{"id":"https://openalex.org/W2805464456","doi":"https://doi.org/10.21037/tlcr.2018.05.11","title":"Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions","display_name":"Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2805464456","doi":"https://doi.org/10.21037/tlcr.2018.05.11","mag":"2805464456","pmid":"https://pubmed.ncbi.nlm.nih.gov/30050769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6037967"},"language":"en","primary_location":{"id":"doi:10.21037/tlcr.2018.05.11","doi":"https://doi.org/10.21037/tlcr.2018.05.11","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr.2018.05.11","pdf_url":"https://tlcr.amegroups.com/article/viewFile/21817/pdf","source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://tlcr.amegroups.com/article/viewFile/21817/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026197982","display_name":"Ryan Clay","orcid":"https://orcid.org/0000-0002-1720-569X","observed_orcids":["https://orcid.org/0000-0002-1720-569X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan Clay","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","Department of Pulmonary and Critical Care Medicine, 2Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, 2Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105788130","display_name":"Srinivasan Rajagopalan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivasan Rajagopalan","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110334084","display_name":"Ronald A. Karwoski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Karwoski","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030115976","display_name":"Fabien Maldonado","orcid":"https://orcid.org/0000-0002-6504-2063","observed_orcids":["https://orcid.org/0000-0002-6504-2063"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabien Maldonado","raw_affiliation_strings":["Department of Internal Medicine, Division of Allergy, Pulmonary and Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Allergy, Pulmonary and Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108726564","display_name":"Tobias Peikert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tobias Peikert","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","Department of Pulmonary and Critical Care Medicine, 2Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, 2Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084606087","display_name":"Brian J. Bartholmai","orcid":"https://orcid.org/0000-0001-7834-6579","observed_orcids":["https://orcid.org/0000-0001-7834-6579"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Bartholmai","raw_affiliation_strings":["Department of Radiology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026197982"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.2245,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.23758004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"313","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.625,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.625,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canaries","display_name":"canaries","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"quantitative computed tomography","score":0.550000011920929},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8510000109672546},{"id":"https://openalex.org/keywords/unsupervised-learning","display_name":"unsupervised learning","score":0.7879999876022339},{"id":"https://openalex.org/keywords/histopathological-correlation","display_name":"histopathological correlation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8659999966621399},{"id":"https://openalex.org/keywords/minimally-invasive-adenocarcinoma","display_name":"minimally invasive adenocarcinoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/adenocarcinoma-in-situ","display_name":"adenocarcinoma in situ","score":0.9900000095367432},{"id":"https://openalex.org/keywords/active-surveillance","display_name":"active surveillance","score":0.5929999947547913},{"id":"https://openalex.org/keywords/adjuvant-therapy-selection","display_name":"adjuvant therapy selection","score":0.9020000100135803},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.7409999966621399},{"id":"https://openalex.org/keywords/targeted-therapy-response","display_name":"targeted therapy response","score":0.6570000052452087},{"id":"https://openalex.org/keywords/pulmonary-nodule-segmentation","display_name":"lung nodule segmentation","score":0.5}],"concepts":[{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.8326719999313354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.818347692489624},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.530552864074707},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4953974485397339},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4671133756637573},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.44193384051322937},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3286857604980469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21292325854301453},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21204715967178345},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.09301650524139404},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/tlcr.2018.05.11","doi":"https://doi.org/10.21037/tlcr.2018.05.11","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr.2018.05.11","pdf_url":"https://tlcr.amegroups.com/article/viewFile/21817/pdf","source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5012367","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6037967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6037967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6037967","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Lung Cancer Res","raw_type":"Text"},{"id":"pmid:30050769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30050769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational lung cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/tlcr.2018.05.11","doi":"https://doi.org/10.21037/tlcr.2018.05.11","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr.2018.05.11","pdf_url":"https://tlcr.amegroups.com/article/viewFile/21817/pdf","source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805464456.pdf","grobid_xml":"https://content.openalex.org/works/W2805464456.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W130099911","https://openalex.org/W1501998941","https://openalex.org/W1840700012","https://openalex.org/W1929572668","https://openalex.org/W1965612776","https://openalex.org/W1966467711","https://openalex.org/W1974903221","https://openalex.org/W1979774070","https://openalex.org/W2002181866","https://openalex.org/W2009874304","https://openalex.org/W2021819819","https://openalex.org/W2027813187","https://openalex.org/W2031300874","https://openalex.org/W2033983059","https://openalex.org/W2043696829","https://openalex.org/W2049674541","https://openalex.org/W2069589718","https://openalex.org/W2079347556","https://openalex.org/W2081867011","https://openalex.org/W2089006509","https://openalex.org/W2090103410","https://openalex.org/W2103004421","https://openalex.org/W2104504726","https://openalex.org/W2106041937","https://openalex.org/W2107692993","https://openalex.org/W2110062437","https://openalex.org/W2118004874","https://openalex.org/W2132513126","https://openalex.org/W2139277921","https://openalex.org/W2142677314","https://openalex.org/W2160982674","https://openalex.org/W2162188634","https://openalex.org/W2165232124","https://openalex.org/W2208081170","https://openalex.org/W2235523093","https://openalex.org/W2253150690","https://openalex.org/W2313039124","https://openalex.org/W2318225718","https://openalex.org/W2321189687","https://openalex.org/W2329272877","https://openalex.org/W2333277922","https://openalex.org/W2372669185","https://openalex.org/W2582043099","https://openalex.org/W2735769336","https://openalex.org/W2749088284","https://openalex.org/W2775805938","https://openalex.org/W2805279773","https://openalex.org/W2805464456","https://openalex.org/W4406565004"],"related_works":["https://openalex.org/W2546039041","https://openalex.org/W2089006509","https://openalex.org/W3040766055","https://openalex.org/W2027813187","https://openalex.org/W1929572668","https://openalex.org/W4405012243","https://openalex.org/W3135135023","https://openalex.org/W2805279773","https://openalex.org/W3172988561","https://openalex.org/W2775805938"],"abstract_inverted_index":{"The":[0,124,261],"majority":[1],"of":[2,12,66,83,85,99,102,115,121,126,138,180,186,208,248],"incidentally":[3],"and":[4,24,37,50,78,162,177,183,226,241,282],"screen-detected":[5],"lung":[6,252],"cancers":[7],"are":[8],"adenocarcinomas.":[9],"Optimal":[10],"management":[11],"these":[13,127],"tumors":[14],"is":[15,29,54,174,218],"clinically":[16],"challenging":[17],"due":[18,211],"to":[19,171,212,229],"variability":[20],"in":[21,34,119,129,196,204,221,255,264,273,284],"tumor":[22,67,227],"histopathology":[23],"behavior.":[25],"Invasive":[26],"adenocarcinoma":[27,33,40,84,120,188,278,289],"(IA)":[28],"generally":[30],"aggressive":[31],"while":[32],"situ":[35],"(AIS)":[36],"minimally":[38],"invasive":[39],"(MIA)":[41],"may":[42,71,191,201,253],"be":[43,203,268],"extremely":[44],"indolent.":[45],"Computer":[46],"Aided":[47],"Nodule":[48],"Analysis":[49],"Risk":[51],"Yield":[52],"(CANARY)":[53],"a":[55,130],"quantitative":[56,243],"computed":[57],"tomography":[58],"(CT)":[59],"analysis":[60,70,237,247],"tool":[61],"that":[62,111,145],"allows":[63],"non-invasive":[64],"assessment":[65],"characteristics.":[68],"This":[69,105],"obviate":[72],"the":[73,80,86,103,113,122,159,205,209,233,249],"need":[74],"for":[75,279,290],"tissue":[76],"biopsy":[77],"facilitate":[79],"risk":[81],"stratification":[82],"lung.":[87,104,123],"CANARY":[88,139,154,190,236,265],"was":[89],"developed":[90],"by":[91],"unsupervised":[92],"machine":[93],"learning":[94],"techniques":[95,244],"using":[96],"CT":[97,116],"data":[98],"histopathologically-characterized":[100],"adenocarcinomas":[101],"technique":[106],"identified":[107],"9":[108],"distinct":[109,143],"exemplars":[110],"constitute":[112],"spectrum":[114],"features":[117,128],"found":[118],"distributions":[125],"nodule":[131],"correlate":[132],"with":[133,189,238],"histopathology.":[134],"Further":[135],"automated":[136],"clustering":[137],"nodules":[140],"defined":[141],"three":[142],"groups":[144],"have":[146],"distinctly":[147],"different":[148],"post-resection":[149],"disease":[150],"free":[151],"survival":[152],"(DFS).":[153],"has":[155],"been":[156],"validated":[157],"within":[158],"NLST":[160],"cohort":[161],"multiple":[163],"other":[164,242],"cohorts.":[165],"Using":[166],"semi-automated":[167],"segmentation":[168],"as":[169,246],"input":[170],"CANARY,":[172],"there":[173],"excellent":[175],"repeatability":[176],"interoperator":[178],"correlation":[179],"results.":[181],"Confirmation":[182],"longitudinal":[184],"tracking":[185],"indolent":[187],"ultimately":[192],"add":[193],"decision":[194],"support":[195],"nuanced":[197],"cases":[198],"where":[199],"surgery":[200],"not":[202],"best":[206],"interest":[207],"patient":[210],"competing":[213],"comorbidity.":[214],"Currently":[215],"under":[216],"investigation":[217,266,283],"CANARY's":[219],"role":[220],"detecting":[222],"differing":[223],"driver":[224],"mutations":[225],"response":[228],"targeted":[230],"chemotherapeutics.":[231],"Combining":[232],"results":[234],"from":[235],"clinical":[239],"information":[240],"such":[245],"tumor-free":[250],"surrounding":[251],"aid":[254],"building":[256],"more":[257],"powerful":[258],"predictive":[259],"models.":[260],"next":[262],"step":[263],"will":[267],"its":[269],"prospective":[270],"application,":[271],"both":[272],"selecting":[274,285],"low-risk":[275],"stage":[276,288],"1":[277],"active":[280],"surveillance":[281],"high-risk":[286],"early":[287],"adjuvant":[291],"therapy.":[292]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-13T00:00:00"}