[118],"determination":[119],"via":[120,132],"phosphorylation":[122],"SUMOylation":[124],"SOX9,":[126],"mediated":[127],"at":[128],"least":[129],"part":[131],"PKA":[134],"pathway.":[136],"Our":[137],"data":[138],"indicate":[139],"is":[142],"critical":[143],"cell":[146],"differentiation":[148],"could":[150],"thus":[151],"be":[152],"pharmacologic":[154],"bone":[157],"regeneration.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2018-06-13T00:00:00"}
