{"id":"https://openalex.org/W2805462015","doi":"https://doi.org/10.1249/01.mss.0000536715.34904.a3","title":"Precapillary Pulmonary Hypertension in Heart Failure","display_name":"Precapillary Pulmonary Hypertension in Heart Failure","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2805462015","doi":"https://doi.org/10.1249/01.mss.0000536715.34904.a3","mag":"2805462015"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000536715.34904.a3","doi":"https://doi.org/10.1249/01.mss.0000536715.34904.a3","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000536715.34904.a3","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105405525","display_name":"Bryan J. Taylor","orcid":"https://orcid.org/0000-0001-5229-941X","observed_orcids":["https://orcid.org/0000-0001-5229-941X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Bryan J. Taylor","raw_affiliation_strings":["Mayo Clinic, Rochester, MN","Mayo Clinic, Rochester, MN; University of Leeds, Leeds, United Kingdom","University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN; University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816","https://openalex.org/I1330342723"]},{"raw_affiliation_string":"University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030461468","display_name":"Barry A. Borlaug","orcid":"https://orcid.org/0000-0001-9375-0596","observed_orcids":["https://orcid.org/0000-0001-9375-0596"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry A. Borlaug","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078732560","display_name":"Robert P. Frantz","orcid":"https://orcid.org/0000-0003-4128-3978","observed_orcids":["https://orcid.org/0000-0003-4128-3978"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Frantz","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew D. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Miller","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078998559","display_name":"Thomas Patrick Olson","orcid":"https://orcid.org/0000-0002-3446-0414","observed_orcids":["https://orcid.org/0000-0002-3446-0414"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Olson","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017952950","display_name":"Bruce D. Johnson","orcid":"https://orcid.org/0000-0002-6283-783X","observed_orcids":["https://orcid.org/0000-0002-6283-783X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Johnson","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"5S","first_page":"497","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combined-pre-and-post-capillary-pulmonary-hypertension","display_name":"combined pre- and post-capillary pulmonary hypertension","score":0.9399999976158142},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pulmonary-vasoconstriction","display_name":"pulmonary vasoconstriction","score":0.6349999904632568},{"id":"https://openalex.org/keywords/transpulmonary-gradient","display_name":"transpulmonary gradient","score":0.7990000247955322},{"id":"https://openalex.org/keywords/oxygen-desaturation","display_name":"oxygen desaturation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pulmonary-hemodynamics","display_name":"pulmonary hemodynamics","score":0.5490000247955322},{"id":"https://openalex.org/keywords/right-ventricular-function","display_name":"right ventricular function","score":0.5419999957084656},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.37299999594688416},{"id":"https://openalex.org/keywords/systemic-oxygenation","display_name":"systemic oxygenation","score":0.3959999978542328},{"id":"https://openalex.org/keywords/neurohormones","display_name":"neurohormones","score":0.6679999828338623},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.5339999794960022},{"id":"https://openalex.org/keywords/right-heart-catheterization","display_name":"right heart catheterization","score":0.734000027179718},{"id":"https://openalex.org/keywords/incremental-exercise","display_name":"incremental exercise","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7579545974731445},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7344363927841187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7333989143371582},{"id":"https://openalex.org/C146556889","wikidata":"https://www.wikidata.org/wiki/Q1414127","display_name":"Pulmonary wedge pressure","level":3,"score":0.732136070728302},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6318057775497437},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6242183446884155},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6183009147644043},{"id":"https://openalex.org/C2993634958","wikidata":"https://www.wikidata.org/wiki/Q2302681","display_name":"Right heart catheterization","level":3,"score":0.5103775858879089},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.4258309304714203}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000536715.34904.a3","doi":"https://doi.org/10.1249/01.mss.0000536715.34904.a3","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000536715.34904.a3","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2780205806","https://openalex.org/W3134244582","https://openalex.org/W2544840414","https://openalex.org/W4377292630","https://openalex.org/W2565137407","https://openalex.org/W2754602500","https://openalex.org/W2158171302","https://openalex.org/W3109074982","https://openalex.org/W2097841320","https://openalex.org/W2283716994"],"abstract_inverted_index":{"Combined":[0],"pre-":[1],"and":[2,15,65,70,106,111,123,133,166,176,186,199,209,243,266,285,297,306,360,392,405],"post-capillary":[3,152],"pulmonary":[4,45,78,402,408],"hypertension":[5],"(CpcPH)":[6],"develops":[7],"in":[8,33,50,83,170,213,245,274,291,315,373,378,385,414,418],"10-40%":[9],"of":[10,20,31,41,68,74,101,301,376,388,396],"heart":[11],"failure":[12],"(HF)":[13],"patients":[14,89,141],"is":[16,398],"a":[17,371,382,406],"powerful":[18],"predictor":[19],"short-term":[21],"mortality.":[22],"However,":[23],"the":[24,28,39,44,59,66,72,77,99,246,302,355,374,389,394],"mechanisms":[25],"that":[26],"underpin":[27],"pathophysiological":[29],"development":[30,375,395],"CpcPH":[32,42,75,159,171,214,247,275,292,316,361,377,397],"HF":[34,51,84,88,419],"remain":[35],"elusive.":[36],"In":[37],"addition,":[38],"impact":[40,73],"on":[43,76],"haemodynamic":[46,79],"response":[47,80,415],"to":[48,81,173,239,294,416],"exercise":[49,82,312,417],"requires":[52],"further":[53],"investigation.":[54],"PURPOSE:":[55],"To":[56],"determine":[57],"1)":[58,366],"relationship":[60,310,413],"between":[61,357],"systemic":[62],"oxygen":[63],"levels":[64],"presence":[67],"CpcPH;":[69],"2)":[71,393],"patients.":[85,420],"METHODS:":[86],"Thirty-nine":[87],"undergoing":[90],"right-heart":[91],"catheterisation":[92],"were":[93,129,142,168,211,289,362],"studied.":[94],"Blood":[95],"was":[96,236,313],"drawn":[97],"for":[98],"determination":[100],"PaO2,":[102,240,260],"SaO2,":[103,242],"PvO2,":[104,241,261],"SvO2,":[105],"vasoactive":[107],"neurohormones.":[108],"Pulmonary":[109],"arterial":[110],"wedge":[112],"pressure":[113,117],"(PAP;":[114],"PWP),":[115],"transpulmonary":[116],"gradient":[118],"(TPG;":[119],"PAP":[120,283],"-":[121],"PWP)":[122],"cardiac":[124],"output":[125],"(Q[Combining":[126],"Dot":[127,304,308,323,339,411],"Above])":[128],"assessed":[130],"at":[131],"rest":[132],"throughout":[134],"exhaustive":[135],"incremental":[136],"exercise.":[137],"RESULTS:":[138],"Post":[139],"catheterization,":[140],"classified":[143],"as":[144],"having":[145],"no":[146,174,216,295,320,358],"PH":[147,153,175,217,296,321,359],"(n":[148,155,160],"=":[149,156,161,269],"11),":[150,157],"isolated":[151],"(IpcPH)":[154],"or":[158],"17).":[162],"At":[163,279],"rest:":[164],"PaO2":[165],"PvO2":[167],"lower":[169,212],"compared":[172,293],"IpcPH":[177,318],"(65":[178],"\u00b1":[179,183,188,192,196,201,219,223,226,230,326,330,334,342,346,350],"9":[180],"vs":[181,194,221,228,317,319,328,332,344,348],"78":[182],"11":[184],"mmHg":[185,198],"75":[187],"14":[189],"mmHg;":[190,203],"29":[191],"4":[193],"36":[195],"3":[197],"33":[200],"2":[202],"P":[204,232,252],"<":[205,233,253,272],"0.05).":[206,234,254],"Also,":[207],"SaO2":[208],"SvO2":[210,244,262],"vs.":[215],"(93":[218],"3%":[220],"96":[222],"3%;":[224],"51":[225],"11%":[227],"68":[229],"4%;":[231],"TPG":[235,267],"inversely":[237],"related":[238],"only":[248,354],"(r":[249,263,268],"\u2264":[250,264],"-0.557;":[251],"Similarly,":[255],"plasma":[256],"endothelin-1":[257],"correlated":[258],"with":[259,400],"-0.495)":[265],"0.662)":[270],"(P":[271],"0.05)":[273],"only.":[276],"With":[277],"exercise:":[278],"peak":[280],"exercise,":[281],"mean":[282,286],"(mPAP)":[284],"PWP":[287],"(mPWP)":[288],"greater":[290,314,401],"IpcPH.":[298],"The":[299],"slope":[300],"mPAP-Q[Combining":[303],"Above]":[305,309,412],"mPWP-Q[Combining":[307,338],"during":[311],"(mPAP-Q[Combining":[322],"Above]:":[324,340],"6.7":[325],"3.2":[327],"4.1":[329],"3.9":[331],"2.6":[333],"1.7":[335],"mmHg/L/":[336],"min;":[337],"4.2":[341],"1.4":[343],"3.3":[345],"1.2":[347],"2.9":[349],"1.5":[351],"mmHg/L/min);":[352],"however,":[353],"differences":[356],"statistically":[363],"significant.":[364],"CONCLUSION:":[365],"Systemic":[367],"hypoxaemia":[368],"may":[369],"play":[370],"role":[372],"HF,":[379],"potentially":[380],"via":[381],"hypoxia-induced":[383],"increase":[384],"endothelial":[386],"release":[387],"vasoconstrictor":[390],"endothelin-1;":[391],"associated":[399],"vascular":[403,409],"pressures":[404],"steeper":[407],"pressure-to-Q[Combining":[410]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-06-13T00:00:00"}